Estimating Partial Standardized Mean Differences from Regression Models

Author(s):  
Ariel M. Aloe ◽  
Christopher G. Thompson ◽  
Zhijiang Liu ◽  
Lifeng Lin
2021 ◽  
pp. bmjspcare-2020-002312
Author(s):  
Laura B Oswald ◽  
Adriano Venditti ◽  
David Cella ◽  
Francesco Cottone ◽  
Anna Candoni ◽  
...  

ObjectivesThis study compared the burden of fatigue between treatment-naïve patients with newly diagnosed acute myeloid leukaemia (AML) and the general population and investigated patient factors associated with fatigue severity.MethodsPretreatment patient-reported fatigue was assessed with the Functional Assessment of Chronic Illness Therapy-Fatigue questionnaire in a sample of 463 newly diagnosed patients with AML who were enrolled in a clinical trial. Multivariable linear regression models were used to estimate the adjusted mean differences in fatigue between patients with AML and adults from the general population (n=847) by AML disease risk categories. A clinically meaningful difference in fatigue was defined as ≥3 points. Univariable and multivariable linear regression models were used to identify sociodemographic, clinical and molecular correlates of worse fatigue in patients with AML.ResultsPatients with AML reported adjusted mean fatigue scores that were 7.5 points worse than the general population (95% CI −8.6 to −6.4, p<0.001). Across AML disease risk categories, adjusted mean differences in fatigue compared with the general population ranged from 6.7 points worse (patients with favourable risk: 95% CI −8.6 to −4.8, p<0.001) to 8.9 points worse (patients with poor risk, 95% CI −10.5 to −7.2, p<0.001). Overall, 91% of patients with AML reported fatigue that was equal to or worse than the general population’s median fatigue score. Higher pretreatment fatigue was independently associated with female sex, WHO performance status ≥1 and lower platelet levels.ConclusionsPatients with newly diagnosed AML reported worse fatigue than the general population, and mean differences exceeded twice the threshold for clinical significance. Our findings may help to identify patients with AML most likely to benefit from supportive care interventions to reduce fatigue.


Methodology ◽  
2013 ◽  
Vol 9 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Holger Steinmetz

Although the use of structural equation modeling has increased during the last decades, the typical procedure to investigate mean differences across groups is still to create an observed composite score from several indicators and to compare the composite’s mean across the groups. Whereas the structural equation modeling literature has emphasized that a comparison of latent means presupposes equal factor loadings and indicator intercepts for most of the indicators (i.e., partial invariance), it is still unknown if partial invariance is sufficient when relying on observed composites. This Monte-Carlo study investigated whether one or two unequal factor loadings and indicator intercepts in a composite can lead to wrong conclusions regarding latent mean differences. Results show that unequal indicator intercepts substantially affect the composite mean difference and the probability of a significant composite difference. In contrast, unequal factor loadings demonstrate only small effects. It is concluded that analyses of composite differences are only warranted in conditions of full measurement invariance, and the author recommends the analyses of latent mean differences with structural equation modeling instead.


2020 ◽  
Vol 21 (2) ◽  
pp. 169-194
Author(s):  
Marta Kajzer-Wietrzny ◽  
Ilmari Ivaska

Empirical Translation Studies have recently extended the scope of research to other forms of constrained and mediated communication, including bilingual communication, editing, and intralingual translation. Despite the diversity of factors accounted for so far, this new strand of research is yet to take the leap into intermodal comparisons. In this paper we look at Lexical Diversity (LD), which under different guises, has been studied both within Translation Studies (TS) and Second Language Acquisition (SLA). LD refers to the rate of word repetition, and vocabulary size and depth, and previous research indicates that translated and non-native language tends to be less lexically diverse. There is, however, no study that would investigate both varieties within a unified methodological framework. The study reported here looks at LD in spoken and written modes of constrained and non-constrained language. In a two-step analysis involving Exploratory Factor Analysis and linear mixed-effects regression models we find interpretations to be least lexically diverse and written non-constrained texts to be most diverse. Speeches delivered impromptu are less diverse than those read out loud and the non-constrained texts are more sensitive to such delivery-related differences than the constrained ones.


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