Increased serum selenium levels are associated with reduced risk of advanced liver fibrosis and all-cause mortality in NAFLD patients: National Health and Nutrition Examination Survey (NHANES) III

AbstractObjectiveTo evaluate the association between ultra-processed food intake and all-cause mortality and CVD mortality in a nationally representative sample of US adults.DesignProspective analyses of reported frequency of ultra-processed food intake in 1988–1994 and all-cause mortality and CVD mortality through 2011.SettingThe Third National Health and Nutrition Examination Survey (NHANES III, 1988–1994).ParticipantsAdults aged ≥20 years (n11898).ResultsOver a median follow-up of 19 years, individuals in the highest quartile of frequency of ultra-processed food intake (e.g. sugar-sweetened or artificially sweetened beverages, sweetened milk, sausage or other reconstructed meats, sweetened cereals, confectionery, desserts) had a 31% higher risk of all-cause mortality, after adjusting for demographic and socio-economic confounders and health behaviours (adjusted hazard ratio=1·31; 95% CI 1·09, 1·58;P-trend = 0·001). No association with CVD mortality was observed (P-trend=0·86).ConclusionsHigher frequency of ultra-processed food intake was associated with higher risk of all-cause mortality in a representative sample of US adults. More longitudinal studies with dietary data reflecting the modern food supply are needed to confirm our results.

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Selenium, Copper, Zinc and Hypertension: An Analysis of the National Health and Nutrition Examination Survey (2011-2016)

10.21203/rs.2.12017/v2 ◽

2019 ◽

Author(s):

Mrigendra Mani Bastola ◽

Craig Locatis ◽

Richard Maisiak ◽

Paul Fontelo

Keyword(s):

Trace Elements ◽

National Health ◽

Serum Zinc ◽

Positive Association ◽

Reference Level ◽

Serum Selenium ◽

Nutrition Examination Survey ◽

Health And Nutrition ◽

Serum Selenium Levels

Abstract Background: Hypertension is a major cardiovascular illness worldwide with many underlying causes. The role of trace elements selenium, copper, and zinc in hypertension is uncertain. The objective of this study was to evaluate the role of these trace elements in hypertension. Method: Data from 6683 National Health and Nutrition Examination Survey (NHANES) participants from 2011 to 2016 were analyzed using Statistical Analytical System (SAS, version 9.4) software for the role of trace elements in hypertension in age range 8 to 80 years, irrespective of the antihypertensive medication taken. Recent American Heart Association guidelines and pediatric practice guidelines for hypertension were used.Results: Findings showed a significant positive association between serum selenium levels and hypertension but not serum zinc and copper. At optimal levels for transport and distribution, serum selenium levels of 120 µg/L or higher (reference level 70 -150 µg/L) were significantly associated with hypertension (OR = 1.46, 95% CI= 1.29 – 1.66) after adjusting for confounding factors. At serum selenium level greater than 150 µg/L, the association with hypertension strengthened (OR= 1.69, 95% CI = 1.32-2.17). Conclusion: A positive association was found between serum selenium and hypertension, irrespective of age or anti-hypertensive medications intake. These findings also suggest that the reference levels of serum levels in healthy individuals may need to be re-determined, if supported by additional studies. If validated, patients with hypertension may also need to be cautioned about selenium intake.

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Association of serum levels of antioxidant micronutrients with mortality in US adults: National Health and Nutrition Examination Survey 1999–2002

Public Health Nutrition ◽

10.1017/s1368980020004619 ◽

2020 ◽

pp. 1-10

Author(s):

Noah C Peeri ◽

Weiwen Chai ◽

Robert V Cooney ◽

Meng-Hua Tao

Keyword(s):

Vitamin E ◽

National Health ◽

Nutrition Examination Survey ◽

Health And Nutrition ◽

All Cause Mortality ◽

Specific Mortality ◽

Race Ethnicity ◽

Risk Of Cancer ◽

Reduced Risk ◽

Cvd Mortality

Abstract Objective: To examine associations between serum antioxidant levels and mortality (all-cause, cancer and CVD) among US adults. Design: We examined the risk of death from all-cause and cause-specific mortality associated with serum antioxidant (vitamin E and carotenoids) and vitamin A levels using Cox regression models to estimate hazards ratios (HR) and 95 % CI. Setting: The National Health and Nutrition Examination Survey (NHANES) 1999–2002 was followed up through 31 December 2015. Participants: The NHANES 1999–2002 cohort included 8758 participants aged ≥ 20 years. Serum carotenoid levels were only assessed for the 1999–2000 cycle. Therefore, sample size for each assessed antioxidant ranged from 4633 to 8758. Results: Serum vitamin E level was positively associated with all-cause mortality (HR = 1·22, 95 % CI 1·04, 1·43, highest v. lowest quartile). No other antioxidants were associated with mortality in overall analysis. In race/ethnicity-specific analyses, high vitamin E and α-tocopherol levels were associated with increased risk of all-cause mortality among non-Hispanic Whites. Among non-Hispanic Blacks, serum α-tocopherol level was associated with decreased risk of cancer mortality (HR = 0·30, 95 % CI 0·12, 0·75, third v. first quartile) and total carotenoid levels with reduced risk of CVD mortality (HR = 0·26; 95 % CI 0·07, 0·97, second v. lowest quartile). Hispanics with high β-carotene levels had reduced risk of CVD mortality. Conclusions: Serum antioxidant levels may be related to mortality; these associations may differ by race/ethnicity and appeared to be non-linear for all-cause and cause-specific mortality. Further studies are needed to confirm our results.

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Serum Selenium Levels in the US Population : Third National Health and Nutrition Examination Survey, 1988-1994

Biological Trace Element Research ◽

10.1385/bter:91:1:1 ◽

2003 ◽

Vol 91 (1) ◽

pp. 1-10 ◽

Cited By ~ 66

Author(s):

Amanda S. Niskar ◽

Daniel C. Paschal ◽

Stephanie M. Kieszak ◽

Katherine M. Flegal ◽

Barbara Bowman ◽

...

Keyword(s):

National Health ◽

Serum Selenium ◽

Nutrition Examination Survey ◽

Health And Nutrition ◽

The Us ◽

Serum Selenium Levels

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Selenium, Copper, Zinc and Hypertension: An Analysis of the National Health and Nutrition Examination Survey (2011-2016)

10.21203/rs.2.12017/v1 ◽

2019 ◽

Author(s):

Mrigendra Mani Bastola ◽

Craig Locatis ◽

Richard Maisiak ◽

Paul Fontelo

Keyword(s):

Trace Elements ◽

National Health ◽

Positive Association ◽

Reference Level ◽

Serum Selenium ◽

Nutrition Examination Survey ◽

Health And Nutrition ◽

Copper And Zinc ◽

Serum Selenium Levels

Abstract Abstract: Background: Hypertension is a major cardiovascular illness worldwide with many underlying causes. The role of trace elements selenium, copper, and zinc in hypertension is uncertain with only a few studies reported. The objective of this study was to evaluate the role of these trace elements in hypertension. Method: Data from 6683 National Health and Nutrition Examination Survey (NHANES) participants from 2011 to 2016 were analyzed using Statistical Analytical System (SAS, version 9.4) software for the role of trace elements in hypertension in age range 8 to 80 years, irrespective of the antihypertensive medication taken. Results: Findings showed a significant positive association between serum selenium levels and hypertension but not with serum copper and zinc. At optimal levels for transport and distribution, serum selenium levels of 120 µg/L or higher (reference level 70 -150 µg/L) were significantly associated with hypertension (OR = 1.56, 95% CI= 1.38 – 1.76) after adjusting for confounding factors. At serum selenium greater than 150 µg/L, the association with hypertension strengthened (OR= 1.91, 95% CI = 1.54-2.36). Conclusion: A positive association was found between serum selenium and hypertension, irrespective of age or anti-hypertensive medications intake. These findings also suggest that the reference levels of serum selenium levels in healthy individuals may need to be re-determined. If validated, patients with hypertension may also need to be cautioned about selenium intake.

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Association between selenium intake, diabetes, and mortality in adults: findings from National Health and Nutrition Examination Survey (NHANES) 2003-2014

British Journal Of Nutrition ◽

10.1017/s000711452100177x ◽

2021 ◽

pp. 1-24

Author(s):

Bushra Hoque ◽

Zumin Shi

Keyword(s):

National Health ◽

Cox Regression ◽

Inverse Association ◽

Nutrition Examination Survey ◽

Health And Nutrition ◽

Hazard Ratios ◽

The Us ◽

All Cause Mortality ◽

Cvd Mortality

Abstract Selenium (Se) is a trace mineral that has antioxidant and anti-inflammatory properties. This study aimed to investigate the association between Se intake, diabetes, all-cause and cause-specific mortality in a representative sample of US adults. Data from 18,932 adults who attended the 2003-2014 National Health and Nutrition Examination Survey (NHANES) were analysed. Information on mortality was obtained from the US mortality registry updated to 2015. Multivariable logistic regression and Cox regression were used. Cross-sectionally, Se intake was positively associated with diabetes. Comparing extreme quartiles of Se intake, the odds ratio (OR) for diabetes was 1.44 (95% CI: 1.09–1.89). During a mean of 6.6 years follow-up, there were 1627 death (312 CVD, 386 cancer). High intake of Se was associated with a lower risk of all-cause mortality. When comparing the highest with the lowest quartiles of Se intake, the hazard ratios (HRs) for all-cause, CVD mortality, cancer mortality and other mortality were: 0.77 (95% CI 0.59-1.01), 0.62 (95% CI, 0.35-1.13), 1.42 (95% CI, 0.78-2.58) and 0.60 (95% CI,0.40-0.80), respectively. The inverse association between Se intake and all-cause mortality was only found among white participants. In conclusion, Se intake was positively associated with diabetes but inversely associated with all-cause mortality. There was no interaction between Se intake and diabetes in relation to all-cause mortality.

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