Comparison between ventilatory and mouth occlusion pressure responses to hypoxia and hypercapnia in healthy sleeping man

2008 ◽  
Vol 6 (6) ◽  
pp. 589-601 ◽  
Author(s):  
Armelle Sautegeau ◽  
Bernard Hannhart ◽  
René Peslin ◽  
Michel Bagard ◽  
Paul Sadoul
Keyword(s):  
Occlusion Pressure ◽  
Mouth Occlusion Pressure

Effect of chest wall distortion on occlusion pressure and the preterm diaphragm

1983 ◽  
Vol 55 (2) ◽  
pp. 359-364 ◽  
Author(s):  
P. N. LeSouef ◽  
J. M. Lopes ◽  
S. J. England ◽  
M. H. Bryan ◽  
A. C. Bryan
Keyword(s):  
Chest Wall ◽  
Preterm Infants ◽  
Face Mask ◽  
Respiratory Drive ◽  
Occlusion Pressure ◽  
Transdiaphragmatic Pressure ◽  
Airway Occlusion ◽  
Mouth Pressure ◽  
Gastric Pressure ◽  
Mouth Occlusion Pressure

We studied the effect of chest wall distortion (CWD) on transdiaphragmatic pressure (Pdi) and/or mouth pressure during end-expiratory airway occlusions in seven preterm infants. We measured mouth occlusion pressure (Pmo) with a face mask and pressure transducer, gastric pressure (Pga) with a fluid-filled catheter, diaphragmatic electromyogram (Edi) using surface electrodes, and rib cage and abdominal motion using magnetometers. We reasoned that Pdi = Pmo - Pga on airway occlusion. Periods with maximal and periods with minimal CWD were compared. We found that 1) when CWD was minimal, an increase in Edi produced an increase in Pmo and Pdi in all infants; when CWD was greatest, large increases in Edi produced no increase in Pmo or Pdi in four infants; 2) when breaths with the same Pmo or Pdi from each period in each infant were compared, those from the period with greatest CWD had an increased Edi (mean increase 76%, P less than 0.005, and 144%, P less than 0.01, for Pmo and Pdi, respectively). We conclude that in preterm infants, Pmo can be a poor indicator of respiratory drive, and CWD markedly limits the effectiveness of the diaphragm as a force generator.

Relationship between inspiratory drive and perceived inspiratory effort in normal man

1990 ◽  
Vol 78 (5) ◽  
pp. 493-496 ◽  
Author(s):  
J. E. Clague ◽  
J. Carter ◽  
M. G. Pearson ◽  
P. M. A. Calverley
Keyword(s):  
Ventilatory Response ◽  
Free Breathing ◽  
Normal Subjects ◽  
Inspiratory Effort ◽  
Respiratory Drive ◽  
Occlusion Pressure ◽  
Resistive Loading ◽  
Mouth Occlusion Pressure ◽  
The Individual ◽  
Induced Changes

1. To examine the relationship between the inspiratory effort sensation (IES) and respiratory drive as reflected by mouth occlusion pressure (P0.1) we have studied loaded and unloaded ventilatory responses to CO2 in 12 normal subjects. 2. The individual coefficient of variation of the effort sensation response to CO2 (IES/Pco2) between replicate studies was 21% and was similar to the variability of the ventilatory response (VE/Pco2) (18%) and the occlusion pressure response (P0.1/Pco2) (22%). 3. IES was well correlated with P0.1 (r >0.9) for both free-breathing and loaded runs. 4. Resistive loading reduced the ventilatory response to hypercapnia from 19.3 1 min−1 kPa−1 (sd 7.5) to 12.6 1 min−1 kPa−1 (sd 3.9) (P <0.01). IES and P0.1 responses increased with resistive loading from 2.28 (sd 0.9) to 3.15 (sd 1.1) units/kPa and 2.8 (sd 1.2) to 3.73 (sd 1.5) cmH2O/kPa, respectively (P <0.01). 5. Experimentally induced changes in Pco2 and respiratory impedance were accompanied by increases in IES and P0.1. We found no evidence that CO2 increased IES independently of its effect on respiratory drive.

The Relationship of Resting Ventilation to Mouth Occlusion Pressure

CHEST Journal ◽  
1990 ◽  
Vol 98 (4) ◽  
pp. 900-906 ◽  
Author(s):  
Graham C. Scott ◽  
Nausherwan K. Burki
Keyword(s):  
Occlusion Pressure ◽  
Mouth Occlusion Pressure ◽  
Relationship Of ◽  
The Relationship

Mouth Occlusion Pressure in Young Subjects with a Brief Smoking History

CHEST Journal ◽  
1992 ◽  
Vol 101 (4) ◽  
pp. 1183-1184
Author(s):  
Julio Marín ◽  
Máximo Pérez ◽  
Emilio Servera ◽  
Juan Díaz ◽  
Servicio de Neumología
Keyword(s):  
Smoking History ◽  
Occlusion Pressure ◽  
Young Subjects ◽  
Mouth Occlusion Pressure

Control of Breathing in Patients with Chronic Obstructive Lung Disease

1978 ◽  
Vol 54 (3) ◽  
pp. 295-304 ◽  
Author(s):  
J. Šorli ◽  
A. Grassino ◽  
G. Lorange ◽  
J. Milic-Emili
Keyword(s):  
Lung Disease ◽  
Tidal Volume ◽  
Obstructive Lung Disease ◽  
Pulmonary Ventilation ◽  
Chronic Obstructive Lung Disease ◽  
Control Of Breathing ◽  
Chronic Obstructive ◽  
Occlusion Pressure ◽  
Lower Tidal Volume ◽  
Mouth Occlusion Pressure

1. Using the mouth occlusion pressure technique, we have studied the control of breathing in seven hypercapnic and eight non-hypercapnic patients with chronic obstructive lung disease. 2. When breathing room air, pulmonary ventilation, mean inspiratory flow and P0·1 (mouth occlusion pressure developed 0·1 s after the onset of occluded inspiration at functional residual capacity) were not significantly different between the two groups of patients. Tidal volume, however, was significantly lower in the hypercapnic than in the non-hypercapnic patients, as a result of a significantly lower duration of inspiration. 3. The lower tidal volume in the hypercapnic patients leads to decreased alveolar ventilation, and appears to be the main cause of retention of carbon dioxide.

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