scholarly journals Chlorine redox chemistry is not rare in biology

2021 ◽  
Author(s):  
Tyler P. Barnum ◽  
John D. Coates
Keyword(s):  
Hypochlorous Acid ◽  
Redox Chemistry ◽  
Regulatory Elements ◽  
Future Research ◽  
Alternative Substrate ◽  
Natural Habitats ◽  
Chlorite Dismutase ◽  
Oxidative Processes ◽  
Intermediate Oxidation ◽  
Chlorine Oxidation

AbstractChlorine is abundant in cells and biomolecules, yet the biology of chlorine oxidation and reduction is poorly understood. Some bacteria encode the enzyme chlorite dismutase (Cld), which detoxifies chlorite (CIO2-) by converting it to chloride (Cl-) and molecular oxygen (O2). Cld is highly specific for chlorite and aside from low hydrogen peroxide activity has no known alternative substrate. Here, we reasoned that because chlorite is an intermediate oxidation state of chlorine, Cld can be used as a biomarker for oxidized chlorine species in microorganisms and microbial habitats. Cld was abundant in metagenomes from soils and freshwater to water treatment systems. About 5% of bacterial and archaeal genera contain an organism encoding Cld in its genome, and within some genera Cld is nearly conserved. Cld has been subjected to extensive horizontal gene transfer, suggesting selection by chlorite is episodic yet strong. Cld was also used as a biomarker to predict genes related to chlorine redox chemistry. Genes found to have a genetic association with Cld include known genes for responding to reactive chlorine species and uncharacterized genes for transporters, regulatory elements, and putative oxidoreductases that present targets for future research. Cld was repeatedly co-located in genomes with genes for enzymes that can inadvertently reduce perchlorate (CIO4-) or chlorate (CIO3-), confirming that in nature (per)chlorate reduction does not only occur in specialized anaerobic respiratory metabolisms. The presence of Cld in genomes of obligate aerobes without such enzymes suggested that chlorite, like hypochlorous acid (HOCl), might be formed by oxidative processes within natural habitats. In summary, the comparative genomics of Cld has provided an atlas for a deeper understanding of chlorine oxidation and reduction reactions that are an underrecognized feature of biology.

scholarly journals Numerical assessment in the wild: insights from social carnivores

2018 ◽  
Vol 373 (1740) ◽  
pp. 20160508 ◽  
Author(s):  
Sarah Benson-Amram ◽  
Geoff Gilfillan ◽  
Karen McComb
Keyword(s):  
Cognitive Abilities ◽  
Future Research ◽  
Wild Animals ◽  
Playback Experiments ◽  
Natural Habitats ◽  
Numerical Assessment ◽  
Individual Discrimination ◽  
In Captivity ◽  
Assessment Skills ◽  
In The Wild

Playback experiments have proved to be a useful tool to investigate the extent to which wild animals understand numerical concepts and the factors that play into their decisions to respond to different numbers of vocalizing conspecifics. In particular, playback experiments have broadened our understanding of the cognitive abilities of historically understudied species that are challenging to test in the traditional laboratory, such as members of the Order Carnivora. Additionally, playback experiments allow us to assess the importance of numerical information versus other ecologically important variables when animals are making adaptive decisions in their natural habitats. Here, we begin by reviewing what we know about quantity discrimination in carnivores from studies conducted in captivity. We then review a series of playback experiments conducted with wild social carnivores, including African lions, spotted hyenas and wolves, which demonstrate that these animals can assess the number of conspecifics calling and respond based on numerical advantage. We discuss how the wild studies complement those conducted in captivity and allow us to gain insights into why wild animals may not always respond based solely on differences in quantity. We then consider the key roles that individual discrimination and cross-modal recognition play in the ability of animals to assess the number of conspecifics vocalizing nearby. Finally, we explore new directions for future research in this area, highlighting in particular the need for further work on the cognitive basis of numerical assessment skills and experimental paradigms that can be effective in both captive and wild settings. This article is part of a discussion meeting issue ‘The origins of numerical abilities’.

scholarly journals University campuses can contribute to wildlife conservation in urbanizing regions: a case study from Nigeria

2020 ◽  
Vol 12 (13) ◽  
pp. 16736-16741
Author(s):  
Iliyasu Simon ◽  
Jennifer Che ◽  
Lynne Baker
Keyword(s):  
Habitat Use ◽  
Wildlife Conservation ◽  
Energy Use ◽  
Predictor Variable ◽  
Camera Traps ◽  
Future Research ◽  
Natural Habitats ◽  
University Campuses ◽  
Disturbed Areas ◽  
Cricetomys Gambianus

Globally, colleges and universities are increasingly mandating sustainability and environmental protection into their practices.  To date, such institutions have focused their efforts on recycling and energy-use reduction and less on the management and conservation of wildlife and wildlife habitats. However, in an increasingly urbanizing world, well-managed campuses can provide habitat and even refuge for wildlife species.  On the campus of a sustainability-minded university in Nigeria, we used camera traps to determine the presence of wildlife and used occupancy modeling to evaluate factors that influenced the detectability and habitat use of two mammals for which we had sufficient detections: White-tailed Mongoose Ichneumia albicauda and Gambian Rat Cricetomys gambianus.  Our intent was to gather baseline data on campus wildlife to inform future research and make recommendations for maintaining wildlife populations.  We detected wildlife primarily within less-disturbed areas that contained a designated nature area, and the presence of a nature area was the key predictor variable influencing habitat use.  No measured variables influenced detectability.  This study supports other research that highlights the importance of undisturbed or minimally disturbed natural habitats on university campuses for wildlife, especially in increasingly built-up and developed regions.  We recommend that institutions of higher education devote greater resources to making campuses wildlife-friendly and increase opportunities for students to engage in campus-based wildlife research and conservation and other sustainability-related programs. 

scholarly journals Integration and Visualization of Regulatory Elements and Variations of the EPAS1 Gene in Human

Genes ◽  
2021 ◽  
Vol 12 (11) ◽  
pp. 1793
Author(s):  
Aleša Kristan ◽  
Nataša Debeljak ◽  
Tanja Kunej
Keyword(s):  
Target Genes ◽  
Regulatory Elements ◽  
Future Research ◽  
Protein Abundance ◽  
Interacting Proteins ◽  
Pas Domain ◽  
Expression Stability ◽  
Post Translational Modifications ◽  
Oxygen Homeostasis ◽  
Cancer Types

Endothelial PAS domain-containing protein 1 (EPAS1), also HIF2α, is an alpha subunit of hypoxia-inducible transcription factor (HIF), which mediates cellular and systemic response to hypoxia. EPAS1 has an important role in the transcription of many hypoxia-responsive genes, however, it has been less researched than HIF1α. The aim of this study was to integrate an increasing number of data on EPAS1 into a map of diverse OMICs elements. Publications, databases, and bioinformatics tools were examined, including Ensembl, MethPrimer, STRING, miRTarBase, COSMIC, and LOVD. The EPAS1 expression, stability, and activity are tightly regulated on several OMICs levels to maintain complex oxygen homeostasis. In the integrative EPAS1 map we included: 31 promoter-binding proteins, 13 interacting miRNAs and one lncRNA, and 16 post-translational modifications regulating EPAS1 protein abundance. EPAS1 has been associated with various cancer types and other diseases. The development of neuroendocrine tumors and erythrocytosis was shown to be associated with 11 somatic and 20 germline variants. The integrative map also includes 12 EPAS1 target genes and 27 interacting proteins. The study introduced the first integrative map of diverse genomics, transcriptomics, proteomics, regulomics, and interactomics data associated with EPAS1, to enable a better understanding of EPAS1 activity and regulation and support future research.

scholarly journals Identification of key genes and associated pathways in neuroendocrine tumors through bioinformatics analysis and predictions of small drug molecules

2020 ◽  
Author(s):  
Praveenkumar Devarbhavi ◽  
Basavaraj Vastrad ◽  
Anandkumar Tengli ◽  
Chanabasayya Vastrad ◽  
Iranna Kotturshetti
Keyword(s):  
Drug Target ◽  
Target Gene ◽  
Molecular Mechanisms ◽  
Target Genes ◽  
Regulatory Elements ◽  
Future Research ◽  
High Morbidity ◽  
Hub Genes ◽  
Go Enrichment ◽  
Significant Difference

AbstractNeuroendocrine tumor (NET) is one of malignant cancer and is identified with high morbidity and mortality rates around the world. With indigent clinical outcomes, potential biomarkers for diagnosis, prognosis and drug target are crucial to explore. The aim of this study is to examine the gene expression module of NET and to identify potential diagnostic and prognostic biomarkers as well as to find out new drug target. The differentially expressed genes (DEGs) identified from GSE65286 dataset was used for pathway enrichment analyses and gene ontology (GO) enrichment analyses and protein - protein interaction (PPI) analysis and module analysis. Moreover, miRNAs and transcription factors (TFs) that regulated the up and down regulated genes were predicted. Furthermore, validation of hub genes was performed. Finally, molecular docking studies were performed. DEGs were identified, including 453 down regulated and 459 up regulated genes. Pathway and GO enrichment analysis revealed that DEGs were enriched in sucrose degradation, creatine biosynthesis, anion transport and modulation of chemical synaptic transmission. Important hub genes and target genes were identified through PPI network, modules, target gene - miRNA network and target gene - TF network. Finally, survival analyses, receiver operating characteristic (ROC) curve and RT-PCR validated the significant difference of ATP1A1, LGALS3, LDHA, SYK, VDR, OBSL1, KRT40, WWOX, NINL and PPP2R2B between metastatic NET and normal controls. In conclusion, the DEGs and hub genes with their regulatory elements identified in this study will help us understand the molecular mechanisms underlying NET and provide candidate targets for future research.

scholarly journals Genome-Wide Systematic Characterization of the NPF Family Genes and Their Transcriptional Responses to Multiple Nutrient Stresses in Allotetraploid Rapeseed

2020 ◽  
Vol 21 (17) ◽  
pp. 5947 ◽  
Author(s):  
Hao Zhang ◽  
Shuang Li ◽  
Mengyao Shi ◽  
Sheliang Wang ◽  
Lei Shi ◽  
...  
Keyword(s):  
N Uptake ◽  
Expression Patterns ◽  
Regulatory Elements ◽  
Peptide Transporter ◽  
Future Research ◽  
Whole Genome ◽  
Transcriptional Responses ◽  
Ammonium Toxicity ◽  
Genome Wide

NITRATE TRANSPORTER 1 (NRT1)/PEPTIDE TRANSPORTER (PTR) family (NPF) proteins can transport various substrates, and play crucial roles in governing plant nitrogen (N) uptake and distribution. However, little is known about the NPF genes in Brassica napus. Here, a comprehensive genome-wide systematic characterization of the NPF family led to the identification of 193 NPF genes in the whole genome of B. napus. The BnaNPF family exhibited high levels of genetic diversity among sub-families but this was conserved within each subfamily. Whole-genome duplication and segmental duplication played a major role in BnaNPF evolution. The expression analysis indicated that a broad range of expression patterns for individual gene occurred in response to multiple nutrient stresses, including N, phosphorus (P) and potassium (K) deficiencies, as well as ammonium toxicity. Furthermore, 10 core BnaNPF genes in response to N stress were identified. These genes contained 6–13 transmembrane domains, located in plasma membrane, that respond discrepantly to N deficiency in different tissues. Robust cis-regulatory elements were identified within the promoter regions of the core genes. Taken together, our results suggest that BnaNPFs are versatile transporters that might evolve new functions in B. napus. Our findings benefit future research on this gene family.

scholarly journals Functional Divergence Drives Invasibility of Plant Communities at the Edges of a Resource Availability Gradient

Diversity ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 148 ◽  
Author(s):  
Enrico Tordoni ◽  
Francesco Petruzzellis ◽  
Andrea Nardini ◽  
Giovanni Bacaro
Keyword(s):  
Drought Resistance ◽  
Resource Availability ◽  
Native Species ◽  
Functional Divergence ◽  
Environmental Filtering ◽  
Functional Space ◽  
Future Research ◽  
Natural Habitats ◽  
Niche Divergence ◽  
Functional Features

Invasive Alien Species (IAS) are a serious threat to biodiversity, severely affecting natural habitats and species assemblages. However, no consistent empirical evidence emerged on which functional traits or trait combination may foster community invasibility. Novel insights on the functional features promoting community invasibility may arise from the use of mechanistic traits, like those associated with drought resistance, which have been seldom included in trait-based studies. Here, we tested for the functional strategies of native and invasive assemblage (i.e., environmental filtering hypothesis vs. niche divergence), and we assessed how the functional space determined by native species could influence community invasibility at the edges of a resource availability gradient. Our results showed that invasive species pools need to have a certain degree of differentiation in order to persist in highly invaded communities, suggesting that functional niche divergence may foster community invasibility. In addition, resident native communities more susceptible to invasion are those which, on average, have higher resource acquisition capacity, and lower drought resistance coupled with an apparently reduced water-use efficiency. We advocate the use of a mechanistic perspective in future research to comprehensively understand invasion dynamics, providing also new insights on the factors underlying community invasibility in different ecosystems.

scholarly journals Pharmacological treatment of hyperactive delirium in people with COVID-19: rethinking conventional approaches

2020 ◽  
Vol 10 ◽  
pp. 204512532094270
Author(s):  
Giovanni Ostuzzi ◽  
Chiara Gastaldon ◽  
Davide Papola ◽  
Andrea Fagiolini ◽  
Serdar Dursun ◽  
...  
Keyword(s):  
Intensive Care ◽  
Drug Interactions ◽  
Systematic Reviews ◽  
Pharmacological Treatment ◽  
Medical Condition ◽  
Regulatory Elements ◽  
Rapid Review ◽  
Cochrane Library ◽  
Future Research ◽  
Acute Psychosis

People with coronavirus disease (COVID-19) might have several risk factors for delirium, which could in turn notably worsen the prognosis. Although pharmacological approaches for delirium are debated, haloperidol and other first-generation antipsychotics are frequently employed, particularly for hyperactive presentations. However, the use of these conventional treatments could be limited in people with COVID-19, due to the underlying medical condition and the risk of drug–drug interactions with anti-COVID treatments. On these premises, we carried out a rapid review in order to identify possible alternative medications for this particular population. By searching PubMed and the Cochrane Library, we selected the most updated systematic reviews of randomised trials on the pharmacological treatment of delirium in both intensive and non-intensive care settings, and on the treatment of agitation related to acute psychosis or dementia. We identified medications performing significantly better than placebo or haloperidol as the reference treatment in each population considered, and assessed the strength of association according to validated criteria. In addition, we collected data on other relevant clinical elements (i.e. common adverse events, drug-drug interactions with COVID-19 medications, daily doses) and regulatory elements (i.e. therapeutic indications, contra-indications, available formulations). A total of 10 systematic reviews were included. Overall, relatively few medications showed benefits over placebo in the four selected populations. As compared with placebo, significant benefits emerged for quetiapine and dexmedetomidine in intensive care unit (ICU) settings, and for none of the medications in non-ICU settings. Considering also data from indirect populations (agitation related to acute psychosis or dementia), aripiprazole, quetiapine and risperidone showed a potential benefit in two or three different populations. Despite limitations related to the rapid review methodology and the use of data from indirect populations, the evidence retrieved can pragmatically support treatment choices of frontline practitioners involved in the COVID-19 outbreak, and indicate future research directions for the treatment of delirium in particularly vulnerable populations.

scholarly journals Investigating Sustainable NGO–firm Partnerships: An Experimental Study of Consumer Perception of Co-Branded Products

2021 ◽  
Vol 13 (22) ◽  
pp. 12761
Author(s):  
Laura Therese Heinl ◽  
Anna Baatz ◽  
Markus Beckmann ◽  
Peter Wehnert
Keyword(s):  
Experimental Study ◽  
Sustainable Consumption ◽  
Informed Choice ◽  
Consumer Perception ◽  
Future Research ◽  
Human Consumption ◽  
Natural Habitats ◽  
Sustainable Products ◽  
Non Governmental Organizations ◽  
The Impact

With crises like climate change and degradation of the earth’s natural habitats, human consumption needs to become more sustainable to decrease humanity’s environmental footprint. Fostering sustainable consumer behavior by enabling consumers to make an informed choice for sustainable products is vital in changing human consumption for the better. To optimize consumers’ perception of sustainable products, companies can establish partnerships with environmental non-governmental organizations (NGOs). In practice, retailers and NGOs can engage in NGO–firm co-branding of sustainable products. Yet, little is known about the impact of this NGO–firm co-branding on consumer perception. We fill this gap based on a 2 × 2 × 2 experimental study. We test consumers’ trust, product and brand perception of co-branded sustainable products. Our study finds that NGO–firm co-branding has a significant positive effect on all the above. The effect is moderated by familiarity with the co-branding partnership and consumer attitudes. We discuss how those NGO–firm partnerships can be a useful tool to guide customers to more sustainable consumption choices. The results are discussed in light of sustainability communication and cross-sector partnership theory. We offer important insights for consumer perspectives on sustainability communication, business engagement of NGO–firm partnerships and develop future research ideas for consumer behaviour.

scholarly journals Evolutionary Diversification in Insect Vector–Phytoplasma–Plant Associations

2020 ◽  
Author(s):  
V Trivellone ◽  
C H Dietrich
Keyword(s):  
Pathogenic Bacteria ◽  
Diet Breadth ◽  
Functional Ecology ◽  
Future Research ◽  
Insect Herbivores ◽  
Insect Vector ◽  
Natural Habitats ◽  
Host Shifts ◽  
Evolutionary Diversification ◽  
Relative Prevalence

Abstract The association between insect herbivores and vascular plants represents one of the greatest success stories in terrestrial evolution. Specific mechanisms generating diversity in the association remain poorly understood, but it has become increasingly clear that microbes play important roles in mediating plant–insect interactions. Previous research on phytoplasmas (Acholeplasmatales: Acholeplasmataceae), a diverse group of plant-pathogenic bacteria, and their hemipteran insect vectors suggests that this system provides a new model for understanding how interactions among distantly related but ecologically associated groups of organisms can drive evolutionary diversification. Phytoplasma infections affect the phenotypes of both plants and vectors, altering functional traits (e.g., diet breadth) and mediating host shifts which may, in turn, alter genetic and phylogenetic patterns. This review highlights previous research on the functional ecology and phylogenetic components of phytoplasma-plant-vector (PPV) associations relevant to the evolutionary diversification of this system. Although phytoplasmas and their hosts occur in most terrestrial biomes and have evolved together over the past 300+ million years, major gaps in knowledge of PPV associations remain because most prior research on the system focused on strategies for mitigating effects of phytoplasma diseases in agroecosystems. Study of this system within a broader evolutionary context could help elucidate mechanisms by which interactions between insect herbivores, microbes, and plants drive biological diversification and also help predict the emergence of diseases affecting agriculture. Future research should more thoroughly document PPV associations in natural habitats, examine the relative prevalence of cospeciation versus host shifts in this system, and test possible macroevolutionary consequences of host manipulation by phytoplasmas.

Advances in Ethnobotany, Synthetic Phytochemistry and Pharmacology of Endangered Herb Picrorhiza kurroa (Kutki): A comprehensive review (2010-2020)

2021 ◽  
Vol 21 ◽  
Author(s):  
Sharuti Mehta ◽  
Anil Kumar Sharma ◽  
Rajesh K. Singh
Keyword(s):  
Iridoid Glycosides ◽  
Review Article ◽  
Bioactive Metabolites ◽  
Future Research ◽  
Picrorhiza Kurroa ◽  
Bioactive Constituents ◽  
Active Metabolites ◽  
Natural Habitats ◽  
Picroside Ii ◽  
Endangered Status

: Picrorhiza kurroa Royle ex Benth. (Family: Plantaginaceae) is a well-recognized an Ayurvedic herb. It is commonly called “Kutki” or “Kurro” and ‘Indian gentian’. Iridoid glycosides are the plant’s bioactive constituents and accountable for the bitter taste and medicinal properties of the plant. The iridoid glycosides such as picrosides and other active metabolites of the plant exhibited many pharmacological activities like hepatoprotective, antioxidant, anti-inflammatory, anticancer, immunomodulator, anti-ulcerative colitis, antimicrobial etc. This review aims to provide updated information on the ethnobotany, synthetic phytochemistry, pharmacological potential, safety and toxicology of P. kurroa and its active metabolites. Indiscriminate exploitation, ecological destruction of natural habitats, slower plant growth and unawareness regarding cultivation and uprooting of plants has brought kutki as an endangered status. So, various techniques used for the conservation and production of bioactive metabolites from P. kurroa have also been reported. Information on the plant has been collected from Science Direct, Google Scholar, PubMed, Scopus by using ‘Picrorhiza kurroa’, ‘Picroside-‘, ‘Picroside-II’, ‘Picroliv’, ‘Immunomodulator’ keywords. All studies on ethnobotany, phytochemistry and pharmacology of plant from 2010- 2020 were comprised in this review article. The possible directions for the future research have also been outlined in brief in review article.

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