scholarly journals Effect of fish oil and telmisartan on dehydroepiandrosterone‐induced polycystic ovarian syndrome in rats: The role of oxidative stress, transforming growth factor beta‐1, and nuclear factor kappa B

2020 ◽  
Vol 8 (9) ◽  
pp. 5149-5159
Author(s):  
Ahmed M. Kabel ◽  
Ahmed M. Ashour ◽  
Mohamed S. Omar ◽  
Remon S. Estfanous
Keyword(s):  
Oxidative Stress ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Nuclear Factor Kappa B ◽  
Polycystic Ovarian Syndrome ◽  
Transforming Growth Factor ◽  
Nuclear Factor ◽  
Growth Factor Beta ◽  
Ovarian Syndrome

Cellular and molecular mechanisms of chronic rhinosinusitis and potential therapeutic strategies: review on cytokines, nuclear factor kappa B and transforming growth factor beta

2015 ◽  
Vol 129 (S3) ◽  
pp. S2-S7 ◽  
Author(s):  
N T Phan ◽  
P J Cabot ◽  
B D Wallwork ◽  
A U Cervin ◽  
B J Panizza
Keyword(s):  
Growth Factor ◽  
Chronic Rhinosinusitis ◽  
Transforming Growth Factor Beta ◽  
Nuclear Factor Kappa B ◽  
Transforming Growth Factor ◽  
Therapeutic Strategies ◽  
Nuclear Factor ◽  
T Helper ◽  
Nuclear Factor Kappa ◽  
Growth Factor Beta

AbstractBackground:Chronic rhinosinusitis is characterised by persistent inflammation of the sinonasal mucosa. Multiple pathophysiological mechanisms are likely to exist. Previous research has focused predominantly on T-helper type cytokines to highlight the inflammatory mechanisms. However, proteins such as nuclear factor kappa B and transforming growth factor beta are increasingly recognised to have important roles in sinonasal inflammation and tissue remodelling.Objective:This review article explores the roles of T-helper type cytokines, nuclear factor kappa B and transforming growth factor beta in the pathophysiological mechanisms of chronic rhinosinusitis. An understanding of these mechanisms will allow for better identification and classification of chronic rhinosinusitis endotypes, and, ultimately, improved therapeutic strategies.

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