scholarly journals Bone turnover markers can predict healing time in medication-related osteonecrosis of the jaw

2021 ◽  
Author(s):  
Lorenz Schubert ◽  
Guenter Russmueller ◽  
Heimo Lagler ◽  
Selma Tobudic ◽  
Elisabeth Heindel ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Cox Regression ◽  
Mucosal Healing ◽  
Osteonecrosis Of The Jaw ◽  
Healing Time ◽  
Bone Specific Alkaline Phosphatase ◽  
Dental Procedures ◽  
Patients At Risk ◽  
Turnover Markers

Abstract Objectives Medication-related osteonecrosis of the jaw (MRONJ) is a severe and difficult-to-treat adverse event of bone-modifying agents. Therefore predictive strategies determining patients at risk for a prolonged healing duration are needed to optimize treatment. Thus, the present study evaluates whether or not bone turnover markers can be used to predict the healing duration in MRONJ patients. Materials and methods The present study is a retrospective data analysis of patients suffering from MRONJ and positive histology for Actinomyces spp., who were identified at the General Hospital Vienna from 2014 to 2018. During the first visit, the patients’ demographics and levels of bone formation parameters were compiled. Healing times were analysed by Cox regression in dependence on these factors. Results A total of 52 patients were identified who fulfilled the inclusion criteria. The indication for bone-modifying agents was breast cancer (n = 21), prostate cancer (n = 14), multiple myeloma (n = 6) and other malignant diseases (n = 11). In 43 (82.7%) of our patients, we were able to document complete mucosal healing. Furthermore, patients who responded faster to therapy showed higher levels of C-telopeptide (P < 0.05), osteocalcin (P < 0.05) and bone-specific alkaline phosphatase (P < 0.05), but lower levels of 1.25-dihydroxyvitamin D (P < 0.05) than slower responding patients. No correlation was found regarding parathyroid hormone or calcitonin levels. Interestingly, patients who had a slower response were less likely to report dental procedures, but more likely to report a history of chemotherapy. Conclusion CTX and osteocalcin levels may be used for predicting healing duration for MRONJ.

scholarly journals Changes of Bone Turnover Markers in Long Bone Nonunions Treated with a Regenerative Approach

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Donatella Granchi ◽  
Enrique Gómez-Barrena ◽  
Markus Rojewski ◽  
Philippe Rosset ◽  
Pierre Layrolle ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Healing ◽  
Bone Turnover Markers ◽  
Bone Fractures ◽  
Long Bone ◽  
Type I ◽  
Bone Specific Alkaline Phosphatase ◽  
Bone Formation Markers ◽  
Imaging Results ◽  
Turnover Markers

In this clinical trial, we investigated if biochemical bone turnover markers (BTM) changed according to the progression of bone healing induced by autologous expanded MSC combined with a biphasic calcium phosphate in patients with delayed union or nonunion of long bone fractures. Bone formation markers, bone resorption markers, and osteoclast regulatory proteins were measured by enzymatic immunoassay before surgery and after 6, 12, and 24 weeks. A satisfactory bone healing was obtained in 23 out of 24 patients. Nine subjects reached a good consolidation already at 12 weeks, and they were considered as the “early consolidation” group. We found that bone-specific alkaline phosphatase (BAP), C-terminal propeptide of type I procollagen (PICP), and beta crosslaps collagen (CTX) changed after the regenerative treatment, BAP and CTX correlated to the imaging results collected at 12 and 24 weeks, and BAP variation along the healing course differed in patients who had an “early consolidation.” A remarkable decrease in BAP and PICP was observed at all time points in a single patient who experienced a treatment failure, but the predictive value of BTM changes cannot be determined. Our findings suggest that BTM are promising tools for monitoring cell therapy efficacy in bone nonunions, but studies with larger patient numbers are required to confirm these preliminary results.

Cross-Sectional Study of four Serological Bone Turnover Markers for the Risk Assessment of Medication-Related Osteonecrosis of the Jaw

2018 ◽  
Vol 29 (2) ◽  
pp. e137-e140 ◽  
Author(s):  
Andre Peisker ◽  
Gregor F. Raschke ◽  
Mina D. Fahmy ◽  
Arndt Guentsch ◽  
Korosh Roshanghias ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Cross Sectional Study ◽  
Osteonecrosis Of The Jaw ◽  
Sectional Study ◽  
Cross Sectional ◽  
Turnover Markers

MO807CORRELATIONS BETWEEN THE INFLAMMATORY AND THE BIOCHEMICAL BONE PROFILE OF PATIENTS ON HEMODIALYSIS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Pascale Khairallah ◽  
Thomas Nickolas ◽  
Stylianos Panagoutsos ◽  
Ploumis Pasadakis ◽  
Fiona McCann ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Inflammatory Markers ◽  
Cross Sectional Study ◽  
P Value ◽  
Dialysis Patients ◽  
Cross Sectional ◽  
Bone Specific Alkaline Phosphatase ◽  
Healthy Cohort ◽  
Turnover Markers

Abstract Background and Aims End stage kidney disease (ESKD) is associated with a malnutrition-inflammation complex that results in several endocrine, musculoskeletal, and metabolic abnormalities. Despite the known resultant derangements from this process, few studies have evaluated the associations between inflammation and skeletal status in ESKD patients. Our goal is to evaluate correlations between inflammatory and biochemical bone profile within and between dialysis patients and a healthy cohort. Method This analysis is a cross-sectional evaluation of a cohort of 40 dialysis patients and 20 healthy controls. Results Significant differences were found between the dialysis and healthy cohort in biochemical bone profile, inflammatory markers and adipokine levels. Dialysis patients with low vs. high PTH (cutoff 50 pg/mL) had differences in bone turnover markers but no differences in inflammatory or adipokine levels (Table 1). More specifically, bone-specific alkaline phosphatase (BSAP), osteocalcin (OCN) and osteoprotegerin (OPG) were positively correlated with insulin-like growth factors but this correlation was not present after adjustment for parathyroid hormone (PTH) levels. C-terminal cross-linking telopeptide (CTX) positively correlated with IGF1 (p-value 0.02, 95% CI (0.14-1.69)) and with IGFBP3 (p-value 0.007 and 95% CI (0.31- 1.84)) after multivariate adjustment for PTH, albumin and sex. Adiponectin positively correlated with IGFBP3 and this remained significant after adjustment for PTH, albumin and sex (p=0.02). IL6, IL8 and TNF did not correlate with bone turnover markers or with adipokine levels after multivariate adjustments. Conclusion In this cross-sectional study, significant differences were found between the dialysis and healthy cohort in biochemical bone profile, inflammatory markers and adipokine levels. In the dialysis cohort, inflammatory markers did not correlate with bone turnover markers or with adipokine levels in dialysis patients. Dialysis patients with high vs. low PTH (cutoff 50 pg/mL) had higher levels of bone formation and bone resorption markers. Inflammatory and adipokine levels did not differ between those with high vs. low PTH.

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