Groundwater in New Valley and kidney disease

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Howaida A Elshinnawy ◽  
Tamer W Elsaid ◽  
Hussein A Hussein
Keyword(s):  
Kidney Disease ◽  
Rural Community ◽  
Urine Analysis ◽  
General Information ◽  
Cross Sectional ◽  
Mdrd Equation ◽  
Groundwater Samples ◽  
Groundwater Supply ◽  
Nile Water ◽  
Groundwater Consumption

Abstract Background This study was performed to assess the possible association between groundwater and kidney disease in new valley governorate . Methods This hospital-based cross-sectional observational study was conducted at the Department of Nephrology, Ain Shams University, Cairo, Egypt, during the period from August 2018 to January 2019. After obtaining verbal consent from all participants; the general information of each participant was recorded, full history taken and general examination was done for each participant, then urine samples and serum blood samples taken for urine analysis, serum urea and serum creatinine, then estimated glomulurar filtratin rate (eGFR) was calculated for healthy subjects groups using MDRD Equation; after that three different groundwater samples and Nile water sample collected and analyzed for different solutes and heavy metals contents. Result Our data suggests that rural community as in Eldakhla; which depends on groundwater supply may affected by more risk of CKD than urban community as in Cairo city, which depends on Nile water supply. Conclusion there are increased prevalence of CKD in New Valley governorate and this may be due to groundwater consumption .

scholarly journals Performance of CKD-EPI equation to estimate glomerular filtration rate as compared to MDRD equation in South Brazilian individuals in each stage of renal function

2014 ◽  
Vol 52 (12) ◽  
Author(s):  
Francisco Veríssimo Veronese ◽  
Eduardo C. Gomes ◽  
Joana Chanan ◽  
Maicon A. Carraro ◽  
Eduardo G. Camargo ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Glomerular Filtration Rate ◽  
Kidney Disease ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Disease Epidemiology ◽  
Mdrd Equation ◽  
Estimate Glomerular Filtration Rate

AbstractThe Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation seems to correct the overdiagnosis of chronic kidney disease (CKD) provided by Modification of Diet in Renal Disease (MDRD) equation. However, this point has not been tested in some ethnic groups. This study investigated the performance of MDRD and CKD-EPI equations in South Brazilian individuals.This cross-sectional study included 354 individuals including healthy volunteers, diabetic and non-diabetic individuals with or without CKD. Glomerular filtration rate (GFR) was measured by theIn the group as a whole,CKD-EPI reduces GFR underestimation in individuals with GFRs >60, but still presents a quite low accuracy at this GFR range. Moreover, it tends to overestimate GFR in subjects with GFRs <60 mL/min/1.73 m

scholarly journals Estimated GFR (eGFR) by prediction equation in staging of chronic kidney disease compared to gamma camera GFR

2016 ◽  
Vol 8 (1) ◽  
pp. 44
Author(s):  
Mohammad Masum Alam ◽  
Md. Mozammel Hoque ◽  
Shamim Momtaz Ferdousi Begum ◽  
Naila Atik Khan
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Gamma Camera ◽  
Prediction Equation ◽  
Cross Sectional ◽  
Mdrd Equation ◽  
Kappa Value ◽  
Mdrd Formula ◽  
Bangladeshi Population ◽  
Medical University

<p><strong>Background:</strong> Glomerular filtration rate is an effective tool for diagnosis and staging of chronic kidney disease. The effect ofrenal insufficiency by different method of this tool among patients with CKD is controversial.</p><p><strong>Objective:</strong> The objec­tive of this study was to evaluate the performance of eGFR in staging of CKD compared to gamma camera based GFR.</p><p><strong>Methods:</strong> This cross sectional analytical study was conducted in the Department of Biochemistry Bangabandhu Sheikh Mujib Medical University (BSMMU) with the collaboration with National Institute of Nuclear Medicine and Allied Sciences, BSMMU during the period of January 2011 to December 2012. Gama camera based GFR was estimated from DTP A reno gram and eGFR was estimated by three prediction equations. Comparison was done by Bland Altman agree­ment test to see the agreement on the measurement of GFR between three equation based eGFR method and gama camera based GFR method. Staging comparison was done by Kappa analysis to see the agreement between the stages identified by those different methods.</p><p><strong>Results:</strong> Bland-Altman agreement analysis between GFR measured by gamma camera, CG equation ,CG equation corrected by BSA and MDRD equation shows statistically significant. CKD stages determined by CG GFR, CG GFR corrected by BSA , MDRD GFR and gamma camera based GFR was compared by Kappa statistical analysis .The kappa value was 0.66, 0.77 and 0.79 respectively.</p><p><strong>Conclusions:</strong> This study findings suggest that GFR estimation by MDRD equation in CKD patients shows good agreement with gamma camera based GFR and for staging of CKD patients, eGFR by MDRD formula may be used as very effective tool in Bangladeshi population.</p>

scholarly journals Early detection of kidney disease in Ghana - A situational survey of secondary hospitals in the Ashanti Region of Ghana

2021 ◽  
Vol 4 (2) ◽  
Author(s):  
Elliot Koranteng Tannor ◽  
Kamarudeen Korku Hussein ◽  
Martin Agyei ◽  
Vincent Boima
Keyword(s):  
Kidney Disease ◽  
Primary Healthcare ◽  
Urine Analysis ◽  
Health Staff ◽  
Healthcare Staff ◽  
Cross Sectional ◽  
Ashanti Region ◽  
District Hospitals ◽  
Patients With Diabetes ◽  
Almost All

Background Patients with kidney disease are referred late to tertiary institutions with increased morbidity and mortality. The accurate diagnoses and management of kidney disease by primary healthcare staff is dependent on the requisite knowledge and availability of adequate laboratory services. We set out to describe the practice pattern of districts Hospitals. Methods We conducted a situational cross-sectional descriptive survey of district hospitals within the Ashanti region of Ghana. A structured questionnaire was designed via google survey and the links sent to medical superintendents and/or administrators for completion. Data was exported onto an Excel sheet and analyzed with Stata 13. Summary statistics with means ± standard deviation and medians with interquartile range were used where appropriate. Percentages and proportions were used for categorical data. Results We surveyed 26 hospitals in the Ashanti region of Ghana. This included 23(88.5%) public facilities. Most 25(96.2%) of hospitals had a dedicated diabetes mellitus clinic and 24(92.3%) had dedicated hypertension clinic. Only 5(19.2%) hospitals routinely requested urinalysis for patients with diabetes and hypertension during visits. Almost all 25(96.2%) hospitals could carry out routine urine analysis in their laboratory but only 16 (61.5%) of the hospitals could run serum urea and creatinine test. Most 25(96.2%) of respondents suggested that the training of health staff for the early diagnosis and management of kidney disease as key to improve care. Conclusion Primary healthcare staff in district hospitals do not routinely screen high risk patients for kidney disease and call for training to manage patients with kidney disease appropriately.

Outcome of Febuxostat treatment in hyperuricemic pre-dialysis chronic kidney disease patients

2020 ◽  
Vol 7 (2) ◽  
pp. 45-52
Author(s):  
Dineshowri Shrestha ◽  
Anil Baral ◽  
Kashyap Dahal ◽  
Juju Raj Shrestha ◽  
Rajani Hada
Keyword(s):  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Kidney Disease ◽  
Adverse Effects ◽  
Serum Uric Acid ◽  
Kidney Injury ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Mdrd Equation ◽  
Ckd Stage

Introduction: Hyperuricemia is a cause and effect of chronic kidney disease (CKD), accelerates its progression and predisposes to acute kidney injury. Present study aimed to find out the outcome of Febuxostat treatment in hyperuricemic pre-dialysis CKD patients. Method: This was a cross sectional study conducted in Nephrology department, Bir hospital, Nepal, during from February 2019 to January 2020, among pre-dialysis CKD stage 3-5 non dialysis (ND) patients with serum uric acid (SUA) >7 mg/d L who were treated with Febuxostat 40 mg once a day and followed up at one, two and three months. The baseline SUA, creatinine, estimated glomerular filtration rate (eGFR) calculated by the modification of diet in renal disease (MDRD) equation compared with values at follow up and according to CKD stages. The adverse effects and liver enzymes were recorded. Result: There were total 50 patients, mean age 54.2±16.5 years, male 31 (62%).There were significant reductions of SUA from baseline of 8.9±1.4to 7.1±1.2 vs 5.9±0.9 vs 4.7±1.0) at one, two and three month respectively, p=0.000 and increment of eGFR (ml/min/1.73m2) from 29.6±15.0 to 31.6±16.0, 33.6±16.6, 34.1±17.1, p=0.000.And 41 (82%) patients achieved uric acid < 6 mg/dl at three month. Significant reduction of uric acid in all CKD stages and increment of eGFR in CKD stage 3 and 4 were observed. Adverse effects were epigastralgia in 5 (10%) and joint pain in 13 (26%). Conclusion: Febuxostat is an effective serum uric acid lowering drug in pre-dialysis chronic kidney disease patients with improvement of kidney function.

scholarly journals Prevalence of Chronic Kidney Disease and Its Association with Risk Factors in Disadvantageous Population

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Md Nurul Huda ◽  
Kazi Shahnoor Alam ◽  
Harun-Ur-Rashid
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Normal Population ◽  
Sociodemographic Factors ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Mdrd Equation ◽  
The World ◽  
The Difference

The prevalence of kidney disease, particularly diabetic and hypertensive kidney disease is increasing rapidly specially in the disadvantageous group of population throughout the world. A cross sectional survey was carried out at certain selected slum areas of Mirpur in Dhaka city of Bangladesh over the period from July 2003 to June 2005, and a total of participants ranging from 15 to 65 years were studied. The analysis discovered that 4.1% of the participants were diabetic, 11.6% were hypertensive, and 7.7% had proteinuria. Based on MDRD equation, 13.1% of the participants were detected as having chronic kidney disease (CKD) while with Cockcroft-Gault equation 16% had CKD. Accordingly, the difference between the two equations was not significant. Association of sociodemographic factors with CKD was not significant except age more than 40 years and marital status. The association between CKD and risk factors like proteinuria, obese and overweight, use of tobacco, diabetes mellitus, and hypertension was highly significant. Combined prevalence of DM, hypertension, and proteinuria among CKD group was also demonstrated to be significantly higher (3.8% with Cockcroft-Gault equation and 5.3% with MDRD equation) than that of normal population. The survey data revealed that CKD and its risk factors like DM and hypertension are alarmingly high in disadvantageous population and adding further pressure to the existing burden of CKD.

scholarly journals CHRONIC KIDNEY DISEASE

2018 ◽  
Vol 25 (09) ◽  
pp. 1380-1385
Author(s):  
Pooran Mal ◽  
Muhammad Nadeem Ahsan ◽  
Mehwish Bukhari ◽  
Abdul Manan Junejo
Keyword(s):  
Health Care ◽  
Kidney Disease ◽  
Urine Analysis ◽  
Final Diagnosis ◽  
Cost Burden ◽  
Cross Sectional ◽  
Clinical Investigations ◽  
Screening Study ◽  
Close Relatives ◽  
Close Family

INTRODUCTION:Chronic kidney disease (CKD) is a progressive health care issue that is increasing cost burden on patients and health care system. In different researches it was concluded that relatives of patients suffering from CKD are at more risk of development of kidney problems and diagnosed with CKD. OBJECTIVE: To evaluate the early diagnosis of CKD in at risk population by screening the close family relatives of CKD patients. PATIENTS AND METHODS: A cross-sectional screening study of family members of CKD patients performed in Nephrology department of Jinnah Postgraduate Medical Centre (JPMC), Karachi from September 2015 to January 2017. Total 200 relatives (58% male and 42% female) of CKD patients close relatives  were enrolled and screened for medical history, physical examination (weight, height and BMI) and clinical investigations such as urine analysis,  serum Creatinine  and Glomerular filtration rate (GFR)  calculated by Cock GraftGault equation for assessment of renal functions.RESULTS: we observed53 abnormalities in relatives of CKD patients. Family history for Diabetes was present in 58(29%) relatives, Hypertension in 42(21%) relatives,  26 (13%) relatives with Glomerulonephritis (GN), and 74 patients (37%) with Tuberculosis (TB), Kidney damage and Stone diseases. Albuminuria was high in 33% relatives of CKD patients, mostly affecting first degree relatives 20.5% as compared to second degree relatives 2.5%. Relatives of CKD patients were diagnosed with high albuminuria in DM (36.2%) as compare to HTN (35.8%) and GN (27.0%).  For final diagnosis, albuminuria and CrCl were monitored, that were found abnormalin 26.5% relatives of CKD patients.CONCLUSION:The screened relatives of CKD patients are at higher risk of kidney problems in the future, especially patients suffering from DM, HTN and GN.

Association of Vitamin D Status With Liver and Kidney Disease: A Systematic Review of Clinical Trials, and Cross-Sectional and Cohort Studies

2019 ◽  
pp. 1-13 ◽  
Author(s):  
Seyed Mostafa Parizadeh ◽  
Majid Rezayi ◽  
Reza Jafarzadeh-Esfehani ◽  
Amir Avan ◽  
Hamideh Ghazizadeh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Kidney Disease ◽  
Renal Disease ◽  
Cohort Studies ◽  
Cochrane Library ◽  
Major Public Health Problem ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Beneficial Effects ◽  
Vitamin D Levels

Abstract. Background: Vitamin D deficiency (VDD) is a major public health problem. There are few comprehensive systematic reviews about the relationship between Vitamin D status and liver and renal disease in Iran. Methods: We systemically searched the following databases: Web of Science; PubMed; Cochrane Library; Scopus; Science Direct; Google Scholar and two Iranian databases (Scientific Information Database (SID) and IranMedex) up until November 2017 to identify all randomized control trials (RCTs), case control, cross-sectional and cohort studies investigating the association between vitamin D and any form of liver or kidney disease. Results: Vitamin D insufficiency, or deficiency (VDD), is highly prevalent in Iran, reports varying between 44.4% in Isfahan to 98% in Gorgan. There is also a high prevalence of VDD among patients with liver or kidney disease, and the administration of vitamin D supplements may have beneficial effects on lipid profile, blood glucose, liver function and fatty liver disease, and bone health. Low serum vitamin D levels are related with abnormalities in these laboratory and clinical parameters. Conclusion: VDD is prevalent in patients with chronic liver or renal disease in Iran. There appear to be several beneficial effects of vitamin D supplementation in vitamin D deficient patients with liver or kidney disease.

HUBUNGAN EFIKASI DIRI DENGAN KUALITAS HIDUP PASIEN GAGAL GINJAL KRONIK YANG MENJALANI HEMODIALISIS

2018 ◽  
Vol 5 (2) ◽  
pp. 56-63
Author(s):  
Abdul Wakhid ◽  
Estri Linda Wijayanti ◽  
Liyanovitasari Liyanovitasari
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Self Efficacy ◽  
Healing Process ◽  
Sampling Technique ◽  
P Value ◽  
Cross Sectional ◽  
Kolmogorov Smirnov

Background: Self efficacy can optimize the quality of life of clients who undergo the healing process due to chronic diseases. Individuals with higher self-efficacy move their personal and social resources proactively to maintain and improve the quality and length of their lives so that they experience a better quality of life. Objectives: the purpose of this study was to find the correlation between self efficacy and quality of life of patients with chronic kidney disease who undergo hemodialysis at RSUD Semarang Regency. Metode: This type of research was descriptive correlation with cross sectional approach. The samples in this study more 76 people with total sampling technique. The data collection tool for self efficacy was measured by General Self-Efficacy scale, for quality of life with WHOQoL-BREF. Statistical test used Kolmogorov-smirnov. Result: The result showed that self efficacy in patients with chronic kidney disease was mostly in moderate category (53,9%), quality of life in patients with chronic kidney disease was mostly in good category (68,4%). There was a correlation between self efficacy and quality of life of patients with chronic kidney disease who undergo hemodialysis at RSUD Semarang Regency, the result obtained p-value of 0.000 <α (0,05). Suggestion: Patients with chronic kidney disease can maintain good quality of life by helping to generate positive self-esteem and high self efficacy.

scholarly journals Elevated alanine aminotransferase and low aspartate aminotransferase/alanine aminotransferase ratio are associated with chronic kidney disease among middle-aged women: a cross-sectional study

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Hirotaka Ochiai ◽  
Takako Shirasawa ◽  
Takahiko Yoshimoto ◽  
Satsue Nagahama ◽  
Akihiro Watanabe ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Venous Blood ◽  
Cross Sectional Study ◽  
Middle Aged ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Relationship Of

Abstract Background Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) to ALT ratio (AST/ALT ratio) have been shown to be related to non-alcoholic fatty liver disease or insulin resistance, which was associated with chronic kidney disease (CKD). However, it is unclear whether ALT and AST/ALT ratio are associated with CKD. In this study, we examined the relationship of ALT and AST/ALT ratio to CKD among middle-aged females in Japan. Methods The present study included 29,133 women aged 40 to 64 years who had an annual health checkup in Japan during April 2013 to March 2014. Venous blood samples were collected to measure ALT, AST, gamma-glutamyltransferase (GGT), and creatinine levels. In accordance with previous studies, ALT > 40 U/L and GGT > 50 U/L were determined as elevated, AST/ALT ratio < 1 was regarded as low, and CKD was defined as estimated glomerular filtration rate < 60 mL/min/1.73 m2 and/or proteinuria. Logistic regression model was used to calculate the odds ratio (OR) and 95% confidence interval (CI) for CKD. Results “Elevated ALT and elevated GGT” and “elevated ALT and non-elevated GGT” significantly increased the OR for CKD when compared with “non-elevated ALT and non-elevated GGT” (OR: 2.56, 95% CI: 2.10–3.12 and OR: 2.24, 95% CI: 1.81–2.77). Compared with “AST/ALT ratio ≥ 1 and non-elevated GGT”, “AST/ALT ratio < 1 and elevated GGT” and “AST/ALT ratio < 1 and non-elevated GGT” significantly increased the OR for CKD (OR: 2.73, 95% CI: 2.36–3.15 and OR: 1.68, 95% CI: 1.52–1.87). These findings still remained after adjustment for confounders. Conclusions Elevated ALT was associated with CKD regardless of GGT elevation. Moreover, low AST/ALT ratio was also associated with CKD independent of GGT elevation.

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