Effectiveness of green tea cream in comparison with silver sulfadiazine cream in treatment of second degree burn in human subjects

2022 ◽  
pp. 100533
Author(s):  
Amir Siyahpoosh ◽  
Abdul Reza Sheikhi ◽  
Elham Jafarzadeh ◽  
Mahsa Pipelzadeh
Keyword(s):  
Green Tea ◽  
Human Subjects ◽  
Silver Sulfadiazine ◽  
Degree Burn ◽  
Second Degree

673 Effect of Subcutaneous Topical Ozone Therapy on Second Degree Burn Wounds in Rats: An Experimental Study

2021 ◽  
Vol 42 (Supplement_1) ◽  
pp. S193-S193
Author(s):  
Emre Karakaya ◽  
Aydincan Akdur ◽  
H Ebru ◽  
Ayvazoglu Soy ◽  
Alev Ok Atilgan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Silver Sulfadiazine ◽  
Male Rats ◽  
Control Group ◽  
Ozone Therapy ◽  
Burn Wounds ◽  
Degree Burn ◽  
Significant Difference ◽  
Second Degree

Abstract Introduction Burn is one of the most severe traumas that causes coagulative destruction of the skin. The use of various products that accelerate wound healing in patients with burn may affect the patient’s survival and reduce the complications that may be seen. In the present study we aimed effects of subcutaneous ozone injection on second degree burn wound. Methods A total of 72 Sprague-Dawley male rats included in the study were divided randomly into three groups (control group (CG), silver sulfadiazine group (SG), ozone group (OG)) and each group was divided randomly two subgroups (as sacrificed on d7 and on d14).A deep second degree scald burns were created on the lower back. In CG subcutaneous 0.9% serum saline was injected daily into the burn area. In SG, burns were dressed with silver sulfadiazine daily and in OG subcutaneous ozone was injected daily into the burn area. Tissue hydroxyproline level measurement and histopathological evaluation were done. Results When the groups were compared in terms of weight change, no significant difference was found on the 7th and 14th days. In the evaluation made in terms of tissue hydroxyproline, tissue hydroxyproline level in OG was found to be significantly higher on both the 7th and 14th days (p < 0.001). In histopathological evaluations, it was determined that wound healing in OG was significantly higher than in the other groups. Conclusions According to the results, subcutaneous ozone therapy is more effective than silver sulphadiazine in the healing process of second-degree burn wounds and it can be safely used in the treatment of burn wounds.

scholarly journals Effect of green tea on the second degree burn wounds in rats

2014 ◽  
Vol 47 (03) ◽  
pp. 370-374 ◽  
Author(s):  
Mohammad Javad Fatemi ◽  
Babak Nikoomaram ◽  
Amir Asadollah Khajeh Rahimi ◽  
Donya Talayi ◽  
Shahrzad Taghavi ◽  
...  
Keyword(s):  
Green Tea ◽  
Healing Process ◽  
Digital Camera ◽  
First Aid ◽  
Control Group ◽  
Burn Wounds ◽  
Beneficial Effects ◽  
Pathologic Evaluation ◽  
Degree Burn ◽  
Second Degree

ABSTRACT Background: Various studies indicate that the green tea has anti-inflammatory and anti-oxidative properties. Moreover, a few studies have been carried out that demonstrate beneficial effects of green tea on burned patients. Materials and Methods: In this study, green tea, Vaseline, and silver sulfadiazine dressings were used as first-aid treatment to deep dermal contact burns in rats, compared with a control of nothing. After creating second-degree burn on the dorsum of rats, the treatments were applied for 15 min in four groups. Wound dressing changes were daily. Macroscopic study was performed on days 1, 3, 7, and 14 by using a digital camera and software processing of photos. Microscopic examination was done by pathologic evaluation of skin specimens on day 14. Results: We observed that green tea usage significantly decreased burn size in comparison to the control group (P = 0.004). Conclusion: Green tea is effective on healing process of second degree burn wounds.

scholarly journals ALOE VERA VS. SILVER SULFADIAZINE FOR TREATING SECOND-DEGREE BURN WOUNDS: EVIDENCE-BASED CASE REPORT

2019 ◽  
pp. 146-148
Author(s):  
CLARA MENNA ◽  
NABILLA CALISTA ◽  
LEORCA AURINO ◽  
ADISTI DWIJAYANTI
Keyword(s):  
Clinical Trials ◽  
Risk Reduction ◽  
Randomized Clinical Trials ◽  
Aloe Vera ◽  
Silver Sulfadiazine ◽  
Number Needed To Treat ◽  
Burn Wounds ◽  
The Third ◽  
Degree Burn ◽  
Second Degree

Objective: Current treatment for second-degree burn wounds, including silver sulfadiazine (SSD) application, may cause side effects such as delayed and incomplete wound healing, leaving a scar. Traditional plants empirically used for burn wounds, such as Aloe vera, seem to be a promising option with good safety profiles. Methods: We therefore compared Aloe vera to SSD for second-degree burn wounds based on a review of clinical trials obtained by an organized search through the Cochrane, PubMed, and DynaMed databases. Three randomized clinical trials studies were selected, two of which were critically appraised. The third study, with a different outcome assessment, was analyzed separately. Results: Two studies showed that Aloe vera was more effective in treating second-degree burn wounds than SSD 1% with an absolute risk reduction of 0.2, relative risk reduction of 0.83–1.0, and number needed to treat five patients. The Aloe vera group showed faster healing, earlier epithelialization, and earlier pain alleviation. The third study combined Aloe vera with other herbs, which showed better healing ability and restored skin hydration than those with SSD. Conclusion: Each of the three articles stated that Aloe vera was more effective than SSD for treating second-degree burn wounds. Nevertheless, each of the studies lacked methodology and comprehensive data reporting.

scholarly journals Nanocrystalline silver gel versus conventional silver sulfadiazine cream as topical dressing for second-degree burn wound: A clinicopathological comparison

2018 ◽  
Vol 26 (1) ◽  
pp. 29 ◽  
Author(s):  
Gouranga Dutta ◽  
Nandini Das ◽  
Abhishek Adhya ◽  
Kinkar Munian ◽  
BijayKumar Majumdar
Keyword(s):  
Silver Sulfadiazine ◽  
Burn Wound ◽  
Degree Burn ◽  
Second Degree

scholarly journals A comparative study of the efficacy of nanocrystalline silver gel and silver sulfadiazine cream on the healing of second degree burn wound

2020 ◽  
Vol 7 (12) ◽  
pp. 4076
Author(s):  
Bikash Maiti ◽  
Sabyasachi Bakshi
Keyword(s):  
Healing Time ◽  
Silver Sulfadiazine ◽  
Tissue Type ◽  
Necrotic Tissue ◽  
Burn Wound ◽  
Chi Square ◽  
After Effects ◽  
Nano Crystalline ◽  
Degree Burn ◽  
Second Degree

Background: The final aim of burn management is to prevent infection, to promote early epithelialization as well as healing of wound and betterment of functional and asthetic after effects. The present study aimed to compare the effect of nano crystalline silver gel and silver sulfadiazine cream on the healing of second-degree burn wounds.Methods: After matching the inclusion and exclusion criteriaburn wounds of patients were divided into two parts (sides); one part was dressed with silver sulfadiazine cream and the other one was dressed with nano crystalline silver gel. The wound dressing was changed everyday after washing the wound with normal saline. Wound parameters were measured on the ninth day and twenth day of dressing, using clinical assessment and photographic tool. The obtained data were statistically analyzed using the Chi-square test.Results: In our study, most patients were noted to have increased epithelization, increased granulation tissue, decreased inflammation, decreased wound infection as well as decreased slough following dressing with both nanocrystalline silver gel and silver sulfadiazine cream but there were more in numbers of patients dressing with nanocrystalline silver gel.Conclusions: The effect of nanocrystalline silver gel on the reduction of the healing time and necrotic tissue amount and increasing the granulation, epithelialization, and necrotic tissue type was greater. Considering the above findings nanocrystalline silver gel is more recommended to be used for burn wounds.

Therapeutic Intervention of Aloe Gel Containing Nano-Sized and Micron-Sized Silver Sulfadiazine Gel on Second-Degree Burn: A Comparative Study

2018 ◽  
Vol 17 (3) ◽  
pp. 176-183 ◽  
Author(s):  
Md Abul Barkat ◽  
Harshita ◽  
Faheem Hyder Pottoo ◽  
Satya Prakash Singh ◽  
Farhan J. Ahmad
Keyword(s):  
Wound Healing ◽  
Drug Release ◽  
Silver Sulfadiazine ◽  
Control Group ◽  
Formulation Development ◽  
Topical Gel ◽  
Degree Burn ◽  
Carbopol 940 ◽  
Aloe Gel ◽  
Second Degree

The current work focuses on the formulation development, optimization, and in vivo assessment of nano-sized silver sulfadiazine ( nSSD) and micron-sized silver sulfadiazine ( mSSD) topical gel composed of Aloe vera gel ( Aloe gel) and Carbopol 940 for the management of second-degree burn wound. The optimized concentration of gel-forming agent (Carbopol 940) was chosen based on best possible consistency and spreadability of the gel. The second-degree burn infliction was developed in the posterior region of rats followed by anesthesia. Afterward, the created wounds were further treated individually by both the gel formulation (1 application daily) for 14 days and observations were recorded. The nSSD gel showed better wound healing and a higher degree of tissue hyperplasia as compared with mSSD gel in rats. In vitro drug release study showed better drug release from nSSD gel (74.25 ± 3.331%) as compared with mSSD gel formulation (61.32 ± 2.112%) after 24 hours. The nSSD and mSSD topical gel-treated rats showed 95.63% and 78.75% wound healing after 14 days, while in the case of control group rats, 48.65% wound contraction was seen after 14 days. Furthermore, the histopathological study revealed that the nSSD gel was more efficient in controlling the wound infection and showed better wound healing as compared with mSSD gel formulation.

scholarly journals Heterogeneity of mast cells and expression of Annexin A1 protein in a second degree burn model with silver sulfadiazine treatment

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0173417 ◽  
Author(s):  
Helena Ribeiro Souza ◽  
Lucas Ribeiro de Azevedo ◽  
Lucas Possebon ◽  
Sara de Souza Costa ◽  
Melina Mizusaki Iyomasa-Pilon ◽  
...  
Keyword(s):  
Mast Cells ◽  
Silver Sulfadiazine ◽  
Annexin A1 ◽  
Degree Burn ◽  
Second Degree

Effect of Subcutaneous Topical Ozone Therapy on Second-Degree Burn Wounds in Rats: An Experimental Study

2021 ◽  
Author(s):  
Emre Karakaya ◽  
Aydincan Akdur ◽  
Ebru Ayvazoğlu Soy ◽  
Coşkun Araz ◽  
Alev Ok Atilgan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Silver Sulfadiazine ◽  
Male Rats ◽  
Control Group ◽  
Ozone Therapy ◽  
Burn Wounds ◽  
Degree Burn ◽  
Significant Difference ◽  
Second Degree

Abstract Burns are one of the most severe traumas, causing coagulative destruction of the skin. The use of various products that accelerate wound healing in patients with burns may affect rates of patient survival and reduce complications. We studied the effects of subcutaneous ozone injection on second-degree burn wounds in animal model. For this study, 72 Sprague-Dawley male rats were divided randomly into the following three groups: control group , silver sulfadiazine group, and ozone group; each group was then divided randomly into two subgroups (day 7 or day 14 examination and sacrifice). Superficial partial thickness burns were created on the lower back. In the control group, subcutaneous 0.9% serum saline was injected daily into the burn area. In the silver sulfadiazine group, burns were dressed daily with silver sulfadiazine. In the ozone group, subcutaneous ozone was injected daily into the burn area. We performed tissue hydroxyproline level measurements and histopathological evaluations. When groups were compared in terms of weight change, no significant difference was found between day 7 and day 14. With regard to tissue hydroxyproline levels the ozone group had significantly higher levels on both day 7 and day 14 (P < .001). In histopathological evaluations, we determined that wound healing in the ozone group was significantly higher than in the other groups. We found that subcutaneous ozone therapy was more effective than silver sulfadiazine in the healing process of second-degree burn wounds and could be safely used in the treatment of burn wounds.

scholarly journals Therapeutic Effect and Mechanism of Oxytropis falcata Gel on Deep Second-Degree Burn in Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Xiao-Feng Lin ◽  
Kai-Jie Chen ◽  
He-Kun Shi ◽  
Le Yu ◽  
Jin-Shan Chen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Therapeutic Effect ◽  
Wistar Rats ◽  
Molecular Mechanisms ◽  
Inflammatory Cells ◽  
Silver Sulfadiazine ◽  
Degree Burn ◽  
Immunohistochemical Assessment ◽  
Second Degree

Oxytropis falcata has long been used to treat inflammation, sores, and bleeding in Tibet. However, the burn remedy and underlying molecular mechanisms are not well understood. This study is aimed at assessing the effect of Oxytropis falcate gel (OFG) on deep second-degree burn rats and exploring its mechanism. Wistar rats with second-degree burn were treated with OFG and silver sulfadiazine. Immunohistochemical detections for EGF and VEGF were performed, and ELISA detections for EGF, VEGF, p38, and IL-1β in serum were determined. Rats treated with OFG (25, 50 g/kg) consisted of the major rhamnocitrin-3-O-β-neohesperidoside significantly accelerated incrustation (P<0.001) and decrustation (P<0.001). According to HE staining, edema and infiltration of inflammatory cells decrease apparently with good hyperplasia and incrustation in administration groups (7 d). The expressions of EGF and CD34 in OFG (25, 50 g/kg) treatment increased obviously from immunohistochemical assessment (7 d). Serum EGF expression reached 321.27±7.20 ng/mL by OFG treatment, while p38 (P<0.05) and IL-1β (P<0.05) levels were significantly lower than the model and vehicle groups from day 1 to day 7. OFG possesses potential wound healing activities. The mechanism may be related to the increasing of biosynthesis and the releasing of EGF and CD34 and the decreasing p38 and IL-1β levels.

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