Histo-Blood Group Antigen and Human Milk Oligosaccharides

2004 ◽  
pp. 135-143 ◽  
Author(s):  
Jacques Le Pendu
Keyword(s):  
Human Milk ◽  
Blood Group ◽  
Blood Group Antigen ◽  
Human Milk Oligosaccharides ◽  
Milk Oligosaccharides

scholarly journals Avidity of α-fucose on human milk oligosaccharides and blood group–unrelated oligo/polyfucoses is essential for potent norovirus-binding targets

2018 ◽  
Vol 293 (30) ◽  
pp. 11955-11965 ◽  
Author(s):  
Franz-Georg Hanisch ◽  
Grant S. Hansman ◽  
Vasily Morozov ◽  
Clemens Kunz ◽  
Horst Schroten
Keyword(s):  
Human Milk ◽  
Blood Group ◽  
Human Milk Oligosaccharides ◽  
Milk Oligosaccharides

scholarly journals Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides

2016 ◽  
Vol 90 (9) ◽  
pp. 4843-4848 ◽  
Author(s):  
Stefan Weichert ◽  
Anna Koromyslova ◽  
Bishal K. Singh ◽  
Satoko Hansman ◽  
Stefan Jennewein ◽  
...  
Keyword(s):  
Human Milk ◽  
Blood Group ◽  
Structural Basis ◽  
Blood Group Antigens ◽  
Human Milk Oligosaccharides ◽  
Milk Oligosaccharides ◽  
X Ray ◽  
X Ray Crystallography ◽  
Naturally Occurring

Histo-blood group antigens (HBGAs) are important binding factors for norovirus infections. We show that two human milk oligosaccharides, 2′-fucosyllactose (2′FL) and 3-fucosyllactose (3FL), could block norovirus from binding to surrogate HBGA samples. We found that 2′FL and 3FL bound at the equivalent HBGA pockets on the norovirus capsid using X-ray crystallography. Our data revealed that 2′FL and 3FL structurally mimic HBGAs. These results suggest that 2′FL and 3FL might act as naturally occurring decoys in humans.

scholarly journals Human Norovirus Interactions with Histo-Blood Group Antigens and Human Milk Oligosaccharides

2016 ◽  
Vol 90 (13) ◽  
pp. 5855-5859 ◽  
Author(s):  
Horst Schroten ◽  
Franz-Georg Hanisch ◽  
Grant S. Hansman
Keyword(s):  
Virus Infection ◽  
Human Milk ◽  
Blood Group ◽  
Blood Group Antigens ◽  
Human Milk Oligosaccharides ◽  
Binding Studies ◽  
Human Norovirus ◽  
Milk Oligosaccharides ◽  
Human Noroviruses ◽  
Binding Pockets

Human noroviruses interact with both human histo-blood group antigens (HBGAs) and human milk oligosaccharides (HMOs). The former are believed to be important for a virus infection, while the latter might act as natural decoys in the host during an infection. However, certain noroviruses are known to bind poorly to HBGAs and yet still cause infections; some interact with numerous HBGA types but are nonprevalent; and yet others bind HBGAs and seem to be increasing in prevalence. HBGAs and HMOs can be found as soluble antigens in humans, can be structurally alike, and can interact with equivalent residues at identical binding pockets on the capsid. In this Gem, we discuss HBGA and HMO binding studies for human noroviruses, concentrating on the clinically important genogroup II noroviruses. In short, the roles of HBGA and HMO interactions in norovirus infections are still unclear.

High-throughput mass finger printing and Lewis blood group assignment of human milk oligosaccharides

2011 ◽  
Vol 401 (8) ◽  
pp. 2495-2510 ◽  
Author(s):  
Dennis Blank ◽  
Sabine Gebhardt ◽  
Kai Maass ◽  
Günter Lochnit ◽  
Viktoria Dotz ◽  
...  
Keyword(s):  
Human Milk ◽  
Blood Group ◽  
High Throughput ◽  
Human Milk Oligosaccharides ◽  
Milk Oligosaccharides ◽  
Lewis Blood Group ◽  
Group Assignment ◽  
Finger Printing

scholarly journals Human Milk Oligosaccharides and Blood Group Type

1999 ◽  
Vol 45 ◽  
pp. 745-745
Author(s):  
David S Newburg ◽  
Christopher D Warren ◽  
Prasoon Chaturvedi ◽  
Guillermo Ruiz-Palacios
Keyword(s):  
Human Milk ◽  
Blood Group ◽  
Human Milk Oligosaccharides ◽  
Milk Oligosaccharides ◽  
Group Type ◽  
Blood Group Type

scholarly journals Effects of Different Human Milk Oligosaccharides on Growth of Bifidobacteria in Monoculture and Co-culture With Faecalibacterium prausnitzii

2020 ◽  
Vol 11 ◽  
Author(s):  
Lianghui Cheng ◽  
Mensiena B. G. Kiewiet ◽  
Madelon J. Logtenberg ◽  
Andre Groeneveld ◽  
Arjen Nauta ◽  
...  
Keyword(s):  
Human Milk ◽  
Human Milk Oligosaccharides ◽  
Milk Oligosaccharides ◽  
Faecalibacterium Prausnitzii
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