Microencapsulation of vitamin D in protein matrices: in vitro release and storage stability

2020 ◽  
Vol 14 (3) ◽  
pp. 1172-1182 ◽  
Author(s):  
Wahab Ali Khan ◽  
Masood Sadiq Butt ◽  
Imran Pasha ◽  
Amer Jamil
Keyword(s):  
Vitamin D ◽  
Storage Stability ◽  
In Vitro Release ◽  
Protein Matrices ◽  
And Storage ◽  
Vitro Release

scholarly journals Microencapsulation of Thymol in Poly(lactide-co-glycolide) (PLGA): Physical and Antibacterial Properties

Materials ◽  
2019 ◽  
Vol 12 (7) ◽  
pp. 1133 ◽  
Author(s):  
Zhu Zhu ◽  
Tiantian Min ◽  
Xueji Zhang ◽  
Yongqiang Wen
Keyword(s):  
Storage Stability ◽  
In Vitro Release ◽  
Antibacterial Properties ◽  
Spherical Shape ◽  
Food Preservative ◽  
And Storage ◽  
Fast Release ◽  
Vitro Release ◽  
And Staphylococcus Aureus

Thymol has been shown to be a safe and effective broad-spectrum antimicrobial agent that can be used as a food preservative. However, its volatile characteristics and strong odor limit its use in food products. The microencapsulation of this essential oil in biopolymers could overcome these disadvantages. In this work, thymol-loaded poly(lactide-co-glycolide) (PLGA) microparticles were successfully prepared and the optimal encapsulation efficiency was obtained at 20% (w/w) thymol. Microparticles containing thymol presented a spherical shape and smooth surface. Microencapsulation significantly improved the thermal and storage stability of thymol. In vitro release profiles demonstrated an initial fast release followed by a slow and sustained release. Thymol-loaded microparticles had strong antibacterial activity against Escherichia coli and Staphylococcus aureus, and the effectiveness of their antibacterial properties was confirmed in a milk test. Therefore, the thymol-loaded microparticles show great potential for use as an antimicrobial and as preservation additives in food.

Nanostructured lipid carriers containing Amphotericin B: Development, in vitro release assay, and storage stability

2018 ◽  
Vol 48 ◽  
pp. 372-382 ◽  
Author(s):  
Rosilene Rodrigues Santiago ◽  
Kattya Gyselle de Holanda e Silva ◽  
Nednaldo Dantas dos Santos ◽  
Julieta Genre ◽  
Viviane Freitas de Oliveira Lione ◽  
...  
Keyword(s):  
Amphotericin B ◽  
Storage Stability ◽  
In Vitro Release ◽  
Nanostructured Lipid Carriers ◽  
Release Assay ◽  
Development In Vitro ◽  
And Storage ◽  
Vitro Release

Microencapsulation of fish oil using thiol-modified β-lactoglobulin fibrils/chitosan complex: A study on the storage stability and in vitro release

2018 ◽  
Vol 80 ◽  
pp. 186-194 ◽  
Author(s):  
Hon Weng Chang ◽  
Tai Boon Tan ◽  
Phui Yee Tan ◽  
Faridah Abas ◽  
Oi Ming Lai ◽  
...  
Keyword(s):  
Fish Oil ◽  
Storage Stability ◽  
In Vitro Release ◽  
Β Lactoglobulin ◽  
Vitro Release

Liposomes as delivery systems for carotenoids: comparative studies of loading ability, storage stability and in vitro release

2014 ◽  
Vol 5 (6) ◽  
pp. 1232 ◽  
Author(s):  
Chen Tan ◽  
Jin Xue ◽  
Xiaowei Lou ◽  
Shabbar Abbas ◽  
Yu Guan ◽  
...  
Keyword(s):  
Comparative Studies ◽  
Storage Stability ◽  
In Vitro Release ◽  
Delivery Systems ◽  
Vitro Release

scholarly journals Chitosan-Graft-Poly(N-Isopropylacrylamide)/PVA Cryogels as Carriers for Mucosal Delivery of Voriconazole

Polymers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1432 ◽  
Author(s):  
Cheaburu-Yilmaz ◽  
Yilmaz ◽  
Kose ◽  
Bibire
Keyword(s):  
Storage Stability ◽  
Flow Behavior ◽  
Drug Loading ◽  
Thermal Studies ◽  
In Vitro Release ◽  
Loading Capacity ◽  
Scanning Calorimetry ◽  
Adhesion Properties ◽  
Vitro Release

The objective of this study was to prepare and characterize physically crosslinked gel formulations of chitosan (CS)-graft-poly(N-isopropyl acrylamide) (PNIPAAm) and polyvinyl alcohol (PVA) for smart delivery of an antifungal drug, Voriconazole, for mucosal applications. For this purpose, cryogels of CS-g-PNIPAAm/PVA and CS/PVA were tested by means of texture profile analysis and rheology to determine optimal matrix properties for topical application. The ratio of 75/25 v/v % CS-g-PNIPAAm/PVA was selected to be used for formulation since it gave low compressibility and hardness (1.2 and 0.6 N) as well as high adhesion properties and non-Newtonian flow behavior. The cryogels and formulations were further characterized by means of FTIR spectroscopy, swelling behavior, texture analysis, scanning electron microscopy (SEM), thermal (differential scanning calorimetry (DSC) and TGA), and rheological behavior. The drug loading capacity and in vitro release profile of the drug, storage stability, and cytotoxicity tests were also performed for the gel formulation. The FTIR, DSC, and TGA results verified the successful formation of cryogels. Swelling studies revealed a pH-dependent swelling ability with a maximum swelling degree of 1200% in acid and 990% in phosphate buffer (pH 7.4). Thermal studies showed that CS-g-PNIPAAm/PVA 75/25 had higher thermal stability proving the structural complexity of the polymer. The loading capacity of Voriconazole was found to be 70% (w/w). The in vitro release profiles of Voriconazole showed Fickian release behavior for CS-g-PNIPAAm/PVA 75/25 gel with an approximate delivery of 38% within 8 h, slower than matrices containing unmodified chitosan. The storage stability test exhibited that the gel formulation was still stable even after aging for two months. Moreover, the cell culture assays revealed a non-toxic character of the polymeric matrix. Overall results showed that the CS-g-PNIPAAm/PVA 75/25 hydrogel has the potential to be used as a smart polymeric vehicle for topical applications.

scholarly journals IBUPROFEN LOADED ORGANOGEL: DEVELOPMENT AND CHARACTERIZATION

2021 ◽  
pp. 224-227
Author(s):  
CHANDRA PRABHA UPADHYAY ◽  
MEENAKSHI BHARKATIYA
Keyword(s):  
Transdermal Delivery ◽  
In Vitro Release ◽  
Stability Study ◽  
Elastic Behavior ◽  
In Vitro Drug Release ◽  
Sorbitan Esters ◽  
And Storage ◽  
Vitro Release ◽  
Water Contents

Objective: This study aimed to develop and in vitro characterize an organogel (OG) loaded Ibuprofen. Methods: Organogel (OG) composed of water, isooctane, sorbitan esters, sorbitan monopalmitate (Span-40), and poly(oxyethylene) sorbitan monostearate (Polysorbate-60) was loaded with Ibuprofen. The partial phase behavior of ibuprofen OG was studied to optimize the formulation composition. 1.0% w/w Ibuprofen loaded OG were characterize for rheological, in vitro release and stability study. Results: Phase diagram showed an isotropic gel region at low water contents, which converted to emulsion on increasing water quantity. The rheological properties of the OG incorporating 1.0% w/w Ibuprofen shows the presence of two Tg’s and elastic behavior of gel, reflects the presence of an entangled network of aqueous tubules. The fractal dimension df value of 2.1 and 2.3 was obtained for the two curves (elastic and storage modulus), which is indicative of the formation of the densest gel structure. The diffusional release exponent (n) was found to be ~0.7 (0.5<n<1), which is indicative of non-Fickian, anomalous diffusion of the drug from the OG. The in vitro drug release exhibited release @ 7.04%/h 0.7/cm2 from the OG. Ibuprofen containing OG was stable for 28 d in terms of chemical potency and gel stiffness at 4 °C and room temperature (~25 °C). Conclusion: The study indicates the potential of OG for improved transdermal delivery of Ibuprofen.

Sign in / Sign up

Export Citation Format

Share Document