Background:Gout is associated with increased risk of cardiovascular disease (CVD) morbidity and mortality. Therefore, an association between coronary heart disease (CHD) and gout deserves careful examination.Objectives:The aim of this study was to determine the prevalence of CHD and factors associated with CHD in patients (pts) with gout.Methods:286 male patients fulfilling Wallace proposed criteria for gout were included: age 51.2 [42.8;59.4] years (ys), disease duration – 6.2 [3.8;12.1] ys. All patients underwent standard clinical examination, screening traditional risk factors (TRF) of CVD, blood chemistry test with estimation of serum uric acid, serum creatinine, C-reactive protein (CRP), as well as lipid profile. Carotid intima-media thickness (cIMT) was measured using a high-resolution B-mode ultrasound machine. CHD included history of angina pectoris and/or myocardial infarction. We estimated the adjusted odds ratio (OR) and 95% confidence interval (95% CI).Results:CHD was found in 111 out of the 286 pts (38.8 %). Compared to individuals with CHD, participants without CHD were older (56.7[52.1; 61.1] vs 46.2[40.6; 53.4] ys), had longer duration of gout (9.3[4.7; 15.1] vs 5.6[3.3; 9.7] ys), higher number of joints involved during disease course (8[6; 15] vs 6[4; 10]), duration of smoking (24[10; 40] vs 20[10; 28]), higher serum creatinine level accordingly, (for all p<0.05). The frequency of family history of CHD (63% vs 46.8%), intraosseous tophi (61.3% vs 33.1%), was higher in pts with CHD compared pts without CHD accordingly, (for all p<0.01). Prevalence of arterial hypertension, diabetes mellitus, nephrolithiasis, heart failure and renal failure was greater in pts with CHD than pts without CHD (p<0.001). Gout pts with CHD had a significantly higher cIMT compare to those without CHD - 0.95[0.8;1.08]/0.8[0.7;0.9] accordingly, p<0.001. We didn’t find differences of lipid profile, serum uric acid, and CRP level in gout pts with/without CHD.Abdominal obesity (OR, 5.5; 95% CI, 2.2-13.6), body mass index >30 kg/m2 (OR, 5.8; 95% CI, 1.8-18.5), family history of CHD (OR, 2.7; 95% CI, 1.3-5.4), disease duration of gout more 10 ys (OR, 2.6; 95% CI, 1.3-5.1), age of gout onset < 35 ys (OR, 3.0; 95% CI, 1.5-6.1), intraosseous tophi (OR, 3.1; 95% CI, 1.4-7.0), C-RP (OR, 2.2; 95% CI, 1.1-4.7), renal failure (OR, 18,8; 95% CI, 1.1-312.9), increased the risk for CHD in patients with a gout.Conclusion:The prevalence of CHD was 38.8% among individuals with gout. Our study showed that both TRFs of CVD and the severity of gout and a history of renal failure contribute to the development of CHD in patients with gout.Disclosure of Interests:None declared.