scholarly journals A Diet Based on Mesquite Seed Improves Atherogenic Index in Mouse Model

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 536-536
Author(s):  
Luis Díaz-Batalla ◽  
Karina Aguilar-Arteaga
Keyword(s):  
Phenolic Compounds ◽  
Total Cholesterol ◽  
Radical Scavenging ◽  
Density Lipoprotein ◽  
Experimental Period ◽  
Atherogenic Index ◽  
Caloric Content ◽  
Free Access ◽  
Casein Diet ◽  
Funding Sources

Abstract Objectives The main objective of this work is to evaluate the effect of a diet rich in antioxidants based on mesquite seed on the atherogenic index of the dislipidemia-prone C57BL/6J mouse. Methods Mesquite seed based diet with 18% of protein was prepared using flour of mesquite seed, corn and micronutrient mix. Additionally, a diet based on casein with 18% of protein was preparing using casein, corn flour, wheat bran and micronutrient mix. Both diets were processed by extrusion. Extruded diets were analyzed for proximal composition, flavonoids content (HPLC) and radical scavenging capacity. For mice biological assay development, a bioethically approved protocol was used. Four-week-old male C57BL/6J mice were used. One group of mice (n = 6) was fed a diet based on mesquite seed and a second group (n = 6) was fed a diet based on casein from week 4 to week 18 of life. Mice were maintained with free access to food and water. At the end of the experimental period, blood samples were taken for the determination of total cholesterol (TC), and high-density lipoprotein cholesterol (HDL-c) using dry-chemistry enzymatic slide technology. The atherogenic index (AI) was calculated using the formula: AI = TC (mg/dL)/HDL-c (mg/dL). Results The caloric content of the diet based on mesquite seed and the diet based on casein were 373.1 and 365.1 kcal/100g,  respectively. The energy intake of mice treated with mesquite and casein diet were 13.43 and 13.51 kcal/day, respectively. The phenolic compounds intake of mice treated with mesquite and casein diet were 8.3 and 1.9 mg/day, respectively. The atherogenic index in mice treated with a diet based on mesquite seed was 2.25 and for the mice treated with a diet based on casein was 3.31. Conclusions After 14 weeks of a diet based on mesquite seed C57BL/6J mice presented significantly lower levels of total cholesterol and atherogenic index than mice treated with a diet based on casein. Diet based on mesquite seed lead to higher intakes of phenolic compounds and antioxidants than a diet based on casein. The C57BL/6J mouse is a nicotinamide nucleotide transhydrogenase deficient model, which induces oxidative stress and insulin resistance. This condition increases the susceptibility to develops dyslipidemia, diabetes and obesity. A diet based on mesquite seed prevents dyslipidemia development in C57BL/6J. Funding Sources No funding.

scholarly journals Study on the influence of 7-β-hydroxy-γ-aryloxypropylxanthinyl-8-thioalkanic acid derivatives on the lipid metabolism in experiment

2021 ◽  
Vol 23 (3) ◽  
pp. 411-416
Author(s):  
I. M. Bilai ◽  
M. I. Romanenko ◽  
D. H. Ivanchenko
Keyword(s):  
Side Effects ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Lipoprotein Cholesterol ◽  
Atherogenic Index ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Xanthine Derivatives

Statin side effects are not a rare occurrence, in particular dyspeptic disorders, insomnia, headache, skin erythema, rash are often noted. All of this determines scientists to find new effective and low-toxic hypolipidemic agents. Various natural and synthetic xanthine derivatives have been recognized as therapeutically potential compounds and reported to control various diseases. Therefore, the study of new xanthine derivatives and their hypolipidemic effects, which would have a significant therapeutic effect with minimal side effects, is relevant. The aim of the study was to examine the effect of 7-β-hydroxy-γ-aryloxypropylxanthinyl-8-thioalkanic acid derivatives on lipidogram parameters in experimental laboratory rats. Materials and methods. The objects of the study were 7-β-hydroxy-γ-aryloxypropylxanthinyl-8-thioalkanic acid derivatives. The experiments were performed in white laboratory Wistar rats weighing 180–220 g. Experimental modeling of hyperlipidemia – tween model: intraperitoneal administration of tween-80 at a dose of 200 mg/100 g body weight. The test compounds were administered orally, simultaneously with tween, at a dose of 1/10 of LD50 (previously calculated by Prozorovsky express method) for 6 days. The following indicators of lipidogram were determined: total cholesterol (TC), high-density lipoprotein cholesterol (HDL cholesterol), low-density lipoprotein cholesterol (LDL cholesterol), triglycerides (TG) and atherogenic index of plasma: TC – HDL cholesterol / HDL cholesterol. The experiments were carried out with respect to Bioethical rules and norms. Results. The studies have shown data on the hypolipidemic activity of 7-β-hydroxy-γ-aryloxypropylxanthinyl-8-thioalkane acid derivatives. According to the conditional efficiency index Ʃ, which included the overall percentage of the following indicators – total cholesterol, low-density lipoprotein cholesterol and triglycerides, the leading compounds were 2439 (87.47 %), 6047 (82.30 %). The reference drug atorvastatin had a value of 82.98 %. Conclusions. The major compound was 2439 identified among all compared to the control group. The prospect of further research is a more detailed study on the ability of xanthine derivatives to exhibit hypolipidemic effects and to influence oxidative stress in various hyperlipidemic models.

scholarly journals Effect of Propolis on Diet-Induced Hyperlipidemia and Atherogenic Indices in Mice

Antioxidants ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 156 ◽  
Author(s):  
Nada Oršolić ◽  
Irena Landeka Jurčević ◽  
Domagoj Đikić ◽  
Dunja Rogić ◽  
Dyana Odeh ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Protective Action ◽  
Radical Scavenging ◽  
Density Lipoprotein ◽  
Reducing Power ◽  
Atherogenic Index ◽  
Traditional Use ◽  
Major Health Problem ◽  
Atherogenic Indices

Obesity, a major health problem worldwide, is associated with increased cardiovascular risk factors, such as dyslipidemia, glucose intolerance, and hypertension. We investigated the antioxidative capacity of the ethanol extract of propolis (EEP) and its effect on the lipid profile, the hepatorenal function, and the atherogenic indices in mice fed with a high-fat diet (HFD). EEP (50 mg/kg) was given orally to mice for 30 days. After the treatments, levels of the serum total triglyceride and cholesterol, the high density lipoprotein (HDL-c) and low density lipoprotein (LDL-c) cholesterols, the serum enzymes, and the metabolites were measured, and atherogenic indices [atherogenic index of plasma (AIP); cardiac risk ratio (CRR); cardioprotective index (CPI); atherogenic coefficient (AC)] were calculated and compared with the antioxidant, the reducing power, the radical-scavenging, and the chelating activity of EEP. The HFD diet with EEP significantly reduced the negative lipid profile and lowered AIP, CRR, and AC and increased CPI in animals on a HFD. In addition, EEP reduced the weight of mice and lipid accumulation in the liver, and it had significant in vitro antioxidative activities. The EEP possesses anti-hyperlipidemic and antioxidant activity and exhibits protective action on the cardiovascular system and hepatorenal functions. Our results contribute towards the validation of the traditional use of propolis as a food supplement in aiding hyperlipidemic disorders.

scholarly journals Phenolic Compounds and the Anti-Atherogenic Effect of Bee Bread in High-Fat Diet-Induced Obese Rats

Antioxidants ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 33 ◽  
Author(s):  
Zaidatul Akmal Othman ◽  
Wan Syaheedah Wan Ghazali ◽  
Liza Noordin ◽  
Nurul Aiman Mohd. Yusof ◽  
Mahaneem Mohamed
Keyword(s):  
Phenolic Compounds ◽  
High Fat Diet ◽  
Fatty Acid Synthase ◽  
Antioxidant Activities ◽  
Density Lipoprotein ◽  
Atherogenic Index ◽  
Sprague Dawley ◽  
High Fat ◽  
Bee Bread ◽  
Obese Rats

This study was undertaken to determine the phenolic compounds and the anti-atherogenic effect of bee bread in high-fat diet (HFD)-induced obese rats. The presence of phenolic compounds in bee bread was determined by liquid chromatography–mass spectrometry. Thirty-two male Sprague Dawley rats were divided into four groups, (n = 8/group); i.e., Normal (N), HFD (high-fat diet), HFD + BB (high-fat diet and 0.5 g/kg/day bee bread), and HFD + O (high-fat diet and 10 mg/kg/day orlistat) groups. After 6 weeks of the experiment, rats were sacrificed. Five phenolic compounds were identified in bee bread; namely, caffeic acid, ferulic acid, kaempferol, apigenin, and isorhamnetin. Bee bread significantly reduced Lee obesity index and levels of total cholesterol (TC), low-density lipoprotein (LDL), fatty acid synthase (FAS) activity, atherogenic index, oxidised-LDL (oxLDL), and malondialdehyde (MDA), and significantly increased aortic antioxidant activities, such as those of superoxide dismutase (SOD) and glutathione peroxidase (GPx). Adipocyte sizes were found to be smaller in the HFD + BB group compared to the N group, and en face aortas showed an absence of atherosclerotic plaque in rats supplemented with bee bread. These changes might suggest an anti-atherogenic effect of bee bread in HFD-induced obese rats via its antioxidant and hypocholesterolaemic properties.

scholarly journals Racial Variation in Serum Lipid and Lipoprotein Levels in Type 2 Diabetic Subjects of Bangladesh

1970 ◽  
Vol 17 ◽  
pp. 113-116 ◽  
Author(s):  
Mohammad Razuanul Hoque ◽  
Md Golam Kabir ◽  
Dwaipayan Sikdar
Keyword(s):  
Total Cholesterol ◽  
Racial Differences ◽  
Serum Lipid ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Atherogenic Index ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Context: Racial and sex differences are documented globally regarding patterns of serum lipids among diabetic patients. Differences of lipid profile of normal and diabetic subjects of the different ethnic groups of Bangladesh may differ.Objectives: To find out if there were any differences in the serum lipid and lipoprotein levels in the type 2 diabetic patients of two different races namely, Bangalee and Chakma of Bangladesh. Materials and Methods: Study population consisted of 76 (Chakma / Bangalee: 35 / 41) patients aged between 40-60 years with type 2 diabetes mellitus who were on follow-up at the Rangamati Diabetes Hospital, Chittagong Hill Tract, Bangladesh and forty (Chakma / Bangalee: 20 / 20) non-diabetic subjects of same age were randomly selected as control. Biochemical parameters analyzed include - Serum total cholesterol and triglyceride (TG), serum high-density lipoprotein (HDL), low-density lipoprotein (LDL) cholesterol and atherogenic index.Results:  Dyslipidemia was found in the diabetic patients of both races and the patients had higher serum TG), atherogenic index and lower serum HDL than their normal counterpart. The Bangalee patients were found to have higher TG and lower atherogenic index compared with the Chakma patients although no racial differences found regarding total, HDL and LDL cholesterol. Also no differences were found between the lipid profiles of normal control subjects of these two races. Conclusion: Present study confirms that racial differences exist in serum lipid abnormalities between Chakma and Bangalee subjects with type 2 diabetes.Key words: Diabetes Type 2; Triglyceride; Lipoprotein; Total cholesterol; Bangalee; Chakma.DOI: 10.3329/jbs.v17i0.7116J. bio-sci. 17: 113-116, 2009

scholarly journals Antihyperlipidemic and antiatherogenic activity of simvastatin may involve modulation of the expression of lecithin:cholesterol acyl transferase.

2013 ◽  
Vol 60 (4) ◽  
Author(s):  
Adeniran Sanmi Adekunle ◽  
John Olabode Fatoki ◽  
Temitope Isaac Adelusi
Keyword(s):  
Serum Concentration ◽  
Total Cholesterol ◽  
Free Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Atherogenic Index ◽  
Albino Rats ◽  
Acyl Transferase ◽  
Reduced Body ◽  
The Difference

The statin-induced effects on high density lipoprotein (HDL) are relatively small compared with those of low density lipoprotein (LDL) and, as a result, most clinical trials of statins are underpowered with respect to HDL parameters. This study experimentally investigated, the effects of statin on serum lipids, atherogenic index and examined the possibility of a relationship amongst serum concentrations of HDL-C, atherogenic index and activity of lecithin:cholesterol acyl transferase. Thirty albino rats equally divided into 2 groups were used for the study. Group 1 was given 0.05mg/g of statin daily for 28 days, while group 2 served as control. HDL concentration was determined as a measure of HDL-C. Total cholesterol (TC), triglyceride (TG) and HDL-C were determined spectrophotometrically while LDL-C was calculated using the Frieldwald formula. Effect on the activity of lecithin:cholesterol acyl transferase was determined by the difference between the amount of free cholesterol converted to cholesteryl ester in the two experimental groups. Effects on body and relative organs weights were also determined. The administration of statin caused a significant increase in serum concentration of HDL-C, while levels of LDL-C, triglyceride and total cholesterol were reduced. Simvastatin caused a significant reduction in the atherogenic index (TC/HDL-C; LDLC/HDL-C). The administration of statin significantly induced the activity of lecithin:cholesterol acyl transferase (LCAT) as evident by reduced serum concentration of free cholesterol when compared with control. The administration of statin caused reduced body and relative organs weights. The study showed that serum antihyperlipidemic and antiatherogenic activity of statin may involve the induction of LCAT.

scholarly journals CHARACTERISTICS OF LIPID METABOLISM IN PATIENTS WITH TYPE 1 DIABETES, DEPENDING ON THE AVAILABILITY OF DIABETIC MICROANGIOPATHY AND DIET

2014 ◽  
Vol 13 (5) ◽  
pp. 87-92
Author(s):  
Yu. G. Samoilova ◽  
Ye. V. Yurchenko
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Nephropathy ◽  
Lipid Metabolism ◽  
Total Cholesterol ◽  
Group Performance ◽  
Density Lipoprotein ◽  
Atherogenic Index ◽  
Lipid Lowering ◽  
Diabetic Microangiopathy

Was investigated 67 children (36 boys and 31 girls) in age from 6 to 18 years old, with type 1 diabetes patients who were treated at the Children's Hospital Endocrinology number 1 inTomsk, average age of the boys at the time of the survey amounted to (13.0 ± 0.4) years, girls – (13.5 ± 0.4) years. All children diagnosed with type 1 diabetes were under subcompensation. Clinical evaluation of patients included a medical history, physical examination, evaluation of physical development. A study of lipid profile (high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL), cholesterol (TC), triglycerides (TG), atherogenic index). Screening for diabetic retinopathy was performed by examining the fundus by direct ophthalmoscopy after pupil dilation. Diagnosis of diabetic nephropathy, retinopathy performed according to the classification. Patients were divided into groups depending on the presence of complications, and the level of compensation lipid metabolism (children with satisfactory compensation of lipid metabolism (total cholesterol level less than 5.2 mmol / l), children with poor compensation lipid metabolism (total cholesterol above 5.2 mmol / l)). Nature of the subjects studied nutrition using  a questionnaire drawn up on the basis of the standard dietary questionnaire program CINDI, allowing to evaluate the eating habits by examining the frequency of intake of various foods, food preferences and priorities. Products, according to the lipid-lowering diet on the recommendations of the European Society for atherosclerosis were combined and divided into groups according to frequency of use: commonly used products, and rarely use the products. Mathematical treatment of the results was performed using the software package Statistica 5.5 for Windows. In the first phase expected to total group performance statistics – the arithmetic mean value M and the error of the mean m, as well as visualization of the distribution of values was performed using frequency histograms. To select a criterion to assess the significance of paired differences check compliance form normal distribution using the criterion χ2, and also controlled the general equality of variances using the F-test Fisher. Given that these conditions are satisfied only part of the empirical distributions of features tested the hypothesis that the general average in all cases was performed using Mann–Whitney U-test for independent variables. Null hypothesis was rejected when p < 0.05.In the study of lipid metabolism in patients with type 1 diabetes, no increase in the level of cholesterol, triglycerides, HDL, LDL and VLDL – cholesterol in patients with a combination of diabetic nephropathy and retinopathy compared with patients with type 1 diabetes without diabetic microangiopathy. Investigation of the nature of power in patients with type 1 diabetes, allowed us to estimate its impact on lipid metabolism.

scholarly journals Antioxidant Potential, Subacute Toxicity, and Beneficiary Effects of Methanolic Extract of Pomelo (Citrus grandisL. Osbeck) in Long Evan Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Md. Yousuf Ali ◽  
Nur-E Noushin Rumpa ◽  
Sudip Paul ◽  
Md. Sakib Hossen ◽  
E. M. Tanvir ◽  
...  
Keyword(s):  
Methanolic Extract ◽  
Risk Index ◽  
Radical Scavenging ◽  
Density Lipoprotein ◽  
The Body ◽  
Lipoprotein Cholesterol ◽  
Atherogenic Index ◽  
Deficiency Anemia ◽  
Antioxidant Power ◽  
Subacute Toxicity

The aim of this study was to investigate the antioxidant potentials, subacute toxicity, and beneficiary effects of methanolic extract of pomelo (Citrus grandisL. Osbeck) in rats. Long Evans rats were divided into four groups of eight animals each. The rats were orally treated with three doses of pomelo (250, 500, and 1000 mg/kg) once daily for 21 days. Pomelo extract contained high concentrations of polyphenols, flavonoids, and ascorbic acid while exhibiting high 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity and ferric reducing antioxidant power values. There was no significant change in the body weight, percentage water content, and relative organ weight at any administered doses. In addition, no significant alterations in the hematological parameters were also observed. However, rats which received 1000 mg/kg dose had a significant reduction in some serum parameters, including alanine transaminase (15.29%), alkaline phosphatase (2.5%), lactate dehydrogenase (15.5%),γ-glutamyltransferase (20%), creatinine (14.47%), urea (18.50%), uric acid (27.14%), total cholesterol (5.78%), triglyceride (21.44%), low-density lipoprotein cholesterol (40.74%), glucose (2.48%), and all atherogenic indices including cardiac risk ratio (24.30%), Castelli’s risk index-2 (45.71%), atherogenic coefficient (42%), and atherogenic index of plasma (25%) compared to control. In addition, the highest dose (1000 mg/kg) caused a significant increase in iron (12.07%) and high-density lipoprotein cholesterol (8.87%) levels. Histopathological findings of the vital organs did not indicate any pathological changes indicating that pomelo is nontoxic, safe, and serves as an important source of natural antioxidants. In addition, the fruit extract has the potential to ameliorate hepato- and nephrotoxicities and cardiovascular diseases as well as iron deficiency anemia.

scholarly journals Gender based differences in lipid profile and other novel atherogenic risk factors in type-2 diabetes mellitus patients

2021 ◽  
Vol 9 (10) ◽  
pp. 3099
Author(s):  
Arpita Jaidev ◽  
Hitesh Shah ◽  
Mayank K. Chaturvedi
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Demographic Data ◽  
Density Lipoprotein ◽  
Atherogenic Index ◽  
Atherogenic Dyslipidemia ◽  
Diabetic Patients ◽  
Men And Women

Background: Utilization of lipids and lipoproteins gets altered in diabetes mellitus (DM) leading to atherogenic dyslipidemia. This study evaluates cardiovascular risk profile of diabetic men and women, including conventional lipid profile and novel risk factors namely lipid ratios, atherogenic coefficient and atherogenic index.Methods: In all 200 diabetic patients (100 males and 100 females) aged 18-65 years who were under treatment were randomly sampled for the study. Socio-demographic data were collected. Glycated hemoglobin levels, lipid profile, fasting blood sugar, were estimated using standard procedures. Anthropometric variables such body mass index (BMI) was measured, systolic and diastolic blood pressures were also taken. There was no difference between men and women with respect to duration of DM and type of treatment.Results: Lipid profile estimates showed that diabetic females had higher level of total cholesterol (TC) (198.07 vs 169.5 mg/dl) and higher level of high-density lipoprotein (HDL)-C (43.99 vs. 41 mg/dl) as compared to males. All the parameters that are raised total cholesterol, triglyceride levels and low-density lipoprotein (LDL) levels were observed in significantly higher proportion of females as compared to males. The values of atherogenic indices [CR1, CR2, AC and atherogenic index of plasma (AIP)] for both genders were higher than the baseline value. In this study females had higher mean non-HDL 154 mg/dl as compared to males mean non-HDL 129 mg/dl and this study showed that female participants held on in high-risk AIP category and so they were at a higher risk of developing coronary heart condition.Conclusions: Dyslipidemia was observed in a greater proportion of female diabetic patients than male diabetic patients.

scholarly journals Higher triglyceride serum level increases atherosclerotic index in subjects 50-70 years of age

2016 ◽  
Vol 34 (3) ◽  
pp. 205
Author(s):  
Martiem Mawi ◽  
Fransisca Chondro ◽  
Juni Chudri
Keyword(s):  
Serum Level ◽  
Total Cholesterol ◽  
Triglyceride Level ◽  
Density Lipoprotein ◽  
Serum Triglyceride ◽  
Hdl Cholesterol ◽  
High Serum ◽  
Atherogenic Index ◽  
Serum Triglyceride Level ◽  
Cross Sectional

Background<br />Atherosclerosis, the underlying cause of heart attack, stroke and peripheral disease, is a main cause of morbidity and mortality worldwide. Hypercholesterolemia and hypertriglyceridemia are independent factors in the development and progression of atherosclerosis. The atherosclerotic index (AI) is a strong indicator of cardiovascular heart disease. The objective of this study was to determine the relationship between lipid serum level and AI in subjects 50-70 years of age. <br /><br />Methods <br />A study of cross-sectional design was conducted among male and female subjects 50-70 years of age. The inclusion criteria were: healthy, and capable of active communication. The exclusion criteria were: subjects not completing the study, currently consuming antihyperlipidemic drugs. Lipid profile comprising total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL), triglycerides, and malondialdehyde (MDA), was analyzed using commercial kits. Systolic and diastolic blood pressure and body mass index was measured in all subjects. Atherogenic index was calculated from (total cholesterol – HDL cholesterol) / HDL cholesterol. Multiple linear regression was used to analyze the data.<br /><br />Results <br />Mean age of the subjects was 60.6 ± 3.30 years and there was a significant relationship of LDL cholesterol and triglycerides with AI (b=0.009; p=0.000 and b=0.008; p=0.000, respectively). Triglyceride level was the most influencing factor for AI (b=0.008; Beta=0.616; p=0.000)<br /><br />Conclusions<br />Higher triglyceride levels increase AI in subjects 50-70 years of age. Subjects with high serum triglyceride level but without symptoms of cardiovascular disease should be examined for the development of coronary artery blockage.

scholarly journals Sweet Potato Leaf Feeding Decreases Cholesterol, Oxidative Stress and Thrombosis Formation in Syrian Hamsters with a High-Cholesterol Diet

Life ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 802
Author(s):  
Hao-Hsiang Chang ◽  
Yi-Chan Lan ◽  
Shiu-Dong Chung ◽  
Chiang-Ting Chien
Keyword(s):  
Total Cholesterol ◽  
Sweet Potato ◽  
Control Diet ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Atherogenic Index ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Potato Leaf

Nutritional strategies to reduce hyperlipidemia and the risk of cardiovascular disease are gaining more public favor and medical professionals’ attention. The authors of this study explored the effect of sweet potato leaf powder (SPLP) feeding on the parameters of plasma lipids, reactive oxygen species, and time to thrombosis formation in Syrian hamsters fed with high-cholesterol diets. The animals were separated into six groups: a feeding control diet, a control diet containing 0.1% cholesterol, a control diet containing 0.2% cholesterol, a control diet containing 0.1% cholesterol plus 2.5% SPLP, a control diet containing 0.1% cholesterol plus 5% SPLP, and a control diet containing 0.2% cholesterol plus 5% SPLP for six weeks. The levels of serum total cholesterol (51% increase), low-density lipoprotein cholesterol (70.6% increase), very-low-density lipoprotein cholesterol (51.3% increase), and the triglyceride and atherogenic index (LDL-C/HDL-C) significantly increased in the high-cholesterol diet groups. Concomitant 5% sweet potato leaf powder ingestion significantly decreased the lipid profiles, with a 20.6% total cholesterol reduction in the 0.1% cholesterol diet groups, a 17.2% reduction in the 0.2% group, a 48.7% LDL reduction in the 0.1% cholesterol group, and a 30.3% reduction in the 0.2% group, with a consequent decrease in the atherogenic index. SPLP feeding was found to be associated with increased fecal sterol contents, with a 188.6% increase in the 0.1% cholesterol-fed group and a 177.3% increase in the 0.2% group. The SPLP-fed groups had depressed ROS levels, elongated FeCl3-induced times to thrombosis formation, and increased liver superoxide dismutase contents and SREBP-1 protein expression. Sweet potato leaf intake could reduce plasma total cholesterol, LDL, and oxidative stress. We suggest sweet potato leaf intake as a choice of nutritional strategy for hyperlipidemia and cardiovascular disease prevention.

Sign in / Sign up

Export Citation Format

Share Document