Recent selection of candidate genes for mammal domestication in Europeans and language change in Europe: a hypothesis

2021 ◽  
pp. 1-8
Author(s):  
Antonio Benítez-Burraco ◽  
Evgeny Chekalin ◽  
Sergey Bruskin ◽  
Tatiana Tatarinova ◽  
Irina Morozova
Keyword(s):  
Candidate Genes ◽  
Language Change ◽  
Selection Of ◽  
Recent Selection

scholarly journals An Exome-seq Based Tool for Mapping and Selection of Candidate Genes in Maize Deletion Mutants

2018 ◽  
Vol 16 (6) ◽  
pp. 439-450 ◽  
Author(s):  
Shangang Jia ◽  
Kyla Morton ◽  
Chi Zhang ◽  
David Holding
Keyword(s):  
Candidate Genes ◽  
Deletion Mutants ◽  
Selection Of

scholarly journals The refuge of a dying variant within the grammar: Patterns of change and continuity in the Spanish verbal periphrasishaber de + infinitive over the past two centuries

2015 ◽  
Vol 27 (1) ◽  
pp. 89-116 ◽  
Author(s):  
José Luis Blas Arroyo ◽  
Javier Vellón Lahoz
Keyword(s):  
Comparative Study ◽  
Detailed Analysis ◽  
20Th Century ◽  
Language Change ◽  
Explanatory Power ◽  
The Past ◽  
History Of ◽  
Selection Of

AbstractBased on a corpus of ego-documents (private letters, diaries, memoirs) from the 19th and the first half of the 20th centuries, this paper presents a variationist comparative study to determine the fate of the modal periphrasishaber de + infinitive in the history of modern Spanish. Detailed analysis of the envelope of variation enables us to show that, despite an abrupt decline in the selection ofhaber derelative totener que, both ‘to have to’, grammatical environments that favor its use remain in the mid-20th century. Many of the factor groups and the hierarchy of constraints during this period are similar to those that operated in previous periods. Nevertheless, a generalized decrease in the explanatory power of these factor groups, as well as some divergent patterns within several of these groups are also observed, mainly as a result of the fact thathaber de + infinitive is increasingly relegated to some restricted areas of the grammar and lexicon. Based on these results, some theoretical implications for changing rates and constraints in language change and grammaticalization are discussed.

scholarly journals Evidence for recent selection of the CCR5-Δ32 deletion from differences in its frequency between Ashkenazi and Sephardi Jews

2000 ◽  
Vol 1 (6) ◽  
pp. 358-361 ◽  
Author(s):  
S Maayan ◽  
L Zhang ◽  
E Shinar ◽  
J Ho ◽  
T He ◽  
...  
Keyword(s):  
Selection Of ◽  
Recent Selection

8735 Selection of candidate genes involved in glioma pathogenesis using bioinformatics tools

2009 ◽  
Vol 7 (2) ◽  
pp. 503
Author(s):  
C. Diez-Tascón ◽  
J.M. López-Martí ◽  
O.M. Rivero-Lezcano ◽  
G. Santín-Piedrafita ◽  
C. González-Cortés ◽  
...  
Keyword(s):  
Candidate Genes ◽  
Bioinformatics Tools ◽  
Selection Of

Selection of Genes and Single Nucleotide Polymorphisms for Fine Mapping Starting From a Broad Linkage Region

2007 ◽  
Vol 10 (6) ◽  
pp. 871-885 ◽  
Author(s):  
An Windelinckx ◽  
Robert Vlietinck ◽  
Jeroen Aerssens ◽  
Gaston Beunen ◽  
Martine A. I. Thomis
Keyword(s):  
Linkage Disequilibrium ◽  
Candidate Gene ◽  
Candidate Genes ◽  
Fine Mapping ◽  
Complex Disease ◽  
Gene Selection ◽  
Candidate Gene Approach ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Selection Of

AbstractFine mapping of linkage peaks is one of the great challenges facing researchers who try to identify genes and genetic variants responsible for the variation in a certain trait or complex disease. Once the trait is linked to a certain chromosomal region, most studies use a candidate gene approach followed by a selection of polymorphisms within these genes, either based on their possibility to be functional, or based on the linkage disequilibrium between adjacent markers. For both candidate gene selection and SNP selection, several approaches have been described, and different software tools are available. However, mastering all these information sources and choosing between the different approaches can be difficult and time-consuming. Therefore, this article lists several of these in silico procedures, and the authors describe an empirical two-step fine mapping approach, in which candidate genes are prioritized using a bioinformatics approach (ENDEAVOUR), and the top genes are chosen for further SNP selection with a linkage disequilibrium based method (Tagger). The authors present the different actions that were applied within this approach on two previously identified linkage regions for muscle strength. This resulted in the selection of 331 polymorphisms located in 112 different candidate genes out of an initial set of 23,300 SNPs.

scholarly journals Prioritization of potato genes involved in the formation of agronomically valuable traits using the SOLANUM TUBEROSUM knowledge base

2019 ◽  
Vol 23 (3) ◽  
pp. 312-319
Author(s):  
P. S. Demenkov ◽  
O. V. Saik ◽  
T. V. Ivanisenko ◽  
N. A. Kolchanov ◽  
A. V. Kochetov ◽  
...  
Keyword(s):  
Solanum Tuberosum ◽  
Knowledge Base ◽  
Candidate Genes ◽  
Genetic Relationships ◽  
Molecular Genetic ◽  
Biological Data ◽  
Targeted Mutagenesis ◽  
Pubmed Database ◽  
Genetic Mechanisms ◽  
Selection Of

The development of highly efficient technologies in genomics, transcriptomics, proteomics and metabolomics, as well as new technologies in agriculture has led to an “information explosion” in plant biology and crop production, including potato production. Only a small part of the information reaches formalized databases (for example, Uniprot, NCBI Gene, BioGRID, IntAct, etc.). One of the main sources of reliable biological data is the scientific literature. The well-known PubMed database contains more than 18 thousand abstracts of articles on potato. The effective use of knowledge presented in such a number of non-formalized documents in natural language requires the use of modern intellectual methods of analysis. However, in the literature, there is no evidence of a widespread use of intelligent methods for automatically extracting knowledge from scientific publications on cultures such as potatoes. Earlier we developed the SOLANUM TUBEROSUM knowledge base (http://www-bionet.sysbio.cytogen. ru/and/plant/). Integrated into the knowledge base information about the molecular genetic mechanisms underlying the selection of significant traits helps to accelerate the identification of candidate genes for the breeding characteristics of potatoes and the development of diagnostic markers for breeding. The article searches for new potential participants of the molecular genetic mechanisms of resistance to adverse factors in plants. Prioritizing candidate genes has shown that the PHYA, GF14, CNIH1, RCI1A, ABI5, CPK1, RGS1, NHL3, GRF8, and CYP21-4 genes are the most promising for further testing of their relationships with resistance to adverse factors. As a result of the analysis, it was shown that the molecular genetic relationships responsible for the formation of significant agricultural traits are complex and include many direct and indirect interactions. The construction of associative gene networks and their analysis using the SOLANUM TUBEROSUM knowledge base is the basis for searching for target genes for targeted mutagenesis and marker-oriented selection of potato varieties with valuable agricultural characteristics.

scholarly journals High-Throughput Genotyping of Resilient Tomato Landraces to Detect Candidate Genes Involved in the Response to High Temperatures

Genes ◽  
2020 ◽  
Vol 11 (6) ◽  
pp. 626
Author(s):  
Fabrizio Olivieri ◽  
Roberta Calafiore ◽  
Silvana Francesca ◽  
Carlo Schettini ◽  
Pasquale Chiaiese ◽  
...  
Keyword(s):  
Candidate Genes ◽  
High Temperatures ◽  
Elevated Temperatures ◽  
Genotyping By Sequencing ◽  
High Impact ◽  
Yield Trait ◽  
Genetic Mechanisms ◽  
Stable Yield ◽  
Selection Of

The selection of tolerant varieties is a powerful strategy to ensure highly stable yield under elevated temperatures. In this paper, we report the phenotypic and genotypic characterization of 10 tomato landraces to identify the best performing under high temperatures. The phenotyping of five yield-related traits allowed us to select one genotype that exhibits highly stable yield performances in different environmental conditions. Moreover, a Genotyping-by-Sequencing approach allowed us to explore the genetic variability of the tested genotypes. The high and stable yielding landrace E42 was the most polymorphic one, with ~49% and ~47% private SNPs and InDels, respectively. The effect of 26,113 mutations on proteins’ structure was investigated and it was discovered that 37 had a high impact on the structure of 34 proteins of which some are putatively involved in responses to high temperatures. Additionally, 129 polymorphic sequences aligned against tomato wild species genomes revealed the presence in the genotype E42 of several introgressed regions deriving from S. pimpinellifolium. The position on the tomato map of genes affected by moderate and high impact mutations was also compared with that of known markers/QTLs (Quantitative Trait Loci) associated with reproductive and yield-related traits. The candidate genes/QTLs regulating heat tolerance in the selected landrace E42 could be further investigated to better understand the genetic mechanisms controlling traits for high and stable yield trait under high temperatures.

What is it then, this Grammaticalization?

2014 ◽  
Vol 48 (2) ◽  
Author(s):  
Ferdinand von Mengden ◽  
Horst J. Simon
Keyword(s):  
Language Change ◽  
Historical Linguistics ◽  
The State ◽  
Great Success ◽  
Present Collection ◽  
To Come ◽  
Selection Of ◽  
State Of The Field

AbstractSo. . . what is it then, this grammaticalization? Probably every linguist who is interested in language change will have raised this question at some point. And many of them will also have some answer more or less at hand. The problem is that these answers may all differ in one detail or other. A likely reason for this is the great success (or, for that matter, popularity) that the concept of grammaticalization has enjoyed in historical linguistics to date. Therefore, maybe inevitably, the proliferation of analyses within the domain of grammaticalization studies has also led to a proliferation of terms and notions, not all of them sharply defined. This, in turn, has produced a certain dissatisfaction with the state of the field among many more sceptical (or maybe just more cautious) linguists. Hence, the most important aim of the present collection of articles (which presents a selection of the papers presented at the workshop “Refining Grammaticalization” at Freie Universität Berlin in February 2012) is to try to come to grips with the notion of grammaticalization and related concepts in the light of recent theorizing in historical linguistics.

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