New important data on the transmission of cutaneous human papillomaviruses

The purpose of the review a synthesis of research data on the role of human papillomavirus infection in the reproductive health of women and men. Key Points. Human papillomavirus (HPV) is one of the most common sexually transmitted viruses worldwide. According to the World Health Organization, HPV is the main cause of the development of HPV-associated diseases among both women and men. Viruses are subdivided into HPV with low carcinogenic risk, which cause benign warts, and HPV with high carcinogenic risk, which cause cancer. Different types of human papillomaviruses depending on their characteristic tropism, are divided into skin and mucous types. Viral infection in men leads to a decrease in the quality of sperm (for example, asthenozoospermia) due to apoptosis in sperm cells and due to the development of antisperm immunity. A negative viral effect on the fertility of women is manifested in an increase in the frequency of spontaneous miscarriages and a premature rupture of the amniotic membranes during pregnancy. There is evidence that HPV decreases the number of trophoblastic cells and abnormal trophoblastic-endometrial adhesion is also observed. In trophoblastic cells transfected with high-risk HPV, the level of apoptosis increases. HPV vaccination is safe, and the results show not only protection against HPV-associated diseases in women and men, but also a reduction of gestational complications, reduced preterm birth rates and the protection of newborns from infection.

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Comparison of Co-Presence of Epstein-Barr Virus and High-Risk Human Papillomaviruses in Colorectal Cancers in the Middle East Region

University of the Future: Re-Imagining Research and Higher Education ◽

10.29117/quarfe.2020.0121 ◽

2020 ◽

Author(s):

Karim Nagi ◽

Ishita Gupta ◽

Hamda A Al-Thawadi ◽

Ayesha Jabeen ◽

Mohammed I. Malk ◽

...

Keyword(s):

Colorectal Cancer ◽

High Risk ◽

Epstein Barr Virus ◽

Human Papillomaviruses ◽

Colorectal Cancers ◽

Barr Virus ◽

Human Carcinomas ◽

Epstein Barr ◽

Invasive Carcinomas ◽

High Risk Hpv

Background: Several studies have shown the presence of onco viral DNA in colorectal tumor tissues. Viral infection by onco-viruses such as Human papillomaviruses (HPVs) and Epstein–Barr virus (EBV) are well-known to be involved in the onset and/or progression of numerous human carcinomas. Methods: We explored the co-presence of high-risk HPVs and EBV in a cohort of colorectal cancer samples from Lebanon (94) and Syria (102) by PCR, immunohistochemistry and tissue microarray. Results: The results of the study point out that 54% of colorectal cancer cases in Syria are positive for high-risk HPVs, while 30% of the cases in Lebanon are positive for these viruses; the most frequent high-risk HPV types in these populations are 16, 18, 31, 33 and 35. Analysis of LMP1 showed similar results in both populations; 36% of Syrian and 31% of Lebanese samples. Additionally, we report that EBV and high-risk HPVs are co-present in these samples. In Syrian samples, EBV and HPVs are co-present in 16% of the population, however, in the Lebanese samples, 20% of the cases are positive for both EBV and HPVs; their co-presence is associated with high/intermediate grade invasive carcinomas. Conclusion: These data suggest that EBV and high-risk HPVs are co-present in human colorectal cancers where they can cooperate in the progression of these cancers. Nevertheless, further studies are needed to elucidate the role of those oncoviruses in the development of human colorectal carcinomas.

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PENERAPAN METODE SEGITIGA PASCAL ALJABAR UNTUK MEMAKSIMALKAN TEKNIK PENYANDIAN ALGORITMA WORD AUTO KEY ENCRYPTION (WAKE)

KOMIK (Konferensi Nasional Teknologi Informasi dan Komputer) ◽

10.30865/komik.v3i1.1582 ◽

2019 ◽

Vol 3 (1) ◽

Author(s):

Kaldius Ndruru ◽

Putri Ramadhani

Keyword(s):

Data Security ◽

Important Data ◽

Pascal Triangle ◽

Absolute Requirement ◽

Cryptographic Algorithms ◽

Secure Data ◽

Triangle Method ◽

Symmetric Key

Security of data stored on computers is now an absolute requirement, because every data has a high enough value for the user, reader and owner of the data itself. To prevent misuse of the data by other parties, data security is needed. Data security is the protection of data in a system against unauthorized authorization, modification, or destruction. The science that explains the ways of securing data is known as cryptography, while the steps in cryptography are called critical algorithms. At this time, there are many cryptographic algorithms whose keys are weak especially the symmetric key algorithm because they only have one key, the key for encryption is the same as the decryption key so it needs to be modified so that the cryptanalysts are confused in accessing important data. The cryptographic method of Word Auto Key Encryption (WAKE) is one method that has been used to secure data where in this case the writer wants to maximize the encryption key and description of the WAKE algorithm that has been processed through key formation. One way is to apply the algebraic pascal triangle method to maximize the encryption key and description of the WAKE algorithm, utilizing the numbers contained in the columns and rows of the pascal triangle to make shifts on the encryption key and the description of the WAKE algorithm.Keywords: Cryptography, WAKE, pascal

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GENETIC STRUCTURE OF HIGH AND LOW RISK HUMAN PAPILLOMAVIRUSES CIRCULATING IN THE RUSSIAN FEDERATION

Molecular Diagnostics and Biosafety – 2020. Russian national scientific and practical conference with international participation (October, 6–8, 2020): Conference Proceedings ◽

10.36233/978-5-9900432-9-9-123 ◽

2020 ◽

Author(s):

E.B. Faizuloev ◽

◽

A.N. Kaira ◽

T.R. Uzbekov ◽

A.A. Poromov ◽

...

Keyword(s):

Genetic Structure ◽

Russian Federation ◽

Human Papillomaviruses ◽

Low Risk ◽

The Russian Federation

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PREDICTION OF THE EFFICIENCY OF RECONSTRUCTIVE INTERVENTIONS ON THE MAJOR NERVES OF THE FOREARM, DEPENDING ON THE DEFECT DURATION AND THE FOLLOWING REHABILITATION

СИСТЕМНЫЙ АНАЛИЗ И УПРАВЛЕНИЕ В БИОМЕДИЦИНСКИХ СИСТЕМАХ ◽

10.36622/vstu.2020.19.3.010 ◽

2020 ◽

pp. 77-88

Author(s):

Дмитрий Валериевич Судаков ◽

Олег Валериевич Судаков ◽

Людмила Валентиновна Кретинина ◽

Наталья Владимировна Якушева ◽

Артём Николаевич Шевцов

Keyword(s):

Nervous Tissue ◽

Clinical Situation ◽

Economic Importance ◽

Important Data ◽

Subsequent Period ◽

Complete Restoration ◽

Reconstructive Microsurgery ◽

The Moment

Статья посвящена построению прогноза эффективности реконструктивных вмешательств на магистральных нервах предплечья в зависимости от протяженности дефекта нервной ткани и особенностей последующего периода реабилитации пациентов. Данная тематика является весьма актуальной, так как с каждым годом во всем мире наблюдается определенный рост случаев травм различного генеза магистральных нервных стволов, которые затем нередко приводят к временной нетрудоспособности и даже инвалидности пациентов. Реконструктивная микрохирургия многие десятилетия пытается решить целый ряд проблем аутотрансплантации нервных стволов и повысить ее общую эффективность. Но из-за определенных проблем связанных с финансированием, некоторые вопросы трансплантологии и реабилитации остаются нерешенными и в настоящий момент. Все это придает представленной работе важное значение не только медицинского, но и социально - экономического плана. Целью работы стала попытка построения прогноза восстановительных операций на нервной ткани, с учетом объема пораженных структур и периода реабилитации. Объектами исследования стало 180 больных, которым по той или иной причине, осуществлялась реконструктивная операция на одном из магистральных нервов предплечья. Все пациенты были разделены на 3 группы по 60 человек, в зависимости от протяженности дефекта магистрального нерва: до 4 см, от 4 до 8 см и от 8 до 12 см. Последующее разделение внутри каждой группы на подгруппы производилось в зависимости от определенного поврежденного нерва (лучевой, локтевой, срединный). В работе изучалось течение раннего послеоперационного воспалительного процесса, с определением бактериальной микрофлоры в ране. Изучались и отдаленные последствия оперативного вмешательства. Своеобразной новизной для данной тематики в целом, стало выявление последующего установления инвалидности пациентов. Кроме того, важные данные были получены и по срокам реабилитации и частичного или полного восстановления утраченных функций по срокам в зависимости от размеров восстанавливаемого дефекта и от наличия или отсутствия необходимой реабилитации. Полученные в работе данные могут представлять интерес не только для врачей хирургов и травматологов, но и для организаторов здравоохранения, позволяя производить прогнозы по выздоровлению пациентов в каждой определенной клинической ситуации The article is devoted to the construction of a forecast of the effectiveness of reconstructive interventions on the main nerves of the forearm, depending on the length of the defect in the nervous tissue and the characteristics of the subsequent period of rehabilitation of patients. This topic is very relevant, since every year all over the world there is a certain increase in cases of injuries of various origins of the main nerve trunks, which then often lead to temporary disability and even disability of patients. For many decades, reconstructive microsurgery has been trying to solve a number of problems of autotransplantation of nerve trunks and improve its overall efficiency. But due to certain problems associated with funding, some issues of transplantation and rehabilitation remain unresolved at the moment. All this gives the presented work important not only medical, but also socio - economic importance. The aim of this work was to attempt to predict restorative operations on the nervous tissue, taking into account the volume of the affected structures and the period of rehabilitation. The objects of the study were 180 patients who, for one reason or another, underwent a reconstructive operation on one of the main nerves of the forearm. All patients were divided into 3 groups of 60 people, depending on the length of the main nerve defect: up to 4 cm, from 4 to 8 cm, and from 8 to 12 cm. Subsequent division within each group into subgroups was performed depending on the specific damaged nerve ( radial, ulnar, median). The work studied the course of the early postoperative inflammatory process, with the determination of bacterial microflora in the wound. The long-term consequences of surgery were also studied. A peculiar novelty for this topic as a whole was the identification of the subsequent establishment of disability in patients. In addition, important data were obtained on the timing of rehabilitation and partial or complete restoration of lost functions in terms of timing, depending on the size of the restored defect and on the presence or absence of the necessary rehabilitation. The data obtained in this work may be of interest not only for surgeons and traumatologists, but also for healthcare organizers, allowing them to make predictions about the recovery of patients in each specific clinical situation

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A System Architecture for Data Storage in the Cloud

International Journal of Distributed and Cloud Computing ◽

10.21863/ijdcc/2015.3.2.008 ◽

2015 ◽

Vol 3 (2) ◽

Author(s):

Maryam Hammami ◽

Hatem Bellaaj

Keyword(s):

Data Storage ◽

System Architecture ◽

Cloud Storage ◽

The Other ◽

Important Data ◽

Work In Progress ◽

Flexible System ◽

Other Hand ◽

Data Manager ◽

And Storage

The Cloud storage is the most important issue today. This is due to a rapidly changing needs and a huge mass of varied and important data to back up. In this paper, we describe a work in progress and propose a flexible system architecture for data storage in the Cloud. This system is centered on the Data Manager module. This module provides various functions such as the dispersion of data in fragments, encryption and storage of fragments... etc. This architecture proves to be very relevant. It ensures consistency between different components. On the other hand, it ensures the security and availability of data.

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