scholarly journals SARS-CoV-2 seroprevalence and asymptomatic viral carriage in healthcare workers: a cross-sectional study

Thorax ◽  
2020 ◽  
Vol 75 (12) ◽  
pp. 1089-1094 ◽  
Author(s):  
Adrian Shields ◽  
Sian E Faustini ◽  
Marisol Perez-Toledo ◽  
Sian Jossi ◽  
Erin Aldera ◽  
...  
Keyword(s):  
Intensive Care ◽  
Healthcare Workers ◽  
Venous Blood ◽  
Cross Sectional Study ◽  
Nasopharyngeal Swab ◽  
Sectional Study ◽  
University Hospitals ◽  
Cross Sectional ◽  
General Internal ◽  
Increased Risk

ObjectiveTo determine the rates of asymptomatic viral carriage and seroprevalence of SARS-CoV-2 antibodies in healthcare workers.DesignA cross-sectional study of asymptomatic healthcare workers undertaken on 24/25 April 2020.SettingUniversity Hospitals Birmingham NHS Foundation Trust (UHBFT), UK.Participants545 asymptomatic healthcare workers were recruited while at work. Participants were invited to participate via the UHBFT social media. Exclusion criteria included current symptoms consistent with COVID-19. No potential participants were excluded.InterventionParticipants volunteered a nasopharyngeal swab and a venous blood sample that were tested for SARS-CoV-2 RNA and anti-SARS-CoV-2 spike glycoprotein antibodies, respectively. Results were interpreted in the context of prior illnesses and the hospital departments in which participants worked.Main outcome measureProportion of participants demonstrating infection and positive SARS-CoV-2 serology.ResultsThe point prevalence of SARS-CoV-2 viral carriage was 2.4% (n=13/545). The overall seroprevalence of SARS-CoV-2 antibodies was 24.4% (n=126/516). Participants who reported prior symptomatic illness had higher seroprevalence (37.5% vs 17.1%, χ2=21.1034, p<0.0001) and quantitatively greater antibody responses than those who had remained asymptomatic. Seroprevalence was greatest among those working in housekeeping (34.5%), acute medicine (33.3%) and general internal medicine (30.3%), with lower rates observed in participants working in intensive care (14.8%). BAME (Black, Asian and minority ethnic) ethnicity was associated with a significantly increased risk of seropositivity (OR: 1.92, 95% CI 1.14 to 3.23, p=0.01). Working on the intensive care unit was associated with a significantly lower risk of seropositivity compared with working in other areas of the hospital (OR: 0.28, 95% CI 0.09 to 0.78, p=0.02).Conclusions and relevanceWe identify differences in the occupational risk of exposure to SARS-CoV-2 between hospital departments and confirm asymptomatic seroconversion occurs in healthcare workers. Further investigation of these observations is required to inform future infection control and occupational health practices.

scholarly journals Seroprevalence of the SARS-CoV-2 antibody in healthcare workers: a multicentre cross-sectional study in 10 Colombian cities

2021 ◽  
pp. oemed-2021-107487
Author(s):  
Jeadran Nevardo Malagón-Rojas ◽  
Marcela Mercado-Reyes ◽  
Yezith G Toloza-Pérez ◽  
Eliana L Parra Barrera ◽  
Marien Palma ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Strong Association ◽  
Cross Sectional Study ◽  
Protective Equipment ◽  
Risk Of Infection ◽  
Sectional Study ◽  
Cross Sectional ◽  
Increased Risk ◽  
Significant Difference ◽  
Automated Immunoassay

BackgroundHealthcare workers are at increased risk of infection due to occupational exposure to SARS-CoV-2-infected patients. The objective of this study was to determine the seroprevalence of SARS-CoV-2 in healthcare workers in Colombia.MethodsThis study is a cross-sectional study focused on estimating the seroprevalence of SARS-CoV-2 antibodies in healthcare workers from 65 hospitals in 10 cities in Colombia during the second semester of 2020. The seroprevalence was determined using an automated immunoassay (Abbott SARS-CoV-2 CLIA IgG). The study included a survey to establish the sociodemographic variables and the risk of infection. A multivariate model was used to evaluate the association between the results of seroprevalence and risk factors.ResultsThe global seroprevalence of antibodies against SARS-CoV-2 was 35% (95% Bayesian CI 33% to 37%). All the personnel reported the use of protective equipment. General services personnel and nurses presented the highest ratios of seroprevalence among the healthcare workers. Low socioeconomic strata have shown a strong association with seropositivity.ConclusionThis study estimates the prevalence of SARS-CoV-2 infection among healthcare workers. Even though all the personnel reported the use of protective equipment, the seroprevalence in the general services personnel and nurses was high. Also, a significant difference by cities was observed.

scholarly journals Knowledge, perception and practices regarding novel coronavirus among sample of Ghanaian healthcare workers: a cross-sectional study

2021 ◽  
Vol 8 (3) ◽  
pp. 1072
Author(s):  
Dorcas Serwaa ◽  
Anthony Baffour Appiah ◽  
Richard Wodag-Seme ◽  
Charles Nkansah ◽  
Selasie Ahiatrogah
Keyword(s):  
Healthcare Workers ◽  
Health Workers ◽  
Healthcare Providers ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Increased Risk ◽  
Precautionary Measures ◽  
Novel Coronavirus

Background: Healthcare workers’ have increased risk of contracting the deadly COVID-19 pandemic due to their exposures to infected persons and their specimens. Ghana, like many other countries, has felt the devastating effects of this virus; it was therefore prudent to assess the levels of knowledge, perception and practice of Ghanaian healthcare providers on the current pandemic.Methods: This descriptive cross-sectional study enlisted 979 healthcare workers’ in Ghana from 1st Apr to 20th Nov, 2020, via self-reported questionnaire. SPSS version 22.0 was used for the analysis. Responses were summarized using frequency and proportions. A chi-square test was utilized to test for association at significant level of p <0.05.Results: Out of the 979 healthcare workers recruited, 56.4% had good knowledge and 59.5% displayed good perception on the novel COVID-19 while 63.1% of them effectively practiced the expected precautionary measures. Age (p=0.001), gender (p=0.034) and profession (p<0.001) significantly affected the practice of precautionary measure among the health personnel. The respondents’ perceptions towards the pandemic were significantly linked to their age (p<0.001), gender (p=0.043), profession (p<0.001), type of occupation (p=0.001) and source of information (p=0.006). Also, knowledge significantly related to good practices but did not influence the perception of HCWs.Conclusions: The current study identifies that more than half of HCWs in Ghana have sufficient knowledge, perception, and practice of precautionary measures; however, it elucidates some significant concerns about the knowledge gap in this COVID-19 outbreak. There is an obvious need for progressive in-service training programs for the health workers to broaden their scopes on the risks and preventive measures. 

scholarly journals Prevalence and Risk Factors of CoronaVac Side Effects: An Independent Cross-Sectional Study among Healthcare Workers in Turkey

2021 ◽  
Vol 10 (12) ◽  
pp. 2629
Author(s):  
Abanoub Riad ◽  
Derya Sağıroğlu ◽  
Batuhan Üstün ◽  
Andrea Pokorná ◽  
Jitka Klugarová ◽  
...  
Keyword(s):  
Risk Factors ◽  
Side Effects ◽  
Healthcare Workers ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Vaccine Hesitancy ◽  
Public Confidence ◽  
Sectional Study ◽  
Cross Sectional ◽  
Increased Risk

Background: COVID-19 vaccine hesitancy is a serious threat to mass vaccination strategies that need to be accelerated currently in order to achieve a substantial level of community immunity. Independent (non-sponsored) studies have a great potential to enhance public confidence in vaccines and accelerate their uptake process. Methods: A nationwide cross-sectional study for the side effects (SE) of CoronaVac was carried out in February 2021 among Turkish healthcare workers who were recently vaccinated. The questionnaire inquired about local and systemic SEs that occurred in the short-term, within four weeks, following vaccination. Results: A total of 780 healthcare workers were included in this study; 62.5% of them experienced at least one SE. Injection site pain (41.5%) was the most common local SE, while fatigue (23.6%), headache (18.7%), muscle pain (11.2%) and joint pain (5.9%) were the common systemic SEs. Female healthcare workers (67.9%) were significantly more affected by local and systemic SEs than male colleagues (51.4%). Younger age, previous infection, and compromised health status (chronic illnesses and regular medicines uptake) can be associated with an increased risk of CoronaVac SEs; Conclusions: The independent research shows a higher prevalence of CoronaVac SEs than what is reported by phase I–III clinical trials. In general, the results of this study confirm the overall safety of CoronaVac and suggest potential risk factors for its SEs. Gender-based differences and SEs distribution among age groups are worth further investigation.

scholarly journals Prevalence of Seropositivity to SARS-CoV-2 among Health Care Workers in Tertiary COVID-19 Hospital, Ahmedabad, Gujarat

2021 ◽  
Author(s):  
Jemil S Makadia ◽  
Mukesh G Gohel ◽  
Chandan Chakrabarti ◽  
Jayshree D Pethani
Keyword(s):  
Occupational Exposure ◽  
Health Care Workers ◽  
Healthcare Workers ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Care Workers ◽  
Increased Risk ◽  
Ancillary Staff ◽  
General Service

Introduction: Healthcare Workers (HCW) are at increased risk of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection due to occupational exposure to infected patients and contaminated surfaces. Aim: To determine the prevalence of seropositivity against SARS-CoV-2 among HCW in a tertiary COVID-19 designated hospital in Ahmedabad, Gujarat. Materials and Methods: This cross-sectional study was conducted between 1st July to 31st July, 2020 on 1333 HCWs. HCWs included doctors, nurses, lab personnel, general service assistants and ancillary staff who work in hospital. Anti SARS-CoV-2 total antibodies were measured in serum sample by chemiluminescent technique. Results: Prevalence of seropositivity was found in 27.76% (370 out of 1333). It was highest among general service assistant 34.76% (especially among house keeping staff, 43.44%) and lowest among doctors (19.33%). The percentage of seropositivity among asymptomatic HCWs was 24.84%. Conclusion: The percentage of seropositivity among asymptomatic HCWs indicates that a large amount of infection passes asymptomatically. The discrepancy between various job categories might be due to differential occupational exposure and risk, lack of awareness and seriousness regarding transmission and risk of getting infection, various demographic factors like literacy, residential environment, community prevalence etc.

scholarly journals Prevalence of Insulin Resistance in Urban Indian School Children Who Are Overweight/Obese: A Cross-Sectional Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Rashmi Ranjan Das ◽  
Manaswini Mangaraj ◽  
Saurav Nayak ◽  
Amit Kumar Satapathy ◽  
Samarendra Mahapatro ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Indian Subcontinent ◽  
Venous Blood ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Vascular Events ◽  
Cross Sectional ◽  
Metabolic Complications ◽  
School Based ◽  
Increased Risk

Background: Limited data are available for insulin resistance (IR) in over-weight/obese children from the Indian subcontinent. Identifying predictors of IR in this population is important, as they may be used as a screening tool for future metabolic complications.Materials and Methods: This school-based cross-sectional study was conducted in an Eastern Indian city. Anthropometry and blood pressure measurements were carried out as per the published guidelines. Venous blood samples were taken in a fasting state to measure plasma glucose, insulin, and lipid profile. IR was measured quantitatively by a homeostatic model of assessment (HOMA-IR).Results: A total of 545 (28.2%) children who were overweight or obese were included. The male:female ratio was 1:1.27. The overall prevalence of metabolic syndrome (MS) in these children was 21.8%. Around 32.3% of children had HOMA-IR of ≥2.5, and 22.2% had HOMA-IR of ≥3.16. The mean HOMA-IR in children with MS was 5.46 compared to 2.18 in those without MS. An increased risk of IR with low HDL, high triglyceride, increased waist circumference, and increased BP (both systolic and diastolic) was found. This means that insulin resistance was more common in children who were overweight or obesity and had underlying MS.Conclusions: The present school-based study found a high prevalence of insulin resistance among children who were overweight or obese. This could predict an increased risk of future adverse cardio-vascular events in the studied children. The findings of this study would help in planning and implementing primary prevention programs targeting weight management and lifestyle change in schoolchildren.

scholarly journals Knowledge, Attitude and Practices of Labor Analgesia amongst healthcare workers and patients: A single center cross sectional study

2019 ◽  
Vol 36 (ICON-Suppl) ◽  
Author(s):  
Maher Ali ◽  
Syed Farjad Sultan ◽  
Anil Kumar ◽  
Nida Ghouri
Keyword(s):  
Healthcare Workers ◽  
Antenatal Clinic ◽  
Cross Sectional Study ◽  
Labor Analgesia ◽  
Sectional Study ◽  
Single Center ◽  
Cross Sectional ◽  
Creative Commons ◽  
Increased Risk ◽  
Special Supplement

Background and Objective: Childbirth ranks amongst the most painful experiences a woman has to endure. In developing countries issues related to awareness, acceptability and availability of analgesia exist. This study aims to assess the knowledge, attitude and practices for labor analgesia amongst healthcare workers and patients. Methods: We performed a cross-sectional study conducted at Shaikh Saeed Memorial Campus of The Indus Hospital (TIH), Karachi. The study was performed in November 2016. Two surveys were conducted for this study; one for healthcare workers with patient interaction and second on patients attending their first antenatal clinic. The participants were asked to complete a survey following consent. Results: A total of 71 healthcare workers and 1005 patients participated in the study. Among healthcare workers, 43.7% felt that pain relief should be administered, 14.1% believed analgesia had adverse effects on fetus and 11.3% reported increased risk of cesarean section. Results from patients showed 27.9% were aware of labor analgesia and when informed, 85.2% were willing to have labor analgesia. In 14.1% of patients, labor analgesia was unsupported as they stated being a mother meant to endure pain. Conclusion: There is a wide gap between knowledge and practice of labor analgesia. Healthcare workers have a role in educating women, to be advocates for labor analgesia and to educate patients timely for this service. doi: https://doi.org/10.12669/pjms.36.ICON-Suppl.1715 How to cite this:Ali M, Sultan SF, Kumar A, Ghouri N. Knowledge, Attitude and Practices of Labor Analgesia amongst healthcare workers and patients: a single center cross sectional study. Pak J Med Sci. Special Supplement ICON 2020. 2020;36(1):S4-S8.  doi: https://doi.org/10.12669/pjms.36.ICON-Suppl.1715 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Frequency of Positive PCR test and Complications in Nasopharyngeal Swabs of Suspected Patients and Contacts of COVID-19 Tested at Allied Hospital Faisalabad

2021 ◽  
Vol 15 (1) ◽  
pp. 25-27
Author(s):  
Saeed Saeed ◽  
Keyword(s):  
Healthcare Workers ◽  
Total Sample ◽  
Cross Sectional Study ◽  
Nasopharyngeal Swab ◽  
Sectional Study ◽  
Rt Pcr ◽  
Cross Sectional ◽  
Frequent Complication ◽  
Corona Virus ◽  
Lab Test

Background: COVID-19 is a severe respiratory disease, started in China. For diagnosis, we need swabs from different regions of respiratory tract. Nasopharyngeal swab is the preferred method. Rt-PCR for Corona virus is the gold standard lab test for diagnosis. Objective: To determine frequency of positive PCR tests and complications in total number of nasopharyngeal samples taken at ENT department of Allied Hospital, Faisalabad Pakistan. Study Design: Descriptive cross-sectional study. Settings: ENT department, Allied Hospital, Faisalabad Pakistan. Duration: 1st May 2020 to 31st August 2020. Methodology: Nasopharyngeal swabs of suspected cases, their contacts, and healthcare workers were taken at ENT department of Allied Hospital. All samples were sent to BSL-LAB. The complication related to procedure were also noted. The result was labelled as detected and non-detected. Results: Total sample taken were 2909 out of which 627 (22%) cases were positive for Corona virus while 2282 (78%) were negative. Pain was most frequent complication (68%) followed by blood staining of swab (31%) and epistaxis (1%). Conclusion: Frequency of positive corona virus case presenting to allied Hospital is 22%. Nasopharyngeal swabs are a safe and effective method of sampling in suspected Corona Virus cases. Pain during the procedure is the most frequent complication.

scholarly journals The burden of SARS-CoV-2 among healthcare workers across 16 hospitals of Kashmir, India—A seroepidemiological study

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259893
Author(s):  
Inaamul Haq ◽  
Mariya Amin Qurieshi ◽  
Muhammad Salim Khan ◽  
Sabhiya Majid ◽  
Arif Akbar Bhat ◽  
...  
Keyword(s):  
Nucleocapsid Protein ◽  
Healthcare Workers ◽  
Cross Sectional Study ◽  
Nasopharyngeal Swab ◽  
Sectional Study ◽  
Cross Sectional ◽  
Healthcare Settings ◽  
First Case ◽  
Present Cross Sectional Study ◽  
Study Results

SARS-CoV-2 pandemic has greatly affected healthcare workers because of the high risk of getting infected. The present cross-sectional study measured SARS-CoV-2 antibody in healthcare workers of Kashmir, India. Methods: Serological testing to detect antibodies against nucleocapsid protein of SARS-CoV-2 was performed in 2003 healthcare workers who voluntarily participated in the study. Results: We report relatively high seropositivity of 26.8% (95% CI 24.8–28.8) for SARS-CoV-2in healthcare workers, nine months after the first case was detected in Kashmir. Most of the healthcare workers (71.7%) attributed infection to the workplace environment. Among healthcare workers who neither reported any prior symptom nor were they ever tested for infection by nasopharyngeal swab test, 25.5% were seropositive. Conclusion: We advocate interval testing by nasopharyngeal swab test of all healthcare workers regardless of symptoms to limit the transmission of infection within healthcare settings.

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