Toxicity of Green-made Bacteriogenic Silver Nanoparticles Against Bacterial Pathogens: A Critical Review

Author(s):  
Adriano Magesky ◽  
Émilien Pelletier
2020 ◽  
Vol 21 (3) ◽  
pp. 206-218 ◽  
Author(s):  
Sadia Nazer ◽  
Saiqa Andleeb ◽  
Shaukat Ali ◽  
Nazia Gulzar ◽  
Tariq Iqbal ◽  
...  

Background: Multi-drug resistance in bacterial pathogens is a major concern of today. Green synthesis technology is being used to cure infectious diseases. Objectives: The aim of the current research was to analyze the antibacterial, antioxidant, and phytochemical screening of green synthesized silver nanoparticles using Ajuga bracteosa. Methods: Extract of A. bracteosa was prepared by maceration technique. Silver nanoparticles were synthesized using A. bracteosa extract and were confirmed by UV-Vis spectrophotometer, Scanning Electron Microscope (SEM) and Fourier Transform Infrared Spectroscopy (FTIR). The antibacterial, anti-biofilm, cell proliferation inhibition, TLC-Bioautography, TLC-Spot screening, antioxidant, and phytochemical screening were also investigated. Results: UV-Vis spectrum and Scanning electron microscopy confirmed the synthesis of green nanoparticles at 400 nm with tube-like structures. FTIR spectrum showed that functional groups of nanoparticles have a role in capping and stability of AgNP. Agar well diffusion assay represented the maximum antibacterial effect of ABAgNPs against Escherichia coli, Klebsiella pneumoniae, Streptococcus pyogenes, Staphylococcus aureus, and Pseudomonas aeruginosa at 0.10 g/mL concentration compared to ABaqu. Two types of interactions among nanoparticles, aqueous extract, and antibiotics (Synergistic and additive) were recorded against tested pathogens. Crystal violet, MTT, TLC-bio-autography, and spot screening supported the findings of the antibacterial assay. Highest antioxidant potential effect in ABaqu was 14.62% (DPPH) and 13.64% (ABTS) while 4.85% (DPPH) and 4.86% (ABTS) was recorded in ABAgNPs. Presence of phytochemical constituents showed pharmacological importance. Conclusion: It was concluded that green synthesis is an innovative technology in which natural products are conjugated with metallic particles and are used against infectious pathogens. The current research showed the significant use of green nanoparticles against etiological agents.


2018 ◽  
Vol 14 (2) ◽  
pp. 601-607 ◽  
Author(s):  
Valerie Aurore ◽  
Fabienne Caldana ◽  
Marianne Blanchard ◽  
Solange Kharoubi Hess ◽  
Nils Lannes ◽  
...  

2020 ◽  
Vol 10 (6) ◽  
pp. 2057-2067 ◽  
Author(s):  
Bilal Javed ◽  
Naveed Iqbal Raja ◽  
Akhtar Nadhman ◽  
Zia-ur-Rehman Mashwani

2015 ◽  
Vol 9 (1) ◽  
Author(s):  
V Lavakumar ◽  
K Masilamani ◽  
V Ravichandiran ◽  
N Venkateshan ◽  
D V R Saigopal ◽  
...  

2022 ◽  
Vol 10 (5) ◽  
pp. 1-13
Author(s):  
Piyush Kumar Gupta ◽  
D. Karthik Kumar ◽  
M. Thaveena ◽  
Soumya Pandit ◽  
Somya Sinha ◽  
...  

Author(s):  
Sneha Thakur ◽  
Krishna Mohan G. ◽  
Sandhya Rani M.

Nanomedicine is a revolutionary science nanoparticles of size 1 - 100nm designed for the utilization in disease diagnostics and therapeutics, targeted drug delivery of drugs which have difficulty in solubility and bioavailability and also to be applied in numerous fields. The present critical review aims at enumerating the advantages, synthesis and characterization methods, as well as diversified applications of green silver nanoparticles. Silver nanoparticles is an attractive proposition due to their distinctive physical, chemical and biological properties including a high electrical as well as thermal conductivity, surface-enhanced Raman scattering, chemical stability, catalytic activity and non linear optical behavior which enables them of potential value in inks, microelectronics, and medical imaging. Plant mediated synthesis of silver nanoparticles (AgNPs) is now-a-day’s gaining enormous interest as it is cost effective, ecofriendly and has less side effects since there is no addition of external stabilizing or capping agents as the plant itself acts as stabilizing or capping agent. The secondary metabolites and other plant products like proteins, metabolites like alkaloids, terpinoids, saponins, glycosides etc are known to act as external stabilizing or capping agents. The plant mediated silver nanoparticles are known to show uniform particles characteristics and morphology. The bottom to top end approach of synthesis is effective to achieve desired particles size, shape and morphology. The synthesized green silver nanoparticles are characterized by UVVis spectroscopy, SEM/TEM analysis, EDAX/EDS, FTIR and other methods zeta potential measurement, thermo gravimetric analysis, Raman scattering. The plant mediated synthesized silver nanoparticles (green silver nanoparticles) are effective in delivering pharmacological activities like antimicrobial, anticancer, larvicidal etc. Also green Silver nanoparticles have diverse applications acting as biosensors, as targeted drug delivery candidates, in diagnostics and therapeutics, in medical and consumer products, as anti pollutant and in agriculture. The future perspective holds promising results in green synthesis of silver nanoparticles involving plants. This review projects a collective sequence of information for synthesizing and evaluation of green silver nanoparticles and scope of its pharmacological actions.


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