scholarly journals GSH-responsive poly-resveratrol based nanoparticles for effective drug delivery and reversing multidrug resistance

Drug Delivery ◽  
2022 ◽  
Vol 29 (1) ◽  
pp. 229-237
Author(s):  
Yang Liping ◽  
He Jian ◽  
Tao Zhenchao ◽  
Zhou Yan ◽  
Yang Jing ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Multidrug Resistance ◽  
Effective Drug

scholarly journals Porous discoidal polymeric particles for effective drug delivery minimizing phagocytosis

2021 ◽  
Vol 49 (1) ◽  
pp. 390-396
Author(s):  
Susmita Aryal ◽  
Sanghyo Park ◽  
Chaewon Park ◽  
Moon Jung Choi ◽  
Jaehong Key
Keyword(s):  
Drug Delivery ◽  
Effective Drug ◽  
Polymeric Particles

Dual pH-responsive micelles with both charge-conversional property and hydrophobic–hydrophilic transition for effective cellular uptake and intracellular drug release

2016 ◽  
Vol 7 (12) ◽  
pp. 2202-2208 ◽  
Author(s):  
Shuai Li ◽  
Zhouxiang Zhao ◽  
Wei Wu ◽  
Chunmei Ding ◽  
Jianshu Li
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cellular Uptake ◽  
Diblock Copolymers ◽  
Effective Drug ◽  
Ph Responsive ◽  
A Charge

Two types of diblock copolymers are synthesized to construct dual pH-responsive micelles with a charge-conversional property for effective drug delivery.

scholarly journals Micro-needles as an effective drug delivery system and associated patents in pharmaceutical field: A Review

2022 ◽  
Vol 01 (01) ◽  
pp. 53-66
Author(s):  
Sumel Ashique ◽  
Vaibhavi mittal ◽  
Tahamina Khatun ◽  
Aakash Upadhyay ◽  
Suryakant Verma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Effective Drug

scholarly journals What Is the Most Effective Drug Delivery System for Cisplatin during the Treatment of Hepatic Tumors with Single-Session Transcatheter Chemotherapy? A Pilot Study

Gut and Liver ◽  
2013 ◽  
Vol 7 (5) ◽  
pp. 576-584 ◽  
Author(s):  
Yusuke Kawamura ◽  
Kenji Ikeda ◽  
Taito Fukushima ◽  
Yuya Seko ◽  
Tasuku Hara ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pilot Study ◽  
Drug Delivery System ◽  
Delivery System ◽  
Effective Drug ◽  
Hepatic Tumors ◽  
Single Session

Glutathione-responsive PLGA nanocomplex for dual delivery of doxorubicin and curcumin to overcome tumor multidrug resistance

Nanomedicine ◽  
2021 ◽  
Author(s):  
Xuandi Lai ◽  
Xinran Geng ◽  
Mengqing Li ◽  
Mengxiong Tang ◽  
Qiong Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Multidrug Resistance ◽  
Blood Circulation ◽  
Release Profile ◽  
Drug Release Profile ◽  
Promising Candidate ◽  
Nano Drug Delivery ◽  
Mdr Reversal

Aim: This work aims to develop an injectable nano-drug delivery system to overcome tumor multidrug resistance (MDR). Methods: A drug delivery nanoplatform based on PEGylated PLGA with glutathione (GSH) responsivity was constructed for dual delivery of doxorubicin and curcumin (termed DCNP), and its MDR reversal efficiency was studied in vitro and in vivo. Results: The DCNPs exhibited a rapid drug release profile under high GSH concentration and could enhance the cellular uptake and cytotoxicity of doxorubicin to MDR cancer cells. Moreover, the DCNPs showed better biocompatibility, longer blood circulation and enhanced antitumor efficiency compared with free drugs. Conclusion: The GSH-responsive nanocarrier is believed to be a promising candidate for overcoming tumor MDR.

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