scholarly journals Evaluation of new polymer-iodine complexes for the fabrication of medical devices.

2021 ◽  
Author(s):  
Marina López-Álvarez ◽  
Herb Ulmer ◽  
Nico Klay ◽  
Jan Maarten van Dijl
Keyword(s):  
Medical Devices ◽  
Infection Prevention ◽  
Wound Care ◽  
Success Story ◽  
Positive Effects ◽  
Base Materials ◽  
Engineering Plastics ◽  
Healthcare Acquired Infections ◽  
Elemental Iodine ◽  
Iodine Complexes

Povidone-iodine has been a true success story in the fight against infections by harnessing the antimicrobial and antiviral properties of elemental iodine for water-based applications. However, to date there has been little success in implementing iodine attributes in water-insoluble engineering plastics. Here, we describe the first development of biocidal active polyamide- and polyurethane-iodine complexes at laboratory and commercially relevant scales. These polymer-iodine materials are active against a broad range of microorganisms, including bacteria, yeast and fungi, and can be used as base materials for medical devices. The use of new polymer-iodine complexes for infection prevention in medical devices, such as sutures, catheters and drains, or wound care is expected to have significant positive effects at reducing healthcare-acquired infections. In addition, the materials are expected to find significant applications in other fields, such as air handling with the production of biocidal face masks and air filters to control spread of pathogens.

Considerations for Translating Medical Devices Under Development From the Clinic to the Home: A Case Study in Providing Chronic Wound Care

2021 ◽  
Vol 10 (1) ◽  
pp. 238-242
Author(s):  
Ellen J. Bass ◽  
Justine S. Sefcik ◽  
Elease McLaurin ◽  
Rose Ann DiMaria-Ghalili
Keyword(s):  
Medical Devices ◽  
Chronic Wound ◽  
Wound Care ◽  
Clinical Protocol ◽  
Structured Interviews ◽  
Home Setting ◽  
Ultrasound Application ◽  
Research Assistants ◽  
Current Device

A prototype medical device and protocol that work well in a clinic would not necessarily work reliably in the home setting. The goal of this work is to identify factors to consider when translating a device evaluated in a clinic for use by home caregivers providing chronic wound care for persons living with dementia. One must consider the current device, the associated bundle, the protocol and how they may need to be modified. Semi-structured interviews with the research assistants who have applied a prototype device were conducted to generate a list of known issues with the current clinical protocol in terms of ultrasound application The researchers performed a set of specified tasks by following the current device protocol and explaining any difficulties with use\execution. They embellished the descriptions with details about what had happened with actual patients in the clinic. Using thematic analysis, analysts identified themes and subthemes. Issues potentially relevant to translating medical devices to the home are discussed.

Study of friction stir spot welding for thermotolerant engineering thermoplastic polyimide joints

2021 ◽  
pp. 095440542199561
Author(s):  
Jicheng Gao ◽  
Jiachen Dong ◽  
Sunyi Zhang ◽  
Liang Yu ◽  
Huiming Jin ◽  
...  
Keyword(s):  
Shear Strength ◽  
Spot Welding ◽  
Dwell Time ◽  
Rotation Speed ◽  
Mixing Time ◽  
Friction Stir Spot Welding ◽  
Scanning Calorimetry ◽  
Friction Stir ◽  
Base Materials ◽  
Engineering Plastics

In this research, thermoplastic polyimide (TPI) were welding via friction stir spot welding (FSSW) in order to evaluate the feasibility of the technology. The welding tool with a tri-flute pin was used for keeping the welding effectiveness. The effect of the rotation speed and dwell time on the microstructure and shear strength was studied. The results shows that the number of gap defects between the shoulder affect zone and the pin affect zone decreased with the increase of the rotation speed. The boundary of the shoulder affect zone and the pin affect zone was no clear when increasing the dwell time from 10 s to 20 s. Long dwell time could increase the mixing time and reduce the materials viscosity, which made the structure was denser. The maximal shear strength was obtained 85.5% of the base materials. The differential scanning calorimetry (DSC) results indicated that the melting behaviour of different regions was no obvious difference. It indicated that FSSW had a feasible and potential technology to join the high temperature resistant engineering plastics.

scholarly journals La membrana L-PRF e suoi derivati utili nella chirurgia del wound care/The L-PRF membrane and its derivatives useful in wound care surgery

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Alessandro Crisci ◽  
Carmela Rescigno ◽  
Michela Crisci
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Wound Care ◽  
Platelet Concentrates ◽  
Clinical Routine ◽  
Soft Tissue Regeneration ◽  
Positive Effects ◽  
Sono Stati ◽  
Care Surgery ◽  
Tissue Defects

Il crescente settore multidisciplinare dell’ingegneria tissutale mira a rigenerare, migliorare o sostituire in modo prevedibile i tessuti danneggiati o mancanti per una varietà di condizioni causate da traumi, malattie e vecchiaia. Per garantire che i metodi per l’ingegneria tissutale siano ampiamente applicabili in ambito clinico, è necessario modificarli in modo da renderli prontamente disponibili e relativamente facili da usare nella routine clinica quotidiana. Pertanto, i passaggi tra la preparazione e l’applicazione devono essere ridotti al minimo e ottimizzati per renderli pratici e l’implementazione realistica. L’obiettivo generale di sviluppare concentrati piastrinici di origine naturale può essere prodotto vicino al paziente e accelerare il processo di impianto essendo finanziariamente realistico per il paziente e per il sistema sanitario. La fibrina ricca di piastrine (PRF) e i suoi derivati sono stati utilizzati in un’ampia varietà di campi medici per la rigenerazione dei tessuti molli. In conclusione, i risultati della presente revisione sistematica evidenziano gli effetti positivi del PRF sulla guarigione delle ferite dopo terapia rigenerativa per la gestione di vari difetti dei tessuti molli riscontrabili nel wound care. Growing multidisciplinary field of tissue engineering aims to regenerate, improve or replace predictably damaged or missing tissues for a variety of conditions caused by trauma, disease and old age. To ensure that tissue engineering methods are widely applicable in the clinical setting, it is necessary to modify them in such a way that they are readily available and relatively easy to use in daily clinical routine. Therefore, the steps between preparation and application must be minimized and optimized to make them realistic implementation. General objective of developing platelet concentrates of natural origin can be produced close to the patient and accelerate the implantation process, being financially realistic for the patient and the health system. Fibrin rich in platelets and leukocytes (PRF) and its derivatives have been used in a wide variety of medical fields for soft tissue regeneration. In conclusion, the results of this systematic review highlight the positive effects of PRF on wound healing after regenerative therapy for the management of various soft tissue defects found in wound care.

scholarly journals Nursing diagnoses and interventions in children submitted to cochlear implantation

2017 ◽  
Vol 51 (0) ◽  
Author(s):  
Patrícia Juliana Santos Pereira ◽  
Natália Fernanda Higa de Souza ◽  
Raissa Janine de Almeida ◽  
Daiane Cabrera Menezes ◽  
Gesiane Cristina Bom ◽  
...  
Keyword(s):  
Cochlear Implant ◽  
Postoperative Period ◽  
Infection Prevention ◽  
Wound Care ◽  
Well Being ◽  
Nursing Intervention ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Integrity Risk ◽  
Nursing Diagnoses

Abstract OBJECTIVE Identifying the main nursing diagnoses and interventions in children submitted to cochlear implant in the immediate postoperative period. METHOD A cross-sectional study conducted between February and April 2016, considering nursing history (anamnesis and physical examination) and nursing diagnoses (NANDA - International) with their respective interventions (Nursing Intervention Classification - NIC). Descriptive statistical analysis was used to construct the results. RESULTS A total of 19 children participated in this study. The main nursing diagnoses listed were: impaired verbal communication, impaired skin integrity, risk for infection, risk for falls, and risk for bleeding (n=19; 100%). Regarding the nursing interventions, the following prevailed: Improvement in communication: auditory deficit, Skin surveillance, Protection against infection, Prevention of falls and Precautions against bleeding (n=19; 100%). CONCLUSION Nursing diagnoses and interventions related to the cochlear implant postoperative period were related to communication, bleeding control, surgical wound care, infection prevention, comfort and well-being.

scholarly journals Evaluation of a quality improvement program to prevent healthcare acquired infections in an acute care hospital

2021 ◽  
Vol 11 (5) ◽  
pp. 24
Author(s):  
Laurence Bernard ◽  
Alain Biron ◽  
Anaïck Briand ◽  
Samy Taha ◽  
Mélanie Lavoie-Tremblay
Keyword(s):  
Prevention Program ◽  
Infection Prevention ◽  
Team Building ◽  
Acute Care Hospital ◽  
General Purpose ◽  
Care Hospital ◽  
Structured Interviews ◽  
Improvement Program ◽  
Mortality And Morbidity ◽  
Positive Effects

Objective: The general purpose of the study was to evaluate a specific prevention program and its effects on infection prevention practices as part of continuous improvements in patient safety. Infection prevention is a global priority aimed at reducing mortality and morbidity rates related to infections acquired while under care.Methods: A descriptive study was carried out through a documentation analysis and semi-structured interviews with 13 healthcare professionals working in a healthcare centre where the infection prevention program was developed and implemented.Results: The thematic analysis identified three major axes: perceptions concerning audits and huddles strategies, the positive effects of the program on team building and, finally, its sustainability and continuous improvement.Conclusions: Globally, program enhanced the habits of professionals by developing an accurate perception of infections and the way to manage the related risk. The program Controlling Specific Infections Successful Strategies (CSISS) is seen as effective and sustainable by the participants. It contributes to a collaborative safety culture to reduce nosocomial infection rates.

scholarly journals Current Trends in Metallic Orthopedic Biomaterials: From Additive Manufacturing to Bio-Functionalization, Infection Prevention, and Beyond

2018 ◽  
Vol 19 (9) ◽  
pp. 2684 ◽  
Author(s):  
Amir Zadpoor
Keyword(s):  
Additive Manufacturing ◽  
Medical Devices ◽  
Biomedical Engineering ◽  
Infection Prevention ◽  
The Other ◽  
Prevention Strategies ◽  
Special Issue ◽  
Metallic Biomaterials ◽  
Current Trends ◽  
Recent Developments

There has been a growing interest in metallic biomaterials during the last five years, as recent developments in additive manufacturing (=3D printing), surface bio-functionalization techniques, infection prevention strategies, biodegradable metallic biomaterials, and composite biomaterials have provided many possibilities to develop biomaterials and medical devices with unprecedented combinations of favorable properties and advanced functionalities. Moreover, development of biomaterials is no longer separated from the other branches of biomedical engineering, particularly tissue biomechanics, musculoskeletal dynamics, and image processing aspects of skeletal radiology. In this editorial, I will discuss all the above-mentioned topics, as they constitute some of the most important trends of research on metallic biomaterials. This editorial will, therefore, serve as a foreword to the papers appearing in a special issue covering the current trends in metallic biomaterials.

scholarly journals Efektivitas Sterilisasi Metode Panas Kering pada Alat Medis Ruang Perawatan Luka Rumah Sakit dr. H. Soemarno Sosroatmodjo Kuala Kapuas

2017 ◽  
Vol 14 (1) ◽  
pp. 425
Author(s):  
Raudah Raudah ◽  
Tien Zubaidah ◽  
Imam Santoso
Keyword(s):  
Medical Devices ◽  
Wound Care ◽  
Variable Number ◽  
Statistical Data Analysis ◽  
Anova Test ◽  
Dry Heat ◽  
Significant Difference ◽  
Type C ◽  
Tool Set ◽  
Number Of Bacteria

Abstract: Effectiveness Of Sterilization Method Of Dry Heat At The Wound Care Medical Devices Hospital Room Dr. H. Soemarno Sosroatmodjo Kuala Kapuas. Hospital Dr. H. Soemarno Sosroatmodjo is a Type C hospitals that provide 24-hour medical services.Bed capacity of 145 with the number BOR (Bed Occupancy Rate) 51.36%.Efforts to prevent the occurrence of nosocomial infections from medical devices one of which is the process of sterilization with dry heat heating process.The purpose of this study was to determine the effectiveness of dry heat sterilization methods on medical devices in the Hospital Dr. H. Soemarno Sosroatmodjo. This type of research is quasi-experimental.Type variables used are the independent variables (temperature variation with the dry heat oven), the dependent variable (number of bacteria).Samples taken medication is a tool set consisting of a pair of tweezers and tub instruments. Analysis of data use Oneway Anova test. Based on the results of the examination, in the highest number of bacteria known medical tool tweezers is the average number of bacteria colonies 1.33 / cm at 125oC, and the highest number of bacteria of medical tools like instrument that is the average number of bacteria colonies 0.66 / cm at the temperature of 125oC. Statistical data analysis for medical devices tweezers with Oneway Anova test, after sterilized generate significant value of 0.09, which sig> 0.05 so that Ho is accepted, meaning there is no significant difference and statistical analysis for medical devices like instrument with Oneway Anova test produces the significant value of 0.40, which sig> 0.05 means that there is no significant difference. Keywords: Hospitals; medical device; numbers germs; sterilization.

scholarly journals L-PRF Membrane (Fibrin Rich in Platelets and Leukocytes) and Its Derivatives (A-PRF, i-PRF) are Helpful as a Basis of Stem Cells in Regenerative Injury Treatment: Trial Work on the Horse

2020 ◽  
pp. 1-14
Author(s):  
Alessandro Crisci ◽  
Maria Chiara Barillaro ◽  
Giovanni Lepore ◽  
Federica Cardillo
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Wound Care ◽  
Cell Types ◽  
Membrane Extraction ◽  
Positive Effects ◽  
Injury Treatment ◽  
And Migration ◽  
And Control ◽  
Tissue Restoration

Developing a multidisciplinary field of tissue engineering aims to recover, improve or supplant typically damaged or missing tissues for a collection of conditions brought about by trauma, malady and old age. To guarantee that tissue engineering techniques are generally relevant in the clinical setting, it is important to adjust them so that they are promptly accessible and moderately simple to use in the everyday clinical schedule. Consequently, the steps between preparation and application must be limited and improved to make them practical in application. The general objective of creating platelet concentrates of natural origin can be delivered near the patient to quicken the implantation procedure, being monetarily practical for the patient and the health framework. Fibrin rich in platelets and leukocytes (PRF) and its derivatives (L-PRF, A-PRF, i-PRF) has been utilized in a wide collection of medical fields for delicate tissue restoration. Practically all platelets (> 97%) are missing within test-tubes in groups tested after PRF membrane extraction. Growth Factors liberated by platelets contained in derivatives of L-PRF induce and control the proliferation and migration of other cell types, associated with tissue repair, similar to smooth cell muscles (SMCs) and mesenchymal stem cells (MSCs). Conclusively, the outcomes of this work feature the positive effects of PRF on wound healing after regenerative treatment for the administration of different delicate tissue defects found in wound care.

scholarly journals Structural equation modelling the ‘control of gut overgrowth’ in the prevention of ICU acquired Gram-negative infection.

2020 ◽  
Author(s):  
James C Hurley
Keyword(s):  
Latent Variables ◽  
Structural Equation ◽  
Infection Prevention ◽  
Structural Equation Models ◽  
Published Data ◽  
Parenteral Antibiotic ◽  
Gram Negative ◽  
Positive Effects ◽  
Prevention Studies ◽  
Negative Effect

Abstract Background: Conceptually, the ‘control of gut overgrowth’ (COGO), including ‘abnormal Gram-negative bacilli’ (AGNB), is key to the mediation of infection prevention by Selective Digestive Decontamination (SDD). However, the relative importance of the SDD components; topical (TAP), enteral (EAP) and protocolized parenteral antibiotic prophylaxis (PPAP), versus other methods of infection prevention and versus other contextual exposures cannot be resolved within individual studies. Methods: Generalized structural equation models (GSEM) based on COGO concepts were confronted with data derived from >200 infection prevention studies reporting incidences of overall, Pseudomonas and Acinetobacter bacteremia as well as ventilator associated pneumonia (VAP) data including the following group level exposures; TAP, EAP and PPAP use versus antiseptic versus non-decontamination mode of infection prevention; proportion receiving mechanical ventilation (MV); trauma ICU; mean length of ICU stay and concurrency versus non-concurrency of TAP study control groups. Results: In GSEM modelling of Pseudomonas and Acinetobacter gut overgrowth (GO) as latent variables, anti-septic interventions had the strongest negative effect against Pseudomonas GO but no intervention was significantly negative against Acinetobacter GO. Strikingly, PPAP and concurrency each have positive effects in the model, EAP is neutral and Acinetobacter bacteremia incidences are high within TAP studies, moreso with PPAP exposure. Paradoxically, TAP (moreso with PPAP) appears to provide the strongest summary prevention effects against bacteremia and VAP overall. Conclusions: GSEM modelling of published data provides novel insights into the COGO concept and the complex and profoundly paradoxical relationships between various interventions, concurrency and other exposures in relation to infection with AGNB.

scholarly journals Structural equation modelling the ‘control of gut overgrowth’ in the prevention of ICU acquired Gram-negative infection.

2020 ◽  
Author(s):  
James C Hurley
Keyword(s):  
Latent Variables ◽  
Structural Equation ◽  
Infection Prevention ◽  
Structural Equation Models ◽  
Control Groups ◽  
Parenteral Antibiotic ◽  
Gram Negative ◽  
Positive Effects ◽  
Prevention Studies ◽  
Negative Effect

Abstract Background: Conceptually, the ‘control of gut overgrowth’ (COGO) is key to the mediation of infection prevention with ‘abnormal Gram-negative bacilli’ (AGNB) by Selective Digestive Decontamination (SDD). However, the relative importance of the SDD components; topical (TAP), enteral (EAP) and protocolized parenteral antibiotic prophylaxis (PPAP), versus other methods of infection prevention and versus other contextual exposures cannot be resolved within individual studies. Methods: Seven candidate generalized structural equation models (GSEM) founded on COGO concepts were confronted with Pseudomonas and Acinetobacter bacteremia as well as ventilator associated pneumonia (VAP) data derived from >200 infection prevention studies. The following group level exposures were included in the GSEM models; use of TAP, EAP, PPAP, antiseptic and non-decontamination methods of infection prevention; proportion receiving mechanical ventilation (MV); trauma ICU; mean length of ICU stay and concurrency versus non-concurrency of TAP study control groups. Results: In GSEM modelling of Pseudomonas and Acinetobacter gut overgrowth (GO) as latent variables, anti-septic interventions had the strongest negative effect against Pseudomonas GO but no intervention was significantly negative against Acinetobacter GO. Strikingly, PPAP and concurrency each have positive effects in the model, EAP is neutral and Acinetobacter bacteremia incidences are high within TAP studies, moreso with PPAP exposure. Paradoxically, TAP (moreso with PPAP) appears to provide the strongest summary prevention effects against overall bacteremia and overall VAP. Conclusions: GSEM modelling of published AGNB infection data enables a test of the COGO concept. Paradoxically, Acinetobacter and Pseudomonas bacteremia incidences are unusually high among studies of TAP.

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