The utility of tumour infiltrating lymphocytes as a risk factor for local recurrences of abdominal wall fibromatosis

Background Surgical site infections (SSIs) are an established complication following colorectal operations, with rates up to 30% reported in the literature. Obesity is a known risk factor for SSI; however, body mass index (BMI), body fat percentage, waist-hip ratio, or abdominal circumference are imperfect measures. The purpose of our study was to determine whether abdominal wall thickness (AWT) is predictive of SSI. Methods We queried our American College of Surgeons National Surgical Quality Improvement Project (ACS-NSQIP) database for patients (age ≥18 years) undergoing a colectomy at the University of Kentucky (UK) from January 1, 2013 to December 31, 2018. The exclusion criteria included patients with open abdomens or the lack of preoperative computed tomography (CT) within 3 months of their operation. AWT was measured at the level of the anterior superior iliac spine (ASIS) on abdominal CT. SSI was defined by superficial SSI, deep SSI, and wound dehiscence. Results Of 1261 patients enrolled, 52.2% were female, with an average age of 57.4 years. More patients had laparoscopic operations (51%), and the median length of stay was 7 days. Our study demonstrated an SSI rate of 9.4% and a 30-day readmission rate of 11%. The overall mean AWT was 2.6 cm (range .1-13.1), and patients with the highest AWT quintile were more likely to develop an SSI than the lowest quintile (12% vs. 5%). After controlling for risk factors and confounders, the odds of an SSI were 3.6 times higher for patients with the highest AWT than patients with the lowest AWT. Conclusions Among colorectal surgery patients, AWT is an independent risk factor predictive for SSI.

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Characterization of fresh (uncultured) tumour-infiltrating lymphocytes (TIL) and TIL-derived T cell lines from patients with renal cell carcinoma

Clinical & Experimental Immunology ◽

10.1111/j.1365-2249.1994.tb06088.x ◽

2008 ◽

Vol 97 (2) ◽

pp. 321-327 ◽

Cited By ~ 19

Author(s):

D. MITROPOULOS ◽

S. KOOI ◽

J. RODRIGUEZ-VILLANUEVA ◽

C. D. PLATSOUCAS

Keyword(s):

Renal Cell Carcinoma ◽

T Cell ◽

Cell Carcinoma ◽

Cell Lines ◽

Renal Cell ◽

Tumour Infiltrating Lymphocytes ◽

T Cell Lines ◽

Infiltrating Lymphocytes

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LBA2 Impact of RNA expression signatures and tumour infiltrating lymphocytes (TILs) for pathological complete response (pCR) and survival after 12 week de-escalated neoadjuvant pertuzumab + trastuzumab ± paclitaxel in the WSG-HER2+/HR- ADAPT trial

Annals of Oncology ◽

10.1016/j.annonc.2021.03.215 ◽

2021 ◽

Vol 32 ◽

pp. S48

Author(s):

M. Graeser ◽

O. Gluz ◽

C. Biehl ◽

D. Ulbrich-Gebauer ◽

J. Palatty ◽

...

Keyword(s):

Pathological Complete Response ◽

Complete Response ◽

Rna Expression ◽

Tumour Infiltrating Lymphocytes ◽

Infiltrating Lymphocytes

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The relationship between CD204 M2-polarized tumour-associated macrophages (TAMs), tumour-infiltrating lymphocytes (TILs), and microglial activation in glioblastoma microenvironment: a novel immune checkpoint receptor target

Discover Oncology ◽

10.1007/s12672-021-00423-8 ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Maher Kurdi ◽

Badrah Alghamdi ◽

Nadeem Shafique Butt ◽

Saleh Baeesa

Keyword(s):

Microglial Activation ◽

Inverse Correlation ◽

Idh1 Mutation ◽

High Expression ◽

Kaplan Meier ◽

Significant Difference ◽

Tumour Infiltrating Lymphocytes ◽

Infiltrating Lymphocytes ◽

The Relationship ◽

Low Expression

Abstract Background Tumour associated macrophages (TAMs) and tumour infiltrating lymphocytes (TILs) are considered dominant cells in glioblastoma microenvironment. Aim The purpose of this study was to assess the expression of CD204+ M2-polarized TAMs in glioblastomas and their relationship with CD4+TILs, Iba+microglia, and IDH1 mutation. We also exploreed the prognostic value of these markers on the recurrence-free interval (RFI). Methods The expressions of CD204+TAMs, CD4+TILs, and Iba1+microglia were quantitively assessed in 45 glioblastomas using immunohistochemistry. Kaplan–Meier analysis and Cox hazards were used to examine the relationship between these factors. Results CD204+TAMs were highly expressed in 32 tumours (71%) and the remaining 13 tumours (29%) had reduced expression. CD4+TILs were highly expressed in 10 cases (22%) and 35 cases (77.8%) had low expression. There was an inverse correlation between CD204+TAMs and CD4+TILs, in which 85% of tumours had a high expression of CD204+TAMs and a low expression of CD4+TILs. Nevertheless, there was no significant difference in IDH1 mutation status between the two groups (p = 0.779). There was a significant difference in Iba1+microglial activation between IDH1mutant and IDH1wildtype groups (p = 0.031). For cases with a high expression of CD204+TAMs and a low expression of CD4+TILs, there was a significant difference in RFI after treatment with chemoradiotherapy or radiotherapy (p = 0.030). Conclusion Glioblastoma with a dense CD204+TAMs and few CD4+TILs is associated with IDH1wildtype. These findings suggest that TAMs masks tumour cell and suppress T-cell tumoricidal functions via immunomodulatory mechanisms. Blockade of the CD204-TAM receptor may prevent this mechanism and allow the evolution of TILs.

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