Fruit, vegetable and dietary antioxidant intake in school age, respiratory health up to young adulthood

Dietary antioxidant intake has been hypothesised to influence lung function. The association between total antioxidant capacity (TAC) of the diet at age 8 years and lung function development up to 16 years in 2307 participants from the Swedish population-based birth cohort BAMSE (Children, Allergy, Milieu, Stockholm, Epidemiology) was investigated.Information on TAC was obtained from a food frequency questionnaire at 8 years. Lung function was measured by spirometry at 8 and 16 years, impulse oscillometry (IOS) and exhaled nitric oxide fraction (FeNO) at 16 years. Low lung function was defined as forced expiratory volume in 1 s (FEV1) z-score below the 25th percentile. Longitudinal associations between TAC and lung function were analysed by mixed effect models adjusted for potential confounders. Stratification by asthma at 8 years was performed to examine effect modification.The median TAC intake was 10 067 μmol Trolox equivalents (TE)·g−1, with males having a lower mean compared to females (9963 versus 10 819 μmol TE·g−1). In analyses of lung function change between 8 and 16 years, there were no statistically significant associations between TAC in tertiles and spirometry results for the total study population. Among children with asthma at 8 years (prevalence 7%), higher TAC was associated with higher mean FEV1 (0.46 sd, 95% CI 0.11–0.80) and decreased odds of low lung function at 16 years (OR 0.28, 95% CI 0.12–0.65). There were no associations between TAC and forced vital capacity or IOS/FeNO results.High dietary antioxidant intake in school age may be associated with improved lung function development from school age to adolescence among children with asthma.

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Impact of moderate and late preterm birth on neurodevelopment, brain development and respiratory health at school age: protocol for a longitudinal cohort study (LaPrem study)

BMJ Open ◽

10.1136/bmjopen-2020-044491 ◽

2021 ◽

Vol 11 (1) ◽

pp. e044491

Author(s):

Jeanie Cheong ◽

Kate Lillian Iona Cameron ◽

Deanne Thompson ◽

Peter J Anderson ◽

Sarath Ranganathan ◽

...

Keyword(s):

Cohort Study ◽

Brain Development ◽

Respiratory Health ◽

Brain Mri ◽

Late Preterm ◽

Longitudinal Cohort Study ◽

School Age ◽

Neurodevelopmental Outcomes ◽

Longitudinal Cohort ◽

Increased Risk

IntroductionChildren born moderate to late preterm (MLP, 32–36 weeks’ gestation) account for approximately 85% of all preterm births globally. Compared with children born at term, children born MLP are at increased risk of poor neurodevelopmental outcomes. Despite making up the largest group of preterm children, developmental outcomes of children born MLP are less well studied than in other preterm groups. This study aimed to (1) compare neurodevelopmental, respiratory health and brain magnetic resonance imaging (MRI) outcomes between children born MLP and term at 9 years of age; (2) examine the differences in brain growth trajectory from infancy to 9 years between children born MLP and term; and in children born MLP; (3) examine the relationship between brain development and neurodevelopment at 9 years; and (4) identify risk factors for poorer outcomes at 9 years.Methods and analysisThe ”LaPrem” (Late Preterm MRI Study) study is a longitudinal cohort study of children born MLP and term controls, born at the Royal Women’s Hospital in Melbourne, Australia, between 2010 and 2013. Participants were recruited in the neonatal period and were previously followed up at 2 and 5 years. This 9-year school-age follow-up includes neuropsychology, motor and physical activities, and lung function assessments, as well as brain MRI. Outcomes at 9 years will be compared between birth groups using linear and logistic regressions. Trajectories of brain development will be compared between birth groups using mixed effects models. The relationships between MRI and neurodevelopmental outcomes, as well as other early predictors of poor 9-year outcomes, will be explored using linear and logistic regression.Ethics and disseminationThis study was approved by the human research ethics committee at the Royal Children’s Hospital, Melbourne, Australia. Study outcomes will be disseminated through peer-reviewed publications, conference presentations and social media.

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School-age children enjoyed good respiratory health and fewer allergies despite having lung disease after preterm birth

Acta Paediatrica ◽

10.1111/apa.13526 ◽

2016 ◽

Vol 105 (11) ◽

pp. 1298-1304 ◽

Cited By ~ 3

Author(s):

Eveliina Ronkainen ◽

Tuula Kaukola ◽

Riitta Marttila ◽

Mikko Hallman ◽

Teija Dunder

Keyword(s):

Preterm Birth ◽

Lung Disease ◽

Respiratory Health ◽

School Age Children ◽

School Age

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Racial differences in dietary antioxidant intake and cardiac event-free survival in patients with heart failure

European Journal of Cardiovascular Nursing ◽

10.1177/1474515118755720 ◽

2018 ◽

Vol 17 (4) ◽

pp. 305-313 ◽

Cited By ~ 1

Author(s):

Jia-Rong Wu ◽

Eun Kyeung Song ◽

Debra K Moser ◽

Terry A Lennie

Keyword(s):

Heart Failure ◽

African American ◽

African Americans ◽

Cardiac Event ◽

Event Free Survival ◽

Free Survival ◽

Dietary Antioxidant ◽

Patients With Heart Failure ◽

Antioxidant Intake ◽

Carotene Beta

Background: Heart failure is a chronic, burdensome condition with higher re-hospitalization rates in African Americans than Whites. Higher dietary antioxidant intake is associated with lower oxidative stress and improved endothelial function. Lower dietary antioxidant intake in African Americans may play a role in the re-hospitalization disparity between African American and White patients with heart failure. Objective: The objective of this study was to examine the associations among race, dietary antioxidant intake, and cardiac event-free survival in patients with heart failure. Methods: In a secondary analysis of 247 patients with heart failure who completed a four-day food diary, intake of alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein, zeaxanthin, lycopene, vitamins C and E, zinc, and selenium were assessed. Antioxidant deficiency was defined as intake below the estimated average requirement for antioxidants with an established estimated average requirement, or lower than the sample median for antioxidants without an established estimated average requirement. Patients were followed for a median of one year to determine time to first cardiac event (hospitalization or death). Survival analysis was used for data analysis. Results: African American patients had more dietary antioxidant deficiencies and a shorter cardiac event-free survival compared with Whites ( p = .007 and p = .028, respectively). In Cox regression, race and antioxidant deficiency were associated with cardiac event-free survival before and after adjusting for covariates. Conclusion: African Americans with heart failure had more dietary antioxidant deficiencies and shorter cardiac event-free survival than Whites. This suggests that encouraging African American patients with heart failure to consume an antioxidant-rich diet may be beneficial in lengthening cardiac event-free survival.

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Dietary antioxidant intake, wheeze and atopic status in 5-year-old children

Journal of Human Nutrition and Dietetics ◽

10.1111/j.1365-277x.2008.00865_8.x ◽

2008 ◽

Vol 21 (3) ◽

pp. 286-287

Author(s):

S. Patel ◽

C. Murray ◽

G. Kerry ◽

A. Woodcock ◽

A. Custovic

Keyword(s):

Atopic Status ◽

Dietary Antioxidant ◽

Antioxidant Intake

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Depressive and Anxiety Symptom Trajectories From School Age Through Young Adulthood in Samples With Autism Spectrum Disorder and Developmental Delay

Journal of the American Academy of Child & Adolescent Psychiatry ◽

10.1016/j.jaac.2015.02.005 ◽

2015 ◽

Vol 54 (5) ◽

pp. 369-376.e3 ◽

Cited By ~ 80

Author(s):

Katherine Gotham ◽

Steven M. Brunwasser ◽

Catherine Lord

Keyword(s):

Autism Spectrum Disorder ◽

Developmental Delay ◽

Young Adulthood ◽

Anxiety Symptom ◽

Autism Spectrum ◽

Spectrum Disorder ◽

School Age ◽

Symptom Trajectories

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Maternal dietary antioxidant intake in pregnancy and childhood respiratory and atopic outcomes: birth cohort study

European Respiratory Journal ◽

10.1183/13993003.00507-2018 ◽

2018 ◽

Vol 52 (2) ◽

pp. 1800507 ◽

Cited By ~ 5

Author(s):

Annabelle Bédard ◽

Kate Northstone ◽

John W. Holloway ◽

A. John Henderson ◽

Seif O. Shaheen

Keyword(s):

Cohort Study ◽

Birth Cohort ◽

Birth Cohort Study ◽

Dietary Antioxidant ◽

Antioxidant Intake ◽

In Pregnancy

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Effect of levetiracetam drug on antioxidant and liver enzymes in epileptic patients: case-control study

African Health Sciences ◽

10.4314/ahs.v20i2.55 ◽

2020 ◽

Vol 20 (2) ◽

pp. 984-990

Author(s):

Atena Mahdavi ◽

Amirmansour Alavi Naeini ◽

Mohammadreza Najafi ◽

Mohammadreza Maracy ◽

Mohammadreza Aghaye Ghazvini

Keyword(s):

Healthy Subjects ◽

Case Control Study ◽

Liver Enzymes ◽

Case Control ◽

Dietary Intakes ◽

Dietary Antioxidant ◽

Antioxidant Intake ◽

Epileptic Patients ◽

Total Antioxidant ◽

Control Study

Background: There is a limited amount of data regarding levetiracetam (LEV), an antiepileptic drug. Objective: This study was conducted to assess the effect of LEV on antioxidant status and liver enzymes. Method: In this case-control study, 33 epileptic patients under treatment with LEV for at least 6 months were compared with 35 healthy subjects. We measured serum total antioxidant capacity (TAC), salivary superoxide dismutase (SOD), alanine aminoteransferase (ALT), and aspartate aminoteransferase (AST) levels in both groups. Dietary intakes were collected using a Food Frequency Questionnaire (FFQ). Result: The level of TAC in the healthy subjects was significantly higher than it was in the patients (P=0.02), but the mean of ALT (P=0.02) and AST (P=0.03) was significantly higher in the patients in comparison with the controls. Mean salivary SOD showed no difference between the two groups. In the patients, the duration of drug use was inversely correlated with serum TAC (p=0.04) and had a direct correlation with ALT (p=0.01) and AST (p=0.03.). Conclusion: The results of our study indicated that LEV increased liver enzymes Also, treatment with this drug did not improve oxidative stress, but this could be due to the different in the dietary antioxidant intake. Routine screening of the liver and antioxidant enzymes in patients with chronic use of LEV is recommended. Keywords: Levetiracetam; antioxidant; liver enzymes; epilepsy.

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