scholarly journals Associations between patterns in comorbid diagnostic trajectories of individuals with schizophrenia and etiological factors

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Morten Dybdahl Krebs ◽  
Gonçalo Espregueira Themudo ◽  
Michael Eriksen Benros ◽  
Ole Mors ◽  
Anders D. Børglum ◽  
...  
Keyword(s):  
Latent Factors ◽  
Prospective Longitudinal Study ◽  
Etiological Factors ◽  
Individual Level ◽  
Danish Health ◽  
Stable Clusters ◽  
History Of ◽  
The Individual ◽  
Prospective Longitudinal ◽  
Ordered Pairs

AbstractSchizophrenia is a heterogeneous disorder, exhibiting variability in presentation and outcomes that complicate treatment and recovery. To explore this heterogeneity, we leverage the comprehensive Danish health registries to conduct a prospective, longitudinal study from birth of 5432 individuals who would ultimately be diagnosed with schizophrenia, building individual trajectories that represent sequences of comorbid diagnoses, and describing patterns in the individual-level variability. We show that psychiatric comorbidity is prevalent among individuals with schizophrenia (82%) and multi-morbidity occur more frequently in specific, time-ordered pairs. Three latent factors capture 79% of variation in longitudinal comorbidity and broadly relate to the number of co-occurring diagnoses, the presence of child versus adult comorbidities and substance abuse. Clustering of the factor scores revealed five stable clusters of individuals, associated with specific risk factors and outcomes. The presentation and course of schizophrenia may be associated with heterogeneity in etiological factors including family history of mental disorders.

scholarly journals Natural History of NAFLD

2021 ◽  
Vol 10 (6) ◽  
pp. 1161
Author(s):  
Raluca Pais ◽  
Thomas Maurel
Keyword(s):  
Liver Disease ◽  
Natural History ◽  
Disease Progression ◽  
Specific Treatment ◽  
Alcoholic Fatty Liver ◽  
Individual Level ◽  
Close Relationship ◽  
History Of ◽  
The Individual ◽  
The Impact

The epidemiology and the current burden of chronic liver disease are changing globally, with non-alcoholic fatty liver disease (NAFLD) becoming the most frequent cause of liver disease in close relationship with the global epidemics of obesity, type 2 diabetes and metabolic syndrome. The clinical phenotypes of NAFLD are very heterogeneous in relationship with multiple pathways involved in the disease progression. In the absence of a specific treatment for non-alcoholic steatohepatitis (NASH), it is important to understand the natural history of the disease, to identify and to optimize the control of factors that are involved in disease progression. In this paper we propose a critical analysis of factors that are involved in the progression of the liver damage and the occurrence of extra-hepatic complications (cardiovascular diseases, extra hepatic cancer) in patients with NAFLD. We also briefly discuss the impact of the heterogeneity of the clinical phenotype of NAFLD on the clinical practice globally and at the individual level.

A Prospective Longitudinal Study of Phonological Development in Late Talkers

2003 ◽  
Vol 34 (2) ◽  
pp. 138-153 ◽  
Author(s):  
A. Lynn Williams ◽  
Mary Elbert
Keyword(s):  
Late Onset ◽  
Free Play ◽  
Phonological Development ◽  
Prospective Longitudinal Study ◽  
Error Patterns ◽  
Late Talkers ◽  
Qualitative Variables ◽  
The Individual ◽  
Prospective Longitudinal

Purpose: This study involved prospective longitudinal data on 5 late talkers to provide information about the course of phonological development in order to identify possible predictors of delayed versus deviant development. Method: Five children (3 boys, 2 girls) were identified as late talkers and divided into a younger group and an older group. Each child was followed monthly for 10 to 12 months (22–33 months for the younger group and 30–42 months for the older group). Two types of monthly language samples (free play and elicited) were obtained to describe the individual courses of phonological development for each child. Independent and relational analyses were completed at each age to describe word-initial and word-final phonetic inventories, syllable structure, syllable diversity, percentage of consonants correct (PCC), sound variability, and error patterns. Results: The results indicated that 3 of the children resolved their late onset of speech by 33 to 35 months of age. In addition to quantitative factors, (e.g., limited phonetic inventory, lower PCC, and more sound errors), qualitative variables (e.g., atypical error patterns, greater sound variability, and slower rate of resolution) also were identified as potential markers of long-term phonological delay. Clinical Implications: This study provides information to clinicians so they can identify those children who are less likely to resolve their late onset of phonological development without direct intervention. Procedures are described for assessing early linguistic behaviors that incorporate independent and relational analyses on more extensive speech samples (elicited and free play). From these analyses, clinicians can examine quantitative and qualitative variables to differentiate phonological delay from deviance.

scholarly journals Homebound by COVID19: The Benefits and Consequences of Non-Pharmaceutical Intervention Strategies

2020 ◽  
Author(s):  
Buse Eylul Oruc ◽  
Arden Baxter ◽  
Pinar Keskinocak ◽  
John Asplund ◽  
Nicoleta Serban
Keyword(s):  
School Closure ◽  
Disease Spread ◽  
Contact Network ◽  
Population Mixing ◽  
Individual Level ◽  
History Of ◽  
Potential Benefits ◽  
The Individual ◽  
The Impact ◽  
Infection Spread

Abstract Background. Recent research has been conducted by various countries and regions on the impact of non-pharmaceutical interventions (NPIs) on reducing the spread of COVID19. This study evaluates the tradeoffs between potential benefits (e.g., reduction in infection spread and deaths) of NPIs for COVID19 and being homebound (i.e., refraining from interactions outside of the household).Methods. An agent-based simulation model, which captures the natural history of the disease at the individual level, and the infection spread via a contact network assuming heterogeneous population mixing in households, peer groups (workplaces, schools), and communities, is adapted to project the disease spread and estimate the number of homebound people and person-days under multiple scenarios, including combinations of shelter-in-place, voluntary quarantine, and school closure in Georgia from March 1 to September 1, 2020.Results. Compared to no intervention, under voluntary quarantine, voluntary quarantine with school closure, and shelter-in-place with school closure scenarios 4.5, 23.1, and 200+ homebound adult-days were required to prevent one infection, with the maximum number of adults homebound on a given day in the range of 119K-248K, 465K-499K, 5,388K-5,389K, respectively. Compared to no intervention, school closure only reduced the percentage of the population infected by less than 16% while more than doubling the peak number of adults homebound.Conclusions. Voluntary quarantine combined with school closure significantly reduced the number of infections and deaths with a considerably smaller number of homebound person-days compared to shelter-in-place.

Genocide and Memory

2012 ◽  
Author(s):  
Dan Stone
Keyword(s):  
Western Culture ◽  
Point Of View ◽  
Human Beings ◽  
Life Narratives ◽  
Collective Memories ◽  
Individual Level ◽  
Traumatic Memories ◽  
History Of ◽  
The Individual ◽  
With Memory

This article explores the history of genocide by looking at collective memories, from the point of view of Western culture. Western culture is suffused with autobiographies, especially with traumatic life narratives about the legacies of abusive childhoods. For the individual victims of genocide, traumatic memories cannot be escaped; for societies, genocide has profound effects that are immediately felt and that people are exhorted never to forget. The discussion shows how genocide is bound up with memory, on an individual level of trauma and on a collective level in terms of the creation of stereotypes, prejudice, and post-genocide politics. Despite the risks of perpetuating old divisions or reopening unhealed wounds, grappling with memory remains essential in order to remind the victims that they are not the worthless or less than human beings that their tormentors have portrayed them as such.

scholarly journals Determinants of Antidepressant Treatment and Outpatient Rehabilitation Within the First Year After Stroke

2020 ◽  
pp. 089198872097374
Author(s):  
Simon Ladwig ◽  
Katja Werheid
Keyword(s):  
Depressive Symptoms ◽  
Antidepressant Treatment ◽  
Antidepressant Medication ◽  
Inpatient Rehabilitation ◽  
Outpatient Rehabilitation ◽  
Prospective Longitudinal Study ◽  
Telephone Interviews ◽  
Individual Determinants ◽  
History Of ◽  
Prospective Longitudinal

This study aims to identify individual determinants of antidepressant treatment and outpatient rehabilitation after stroke. People with ischemic stroke ( N = 303) recruited at 2 inpatient rehabilitation clinics were included into a prospective longitudinal study with follow-up telephone interviews 6 and 12 months later. Participants reported on their use of antidepressant medication and psychotherapy as well as physical, occupational, speech, and neuropsychological therapy. The use of antidepressants at discharge ( n = 65, 23.8%) was predicted by the severity of depressive symptoms, severity of stroke, history of depression, and use of antidepressants at admission (all p < .05, R 2= .55). The number of outpatient rehabilitation services used at follow-ups was predicted by higher functional and cognitive impairment, higher education, younger age, severity of depressive symptoms, and lower self-efficacy (all p < .05; R 2 6M = .24, R 2 12M = .49). The relevance of identified determinants for the improvement of treatment rates after stroke is discussed.

Intergenerational Continuity in Child Maltreatment: Explicating Underlying Mechanisms

2020 ◽  
pp. 088626052091454
Author(s):  
Tiffany L. Martoccio ◽  
Lisa J. Berlin ◽  
Elizabeth M. Aparicio ◽  
Karen Appleyard Carmody ◽  
Kenneth A. Dodge
Keyword(s):  
Sexual Abuse ◽  
Child Maltreatment ◽  
Child Protective Services ◽  
Protective Services ◽  
Prospective Longitudinal Study ◽  
Physically Abused ◽  
Child Victimization ◽  
History Of ◽  
Underlying Mechanisms ◽  
Prospective Longitudinal

The current study examined direct and indirect effects of a mother’s history of childhood physical and sexual abuse on her child’s officially reported victimization. This prospective, longitudinal study followed a community-based sample of 499 mothers and their children. Mothers (35% White/non-Latina, 34% Black/non-Latina, 23% Latina, and 7% other) were recruited and interviewed during pregnancy, and child protective services records were reviewed for the presence of the participants’ target child between birth and age 3.5. Whereas both types of maternal maltreatment history doubled the child’s risk of child protective services investigation, mothers’ sexual abuse history conferred significantly greater risk. Pathways to child victimization varied by type of maternal maltreatment history. Mothers who had been physically abused later demonstrated interpersonal aggressive response biases, which mediated the path to child victimization. In contrast, the association between maternal history of sexual abuse and child victimization was mediated by mothers’ substance use problems. Study implications center on targeting child maltreatment prevention efforts according to the mother’s history and current problems.

scholarly journals The Effect of Environmental Stressors on Tinnitus: A Prospective Longitudinal Study on the Impact of the COVID-19 Pandemic

2020 ◽  
Vol 9 (9) ◽  
pp. 2756 ◽  
Author(s):  
Winfried Schlee ◽  
Sondre Hølleland ◽  
Jan Bulla ◽  
Jorge Simoes ◽  
Patrick Neff ◽  
...  
Keyword(s):  
Personality Traits ◽  
Environmental Stressor ◽  
Protection Factor ◽  
Prospective Longitudinal Study ◽  
Individual Perception ◽  
Tinnitus Distress ◽  
Exogenous Factors ◽  
The Individual ◽  
Prospective Longitudinal ◽  
The Impact

Tinnitus, the perception of sound in the absence of a corresponding sound, and the distress caused by it, is rarely a static phenomenon. It rather fluctuates over time depending on endogenous and exogenous factors. The COVID-19 pandemic is a potential environmental stressor that might influence the individually perceived tinnitus distress. Since not all people are affected by the pandemic in the same way, the situation allows one to identify environmental factors and personality traits that impact tinnitus distress differently. In our study, 122 tinnitus patients were included at two time points: in the year 2018 and during the German lockdown in April 2020. We assessed tinnitus-related distress, depressive symptoms, personality characteristics and the individual perception of the pandemic situation. On average, there was only a small increase of tinnitus distress with heterogeneous changes during the lockdown. People perceiving the situation as generally stressful with increased grief, frustration, stress and nervousness reported the worsening of tinnitus distress. People with high values in neuroticism also reported the worsening of tinnitus distress, while the personality traits extraversion, conscientiousness and openness seemed to be a protection factor. The study identifies factors that influence tinnitus distress change during a pandemic and spots those patients that need specific help in the pandemic situation.

Responsible for Destiny

2021 ◽  
Vol 11 ◽  
pp. 198-226
Author(s):  
Katherine Ward ◽  
Keyword(s):  
Being And Time ◽  
Individual Level ◽  
The Future ◽  
History Of ◽  
The Individual ◽  
The Way

Historizing is the way Dasein takes up possibilities and roles to project itself into the future. It is why we experience continuity throughout our lives, and it is the basis for historicality – our sense of a more general continuity of “history.” In Being and Time, Heidegger identifies both inauthentic and authentic modes of historizing that give rise, respectively, to inauthentic and authentic modes of histori­cality. He focuses on historizing at the individual level but gestures at a communal form of historizing. In this paper, I develop the concept of co-historizing in both its authentic and inauthentic modes. I argue that Heidegger’s unarticulated concept of inauthentic co-historizing is what necessitated the planned (but unfinished) second half of Being and Time – the “phenomenological destruction of the history of ontology.” I consider what it means to take responsibility for our destiny as a people and specifically as a community of philosophers.

Exposure to Parental Alcoholism During Childhood and Outcome in Adulthood: A Prospective Longitudinal Study

1986 ◽  
Vol 149 (5) ◽  
pp. 584-591 ◽  
Author(s):  
W. R. Beardslee ◽  
L. Son ◽  
G. E. Vaillant
Keyword(s):  
Longitudinal Study ◽  
Family Environment ◽  
Later Life ◽  
Parental Alcoholism ◽  
Prospective Longitudinal Study ◽  
The Family ◽  
History Of ◽  
Highly Correlated ◽  
Prospective Longitudinal ◽  
Children’S Exposure

The effects of children's exposure to parental alcoholism was assessed using records from an existing prospective 40-year longitudinal study of working-class families: 176 men who had grown up with an alcoholic parent or parents were compared with 230 men without such exposure. Degree of exposure to alcoholism in the childhood family environment was highly correlated in later life with alcohol use, alcoholism, time in jail, sociopathy, and death, but not with increased rates of unemployment, poor physical health, or measures of adult ego functioning. Most of the impairments observed occurred in those subjects who actually developed alcoholism. Exposure to alcoholism in the family environment and family history of alcoholism independently contributed to the later development of alcoholism.

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