O10 Prediction of response to rituximab in SLE using a validated two-score system for interferon status

Pathologische Frakturen werden, bedingt durch die Zunahme der Inzidenz von Karzinomen und die längeren überlebenszeiten, in Zukunft häufiger behandelt werden müssen. Das Skelett ist das dritthäufigste Ziel-Organ von Metastasen. Lungentumor-Metastasen scheinen zuzunehmen, das Mammakarzinom bleibt aber der häufigste Primärtumor. Am häufigsten sind Metastasen im Bereiche der Wirbelsäule lokalisiert, Frakturen treten jedoch meistens am Femur auf. Eine pathologische Fraktur sowie fast immer auch eine "drohende pathologische Fraktur" stellen eine absolute Operationsindikation dar. Eine genaue Definition der "drohenden Fraktur" fehlt zwar, doch ist heute allgemein akzeptiert, dass mindestens 50% der Knochenmasse zerstört sein müssen, damit die Metastase im konventionellen Röntgenbild sichtbar wird und somit von einer drohenden Fraktur gesprochen werden kann. Als Hilfe zur Abschätzung des Frakturrisikos hat sich das Score System nach Mirels bewährt. Anhand von 4 Parametern (Lokalisation, Grösse, Typ, Schmerzen) kann das Frakturrisiko abgeschätzt werden. Ziel der (meist operativen) Behandlung ist die Verbesserung der Lebensqualität über eine effiziente Schmerzlinderung, möglichst durch eine einzige Operation mit kurzer Hospitalisationszeit. Für die chirurgische Behandlung sollten im proximalen Abschnitt des Femurs Prothesen verwendet werden, bei subtrochantären und Schaftfrakturen vornehmlich intramedulläre Kraftträger. Eine postoperative Radiotherapie scheint die lokale Tumorprogression zu verhindern. Bei guter Langzeitprognose sollte der Tumor lokal aggressiv ausgeräumt werden.

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Spermatogenesis and testicular tumours in ageing dogs

Reproduction ◽

10.1530/reprod/120.2.443 ◽

2000 ◽

pp. 443-452 ◽

Cited By ~ 20

Author(s):

MA Peters ◽

DG de Rooij ◽

KJ Teerds ◽

I van Der Gaag ◽

FJ van Sluijs

Keyword(s):

Sertoli Cell ◽

Leydig Cell ◽

Seminiferous Tubules ◽

Score System ◽

Testicular Tumours ◽

Severe Impairment ◽

Per Se ◽

Testicular Disease ◽

Sertoli Cell Tumours ◽

Leydig Cell Tumours

Spermatogenesis was examined in testes from 74 dogs of various breeds without clinically detected testicular disease. A modified Johnsen score system was used to determine whether spermatogenesis deteriorates with ageing. The diameter of seminiferous tubules was measured in dogs without testicular disease to examine other possible effects of ageing on tubular performance. There appeared to be no relation between age and these variables. The influence of testicular tumours on spermatogenesis was also investigated in both affected and unaffected testes. The testes of 28 dogs with clinically palpable tumours and 21 dogs with clinically non-palpable tumours were investigated. In cases of unilateral occurrence of a tumour, impairment of spermatogenesis was observed only in the affected testis of dogs with clinically detected tumours. Bilateral occurrence of tumours, whether detected clinically or non-clinically, was associated with severe impairment of spermatogenesis. The prevalence of tumours increased during ageing. Eighty-six per cent of the clinically detected and 57% of the non-clinically detected tumours were found in old dogs. Multiple types of tumour and bilateral occurrence were very common. Seminomas and Leydig cell tumours were more frequent than Sertoli cell tumours. It was concluded that spermatogenesis per se did not decrease during ageing in dogs but the occurrence of testicular tumours increased with ageing and affected spermatogenesis significantly, as reflected by a lower Johnsen score.

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Authenticity Identification of Carbonated Alcochol-Free Beverages

Food Industry ◽

10.29141/2500-1922-2020-5-1-2 ◽

2020 ◽

Vol 5 (1) ◽

pp. 16-22

Author(s):

Irina Reznichenko ◽

Maria Kondratieva

Keyword(s):

Mass Fraction ◽

Soft Drinks ◽

Alcoholic Beverages ◽

Consumer Market ◽

Score System ◽

Regulatory Documents ◽

Chemical Indicators ◽

Physico Chemical ◽

Alcoholic Drinks ◽

Physical And Chemical

The article concerns the counterfeiting problem of non-alcoholic drinks sold on the consumer market of the Russian Federation; provides data on drinks fraud methods (assortment, qualitative, quantitative and informational types). Strengthening quality control of soft drinks is one of the main directions of providing consumers with qualitative products. The authors presented authenticity identification results of carbonated soft drinks sold on the Kemerovo consumer market for compliance with the current regulatory documents requirements; run the consumer criteria analysis for the drinks identification of various brands. They obtained data on the labeling and packaging identification of selected non-alcoholic carbonated drinks samples for the compliance with current regulatory documents. A man recorded the compliance. There was an absence of the quantitative counterfeiting identification. The study described results of the organoleptic and physico-chemical quality indicators research. According to the GOST 28188-2014 “Non-Alcoholic Beverages. General Technical Conditions” the authors evaluated beverages quality by such physical and chemical indicators as the mass fraction of dry substances, acidity, and the mass fraction of carbon dioxide. The researchers run the organoleptic indicators analysis according to a score system. Authenticity identification of the selected drinks samples showed that there are no signs of counterfeiting and the products are of high quality.

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