Ultrasonic analysis of soft tissue movement in clinical assessment of malignant tumors M. Tristam, D.C. Barbosa, J.C. Bamber, D.O. Cosgrove and C.R. Hill, Physics Department, Institute of Cancer Research, Royal Marsden Hospital, Sutton, Surrey, UK

Purpose: The spectrum of diagnoses and clinical features of hand tumors differ from those of tumors in other body parts. However, only a few reports have comprehensively referenced the diagnosis and clinical features of hand tumors. This study aimed to elucidate the diagnostic distribution and the clinical features of hand tumors undergone surgery in our institute. Patients and methods: A total of 235 lesions in 186 patients diagnosed with hand tumors between 1978 and 2020 were reviewed. Age at surgery, gender, chief complaint, tumor location, and pathological diagnosis were analyzed. Results: There were 121 benign bone tumors, 98 benign soft tissue tumors, and 16 malignant tumors. Chondroma and tenosynovial giant cell tumor were common benign bone and soft tissue tumors at the proximal phalanx of the ring finger and the palm, respectively. Meanwhile, chondrosarcoma and synovial sarcoma were common malignant tumors at the dorsal part of the hand. Local pain and painless mass were the chief complaints in patients with benign bone and soft tissue tumors, respectively. Most patients with malignant tumors were referred after unplanned resection. When patients were classified into two categories by tumor size according to maximal diameter, tumors larger than 19 mm had a significantly higher risk of malignant ( p = 0.031) despite being smaller than other tumors in different body parts. Conclusion: When a tumor malignancy is suspected, the patient should be referred to a specialist to avoid unplanned resection or delayed diagnosis due to misdiagnosis. Knowing the distribution and clinical features should help in diagnosing hand tumors.

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The Role of Natural Killer Cells in Soft Tissue Sarcoma: Prospects for Immunotherapy

Cancers ◽

10.3390/cancers13153865 ◽

2021 ◽

Vol 13 (15) ◽

pp. 3865

Author(s):

Tânia Fortes-Andrade ◽

Jani Sofia Almeida ◽

Luana Madalena Sousa ◽

Manuel Santos-Rosa ◽

Paulo Freitas-Tavares ◽

...

Keyword(s):

Clinical Trials ◽

Soft Tissue ◽

Nk Cells ◽

Nk Cell ◽

Malignant Tumors ◽

Soft Tissue Sarcomas ◽

Good Prognosis ◽

Regulatory Pathways ◽

Immunological Profile ◽

Study Support

Soft-tissue sarcomas (STS) represent about 80% of sarcomas, and are a heterogeneous group of rare and malignant tumors. STS arise from mesenchymal tissues and can grow into structures such as adipose tissue, muscles, nervous tissue and blood vessels. Morphological evaluation has been the standard model for the diagnosis of sarcomas, and even in samples with similar characteristics, they present a diversity in cytogenetic and genetic sequence alterations, which further increases the diversity of sarcomas. This variety is one of the main challenges for the classification and understanding of STS patterns, as well as for their respective treatments, which further decreases patient survival (<5 years). Despite some studies, little is known about the immunological profile of STS. As for the immunological profile of STS in relation to NK cells, there is also a shortage of studies. Observations made in solid tumors show that the infiltration of NK cells in tumors is associated with a good prognosis of the disease. Notwithstanding the scarcity of studies to characterize NK cells, their receptors, and ligands in STS, it is noteworthy that the progression of these malignancies is associated with altered NK phenotypes. Despite the scarcity of information on the function of NK cells, their phenotypes and their regulatory pathways in STS, the findings of this study support the additional need to explore NK cell-based immunotherapy in STS further. Some clinical trials, very tentatively, are already underway. STS clinical trials are still the basis for adoptive NK-cell and cytokine-based therapy.

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Molecular Determinants of Soft Tissue Sarcoma Immunity: Targets for Immune Intervention

International Journal of Molecular Sciences ◽

10.3390/ijms22147518 ◽

2021 ◽

Vol 22 (14) ◽

pp. 7518

Author(s):

Marcella Tazzari ◽

Laura Bergamaschi ◽

Alessandro De Vita ◽

Paola Collini ◽

Marta Barisella ◽

...

Keyword(s):

Soft Tissue ◽

Malignant Tumors ◽

Soft Tissue Sarcomas ◽

Point Of View ◽

Molecular Features ◽

Molecular Determinants ◽

Genetic Landscape ◽

Current Therapies ◽

Cumulative Evidence

Soft tissue sarcomas (STSs) are a family of rare malignant tumors encompassing more than 80 histologies. Current therapies for metastatic STS, a condition that affects roughly half of patients, have limited efficacy, making innovative therapeutic strategies urgently needed. From a molecular point of view, STSs can be classified as translocation-related and those with a heavily rearranged genotype. Although only the latter display an increased mutational burden, molecular profiles suggestive of an “immune hot” tumor microenvironment are observed across STS histologies, and response to immunotherapy has been reported in both translocation-related and genetic complex STSs. These data reinforce the notion that immunity in STSs is multifaceted and influenced by both genetic and epigenetic determinants. Cumulative evidence indicates that a fine characterization of STSs at different levels is required to identify biomarkers predictive of immunotherapy response and to discover targetable pathways to switch on the immune sensitivity of “immune cold” tumors. In this review, we will summarize recent findings on the interplay between genetic landscape, molecular profiling and immunity in STSs. Immunological and molecular features will be discussed for their prognostic value in selected STS histologies. Finally, the local and systemic immunomodulatory effects of the targeted drugs imatinib and sunitinib will be discussed.

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Clinical assessment of Zyplast Implant: A year of experience for soft tissue contour correction

Journal of the American Academy of Dermatology ◽

10.1016/s0190-9622(88)70094-8 ◽

1988 ◽

Vol 18 (4) ◽

pp. 707-713 ◽

Cited By ~ 44

Author(s):

Melvin L. Elson

Keyword(s):

Soft Tissue ◽

Clinical Assessment

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Clinicopathological study of soft tissue sarcoma-retrospective study of tertiary cancer institute in eastern India

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20204907 ◽

2020 ◽

Vol 8 (11) ◽

pp. 4075

Author(s):

Kunhi Mohammed K. P. ◽

Snehasis Pradhan ◽

Supratim Bhattacharyya ◽

Prafulla Kumar Das ◽

Muhammed Navas N. K.

Keyword(s):

Retrospective Study ◽

Soft Tissue ◽

Soft Tissue Sarcoma ◽

Malignant Tumors ◽

Soft Tissue Sarcomas ◽

The Body ◽

Female Ratio ◽

Pleomorphic Sarcoma ◽

Frequent Variety ◽

Male To Female

Background: Soft tissue sarcomas are a rare and heterogeneous group of malignant tumors of mesenchymal origin that comprise less than 1 percent of all adult malignancies. Although they occur anywhere in the body, they involve most commonly in extremities, trunk, retroperitoneum and head and neck. The aim of the study was to analyze clinical and histopathological features of various soft tissue sarcomas.Methods: This was a retrospective study, conducted in tertiary cancer centre in Odisha during the period 2015 to 2018. We collected clinical parameters like age, sex, site of swelling, any associated pain and biopsy reports and these variables were correlated with final histopathology reports.Results: A total of 107 patients were included in the study, with male to female ratio of 2:1(71 and 36) and average age of 43.45 years. All of them presented with a swelling. The lower extremities were the most common sites i.e. 44.62%. Pleomorphic sarcoma was the most frequent histologic variety comprising 43% and less frequent variety were angiosarcoma, and myxoid sarcoma.Conclusions: Soft tissue sarcoma are predominant in males and middle aged population are frequently affected. Most common affected site is lower extremity and pleomorphic sarcoma is the prominent histologic type.

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Histopathological study of soft tissue tumours in a tertiary health centre in southern part of Assam

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20214422 ◽

2021 ◽

Vol 9 (11) ◽

pp. 3391

Author(s):

Khadija S. Tapadar ◽

Manoj K. Deka ◽

R. N. Chaubey ◽

Shah A. Sheikh ◽

Gargi R. Choudhury ◽

...

Keyword(s):

Soft Tissue ◽

Malignant Tumors ◽

Soft Tissue Tumors ◽

The Body ◽

World Health ◽

Vascular Tumors ◽

Benign Tumors ◽

Peripheral Nerve Sheath Tumors ◽

Pleomorphic Sarcoma ◽

Younger Age

Background: Soft tissue tumors are defined as mesenchymal proliferations which occur in the extraskeletal non-epithelial tissues of the body, excluding the viscera, coverings of brain and lymphoreticular system. The objective of this study was to study the histopathological features of soft tissue tumors and to study the occurrence of soft tissue tumors in relation to age, sex and anatomical site.Methods: This study comprised of 89 cases studied over a period of two years. All soft tissue tumors, their gross features, microscopic findings were analysed in detail. Soft tissue tumors were divided into benign and malignant categories and further sub typing were done according to World Health Organization (WHO) classification. The distribution of soft tissue tumors according to the age, sex and site of occurrence was studied.Results: Out of 89 cases of soft tissue tumors, 76 cases were benign, 4 cases belonged to intermediate category and 9 cases were malignant. Adipocytic tumors formed the largest group constituting 39 cases. Vascular tumors were the second commonest (26 cases) followed by peripheral nerve sheath tumors (11 cases). The benign tumors were seen in younger age as compared to malignant tumors. Malignant soft tissue tumors was seen to be more common in male than female and pleomorphic sarcoma and liposarcoma was commonest (3 cases each).Conclusions: Benign tumors were more common than malignant. The most common benign tumors were lipoma followed by hemangioma and schwannoma. The most common malignant tumor was pleomorphic sarcoma. The benign tumors were seen in younger age as compared to malignant tumors.

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How Can a Multidisciplinary Approach Improve Prognosis of Soft-Tissue Sarcomas of Extremities?

International Journal of Surgical Oncology ◽

10.1155/2021/8871557 ◽

2021 ◽

Vol 2021 ◽

pp. 1-8

Author(s):

Asmae Mazti ◽

Mohamed El Idrissi ◽

Abdelhalim El Ibrahimi ◽

Mustapha El Maaroufi ◽

Ghizlane El Koubaiti ◽

...

Keyword(s):

Survival Rate ◽

Soft Tissue ◽

Malignant Tumors ◽

Research Work ◽

Soft Tissue Sarcomas ◽

University Hospital ◽

R0 Resection ◽

Magnetic Resonance Imaging Scan ◽

Tumor Type ◽

Multidisciplinary Meeting

Soft-tissue sarcomas are malignant tumors that require good management within specialized centers. Our study aims to assess the benefit of handling these kinds of tumors using the Multidisciplinary Meeting (MDM) approach. The current paper details this approach through a prospective study that has lasted for 42 months in the HASSAN II University Hospital Center, Fez, Morocco. During this research work, 116 cases were selected with an average age of 53 years. In 95.7% of the cases, it was found that the lower limb was the most frequent tumor type (78.4%). Also, ninety-two (92) patients (79.3%) have had a prior biopsy. Ninety-nine (99) patients (85.3%) have received a magnetic resonance imaging scan (MRI) before surgery. Sixty-three (63) patients were operated on, including R0 resection used for 37 patients, R1 used for 21 patients, and R2 used for five patients. As a result, liposarcomas were the most frequent type (30.1%), followed by synovial sarcomas (14.6%), leiomyosarcomas (9.5%), ewing sarcoma (8.6), and undifferentiated pleomorphic sarcomas (7.7%). In addition, neoadjuvant chemotherapy was used for 36 patients. The other 22 patients received adjuvant chemotherapy and/or radiotherapy. The overall survival rate was 60.56 months, which proves a significant improvement, thanks to the multidisciplinary meeting approach. Conclusion. The conducted investigation has shown that using MDM for managing soft-tissue sarcomas of extremities improves the patients’ survival rate. Moreover, results have proven MDM might allow optimal treatment regarding less local recurrence and metastasis.

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Soft Tissue Sarcomas of Extremities - MRI Role in the Diagnostic Evaluation

Romanian Journal of Orthopaedic Surgery and Traumatology ◽

10.2478/rojost-2018-0056 ◽

2018 ◽

Vol 1 (Supplement) ◽

pp. 45

Author(s):

A.M. Bratu ◽

I.A. Sălcianu ◽

C. Zaharia ◽

G. Iana ◽

A.N. Marinescu

Keyword(s):

Soft Tissue ◽

Malignant Tumors ◽

Soft Tissue Sarcomas ◽

Oblique Muscle ◽

Special Importance ◽

Fatty Tissue ◽

Anatomical Structures ◽

Bony Pelvis ◽

Female Predominance ◽

The Relationship

Abstract Introduction. Soft tissue sarcomas (STS) are rare entities of soft tissue cancers. Their incidence is low, of only 1% of the malignant tumors. In terms of localization, most of the STS affect the extremities, and their incidence is much higher in children than in adults. Material and method. The present paper is a retrospective study that includes tumors with lower limb localizations, including the bony pelvis, over a 3-year period (2013-2016). The study group consisted of 29 patients who, following the MRI examination, were diagnosed with softtissue tumors. Of the 29 patients, 17 patients had a MRI (magnetic resonance imaging) and an anatomopathological diagnosis of leiomyosarcoma. The location of the tumor, its characteristics, and the relationship with the adjacent anatomical structures were analyzed in all cases. Results. The ages of the final group of 17 patients ranged between 28 and 84 years, with female predominance. In terms of localization, one showed a muscle tumor in the pelvis, namely left oblique muscle, other cases being located in the thigh and knee. A special importance was given to the superficial and profound location. In 5 cases, the tumor was localized in subcutaneous fatty tissue, thus superficial. In terms of the contours of the tumor, well-defined margins were present in 11 cases, and poorly defined contour in 6 cases. Regarding the size, the leiomyosarcomas in our study had dimensions between 5.2 cm and 18 cm, and their structure was inhomogeneous, with the presence of necrosis and calcifications. Necrosis was found in 14 cases, and calcifications were present in 68%, being more frequent than necrosis. Except for the necrotic areas, the contrast enhancement was intense. Conclusions. Although the diagnosis is always histopathological, the MRI plays an important role in defining a precise localization and tumor characteristics.

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