Foetal hyperinsulinaemia and increased fat mass correlate negatively with circulating fatty acid concentrations in neonates of gestational diabetic mothers with dietary‐controlled glycaemia

2021 ◽  
Author(s):  
Henar Ortega‐Senovilla ◽  
Ute Schaefer‐Graf ◽  
Emilio Herrera
Keyword(s):  
Fatty Acid ◽  
Fat Mass ◽  
Diabetic Mothers

PLASMA FREE FATTY ACID AND BLOOD SUGAR LEVELS IN NEWBORN INFANTS AND THEIR MOTHERS

PEDIATRICS ◽  
1966 ◽  
Vol 37 (4) ◽  
pp. 597-604
Author(s):  
Doman K. Keele ◽  
Jacob L. Kay
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Newborn Infants ◽  
Plasma Free Fatty Acid ◽  
Significant Negative Correlation ◽  
The Mean ◽  
Sugar Levels ◽  
Diabetic Mothers

Simultaneous plasma free fatty acid (FFA) and blood sugar levels were determined for fasting newborn infants during the first 24 hours of life, for their cord bloods, and for their mothers at delivery. The following observations were made. In control infants the mean FFA level rose about three times the cord level after birth and was accompanied by a 25% drop in the mean blood sugar level. Thereafter, the mean blood sugar level remained relatively constant, but the mean FFA level varied from 2½ to 3 times the cord level. There was no significant correlation between the length of maternal fasting prior to delivery and the infant FFA level; there was, however a significant negative correlation between the length of maternal fasting prior to delivery and the infant blood sugar level at 24 hours of age. High FFA levels occurred in the infants of obese mothers and low levels were observed in infants with delayed respirations, in infants of preeclamptic mothers, and in infants of diabetic mothers.

scholarly journals Association of single nucleotide polymorphisms in the fatty acid synthase, LOC514211, and fat mass and obesity-associated genes with milk traits in Indonesian-Holstein dairy cattle

2019 ◽  
Vol 12 (7) ◽  
pp. 1160-1166
Author(s):  
Amalia Puji Rahayu ◽  
Tety Hartatik ◽  
Agung Purnomoadi ◽  
Edy Kurnianto
Keyword(s):  
Fatty Acid ◽  
Single Nucleotide Polymorphisms ◽  
Fat Mass ◽  
Milk Protein ◽  
Fatty Acid Synthase ◽  
Nucleotide Polymorphisms ◽  
Fat Percentage ◽  
Fto Gene ◽  
Milk Traits ◽  
Single Nucleotide

Aim: The study aimed to identify fatty acid synthase (FASN), LOC514211, and fat mass and obesity-associated (FTO) gene polymorphisms and to investigate their associations with milk traits in an Indonesian-Holstein dairy cow population. Materials and Methods: A total of 100 Indonesian-Holstein cows consisting of 50 heads (0th generation; G0) and 50 heads of their daughters (1st generation; G1) were used. Polymerase chain reaction-restriction fragment length polymorphism was performed to genotype three single nucleotide polymorphisms: rs41919985 in the FASN gene, rs42688595 in the LOC514211 gene, and g.1371T>A in the FTO gene. Results: FASN rs41919985 was associated with milk protein percentage (p<0.05), FTO g.1371T>A was associated with milk fat percentage (p<0.05), and LOC514211 rs42688595 was not associated with any trait (p>0.05). Heterozygote variants showed a higher protein percentage for FASN and the highest fat percentage for FTO. These associations were consistent in the G0 and G1 populations. Conclusion: Our results indicate that the milk protein and fat percentages can be improved by increasing the frequency of the AG genotype of FASN and the AT genotype of FTO, respectively.

scholarly journals Zat gizi, massa lemak tubuh, dan tekanan darah pada wanita vegetarian dan nonvegetarian berusia 20-30 tahun

2017 ◽  
Vol 6 (1) ◽  
pp. 17-28
Author(s):  
Stela Maris Adinda Budi Kirana ◽  
Etisa Adi Murbawani ◽  
Binar Panunggal
Keyword(s):  
Blood Pressure ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acids ◽  
Diastolic Blood Pressure ◽  
Saturated Fatty Acid ◽  
Body Fat ◽  
Fat Mass ◽  
Monounsaturated Fatty Acids ◽  
Body Fat Mass

Background : Vegetarians tend to have a risk of underfat. Several studies have reported that vegetarians have lower fat and higher fiber intake, lower body fat mass and blood pressure than nonvegetarians. There are only few studies about those variabels in 20-30 year-old subject. Objective : To analyze the difference of nutrients intake, body fat mass, and blood pressure between 20-30-year-old vegetarian and nonvegetarian women.Methods : Cross-sectional study design in 26 vegetarian women and 26 nonvegetarian women who was selected by consecutive sampling. Nutrients intake were obtained by Semi Quantitative Food Frequency Questionaire (SQFFQ) and analyzed by Nutrisurvey. Body fat mass was measured using Bioelectrical Impedance Analysis (BIA). Blood pressure was measured using Mercury sphygmomanometer. Data were analyzed using Independent t-test and Mann-Whitney test.Result : There were 38.5% of  vegetarians and 3.8% of nonvegetarians classified as underfat. There were 30.7% of vegetarians and 50% of  nonvegetarians classified as prehypertension. There were difference in fat (p=0.005), saturated fatty acid (p=0.000), monounsaturated fatty acids (p=0.002), polyunsaturated fatty acids (p=0.043), fiber (p=0.000), potassium (p=0.000), magnesium (p=0.004); body fat mass (p=0.021); and sistolic blood pressure (p=0.004) between both of groups. There weren’t difference energy intake (p=0.098), carbohydrate (p=0.207), protein (p=0.535), sodium (p=0.784), calcium (p=0.798), and diastolic blood pressure (p=0.799) between both of groups.Conclusion : Between vegetarian group and nonvegetarian group, there were difference in fat, saturated fatty acid, monounsaturated fatty acids, polyunsaturated fatty acids, fiber, potassium, magnesium intake; body fat mass; and sistolic blood pressure. However, there weren’t diffference in energy, carbohydrate, protein, sodium, calcium intake, and diastolic blood pressure between vegetarian group and nonvegetarian group 

Excess body fat in men decreases plasma fatty acid availability and oxidation during endurance exercise

2004 ◽  
Vol 286 (3) ◽  
pp. E354-E362 ◽  
Author(s):  
Bettina Mittendorfer ◽  
David A. Fields ◽  
Samuel Klein
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Body Fat ◽  
Fat Mass ◽  
Total Fatty Acid ◽  
Acid Oxidation ◽  
Acid Uptake ◽  
Plasma Fatty Acids ◽  
Exercise Induced

The effect of relative body fat mass on exercise-induced stimulation of lipolysis and fatty acid oxidation was evaluated in 15 untrained men (5 lean, 5 overweight, and 5 obese with body mass indexes of 21 ± 1, 27 ± 1, and 34 ± 1 kg/m2, respectively, and %body fat ranging from 12 to 32%). Palmitate and glycerol kinetics and substrate oxidation were assessed during 90 min of cycling at 50% peak aerobic capacity (V̇o2 peak) by use of stable isotope-labeled tracer infusion and indirect calorimetry. An inverse relationship was found between %body fat and exercise-induced increase in glycerol appearance rate relative to fat mass ( r2 = 0.74; P < 0.01). The increase in total fatty acid uptake during exercise [(μmol/kg fat-free mass) × 90 min] was ∼50% smaller in obese (181 ± 70; P < 0.05) and ∼35% smaller in overweight (230 ± 71; P < 0.05) than in lean (354 ± 34) men. The percentage of total fatty acid oxidation derived from systemic plasma fatty acids decreased with increasing body fat, from 49 ± 3% in lean to 39 ± 4% in obese men ( P < 0.05); conversely, the percentage of nonsystemic fatty acids, presumably derived from intramuscular and possibly plasma triglycerides, increased with increasing body fat ( P < 0.05). We conclude that the lipolytic response to exercise decreases with increasing adiposity. The blunted increase in lipolytic rate in overweight and obese men compared with lean men limits the availability of plasma fatty acids as a fuel during exercise. However, the rate of total fat oxidation was similar in all groups because of a compensatory increase in the oxidation of nonsystemic fatty acids.

scholarly journals Diabetes during Pregnancy Does Not Alter Whole Body Bone Mineral Content in Infants

1997 ◽  
Vol 82 (12) ◽  
pp. 3993-3997 ◽  
Author(s):  
Alexandre Lapillonne ◽  
Sophie Guerin ◽  
Pierre Braillon ◽  
Olivier Claris ◽  
Pierre D. Delmas ◽  
...  
Keyword(s):  
Birth Weight ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Fat Mass ◽  
Gestational Age ◽  
Mineral Content ◽  
Whole Body ◽  
X Ray ◽  
Diabetic Mothers ◽  
Body Bone

A previous study using single photon absorptiometry has reported low bone mineral density of the radius in infants of diabetic mothers. The aim of this study was to assess by dual x-ray absorptiometry the whole body bone mineral content (WbBMC) and the body composition of 40 infants of diabetic mothers at birth (mean gestational age ± sd, 37.5 ± 1.3 weeks; mean birth weight ± sd, 3815 ± 641 g). WbBMC was not correlated with gestational age, but was well correlated with birth weight (r = 0.73; P = 0.0001) and also with fat mass (r = 0.87; P = 0.0001) and lean mass (r = 0.42; P = 0.008). The z-scores ± sd adjusted for weight for WbBMC and fat mass were significantly increased (1.3 ± 0.9 and 2.6 ± 1.3, respectively (P &lt; 0.0001), but were not significantly influenced either by in utero growth or by the type of the diabetes mellitus of the mother. Bone mineralization and fat mass studied by whole body dual x-ray absorptiometry are increased at birth in these infants compared with reference curves.

scholarly journals Disorders of serum omega-3 fatty acid composition in dialyzed patients, and their associations with fat mass

Renal Failure ◽  
2017 ◽  
Vol 39 (1) ◽  
pp. 406-412 ◽  
Author(s):  
Małgorzata Sikorska-Wiśniewska ◽  
Adriana Mika ◽  
Tomasz Śledziński ◽  
Sylwia Małgorzewicz ◽  
Piotr Stepnowski ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Fat Mass ◽  
Omega 3 ◽  
Omega 3 Fatty Acid

scholarly journals Propionic acid intervention in obese Ldlr-/-.Leiden mice attenuates NASH development, but negatively affects cognition

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Eveline Gart ◽  
Anouk Tengeler ◽  
Martine Morrison ◽  
Tamas Kosicz ◽  
Wim van Duyvenvoorde ◽  
...  
Keyword(s):  
Risk Factors ◽  
Fatty Acid ◽  
Spatial Memory ◽  
Health Effects ◽  
Propionic Acid ◽  
Fat Mass ◽  
Brain Function ◽  
Ketone Bodies ◽  
Potential Health ◽  
Amyloid A

AbstractIntroduction:There is an increasing interest to elucidate the health effects of short-chain fatty acids (SCFAs) on metabolism, obesity and brain function. Obesity is often associated with the development of non-alcoholic steatohepatitis (NASH) and cognitive impairment. We herein investigated potential health effects of the SCFA propionic acid (PA) on NASH development and brain function including cognition and behavior readouts.Materials and Methods:During 17 weeks of run-in, LDLR-/-.Leiden mice received either high-fat diet (HFD) to establish obesity or chow as control. Obese mice were matched into groups (n = 15/group) and treated with propionic acid (PA + HFD), or a reference fatty acid (caproic acid; CA + HFD), or HFD without supplements (HFD). Cognitive and behavioral effects, as well as metabolic and inflammatory risk factors, were assessed prior to and after 12 weeks of treatment. At endpoint, liver and adipose tissue pathology were histologically and biochemically analyzed.Results:PA, but not reference CA, reduced body weight and this effect was independent of food intake. PA also reduced fasting insulin levels and plasma cholesterol levels relative to the start of intervention. In addition, PA reduced total and subcutaneous fat mass, but did not affect WAT inflammation. Histopathological analysis of the liver demonstrated that PA reduced macrovesicular steatosis, hypertrophy and inflammation. Consistent herewith, PA reduced the inflammatory marker serum amyloid A and tended to increase intrahepatic ketone bodies (β-hydroxybutyrate), and lowered the hepatic collagen content. PA treatment did not affect normal behavior in the open field test but mice showed impaired spatial memory, i.e. the latency to find the platform in the Morris water maze was increased. In line with these findings, synaptophysin expression in the hippocampus and vasoactivity in both the cortex and hippocampus and mitochondrial activity in the cerebellum was decreased by PA. The reference fatty acid CA exerted no effects on the above readouts.Discussion:Overall, PA exerted pronounced positive effects on metabolic risk factors (insulin, cholesterol, adipose mass) and attenuated the development of NASH and liver fibrosis. The observed higher levels of intrahepatic ketone bodies suggest that lipid β-oxidation is increased which may contribute to the health effects in the liver and reduced fat mass. Contrarily, PA negatively affected spatial memory, which could be a result of reduced synaptophysin expression and decreased mitochondrial function in the brain leading to impaired neurotransmitter signaling and cognitive performance.

scholarly journals Dietary fatty acid intake and gut microbiota determine circulating endocannabinoidome signaling beyond the effect of body fat

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Sophie Castonguay-Paradis ◽  
Sébastien Lacroix ◽  
Gabrielle Rochefort ◽  
Lydiane Parent ◽  
Julie Perron ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Gut Microbiota ◽  
Mediterranean Diet ◽  
Body Fat ◽  
Fat Mass ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Omega 3 ◽  
Wide Range ◽  
Circulating Levels

Abstract The endocannabinoidome encompasses several fatty acid (FA)-derived mediators, including the endocannabinoid anandamide (AEA) and 2-arachidonoyl-glycerol (2-AG), which served as targets for anti-obesity drug development, and their congener N-acyl-ethanolamines (NAEs) and 2-monoacyl-glycerols (2‑MAGs), which are involved in food intake and energy metabolism. Body weight and fat distribution have been suggested as determinants of peripheral endocannabinoid levels. We aimed at investigating factors, beyond body fat composition, that are associated with circulating NAE and 2-MAG levels in a heterogeneous human population. Plasma NAEs and 2-MAGs were measured using LC–MS/MS in a cross-sectional sample of healthy men and women (n = 195) covering a wide range of BMI and individuals before and after a 2-day Mediterranean diet (n = 21). Circulating levels of all 2-MAGs and NAEs, other than N-oleoyl-ethanolamine (OEA), correlated with body fat mass and visceral adipose tissue (0.26 < r < 0.54). NAE levels were elevated in individuals with elevated fat mass, while 2-MAGs were increased in individuals with predominantly visceral body fat distribution. Dietary intakes of specific FAs were associated with 2-AG and omega-3-FA-derived NAEs or 2-MAGs, irrespective of the body fat distribution. Some gut bacterial families (e.g. Veillonellaceae, Peptostreptococcaceae and Akkermansiaceae) were associated with variations in most NAEs or omega-3-FA-derived 2‑MAGs, independently of fat mass and dietary FA intake. Finally, a 2-day Mediterranean diet intervention increased circulating levels of NAEs and 2-MAGs in agreement with changes in FA intake (p < 0.01). Self-reported intake and short-term dietary intervention increased in oleic acid and EPA and DHA intake as well as certain gut microbiota taxa are associated to circulating NAEs and 2‑MAGs independently of adiposity measures, thus highlighting the potential importance of these variables in determining endocannabinoidome signaling in humans.

scholarly journals Associations of Mitochondrial Fatty Acid Oxidation with Body Fat in Premenopausal Women

2017 ◽  
Vol 2017 ◽  
pp. 1-7
Author(s):  
Jonathan L. Warren ◽  
Barbara A. Gower ◽  
Gary R. Hunter ◽  
Samuel T. Windham ◽  
Douglas R. Moellering ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acid ◽  
Body Fat ◽  
Fat Mass ◽  
Premenopausal Women ◽  
Muscle Mitochondria ◽  
Skeletal Muscle Mitochondria ◽  
Total Body Fat ◽  
Total Fat ◽  
Total Body

Higherin vivofatty acid (FA) oxidation rates have been reported in obese individuals compared to lean counterparts; however whether this reflects a shift in substrate-specific oxidative capacity at the level of the skeletal muscle mitochondria has not been examined. The purpose of this study was to test the hypothesis that in situ measures of skeletal muscle mitochondria FA oxidation would be positively associated with total body fat. Participants were 38 premenopausal women (BMI=26.5±4.3 kg/m2). Total and regional fat were assessed by dual-energy X-ray absorptiometry (DXA). Mitochondrial FA oxidation was assessed in permeabilized myofibers using high-resolution respirometry and a palmitoyl carnitine substrate. We found positive associations of total fat mass with State 3 (ADP-stimulated respiration) (r=0.379,p<0.05) and the respiratory control ratio (RCR, measure of mitochondrial coupling) (r=0.348,p<0.05). When participants were dichotomized by high or low body fat percent, participants with high total body fat displayed a higher RCR compared to those with low body fat (p<0.05). There were no associations between any measure of regional fat and mitochondrial FA oxidation independent of total fat mass. In conclusion, greater FA oxidation in obesity may reflect molecular processes that enhance FA oxidation capacity at the mitochondrial level.

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