scholarly journals Photodynamic therapy-triggered on-demand drug release from ROS-responsive core-cross-linked micelles toward synergistic anti-cancer treatment

Nano Research ◽  
2019 ◽  
Vol 12 (5) ◽  
pp. 999-1008 ◽  
Author(s):  
Yongjuan Li ◽  
Jian Hu ◽  
Xun Liu ◽  
Yong Liu ◽  
Shixian Lv ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Drug Release ◽  
Cancer Treatment ◽  
On Demand ◽  
Anti Cancer

Fe3O4@mSiO2 core–shell nanocomposite capped with disulfide gatekeepers for enzyme-sensitive controlled release of anti-cancer drugs

2015 ◽  
Vol 3 (6) ◽  
pp. 1010-1019 ◽  
Author(s):  
Chunyu Yang ◽  
Wei Guo ◽  
Liru Cui ◽  
Na An ◽  
Ting Zhang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Cancer Treatment ◽  
Silica Shell ◽  
Core Shell ◽  
Passive Targeting ◽  
Anti Cancer ◽  
Multifunctional Nanocarriers ◽  
Nanoparticle Core

Multifunctional nanocarriers based on the magnetic Fe3O4 nanoparticle core and bis-(3-carboxy-4-hydroxy phenyl) disulfide modified mesoporous silica shell were synthesized for cancer treatment through passive targeting and enzyme-sensitive drug release.

Electroactive Polypyrrole Nanowire Arrays: Synergistic Effect of Cancer Treatment by On-Demand Drug Release and Photothermal Therapy

Langmuir ◽  
2015 ◽  
Vol 31 (14) ◽  
pp. 4264-4269 ◽  
Author(s):  
HyungJae Lee ◽  
Wooyoung Hong ◽  
Seunghyun Jeon ◽  
Yongdoo Choi ◽  
Youngnam Cho
Keyword(s):  
Drug Release ◽  
Synergistic Effect ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Nanowire Arrays ◽  
On Demand

scholarly journals Photodynamic Therapy and Hyperthermia in Combination Treatment—Neglected Forces in the Fight against Cancer

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1147
Author(s):  
Aleksandra Bienia ◽  
Olga Wiecheć-Cudak ◽  
Aleksandra Anna Murzyn ◽  
Martyna Krzykawska-Serda
Keyword(s):  
Photodynamic Therapy ◽  
Combination Therapy ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Combination Treatment ◽  
Therapeutic Agent ◽  
Diagnostic Methods ◽  
Cancer Therapies ◽  
Treatment Side Effects ◽  
Anti Cancer

Cancer is one of the leading causes of death in humans. Despite the progress in cancer treatment, and an increase in the effectiveness of diagnostic methods, cancer is still highly lethal and very difficult to treat in many cases. Combination therapy, in the context of cancer treatment, seems to be a promising option that may allow minimizing treatment side effects and may have a significant impact on the cure. It may also increase the effectiveness of anti-cancer therapies. Moreover, combination treatment can significantly increase delivery of drugs to cancerous tissues. Photodynamic therapy and hyperthermia seem to be ideal examples that prove the effectiveness of combination therapy. These two kinds of therapy can kill cancer cells through different mechanisms and activate various signaling pathways. Both PDT and hyperthermia play significant roles in the perfusion of a tumor and the network of blood vessels wrapped around it. The main goal of combination therapy is to combine separate mechanisms of action that will make cancer cells more sensitive to a given therapeutic agent. Such an approach in treatment may contribute toward increasing its effectiveness, optimizing the cancer treatment process in the future.

Photodynamic therapy-mediated remote control of chemotherapy toward synergistic anticancer treatment

Nanoscale ◽  
2018 ◽  
Vol 10 (30) ◽  
pp. 14554-14562 ◽  
Author(s):  
Yongjuan Li ◽  
Shixian Lv ◽  
Ziyuan Song ◽  
Juanjuan Dang ◽  
Xudong Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Remote Control ◽  
Cancer Therapy ◽  
Drug Release ◽  
Stimuli Responsive ◽  
On Demand ◽  
Release Property ◽  
Anticancer Treatment

Stimuli-responsive nanomedicine (NM) with an on-demand drug release property has demonstrated promising utility toward cancer therapy.

Enzyme and pH-responsive nanovehicles for intracellular drug release and photodynamic therapy

2017 ◽  
Vol 41 (6) ◽  
pp. 2468-2478 ◽  
Author(s):  
Ting Zhang ◽  
Shiying Huang ◽  
Huiming Lin ◽  
Na An ◽  
Ruihan Tong ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Drug Release ◽  
Cancer Treatment ◽  
Potential Application ◽  
The Novel ◽  
Ph Responsive

An enzyme and pH-responsive nanocomposite was constructed for sensitive intracellular drug release and photodynamic therapy (PDT). The novel nanoplatforms provide the potential application in cancer treatment.

Tumor pH-triggered “charge conversion” nanocarriers with on-demand drug release for precise cancer therapy

2020 ◽  
Vol 8 (40) ◽  
pp. 9351-9361
Author(s):  
Bo-Ai Ma ◽  
Chun-Yang Sun
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Drug Release ◽  
X Ray ◽  
On Demand ◽  
Tumor Ph

The pHe-triggered “charge conversion” nanocarriers were developed for combined X-ray-induced photodynamic therapy (X-PDT) and hypoxia-activated chemotherapy.

scholarly journals On-Demand Drug Release System for In Vivo Cancer Treatment through Self-Assembled Magnetic Nanoparticles

2013 ◽  
Vol 52 (16) ◽  
pp. 4384-4388 ◽  
Author(s):  
Jae-Hyun Lee ◽  
Kuan-Ju Chen ◽  
Seung-Hyun Noh ◽  
Mitch André Garcia ◽  
Hao Wang ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Cancer Treatment ◽  
Release System ◽  
On Demand ◽  
Drug Release System ◽  
Self Assembled

scholarly journals Design and Characterisation of pH-Responsive Photosensitiser-Loaded Nano-Transfersomes for Enhanced Photodynamic Therapy

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 210
Author(s):  
Sooho Yeo ◽  
Il Yoon ◽  
Woo Kyoung Lee
Keyword(s):  
Photodynamic Therapy ◽  
Drug Release ◽  
Burst Release ◽  
Ph Responsive ◽  
Pheophorbide A ◽  
Sustained Drug Release ◽  
Non Invasive ◽  
Anti Cancer ◽  
Photodynamic Activity ◽  
The Mean

Photodynamic therapy (PDT) is a non-invasive and tumour-specific therapy. Photosensitizers (PSs) (essential ingredients in PDT) aggregate easily owing to their lipophilic properties. The aim of this study was to synthesise a PS (methyl pheophorbide a, MPa) and design a biocompatible lipid-based nanocarrier to improve its bioavailability and pharmacological effects. MPa-loaded nano-transfersomes were fabricated by sonication. The characteristics of synthesised PS and nano-transfersomes were assessed. The effects of PDT were evaluated by 1,3-diphenylisobenzofuran assay and by measuring photo-cytotoxicity against HeLa and A549 cell lines. The mean particle size and zeta potential for nano-transfersomes ranged from 95.84 to 267.53 nm and −19.53 to −45.08 mV, respectively. Nano-transfersomes exhibited sustained drug release for 48 h in a physiological environment (as against burst release in an acidic environment), which enables its use as a pH-responsive drug release system in PDT with enhanced photodynamic activity and reduced side effects. The formulations showed light cytotoxicity, but no dark toxicity, which meant that light irradiation resulted in anti-cancer effects. Additionally, formulations with the smallest size exhibited photodynamic activity to a larger extent than those with the highest loading capacity or free MPa. These results suggest that our MPa-loaded nano-transfersome system is a promising anti-cancer strategy for PDT.

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