scholarly journals Safety of Graded-doses of Histidine in Healthy Adults (P08-062-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Mary Gheller ◽  
Erica Bender ◽  
Anna Thalacker-Mercer
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Body Weight ◽  
Amino Acid ◽  
Dietary Intake ◽  
Diastolic Pressure ◽  
Adult Population ◽  
Systolic Pressure ◽  
Clinical Safety ◽  
Funding Sources

Abstract Objectives Histidine is an essential amino acid found in the diet through protein-rich foods. Previous research demonstrated benefits of histidine due to anti-inflammatory, anti-oxidant, and glucoregulatory properties. To date, histidine requirement for adults has not be established; current expert opinion for histidine is 8 and 12 mg/(kg body weight × day), an estimate that was extrapolated from the infant requirement for histidine. Further, the clinical safety of histidine supplementation above the average dietary intake has not been determined. Objective: To determine the safety of graded-doses of histidine in a healthy adult population. Methods Our preliminary study includes 30 adults (n = 12 males and n = 18 females, aged 21–50 y). Following the completion and review of a health history questionnaire, vitals, and a biochemical panel, participants were deemed healthy and able to participate. After baseline measures were obtained, participants consumed encapsulated histidine pills daily for four weeks followed by a three-week washout period between each dose. Participants consumed one of three doses (4 g, 8 g, and 12 g) of histidine during each of the four-week supplement periods. A complete biochemical panel was run at baseline, week 2 and 4 of supplement, as well as washout. Anthropometric, body composition, sleep patterns, dietary intake, and urine samples were also collected throughout the study (analyses underway). Results Baseline descriptive statistics are as follows for females [males]: body weight 65 ± 0.55 kg [62.91 ± 3.17 kg], systolic pressure 113 ± .54 mmHg [125 ± 2.93 mmHg], diastolic pressure 70 ±.48 mmHg [74 ± 3.22 mmHg], and heart rate 74 ± 0.56 bpm [63 ±3.17 bpm]. There were no observed differences between baseline and measurements taken at any of the three doses for body weight, systolic blood pressure, diastolic blood pressure, and heart rate. There was no effect of histidine dose on the biochemical measures of aspartarte amino transferase (U/L, P = 0.096), alanine amino transferase (U/L, P = 0.47), creatinine (mg/dL, P = 0.79), glucose (mg/dL, P = 0.06), insulin (μIU/ml, P = 0.48), or c-reactive protein (mg/L, P = 0.19). Conclusions In our current analyses, we observe no deleterious effects of taking up to 12 grams of histidine in healthy young adults. Funding Sources International Council on Amino Acid Science.

Control circulatory values of morphinepentobarbitalized dogs

1960 ◽  
Vol 199 (5) ◽  
pp. 797-799 ◽  
Author(s):  
S. Deavers ◽  
E. L. Smith ◽  
R. A. Huggins
Keyword(s):  
Heart Rate ◽  
Body Weight ◽  
Cell Volume ◽  
Blood Volume ◽  
Plasma Volume ◽  
Protein Concentration ◽  
Diastolic Pressure ◽  
Systolic Pressure ◽  
Control Data ◽  
Plasma Protein Concentration

Mean control data on a series of 100 dogs are presented. Cell volume, measured with Cr51-tagged red cells and plasma volume determined simultaneously by T-1824 dye was 33.5 ± 0.74 cc/kg and 50.2 ± 1.11 cc/kg, respectively. The venous hematocrit was 45.2% and the circulatory/venous hematocrit ratio was 0.89 ± 0.01 for the group. The plasma protein concentration of these animals was 6.25 ± 0.07 gm/100 cc. No difference in blood volume per unit of body weight was found between large (12.6 kg) and small (5.8 kg) dogs. The femoral mean systolic pressure was 139.0 ± 2.53 mm Hg, the diastolic pressure 65.6 ± 1.46 mm Hg and the heart rate 85.9 ± 2.86/min.

Alcohol: Effect on Blood Pressure and Predisposition to Hypertension

1981 ◽  
Vol 61 (s7) ◽  
pp. 373s-375s ◽  
Author(s):  
P. D. Arkwright ◽  
L. J. Beilin ◽  
I. Rouse ◽  
B. K. Armstrong ◽  
R. Vandongen
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Essential Hypertension ◽  
Alcohol Consumption ◽  
Diastolic Pressure ◽  
Systolic Pressure ◽  
Threshold Effect ◽  
Health Questionnaire ◽  
Government Employees ◽  
Weekly Alcohol Consumption

1. The association between alcohol consumption and blood pressure was studied in 491 Government employees. The men, aged 21–45 years, volunteered to complete a health questionnaire and submitted to standardized measurements of blood pressure, heart rate and body size. 2. Average weekly alcohol consumption correlated with systolic pressure (r = 0.18, P < 0.001) but not with diastolic pressure. Systolic pressure increased progressively with increasing alcohol consumption with no obvious threshold effect. The effect of alcohol was independent of age, obesity (Quetelet's index) or cigarette smoking. 3. Results indicate that alcohol ranks close to obesity as a preventable cause of essential hypertension in the community.

Acute Intraarterial Blood Pressure Response to Bench Press Weight Lifting in Children

1990 ◽  
Vol 2 (1) ◽  
pp. 37-45 ◽  
Author(s):  
Karen L. Nau ◽  
Victor L. Katch ◽  
Robert H. Beekman ◽  
Macdonald Dick
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Bench Press ◽  
Diastolic Pressure ◽  
Blood Pressure Response ◽  
Systolic Pressure ◽  
Weight Lifting ◽  
Peak Heart Rate ◽  
Repetition Maximum ◽  
Peak Pressures

Intraarterial blood pressure (BP) response to bench press weight lifting (WL) was evaluated in 11 children. Aortic systolic and diastolic pressures and heart rate (HR) were measured during WL. Baseline systolic and diastolic pressures were 120 and 81 mmHg, and HR was 86 bpm. Subjects lifted to voluntary fatigue weights equaling 60, 75, 90, and 100% of their predetermined one-repetition maximum (1RM). For each weight lifting condition, BP and HR increased as more repetitions were completed. Peak systolic pressure was 168, 177, 166, and 162 mmHg, peak diastolic pressure was 125, 139, 133, and 130 mmHg, and peak heart rate was 142, 148, 142, and 139 bpm at 60, 75, 90, and 100% 1RM, respectively. Peak BP and HR were greater during WL than rest but did not differ between conditions. The relative BP response to WL in children was similar to adult values. For all conditions, pressures increased as more repetitions were completed. It was concluded that peak pressures occur at voluntary fatigue, independent of the combination of resistance and repetitions used to achieve fatigue.

scholarly journals CARDIAC FUNCTION OF BASKETBALL PLAYERS UNDER STRESS TRAINING

2022 ◽  
Vol 28 (1) ◽  
pp. 27-30
Author(s):  
Keyin Liu
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Diastolic Pressure ◽  
Test Procedure ◽  
Systolic Pressure ◽  
Cardiac Response ◽  
Training Methods ◽  
Basketball Players ◽  
Level Of Evidence ◽  
Athletic Ability

ABSTRACT Introduction: Basketball can enhance the physical fitness of young people, promote the growth and development of their bodies, and improve health and athletic ability. Objective: To explore the characteristics of basketball players’ cardiac response to increasing load training. Methods: By analyzing 12 juvenile male amateur basketball training athletes, when performing incremental load exercises on the treadmill, using a 12-lead electrocardiograph to record the electrocardiogram, HR, and blood pressure responses for each level of exercise. Results: The mean heart rate of the basketball players before movement was 82.45± 11.44 bpm, slightly higher than the heart rate at rest. Depending on the exercise load, the blood pressure should increase by 5 to 12 mmHg. Under different load training conditions, each level of blood pressure in the Bruce treadmill test procedure should increase 12.5 ~ 44mmHg. The basketball player’s systolic pressure increased by 2.25 ~ 15.7mmHg, diastolic pressure increased by 0.43 to 11.37 mmHg. Conclusions: In basketball players, the psychological stress is less than that of the average person performing the same exercise. The strong ability to adapt to exercise under incremental load training, the contractility of the ventricular muscles and the development of the heart are good. Level of evidence II; Therapeutic studies - investigation of treatment results.

Development of the Sex Difference in Blood Pressure of the Chick

1957 ◽  
Vol 188 (2) ◽  
pp. 383-386 ◽  
Author(s):  
Harold S. Weiss ◽  
Robert K. Ringer ◽  
Paul D. Sturkie
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Sex Difference ◽  
Diastolic Pressure ◽  
Rapid Development ◽  
Systolic Pressure ◽  
Pressure Measurements ◽  
White Leghorn ◽  
Rate Of Development ◽  
White Leghorn Chicken

In order to establish the age and manner in which the sex difference in blood pressure of the adult white leghorn chicken develops, periodical blood pressure measurements were made on chicks between 3 and 34 weeks of age. There were no consistent differences in pressure between the sexes under 8 weeks of age. Between the 8th and 13th weeks, pressures began to diverge, and within 4–8 weeks a 26–30-mm sex difference in systolic pressure developed. Significant divergences occurred also in diastolic and pulse pressure. The sex divergence was due primarily to a rise in male pressure, the female level remaining comparatively stable. Net changes in male parameters during the period of rapid development of the sex difference in pressure were: body weight + 219 gm, systolic pressure + 26 mm, diastolic pressure + 16 mm and heart rate –22/ min. The age at which the sex difference in pressure begins and its rate of development appear to be related to sexual maturation in the male. However, no significant correlation between the rising male pressure and testes or comb size could be shown. Normal chick blood pressure values prior to the sex divergence differ within strains of white leghorns and for the two groups used here, between 7 and 9 weeks of age, were 150/130 and 162/136 mm Hg.

scholarly journals Blood Pressure and Heart Rate Alterations through Music in Patients Undergoing Cataract Surgery in Greece

2015 ◽  
Vol 7 ◽  
pp. OED.S20960 ◽  
Author(s):  
Kyriakoula Merakou ◽  
Georgia Varouxi ◽  
Anastasia Barbouni ◽  
Eleni Antoniadou ◽  
Georgios Karageorgos ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Systolic Blood Pressure ◽  
Cataract Surgery ◽  
Coping Skills ◽  
Diastolic Pressure ◽  
Intervention Group ◽  
Systolic Pressure ◽  
Control Group ◽  
Stress Coping

Introduction Music has been proposed as a safe, inexpensive, nonpharmacological antistress intervention. The purpose of this study was to determine whether patients undergoing cataract surgery while listening to meditation music experience lower levels of blood pressure and heart rate. Methods Two hundred individuals undergoing cataract surgery participated in the study. Hundred individuals listened to meditation music, through headphones, before and during the operation (intervention group) and 100 individuals received standard care (control group). Patients stress coping skills were measured by the Sense of Coherence Scale (SOC Scale). Systolic and diastolic blood pressure and heart rate were defined as outcome measures. Results According to the SOC Scale, both groups had similar stress coping skills (mean score: 127.6 for the intervention group and 127.3 for the control group). Before entering the operating room (OR) as well as during surgery the rise in systolic and diastolic pressures was significantly lower in the intervention group ( P < 0.001). Among patients receiving antihypertensive therapy, those in the intervention group presented a lower increase only in systolic pressure ( P < 0.001) at both time recordings. For those patients in the intervention group who did not receive antihypertensive treatment, lower systolic blood pressure at both time recordings was recorded ( P < 0.001) while lower diastolic pressure was observed only during entry to the OR ( P = 0.021). Heart rate was not altered between the two groups in any of the recordings. Conclusions Meditation music influenced patients' preoperative stress with regard to systolic blood pressure. This kind of music can be used as an alternative or complementary method for blood pressure stabilizing in patients undergoing cataract surgery.

scholarly journals Blood Pressure Screening Campaign in the Adult Population

Health Scope ◽  
2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Seyed Farzad Jalali ◽  
Mostafa Javanian ◽  
Reza Ghadimi ◽  
Ali Bijani ◽  
Simin Mouodi
Keyword(s):  
Blood Pressure ◽  
Diastolic Pressure ◽  
Screening Program ◽  
Adult Population ◽  
Systolic Pressure ◽  
World Health ◽  
Historical Cohort ◽  
Urban Regions ◽  
Significant Difference ◽  
The Impact

Background: World Health Organization estimated that 1 in 4 men and 1 in 5 women have hypertension (HTN). Considering the impact of high blood pressure (BP) identification to prevent its related complications. Objectives: this study was performed to describe the first national BP screening program conducted in Babol, north of Iran. Methods: In this historical cohort carried out at Babol University of Medical Sciences, data related to the 2019 BP screening mass campaign in adult people ≥ 30 years were collected. BP less than 120/80 mm Hg was considered as normal, and mean BP ≥ 140/90 mm Hg or taking antihypertensive medication was defined as hypertension. When the systolic pressure was 120 - 139 or the diastolic pressure was 80 - 90 mm Hg, the person was classified as a prehypertensive case. Results: Totally, 220,241 adult people, with a mean age of 49.82 ± 14.26 years were screened, of whom 42,107 cases (19.1%; 95% CI: 18.95 - 19.28%) had hypertension, 112,406 cases (51.0%) had normal BP, and 65,728 cases (29.8%) were diagnosed as prehypertensive cases. After controlling for demographic covariates, the logistic regression models showed significantly higher odds of hypertension for married individuals (adjusted OR = 1.23; 95% CI: 1.19 - 1.27; P < 0.0001) and those living in urban regions (adjusted OR = 1.84; 95% CI: 1.79 - 1.88; P < 0.0001). The prevalence of hypertension showed no significant difference between men and women (P = 0.476). Conclusions: As nearly one in five adults had hypertension, and nearly 30% were diagnosed as prehypertensive individuals, a continuous BP screening program is recommended in this region. High BP was observed more in older and married cases and in people living in urban regions.

scholarly journals RESPOSTAS HEMODINÂMICAS DO MÉTODO PILATES EM HIPERTENSOS: UMA REVISÃO SISTEMÁTICA

2019 ◽  
Vol 27 (4) ◽  
pp. 219
Author(s):  
Leonando Pedro Pereira Da Costa ◽  
Gabriela Dos santos ◽  
Patrícia Haas ◽  
Renato Claudino ◽  
Ana Inês Gonzáles
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Young Adult ◽  
High Blood Pressure ◽  
Pulse Rate ◽  
Rate Control ◽  
Diastolic Pressure ◽  
Systolic Pressure ◽  
Heart Rate Control ◽  
Exercise Movement Techniques

Objetivo: levantar na literatura atual, estudos relevantes que identifiquem as possíveis respostas hemodinâmicas encontradas em indivíduos hipertensos praticantes do Método Pilates. Materiais e Métodos: Pesquisa de revisão sistemática conduzida conforme as recomendações PRISMA em cinco bases de dados eletrônicas (PEDro, PubMed, SciELO, LILACS e Cochrane), disponibilizado desde o início das bases até Março de 2019, com descritores do dicionário MESH conforme segue: [(“Adult” OR “Young adult” OR “Middle Aged” OR “Aged” OR “Elderly”) AND (“exercise movement techniques” OR “Pilates-Based Exercises” OR “Pilates Training”) AND (“Hemodynamics” OR “Heart Rate” OR “Cardiac Chronotropy” OR “Heart Rate Control” OR “hypertension” OR “Blood Pressure” OR “High Blood Pressure” OR “Systolic Pressure” OR “Diastolic Pressure” OR “High Blood Pressure” OR “Pulse Rate Determination”)], posteriormente ajustado para as demais bases. Busca complementar manual nas referências dos artigos incluídos na pesquisa e no Google Scholar. Foram incluídos estudos de intervenção, com indivíduos de idade maior ou igual a 18 anos; diagnóstico de hipertensão arterial sistêmica (HAS); que tenham sido submetidos a exercícios de pilates solo e/ou pilates aparelhos como método de intervenção e incluído a descrição de análise das variáveis hemodinâmicas de pressão arterial (PA), frequência cardíaca (FC) e duplo produto (DP). Resultados: Após processo de seleção foi selecionado apenas um único estudo que tenha contemplado todos os critérios de elegibilidade, totalizando 44 indivíduos do sexo feminino, com média de idade de 50,5 anos (±6,3 anos), hipertensas com utilização de medicação, onde 22 foram submetidas ao pilates solo e 22 permaneceram no grupo controle. O estudo apresentou resultados positivos na frequência cardíaca (FC), pressão arterial (PA) e no duplo-produto (DP) em comparação ao grupo controle. Conclusão: O Mat pilates pode ser um método aplicável e hemodinamicamente em pacientes com HAS, entretanto, novos estudos devem ser realizados para a confirmação dos achados.

Pro-health education in the fight against obesity and its complications in school-age children – 6-month programme of cooperation with the child and parents

2018 ◽  
Vol 2 (2) ◽  
pp. 1-6
Author(s):  
Małgorzata Kołpa ◽  
Agnieszka Jankowicz-Szymańska
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Body Weight ◽  
Weight Status ◽  
Fruits And Vegetables ◽  
Diastolic Pressure ◽  
Systolic Pressure ◽  
Educational Programme ◽  
Excess Body Weight ◽  
Arterial Blood

Introduction: The dynamic development of society affects the health of the population. We often address civilization-related diseases affecting increasingly younger people. The lack of both a balanced diet and physical activity leads to hypertension and obesity. These diseases have a number of serious consequences. The aim of the study was to demonstrate the influence of an educational programme on the arterial pressure and body weight status of children between 10 and 12 years of age. Material and methods: The study (education program) involved 60 primary school pupils in grades 4-6, including 40 boys and 20 girls whose BMI and arterial blood pressure values differed, higher from the standard norms. Anthropometric measurements were made, i.e., height, body weight, blood pressure and blood biochemical tests. Then, the pupils were taken care of by a dietician and a trainer. Results: The problem is the small number of fruits and vegetables in the children’s diet, which is far below the recommended standards. In the study group, nearly 12% of the children had elevated TSH levels. Physical activity of the participants was low and was mostly limited to compulsory physical education lessons. According to the surveys carried out the girls were physically active much less frequently than the boys. Conclusions: The increase in the BMI index results in increased systolic pressure in children. An increase in TSH increases the value of diastolic pressure in 10- to 12-year-olds. Children eat too few fruits and vegetables per week compared to the established standards. The implementation of an educational programme in nutrition and physical activity affects the reduction of BMI in children with excess body weight.

Long-Term Study of Relationships between Blood Pressure, Age and Body Weight in Steelmill Workers

1973 ◽  
Vol 45 (s1) ◽  
pp. 107s-110s ◽  
Author(s):  
M. Ulrych ◽  
J. Tauber ◽  
A. P. Shapiro
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Weight Gain ◽  
Diastolic Pressure ◽  
Systolic Pressure ◽  
Positive Influence ◽  
Term Study ◽  
Long Term Study ◽  
Negligible Influence

1. In 404 male steelmill workers blood pressure and body weight were followed for 15–25 years and their relationships analysed. 2. It appears that age on average has a negligible influence on diastolic pressure and has a positive influence on systolic pressure only after 45 years of age. 3. In contrast to this, weight gain influences both pressures positively regardless of age.

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