Expanding the number of validated iPSC-derived cardiomyocytes for safety pharmacology studies

2021 ◽  
Vol 111 ◽  
pp. 107030
Author(s):  
Annie Armstrong ◽  
Sarah Himmerich ◽  
Megan K. Livingston ◽  
Coby B. Carlson ◽  
Cara R. Rieger ◽  
...  
Keyword(s):  
Safety Pharmacology

scholarly journals Improving drug safety predictions by reducing poor analytical practices

2020 ◽  
Vol 4 ◽  
pp. 239784732097863
Author(s):  
Stanley E Lazic ◽  
Dominic P Williams
Keyword(s):  
At Risk ◽  
Drug Discovery ◽  
Drug Safety ◽  
Prediction Models ◽  
Predictive Modelling ◽  
Equal Weight ◽  
Negative Consequences ◽  
Preclinical Data ◽  
Safety Pharmacology ◽  
Patients At Risk

Predicting the safety of a drug from preclinical data is a major challenge in drug discovery, and progressing an unsafe compound into the clinic puts patients at risk and wastes resources. In drug safety pharmacology and related fields, methods and analytical decisions known to provide poor predictions are common and include creating arbitrary thresholds, binning continuous values, giving all assays equal weight, and multiple reuse of information. In addition, the metrics used to evaluate models often omit important criteria and models’ performance on new data are often not assessed rigorously. Prediction models with these problems are unlikely to perform well, and published models suffer from many of these issues. We describe these problems in detail, demonstrate their negative consequences, and propose simple solutions that are standard in other disciplines where predictive modelling is used.

Assessment of sensitivity of three ECG recording methods used in dog toxicology and safety pharmacology studies

2010 ◽  
Vol 62 (2) ◽  
pp. e4
Author(s):  
Pierre Laine ◽  
Mark Deurink ◽  
Alan Bass ◽  
Jonathan Bright ◽  
Richard Briscoe ◽  
...  
Keyword(s):  
Safety Pharmacology

Characterization of db/db mice for efficacy/safety pharmacology assessment of antidiabetic drugs

2013 ◽  
Vol 68 (1) ◽  
pp. e50
Author(s):  
Clarisse Duval ◽  
Martine Lemaire ◽  
Philippe Guillaume ◽  
Daniel Provost ◽  
Guillaume Froget
Keyword(s):  
Antidiabetic Drugs ◽  
Safety Pharmacology

DOG EEG IN SAFETY PHARMACOLOGY

2007 ◽  
Vol 56 (2) ◽  
pp. e24
Author(s):  
Nick Dürmüller ◽  
Pierre Lacroix ◽  
Roger D. Porsolt ◽  
Paul Moser
Keyword(s):  
Safety Pharmacology
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