This chapter examines the politics of global health agenda setting, the process by which global health issues come to receive attention from actors that control or influence the allocation of financial, technical, human, and other kinds of resources. It suggests that the global health agenda is shaped by the capabilities of actors, including policy entrepreneurs, high-level champions, and networks; ideas, especially those surrounding problem definition, solutions, and causal stories; powerful interests, such as the economic and security concerns of wealthy countries and industries; and institutions, such as international law and trade regimes. Most studies of global health agenda setting are of a single case, and many are descriptive. To build the field, future research should supplement these studies with comparative, theoretically grounded inquiry.