scholarly journals The COVID-19 era recalls the importance of ensuring sufficient vitamin D status in the general population

Author(s):  
Cédric Annweiler
2021 ◽  
Vol 22 (6) ◽  
pp. 2896
Author(s):  
Armin Zittermann ◽  
Christian Trummer ◽  
Verena Theiler-Schwetz ◽  
Elisabeth Lerchbaum ◽  
Winfried März ◽  
...  

During the last two decades, the potential impact of vitamin D on the risk of cardiovascular disease (CVD) has been rigorously studied. Data regarding the effect of vitamin D on CVD risk are puzzling: observational data indicate an inverse nonlinear association between vitamin D status and CVD events, with the highest CVD risk at severe vitamin D deficiency; however, preclinical data and randomized controlled trials (RCTs) show several beneficial effects of vitamin D on the surrogate parameters of vascular and cardiac function. By contrast, Mendelian randomization studies and large RCTs in the general population and in patients with chronic kidney disease, a high-risk group for CVD events, largely report no significant beneficial effect of vitamin D treatment on CVD events. In patients with rickets and osteomalacia, cardiovascular complications are infrequently reported, except for an increased risk of heart failure. In conclusion, there is no strong evidence for beneficial vitamin D effects on CVD risk, either in the general population or in high-risk groups. Whether some subgroups such as individuals with severe vitamin D deficiency or a combination of low vitamin D status with specific gene variants and/or certain nutrition/lifestyle factors would benefit from vitamin D (metabolite) administration, remains to be studied.


Author(s):  
Nikita Pahuja ◽  
Nidhi Chauhan ◽  
Vinita Kalra

Background: A balanced, nutritious diet is an important aspect of a healthy pregnancy and its outcome. Vitamin D plays an important role in regular bone growth and in adequate function of innate immune system, including barrier function of mucous membrane. Vitamin D deficiency in adult females may increase risk of pre-eclampsia, gestational diabetes, bacterial vaginosis. The present study was undertaken to find the prevalence of Vitamin D deficiency in the women of Uttarakhand, India.Methods: The study was conducted in the Department of Obstetrics and Gynecology, Himalayan Institute of Medical Sciences (HIMS), Swami Ram Nagar, Dehradun, India over a period of 12 months. Sample size was 100 pregnant females attending antenatal clinic.Results: Out of 100 subjects, 21 (21%) had deficient, 69 (69%) had insufficient and 10 (10%) had sufficient vitamin D status. Out of 21 deficient subjects, 18 (85.71%) were Hindus, 2 (9.52%) were Muslims, 1 (4.76%) was Sikh and no deficiency was seen in Christian. In the present study, deficient vitamin D status was seen in 1 (4.76%) in lower, 16 (76.19%) in middle and 4 (19.04%) subjects in upper socioeconomic status.Conclusions: It is concluded from our study that there is serious vitamin D deficiency and insufficiency in the women of Uttarakhand, India.


2020 ◽  
Vol 31 (6) ◽  
pp. 686-694 ◽  
Author(s):  
Jonatan Leffler ◽  
Cristina Gamez ◽  
Anderson P. Jones ◽  
Kristina Rueter ◽  
James F. Read ◽  
...  

Endocrine ◽  
2013 ◽  
Vol 47 (1) ◽  
pp. 213-220 ◽  
Author(s):  
Tea Skaaby ◽  
Lise Lotte Nystrup Husemoen ◽  
Anders Borglykke ◽  
Torben Jørgensen ◽  
Betina Heinsbæk Thuesen ◽  
...  

Bone ◽  
2012 ◽  
Vol 50 (3) ◽  
pp. 605-610 ◽  
Author(s):  
B. Thuesen ◽  
L. Husemoen ◽  
M. Fenger ◽  
J. Jakobsen ◽  
P. Schwarz ◽  
...  

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