A Case Report and Genetic Characterization of a Massive Acinic Cell Carcinoma of the Parotid with Delayed Distant Metastases
2013 ◽
Vol 2013
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pp. 1-7
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Keyword(s):
We describe the presentation, management, and clinical outcome of a massive acinic cell carcinoma of the parotid gland. The primary tumor and blood underwent exome sequencing which revealed deletions in CDKN2A as well as PPP1R13B, which induces p53. A damaging nonsynonymous mutation was noted in EP300, a histone acetylase which plays a role in cellular proliferation. This study provides the first insights into the genetic underpinnings of this cancer. Future large-scale efforts will be necessary to define the mutational landscape of salivary gland malignancies to identify therapeutic targets and biomarkers of treatment failure.
2002 ◽
Vol 126
(9)
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pp. 1104-1105
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Keyword(s):
2016 ◽
Vol 5
(34)
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pp. 1954-1956
Keyword(s):
1979 ◽
Vol 93
(4)
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pp. 423-426
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Keyword(s):
2008 ◽
Vol 16
(2)
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pp. 202-207
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2017 ◽
Vol 29
(4)
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pp. 309-313
Keyword(s):
1996 ◽
Vol 42
(5)
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pp. 506-508
Keyword(s):