The relationship of dexamethasone nonsuppression to clinical symptoms and cognitive performance in treatment-resistant schizophrenics

1993 ◽  
Vol 9 (2-3) ◽  
pp. 178 ◽  
Author(s):  
A.L. Hoff ◽  
S. Espinoza ◽  
M. Gustafson ◽  
B. Mone ◽  
D. DeVilliers ◽  
...  
Author(s):  
Madhangi V. B. ◽  
Ramany C.

Background: Caesarean scar defect (CSD), also called isthmocele or niche is a long-term complication, which can be asymptomatic or can give rise to chronic pelvic pain, dyspareunia and postmenstrual spotting. The objective of this study was to assess the association of CSD with clinical symptoms, position of the uterus and the number of caesarean sections.Methods: This was a prospective observational study done at a tertiary care teaching hospital from January 2019 to December 2019. The study included women with history of previous one or more caesarean sections with demonstrable CSD on transvaginal ultrasound. Various scar dimensions noted were width and depth of the scar. A deficiency ratio was calculated as a ratio of residual myometrium at the scar to the adjacent myometrium.Univariate analysis was done to assess the relationship of clinical symptoms with the defect parameters and number of previous caesarean sections. Multiple logistic regression analysis was done to find out the association between symptoms and number of previous caesarean sections with the scar defect dimensions.Results: The width, depth and deficiency ratio of the CSD were significantly higher in study subjects with a greater number of caesarean sections. Retroflexed uteri had larger CSD. There was no association of clinical features with the defect dimensions and the position of the uterus.Conclusions: CSD dimensions and deficiency ratio correlate with the number of previous caesarean sections and the position of the uterus. There was no association of clinical symptoms with the defect parameters.


2017 ◽  
Vol 6 (1) ◽  
pp. 20-24
Author(s):  
Wei Li ◽  
Wei Liu ◽  
Guiming Zhou

Abstract Immune reconstitution inflammatory syndrome (IRIS), a common complication of AIDS, is further complicated by tuberculosis. Its clinical symptoms lack specificity but can be evaluated using diagnostic imaging. High-resolution computed tomography (HRCT) is useful in evaluating the morphology and internal microstructure of lesions associated with the syndrome, as well as the relationship of the internal microstructure with the surrounding tissues. This paper summarizes the present state and progress of imaging research on IRIS caused by AIDS and complicated by tuberculosis.


2017 ◽  
Vol 3 (1) ◽  
pp. 5
Author(s):  
Ilham Rahmatullah ◽  
Yuliana Mailinda Sari

Dyspepsia have clinical symptoms consist of pain or discomfort around the pit of the stomach so that the usual interfere with daily activities, both for teens and adults. Some risk factors that cause dyspepsia syndrome is a change in lifestyle, diet and unhealthy habits such as excessive cigarette smoking, excessive drinking, drinking beverages containing caffeine and drink soda.The study design used is analytic, with the design of case control. The research sample of 60 respondents where there were 30 cases and 30 controls with purposive sampliong technique. Data analysis using Chi Square test with a degree of error α=5%.Statistical analysis showed no relationship between diet and dyspepsia with the value (ρ = 0.004 <α = 0.05), there is a relationship of work stress with dyspepsia with the value (ρ = 0,000 <α = 0.05), there is a relationship with the fizzy drinks dyspepsia (ρ = 0.035 <α = 0.05) and the relationship of caffeinated beverages with dyspepsia (ρ = 0.019 <α = 0.05) in Puskesmas Loa Ipuh Tenggarong. It can be concluded that diet, stress, work and drink unhealthy relationship with the incidence of dyspepsia disease in Puskesmas Loa Ipuh Tenggarong. Suggested attention to a regular diet, minimization stres, and reduce unhealthy drinking habits such as drinking carbonated beverages, and drinking beverages that can berkefein excessive risk of disease dyspepsia.


2017 ◽  
Vol 2 (3) ◽  
pp. 2473011417S0000 ◽  
Author(s):  
Judith F. Baumhauer ◽  
Dishan Singh ◽  
Mark Glazebrook ◽  
Chris Blundell ◽  
Gwyneth de Vries ◽  
...  

Category: Midfoot/Forefoot Introduction/Purpose: Hallux rigidus (HR) is a very common symptomatic problem affecting one in 40 patients over the age of 50 years. A variety of treatment options exist and, as is common in surgery, grading systems are used to assess severity of the condition and aid in the guidance of treatment. The most commonly used grading system for HR uses radiographic images, great toe range of motion and clinical symptoms. This study examines the relationship of radiographic and motion findings to observed intra-operative cartilage loss in patients with HR and explores hallux rigidus grade and cartilage loss as predictive variables for treatment outcomes. Methods: A prospective, randomized non-inferiority study examining outcomes of arthrodesis compared to hemiarthroplasty of the first metatarsal phalangeal joint (Cartiva®) was performed.2 All randomized and treated patients were included in this study. Patients underwent pre-operative clinical examination, including measures of joint motion, radiographic assessment and HR grade. Operatively, observations of cartilage loss on the metatarsal head and opposing proximal surfaces were recorded. All patients’ data, irrespective of treatment, were aggregated and Spearman Rank Correlation coefficients used to assess for strength of correlation of active peak dorsiflexion and cartilage loss to HR grade. Outcomes data were then separated by treatment group and two-sided Fisher’s Exact test assessed these variables’ impact on clinical success (p<0.05). Results: In 202 patients, 59 (29%), 110 (55%), and 33 (16%) were classified as Coughlin1 Grades 2, 3, and 4, respectively. There was no correlation between grade and active peak dorsiflexion (-0.02, p=0.78). While rank correlations between grade and cartilage loss on the proximal phalanx and metatarsal head statistically significantly differed from zero, the magnitudes of the correlations were small, 0.176 (p=0.01) and 0.224 (p=0.001), respectively (Table 1). Among Grade 4 patients, 36.4% had no metatarsal cartilage remaining; but this was also found in 8.5% of Grade 2 patients. Similarly, 52.5% of Grade 2 patients had ≥50% metatarsal cartilage remaining; but this was also found in 21.2% of Grade 4 patients. None of the observed factors were significantly associated with likelihood of achieving composite success. Conclusion: This study examines the relationship of motion and intra-operative cartilage loss findings with a commonly used clinical and radiographic grading system for hallux rigidus. This study population included only candidates with HR considered a candidate for arthrodesis based on review of clinical symptoms however the Grade assigned maybe Coughlin Grade 2, 3 or 4. Irrespective of the Grade, positive outcomes were demonstrated within both treatment groups. The weak correlations of preoperative motion and intra-operative cartilage loss to grade suggests that clinical symptoms should be a significant determinant guiding the treatment option rather than radiographic or range of motion factors.


2016 ◽  
pp. sbw090 ◽  
Author(s):  
Letícia Sanguinetti Czepielewski ◽  
Lei Wang ◽  
Clarissa S. Gama ◽  
Deanna M. Barch

2016 ◽  
Vol 1 (1) ◽  
pp. 30-35 ◽  
Author(s):  
I. N. Zakharova ◽  
I. N. Kholodova ◽  
Y. A. Dmitrieva ◽  
N. V. Morozova ◽  
M. V. Mozzhukhina ◽  
...  

The article discusses the problem of teething in babies, the related mechanisms and factors. The research findings demonstrate the importance of different clinical symptoms of teething in infants, the relationship of the process with the baby's body type. Questions of the current therapy of pathological teething are considered.


2021 ◽  
Author(s):  
Daniela Gabiatti Donadel ◽  
Maxciel Zortea ◽  
Iraci Lucena da Silva Torres ◽  
Felipe Fregni ◽  
Wolnei Caumo

Abstract We compared the activation pattern at the motor cortex (MC and prefrontal cortex (PFC) based on the delta value (Δ) of oxy-hemoglobin (HbO) by functional near-infrared spectroscopy (fNIRS). We examined the relationship of the ΔHbO based on the peaks at 5°C and 25°C by right-hand immersion in water in 22 fibromyalgia and 19 controls. Fibromyalgia showed a shorter peak latency for HbO at the left MC. In contrast, at the left MC, their HbO increased 117.64% compared to 92.85% in the controls. A receiver operator characteristics (ROC) analysis showed the ΔHbO cutoffs equal to –0.175 at the left and –0.205 at the right PFC offer sensitivity and specificity of at least 80% in screening fibromyalgia compared to controls. In fibromyalgia, a ROC analysis showed that these cutoff points could discriminate those with higher disability due to pain and more severe central sensitization symptoms (CSS). The ROC with the best discriminatory profile was to the CSS score with the ΔHbO at the left PFC (AUC = 0.82, CI 95% = 0.61–100). These results indicate that cortical activation based on the ΔHbO at the PFC might be a sensitive marker to identify those fibromyalgia patients with more severe clinical symptoms.


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