Plasma/vitamin-k

2022 ◽  
Vol 1889 (1) ◽  
pp. 265-265
Keyword(s):  
Vitamin K ◽  
Plasma Vitamin

Influence of CYP4F2 Polymorphisms and Plasma Vitamin K Levels on Warfarin Sensitivity in Japanese Pediatric Patients

2013 ◽  
Vol 28 (2) ◽  
pp. 132-137 ◽  
Author(s):  
Keita Hirai ◽  
Hideki Hayashi ◽  
Yasuo Ono ◽  
Kohei Izumiya ◽  
Masaki Tanaka ◽  
...  
Keyword(s):  
Vitamin K ◽  
Pediatric Patients ◽  
Plasma Vitamin

scholarly journals Menaquinone-4 in breast milk is derived from dietary phylloquinone

2002 ◽  
Vol 87 (3) ◽  
pp. 219-226 ◽  
Author(s):  
H. H. W. Thijssen ◽  
M.-J. Drittij ◽  
C. Vermeer ◽  
E. Schoffelen
Keyword(s):  
Vitamin E ◽  
Breast Milk ◽  
Vitamin K ◽  
Post Partum ◽  
Dose Effect ◽  
Plasma Vitamin ◽  
Dependent Manner ◽  
Plasma Samples ◽  
Milk Samples ◽  
Lactating Mothers

The effect of maternal phylloquinone supplementation on vitamin K in breast milk was studied to establish: (1) if phylloquinone is the source of menaquinone-4 in breast milk; (2) the dose–effect relationship between intake and obtainable levels. Four groups of lactating mothers with a full-term healthy infant participated and took oral phylloquinone supplements of 0·0 (n8), 0·8 (n8), 2·0 (n8), and 4·0 (n7) mg/d for 12 d, starting at day 4 post-partum. Milk samples were collected on days 4, 8, 16, and 19. Blood samples were collected on days 4 and 16. Vitamin K and vitamin E concentrations, the latter for reason of comparison, were assayed. Phylloquinone and menaquinone-4 were present in all milk samples: 5·84 (SD 2·31) AND 2·98 (sd 1·51) nmol/l (n31) respectively, in colostrum (day 4 sample). A strong correlation between the vitamers was found (r0·78,P<0·001). Breast-milk phylloquinone levels were raised in a dose-dependent manner: 4-, 12-, and 30-fold on day 16 for the 0·8, 2·0, and 4·0 mg group respectively. In addition, menaquinone-4 levels were higher: 2·5- (P<0·05) and 7-fold (P<0·001) in the 2·0 and 4·0 mg groups respectively. Plasma of supplemented subjects contained 3-, 5-, and 10-fold higher phylloquinone levels on day 16. Detectable menaquinone-4 was found in ten of thirty-one day 4 plasma samples. All day 16 plasma samples of the 4 mg supplemented group contained the vitamin. There was no correlation between the K-vitamers in plasma. Vitamin E and phylloquinone appear to differ in their distribution in breast milk, milk:plasma concentration ratios were ≤1 and 3–5 for vitamin E and phylloquinone respectively. The milk:plasma concentration ratio of menaquinone-4 was >10. In conclusion, dietary phylloquinone is a source of menaquinone-4 in breast milk. Phylloquinone supplementation to lactating mothers may be of benefit to the newborn infant, since both phylloquinone and menaquinone-4 are raised by supplementation.

Plasma vitamin K concentration in horses supplemented with several vitamin K homologs1

2011 ◽  
Vol 89 (4) ◽  
pp. 1056-1061 ◽  
Author(s):  
T. Terachi ◽  
Y. Inoue ◽  
N. Ashihara ◽  
M. Kobayashi ◽  
K. Ando ◽  
...  
Keyword(s):  
Vitamin K ◽  
Plasma Vitamin ◽  
K Concentration

Effect of l-asparaginase therapy for acute lymphoblastic leukemia on plasma vitamin K-dependent coagulation factors and inhibitors

1986 ◽  
Vol 108 (5) ◽  
pp. 698-701 ◽  
Author(s):  
Annie Bezeaud ◽  
Ludovic Drouet ◽  
Guy Leverger ◽  
John H. Griffin ◽  
Marie-Claude Guillin
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Vitamin K ◽  
Lymphoblastic Leukemia ◽  
Coagulation Factors ◽  
Plasma Vitamin

scholarly journals Plasma phylloquinone, menaquinone-4 and menaquinone-7 levels and coronary artery calcification

2016 ◽  
Vol 5 ◽  
Author(s):  
S. Torii ◽  
Y. Ikari ◽  
K. Tanabe ◽  
T. Kakuta ◽  
M. Hatori ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Vitamin K ◽  
Coronary Artery Calcification ◽  
Multislice Computed Tomography ◽  
Inverse Correlation ◽  
Matrix Gla Protein ◽  
Plasma Vitamin ◽  
Bone Specific Alkaline Phosphatase ◽  
Collagen Type 1

AbstractVitamin K is considered to be involved in the pathological mechanisms of coronary artery calcification (CAC). Correlation between CAC and plasma vitamin K levels was studied. A total of 103 patients, with at least one coronary risk factor, were studied. CAC was measured using 64-slice multislice computed tomography (MSCT) and divided into three groups: none (CAC score = 0; n 25), mild to moderate (0 < CAC score < 400; n 52) and severe (CAC score > 400; n 26). Phylloquinone (PK) and menaquinone (MK)-4 and MK-7 were measured by HPLC-tandem MS. Mean age of patients was 64 (sd 13) years, of which 57 % were male. Median CAC score was 57·2. Median levels of PK, MK-4 and MK-7 were 1·33, 0 and 6·99 ng/ml, showing that MK-7 was the dominant vitamin K in this population. MK-7 showed a significant inverse correlation with uncarboxylated osteocalcin (ucOC, P = 0·014), protein induced by vitamin K absence of antagonist-2 (PIVKA-2, P = 0·013), intact parathyroid hormone (P = 0·007) and bone-specific alkaline phosphatase (P = 0·018). CAC showed an inverse correlation with total circulating uncarboxylated matrix Gla protein (t-ucMGP, P = 0·018) and Hb (P = 0·05), and a positive correlation with age (P < 0·001), creatinine, collagen type 1 cross-linked N-terminal telopeptide (NTX, P = 0·03), pulse wave velocity (P < 0·001) and osteoprotegerin (P < 0·001). However, CAC did not have a significant correlation with plasma levels of PK, MK-4 or MK-7. In conclusion, plasma MK-7, MK-4 or PK level did not show significant correlation with CAC despite the association between plasma vitamin K levels and vitamin K-dependent proteins such as ucOC or PIVKA-2.

scholarly journals Human plasma protein Z antigen: range in normal subjects and effect of warfarin therapy

Blood ◽  
1987 ◽  
Vol 69 (6) ◽  
pp. 1580-1586
Author(s):  
JP Miletich ◽  
GJ Jr Broze
Keyword(s):  
Vitamin K ◽  
Plasma Protein ◽  
Total Protein ◽  
Protein C ◽  
Warfarin Therapy ◽  
Normal Subjects ◽  
Plasma Vitamin ◽  
Protein Z ◽  
The Mean ◽  
Log Normal

In contrast to the other well-studied vitamin K-dependent proteins that circulate in plasma, protein Z antigen is much more variable. The concentration in plasmas collected in EDTA from 455 normal, healthy donors is normally distributed with a mean of 2.9 micrograms/mL (46 nmol/L) and a SD of 1.0 microgram/mL (95% interval of 32% to 168% of the mean). No significant correlation to age or sex could be detected. In comparison, the concentration of protein C antigen measured with the same type of assay on the same 455 samples has a log normal distribution with a mean of 4.0 micrograms/mL (65 nmol/L) and a 95% interval of 70% to 138% of the mean. Also in marked contrast to other plasma vitamin K-dependent proteins, the total protein Z antigen level is extremely low in patients on stable warfarin therapy (range 1% to 16% of normal). Moreover, even though greater than 95% of the antigen in normal plasmas adsorbs to barium citrate (a crude reflection of the presence of gamma-carboxyglutamic acid (Gla) residues), in the patients taking warfarin almost all of the small amount of the antigen failed to adsorb, suggesting that virtually no protein Z had its full complement of Gla residues. Total protein C antigen in the same 25 patients averaged 53% of normal (34% to 72%) and 54% (average) of the total remaining antigen still adsorbed to barium citrate. The concentration of protein Z antigen in the plasma of a normal individual given a loading dose of warfarin fell at an initial rate of approximately 20% a day, indicating a plasma half-life (t1/2) of 2 to 3 days.

scholarly journals Human plasma protein Z antigen: range in normal subjects and effect of warfarin therapy

Blood ◽  
1987 ◽  
Vol 69 (6) ◽  
pp. 1580-1586 ◽  
Author(s):  
JP Miletich ◽  
GJ Jr Broze
Keyword(s):  
Vitamin K ◽  
Plasma Protein ◽  
Total Protein ◽  
Protein C ◽  
Warfarin Therapy ◽  
Normal Subjects ◽  
Plasma Vitamin ◽  
Protein Z ◽  
The Mean ◽  
Log Normal

Abstract In contrast to the other well-studied vitamin K-dependent proteins that circulate in plasma, protein Z antigen is much more variable. The concentration in plasmas collected in EDTA from 455 normal, healthy donors is normally distributed with a mean of 2.9 micrograms/mL (46 nmol/L) and a SD of 1.0 microgram/mL (95% interval of 32% to 168% of the mean). No significant correlation to age or sex could be detected. In comparison, the concentration of protein C antigen measured with the same type of assay on the same 455 samples has a log normal distribution with a mean of 4.0 micrograms/mL (65 nmol/L) and a 95% interval of 70% to 138% of the mean. Also in marked contrast to other plasma vitamin K-dependent proteins, the total protein Z antigen level is extremely low in patients on stable warfarin therapy (range 1% to 16% of normal). Moreover, even though greater than 95% of the antigen in normal plasmas adsorbs to barium citrate (a crude reflection of the presence of gamma-carboxyglutamic acid (Gla) residues), in the patients taking warfarin almost all of the small amount of the antigen failed to adsorb, suggesting that virtually no protein Z had its full complement of Gla residues. Total protein C antigen in the same 25 patients averaged 53% of normal (34% to 72%) and 54% (average) of the total remaining antigen still adsorbed to barium citrate. The concentration of protein Z antigen in the plasma of a normal individual given a loading dose of warfarin fell at an initial rate of approximately 20% a day, indicating a plasma half-life (t1/2) of 2 to 3 days.

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