scholarly journals Optimization of Extraction Process of Methyl Eugenol and Asarinin in Asarum with Deep Eutectic Solvent Based on the Response Surface Methodology

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Huiwei Bao ◽  
Yang Xu ◽  
Yuejie Wang ◽  
Tao Zhang ◽  
Enpeng Wang ◽  
...  
Keyword(s):  
Response Surface ◽  
Deep Eutectic Solvent ◽  
Extraction Process ◽  
Methyl Eugenol ◽  
Extraction Rate ◽  
Process Conditions ◽  
Surface Model ◽  
Single Factor ◽  
Extraction Technology ◽  
Ultrasonic Time

To explore a green and efficient extraction technology for the extraction of active ingredients of Asarum, the deep eutectic solvent combined with ultrasonic was applied to compare the extraction efficiency of 10 kinds of deep eutectic solvents, taking the extraction rate of methyl eugenol and asarinin as indices. Single-factor experiments were adopted to investigate the influence of molar ratio, liquid-to-solid ratio, eddy time, ultrasonic time, and temperature of the deep eutectic solvent on the extraction rate of methyl eugenol and asarinin. Based on single-factor experiments, the surface response methodology was used to optimize the extraction process conditions. The results showed that the optimum extracting process conditions of methyl eugenol and asarinin in Asarum consisted of a ratio of choline chloride to glycerol of 1 : 3, a DES volume of 2 mL, an ultrasonic temperature of 60°C, an ultrasonic time of 30 min, and a vortex oscillation of 7 min. Under the optimum extracting process conditions, the contents of methyl eugenol and asarinin were 1.9428 mg/g and 0.9989 mg/g, respectively, and the comprehensive index was 2.3280 (RSD of 1.91%). The results were close to the predicted values of the response surface model, demonstrating the applicability of the model. The extraction rate of methyl eugenol and asarinin in Asarum by this method was higher than that of water extraction and alcohol extraction, which fully indicated the high efficiency of ultrasonic-assisted green deep eutectic solvent extraction technology. The results provide data support for further development and utilization of Asarum.

scholarly journals Homogenate Extraction of Crocins from Saffron Optimized by Response Surface Methodology

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Yingpeng Tong ◽  
Yu Jiang ◽  
Dan Guo ◽  
Yongqiu Yan ◽  
Shiping Jiang ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Ethanol Concentration ◽  
Extraction Yield ◽  
Extraction Time ◽  
Process Conditions ◽  
Extraction Temperature ◽  
Single Factor ◽  
Extraction Voltage ◽  
Homogenate Extraction

Saffron, which has many kinds of biological activities, has been widely used in medicine, cosmetics, food, and other fields of health promotion industries. Crocins are the main component of saffron (Crocus sativus L.). At present, most of the extraction methods for crocins require long time or special instruments to complete the process and some of them are not suitable for industrial production at present. In this article, homogenate extraction technology which is a convenient and efficient method was developed for crocins extraction from saffron. Firstly, the influences of extraction voltage, extraction time, ethanol concentration, and temperature on crocins yield were studied by single factor experiments; and then response surface methodology (RSM) was used to optimize levels of four variables based on the result of single factor experiments. Results showed that the optimum extraction process conditions for crocins were as follows: extraction voltage, 110 V; ethanol concentration, 70%; extraction temperature, 57°C; and extraction time, 40 s. Based on these conditions, the extraction yield of crocins can reach 22.76% which is higher than ultrasonic extraction method. Therefore, homogenate extraction is an effective way to extract crocins from saffron with higher extraction yield and shorter extraction time.

scholarly journals Effect of Supercritical Fluid Extraction Process on Chemical Composition of Polianthes tuberosa Flower Extracts

Processes ◽  
2019 ◽  
Vol 7 (2) ◽  
pp. 60 ◽  
Author(s):  
Javier Fragoso-Jiménez ◽  
Ernesto Tapia-Campos ◽  
Mirna Estarron-Espinosa ◽  
Rodrigo Barba-Gonzalez ◽  
Ma. Castañeda-Saucedo ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Supercritical Fluid ◽  
Significant Variation ◽  
Extraction Process ◽  
Methyl Eugenol ◽  
Composition Profile ◽  
Process Conditions ◽  
Methyl Anthranilate ◽  
Benzyl Benzoate ◽  
Volatile Composition

Supercritical fluid extracts from flowers of Polianthes tuberosa var. double were ob tained using carbon dioxide as a solvent. Yield extract obtained was 2.5%. The effects of the pressure process (18 MPa, 28 MPa, and 38 MPa) and temperature process (313 K, 323 K, and 333 K) on the volatile composition of tuberose flowers extracts were evaluated, and a significant variation in chemical composition was found. Characteristic compounds of tuberose as methyl isoeugenol, benzyl benzoate, methyl anthranilate, pentacosene, and heptacosene were obtained mainly at 18 MPa and 333 K process conditions, and could be used in the perfume or fragrance industry. Components such as geraniol, farnesol, and methyl eugenol were also obtained, these extracts could be used in the development of cosmeceutical products. This work allowed to identification of the chemical composition profile and evaluation of the changes in tuberose extracts due to the extraction process.

Optimization of Ultrasonic-Assisted Extraction of Total Saponins from Ophiopholis mirabilis Using Response Surface Methodology

2013 ◽  
Vol 781-784 ◽  
pp. 687-693
Author(s):  
Zhi Yang Shao ◽  
Jin Xia Fu ◽  
Yan Xia Qi ◽  
Qian Cheng Zhao ◽  
Zhi Bo Li
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Ethanol Concentration ◽  
Water Bath ◽  
Ultrasonic Power ◽  
Extraction Technology ◽  
Assisted Extraction ◽  
Ultrasonic Time ◽  
Ultrasonic Assisted ◽  
Ultrasonic Assisted Extraction

Ultrasonic-Assisted extraction (UAE) was applied for saponins extraction from Ophiopholis mirabilis and response surface methodology (RSM) was used to optimize the extraction technology. A first set of experiments were designed to optimize water bath temperature, ethanol concentration, the ratio of liquid to solid, ultrasonic time (min) and ultrasonic power (W) as the main variables affecting the extraction effect. A Box-Behnken design consisting of 15 experimental runs was then applied and a second-order polynomial model was used to explain the interactions between the main factors and the yield of saponins. The developed mathematical model was found to fit well with the experimental data and the optimized conditions were ultrasonic pretreatment time 30.9 min, ethanol concentration 64%, liquid /solid ratio 35:1, ultrasonic power 300W and water bath 70°C. Corresponding saponins content was 0.574%.

Ultrasonic Extraction Chuanxiong Polysaccharide of Influencing Factors

2012 ◽  
Vol 550-553 ◽  
pp. 1071-1075
Author(s):  
Yong Guang Bi ◽  
Chun Chun Liu
Keyword(s):  
Influencing Factors ◽  
Extraction Process ◽  
Extraction Rate ◽  
Ultrasonic Extraction ◽  
Ultrasonic Power ◽  
Extraction Temperature ◽  
Liquid Ratio ◽  
Ultrasonic Time ◽  
Solid Liquid

In order to study the the Chuanxiong polysaccharide ultrasonic extraction process, examine the ultrasonic time, ultrasonic power, solid-liquid ratio and extraction temperature on the Chuanxiong polysaccharide extract rate. The results show that the role of time at 30min Polysaccharide better, the extraction rate is 26.63%. when the ultrasonic power is 320W, Polysaccharide extraction rate is 26.15%.When the solid-liquid ratio is 1:20, polysaccharide extraction rate is 27.73%. When the extraction temperature is 60°C, the polysaccharide extraction rate is 27.73%.

Optimization of Extracting Condition of Active Components in Perilla by Ultrasonic

2014 ◽  
Vol 1033-1034 ◽  
pp. 713-716
Author(s):  
Dan Huang ◽  
You Qing Liu ◽  
Yuan Liang ◽  
Xiang Mao
Keyword(s):  
Rosmarinic Acid ◽  
Extraction Rate ◽  
Ultrasonic Power ◽  
Single Factor ◽  
Liquid Ratio ◽  
Active Components ◽  
Extraction Technology ◽  
Extraction Solvent ◽  
Solid Liquid ◽  
Temperature Time

Using ultrasonic-extraction technology, the condition of extracting the active compounds-flavonoids and rosmarinic acid ofPerillawas studied. The effects of four main factors include ultrasonic power, temperature, time and solid-liquid ratio on the extraction-rate of the flavonoids and the rosmarinic acid ofPerillawere reviewed by single factor experiments,and the flavonoids and the rosmarinic acid was determined by NaNO2-Al (NO3)3-NaOH method and FeSO4method. On the base of single factor experiments, the extraction technique was optimized in the orthogonal test. The result showed that temperature was the most important factor in the influencing factors on the extraction-rate. The subsequence of importance was temperature > time > solid-liquid ratio > ultrasonic. The optimal extraction conditions were: extraction solvent 3%borax, solid-liquid ratio 1:50(w/v), ultrasonic power 300W, time 90min , temperature 75°C. Under the optimum technological conditions, 34.64mg/g of flavonoids and rosmarinic acid fromPerillacould be obtained.

scholarly journals Response surface optimization of ultrasonic assisted extraction of flavonoids from Brucea javanica

2018 ◽  
Vol 238 ◽  
pp. 04005
Author(s):  
Aiping Fei ◽  
Junyu Jiang ◽  
Yong Wang ◽  
Zhigang Fang ◽  
Yingxue Teng ◽  
...  
Keyword(s):  
Response Surface ◽  
Extraction Process ◽  
Process Conditions ◽  
Brucea Javanica ◽  
Response Surface Optimization ◽  
Assisted Extraction ◽  
Ultrasonic Assisted ◽  
Ultrasonic Assisted Extraction ◽  
Surface Optimization ◽  
Optimum Extraction

This text was mainly studied the response surface optimization of ultrasonic assisted extraction of flavonoids from Brucea javanica. The optimum extraction process conditions were obtained by color reaction to prove the presence of flavonoids and by response surface simulation and quantification, the optimum condition was: ethanol concentration was 90%, the ratio of liquid to solid was 10:1, and the extraction time was 2h, the total extraction rate was the largest, up to about 1.43%.

Optimization of Ultrasonic Extraction of Flavonoids from Castanea mollissima Blume Shell

2015 ◽  
Vol 713-715 ◽  
pp. 2775-2778
Author(s):  
Hai Tao Sun ◽  
Xin Ru Shao ◽  
Rui Ping Jiang ◽  
Jun An
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Ethanol Concentration ◽  
Extraction Rate ◽  
Ultrasonic Extraction ◽  
Optimum Conditions ◽  
Ultrasonic Time ◽  
Castanea Mollissima ◽  
Ultrasonic Assisted

Flavonoids extracted fromCastanea mollissimaBlume shell using response surface methodology by ultrasonic-assisted. The effects of liquid/ materials ratio, ethanol concentration, ultrasonic temperature,and ultrasonic time on the flavonoids extraction rate were investigated by Box-Benhnken center composite design. The results showed that the optimum conditions were as follows: liquid/ materials ratio 8:1 (mL/g), ethanol concentration 40 %, ultrasonic temperature 60 °C,and ultrasonic time 25 min, the highest absorbance was obtained under the optimum conditions, and the extract absorbance can be reached 0.702.

scholarly journals Optimization of Extraction Process and the Antioxidant Activity of Phenolics from Sanghuangporus baumii

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3850
Author(s):  
Na Zheng ◽  
Yongfei Ming ◽  
Jianzhi Chu ◽  
Shude Yang ◽  
Guochao Wu ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Response Surface Methodology ◽  
Response Surface ◽  
Choline Chloride ◽  
Deep Eutectic Solvent ◽  
Extraction Process ◽  
Extraction Yield ◽  
Fruiting Bodies ◽  
Factors Affecting ◽  
Medicinal Fungus

Sanghuangporus baumii, is a widely used medicinal fungus. The polyphenols extracted from this fungus exert antioxidant, anti-inflammatory, and hypoglycemic effects. In this study, polyphenols from the fruiting bodies of S. baumii were obtained using the deep eutectic solvent (DES) extraction method. The factors affecting the extraction yield were investigated at different conditions. Based on the results from single-factor experiments, response surface methodology was used to optimize the extraction conditions. The scavenging ability of the polyphenols on •OH, DPPH, and ABTS+ was determined. The results showed that the DES system composed of choline chloride and malic acid had the best extraction yield (6.37 mg/g). The optimal extraction parameters for response surface methodology were as follows: 42 min, 58 ℃, 1:34 solid–liquid (mg/mL), and water content of 39%. Under these conditions, the yield of polyphenols was the highest (12.58 mg/g). At 0.30 mg/mL, the scavenging ability of the polyphenols on •OH, DPPH, and ABTS+ was 95.71%, 91.08%, and 85.52%, respectively. Thus, the method using DES was more effective than the conventional method of extracting phenolic compounds from the fruiting bodies of S. baumii. Moreover, the extracted polyphenols exhibited potent antioxidant activity.

Response Surface Methodology for Salmonella Inactivation during Extrusion Processing of Oat Flour

2018 ◽  
Vol 81 (5) ◽  
pp. 815-826 ◽  
Author(s):  
TUSHAR VERMA ◽  
XINYAO WEI ◽  
SOON KIAT LAU ◽  
ANDREIA BIANCHINI ◽  
KENT M. ESKRIDGE ◽  
...  
Keyword(s):  
Food Safety ◽  
Response Surface ◽  
Interactive Effect ◽  
Fat Content ◽  
Response Surface Model ◽  
Process Conditions ◽  
Surface Model ◽  
Screw Speed ◽  
Oat Flour ◽  
Process Controls

ABSTRACT An increase in the number of foodborne outbreaks and recalls due to Salmonella in low-moisture foods has resulted in the need for the development and validation of process controls to ensure their microbiological safety. Furthermore, the Food Safety Modernization Act Preventive Controls for Human Food final rule requires food processors to validate their process controls to ensure food safety. The objective of this study was to develop a response surface model to predict Salmonella inactivation in oat flour, as affected by moisture, fat content, screw speed, and temperature. Oat flour was adjusted to different moisture (14 to 26% wet basis) and fat (5 to 15% [w/w]) contents and was then inoculated with a five-strain cocktail of Salmonella. Inoculated material was extruded through a single-screw extruder running at different screw speeds (75 to 225 rpm) and temperatures (65 to 85°C), without a die. Once steady-state conditions were attained, extruded samples were collected, cooled, and stored under refrigeration, and Salmonella survivors were enumerated. A split-plot central composite second-order response surface design was used, with the central point replicated six times. Temperature showed a significant (P < 0.0005) positive effect on microbial reduction. Moisture content showed significant linear (P = 0.0014) and quadratic (P = 0.0005) effects, whereas higher fat content showed a significant (P < 0.0001) protective effect on Salmonella destruction. The screw speed did not play a major role in inactivating Salmonella, but it had a significant (P = 0.0004) interactive effect with temperature. Results indicated that a >5.5-log reduction was achieved in oat flour extruded at a temperature above 85°C at all moisture and fat contents evaluated at a screw speed of 150 rpm. The developed response surface model can be used to identify the extrusion process conditions to achieve a desired reduction of Salmonella based on the moisture and fat contents of the product.

scholarly journals Optimization of Baicalin, Wogonoside, and Chlorogenic Acid Water Extraction Process from the Roots of Scutellariae Radix and Lonicerae japonicae Flos Using Response Surface Methodology (RSM)

Processes ◽  
2019 ◽  
Vol 7 (11) ◽  
pp. 854
Author(s):  
Jichang Li ◽  
Rui Wang ◽  
Zunlai Sheng ◽  
Zhiyong Wu ◽  
Chunli Chen ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Chlorogenic Acid ◽  
Response Surface ◽  
Extraction Process ◽  
Extraction Time ◽  
Extraction Temperature ◽  
Single Factor ◽  
Solid Ratio ◽  
Scutellariae Radix ◽  
Optimized Conditions

In this study, a simultaneous water extraction process for baicalin, wogonoside, and chlorogenic acid has been optimized. The effect of extraction temperature, extraction time, and liquid–solid ratio was scrutinized by single factor experiments and further analyzed by Box–Behnken design (BBD) approach using response surface methodology (RSM). The extraction yield of investigated compounds was determined by high performance liquid chromatography (HPLC). Single-factor experiments and response surface analysis results revealed that the optimized conditions are: Liquid to solid ratio 25:1 (mL/g), extraction temperature 93 °C, extraction time 2.4 h, and the extraction cycle two. Importantly, it has been noted that under the above conditions, concentrations of baicalin, wogonoside, and chlorogenic were 0.078, 0.031, and 0.013 mg/mL, respectively, and the overall desirability (OD) value was 0.76 which was higher than the non-optimized conditions and the deviation from the predicted OD value was only 2.44%. Conclusively, it has been suggested that the model was stable and feasible, and fit for extraction of baicalin, wogonoside, and chlorogenic acid from Scutellariae Radix and Lonicerae (L.) japonicae Flos.

Sign in / Sign up

Export Citation Format

Share Document