Focal eosinophilic infiltration of the liver, benign or malignant?

Eosinophilic gastritis often presents with gastrointestinal symptoms in the absence of abnormal endoscopic findings. On the other hand, endoscopic changes due to eosinophilic infiltration in an asymptomatic patient are rare. A 29-year-old woman with a history of asthma on steroid inhalers presented for an annual medical checkup. Esophagogastroduodenoscopy revealed diffuse white granular patches in the body of the stomach, suggestive of eosinophilic gastritis. Histology showed over 100 eosinophils per high-power field, also consistent with eosinophilic gastritis. As the absence of symptoms precluded the diagnosis of eosinophilic gastritis, the patient was diagnosed with asymptomatic eosinophilic infiltration of the stomach.

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Bronchial eosinophilic infiltration in Crohn's disease

Gastroenterology ◽

10.1016/s0016-5085(98)84177-2 ◽

1998 ◽

Vol 114 ◽

pp. A1027

Author(s):

E Louis ◽

R Louis ◽

J Shute ◽

L Lau ◽

D Franchimont ◽

...

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Eosinophilic Infiltration

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EOSINOPHILIC INFILTRATION OF THE STOMACH.

ANZ Journal of Surgery ◽

10.1111/j.1445-2197.1962.tb06319.x ◽

1962 ◽

Vol 32 (1) ◽

pp. 66-74 ◽

Cited By ~ 7

Author(s):

J. B. Blackwell ◽

A. Gild

Keyword(s):

Eosinophilic Infiltration

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EOSINOPHILIC INFILTRATION OF THE GASTRIC WALL WITH FEATURES REMINISCENT OF CANCER

Allergy ◽

10.1111/j.1398-9995.1960.tb03625.x ◽

1960 ◽

Vol 15 (2) ◽

pp. 113-123 ◽

Cited By ~ 2

Author(s):

B. SUNDBERG ◽

V. BACKLUND ◽

H. COLLDAHL ◽

O. SCHUBERTH

Keyword(s):

Gastric Wall ◽

Eosinophilic Infiltration

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EOSINOPHILIC GASTRITIS IN CHILDREN: MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL DIAGNOSTIC CRITERIA

Wiadomości Lekarskie ◽

10.36740/wlek202107129 ◽

2021 ◽

Vol 74 (7) ◽

pp. 1722-1727

Author(s):

Vira I. Bobrova ◽

Anastasia O. Horobets ◽

Julia I. Proshchenko ◽

Ludmila O. Levadna ◽

Zoriana V. Selska

Keyword(s):

Lamina Propria ◽

Collagen Type ◽

Morphological Changes ◽

Prognostic Index ◽

Lymphocytic Infiltration ◽

Eosinophilic Infiltration ◽

Nuclear Antigen ◽

Collagen Type Iv ◽

Eosinophilic Gastritis ◽

Type Iv

The aim: To study peculiarities of morphological and immunohistochemical changes of stomach’s mucosa in eosinophilic gastritis in children Materials and methods: 64.1±6.0% patients with eosinophilic gastritis and 35.9±6.0% patients with lymphocytic gastritis participated in our investigation. In order to verify the diagnosis morphological and immunohistochemical diagnostics of the stomach’s mucosa was performed in all children. To assess morphological changes in tissues the specimens were colored with hematoxylin, eosin and picrofuchsin by van Gieson’s. Indirect streptavidin-peroxydase staining method was used for immunohistochemical investigation and the following indexes were assessed: proliferating cell nuclear antigen – PCNA, Bcl – 2, Вax, Collagen Type ІV, TGFβ and NF-κβ. Results: Comparative analysis of morphologic investigation has demonstrated that eosinophilic gastritis is characterized by fibrosis and fibroblasts proliferation into basal and superficial parts of mucosa’s lamina propria, multiple hemorrhages, thrombosis and erosions on the background of eosinophilic infiltration. Immunohistochemical indexes of cellular restoration in eosinophilic gastritis are characterized by increased proliferative activity and decreased indexes of proapoptotic and antiapoptotic activity. Prevalence of the reaction with the use of monoclonal antibodies to Collagen Type IV in majority of children with eosinophilic gastritis was characterized by separate fragmented foci in basal membranes of superficial epithelium. Remarkable TGFβ immune coloration was detected in majority of children on the background of fibrosis and eosinophilic infiltration of lamina propria. NF-κβ expression in epitheliocytes’ cytoplasm and nuclei was uneven. Homogenous remarkable coloration was detected in majority of patients with lymphocytic infiltration of mucosa. Conclusions: Eosinophilic gastritis course in children is characterized by remarkable inflammation, decreased regeneration of the mucosa, impairment of cellular restoration which is prognostic index of fibrous remodeling development.

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Eosinophilic Pancreatitis Mimicking Pancreatic Neoplasia

Canadian Journal of Gastroenterology ◽

10.1155/2006/386918 ◽

2006 ◽

Vol 20 (5) ◽

pp. 361-364 ◽

Cited By ~ 19

Author(s):

Ali Cay ◽

Mustafa Imamoglu ◽

Umit Cobanoglu

Keyword(s):

Immunoglobulin E ◽

Hypereosinophilic Syndrome ◽

Clinical Manifestations ◽

Oral Prednisolone ◽

Pancreatic Mass ◽

Eosinophilic Infiltration ◽

Oral Steroid ◽

Surgical Biopsy ◽

Pancreatic Tumour ◽

Oral Steroid Therapy

Eosinophilic pancreatitis (EP) is a rare disease. It typically occurs in the setting of either eosinophilic gastroenteritis or the hypereosinophilic syndrome. Isolated eosinophilic infiltration of the pancreas is less common. EP usually presents as a pancreatic tumour with abdominal pain and/or obstructive jaundice. The diagnosis is often not made until after pancreatic resection under suspicion of a pancreatic tumour.The case of a 14-year-old boy whose initial presentation was suggestive of a pancreatic tumour is reported. Radiological evaluation revealed a pancreatic mass suggestive of a pancreatic tumour obstructing the duodenum and common bile duct. The patient underwent surgery and a gastrojejunal anostomosis, tube cholecystostomy and biopsy were performed with no postoperative complications. The diagnosis of EP was established after surgical biopsy. The biopsy specimen revealed prominent eosinophilic infiltration. Serum immunoglobulin E levels were elevated. The patient was treated with oral prednisolone (40 mg/day). After two months of oral steroid therapy, clinical manifestations rapidly improved and peripheral eosinophilia subsided. Computed tomography scan revealed remission of the pancreatic mass-like lesion.

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