scholarly journals Lung Denervation and Its Effect on Bronchial Responsiveness Following Lung Transplant Surgery

2020 ◽  
Author(s):  
M. Zantah ◽  
A. Pandya ◽  
N. Marchetti ◽  
M.R. Jacobs ◽  
G.J. Criner
Keyword(s):  
Lung Transplant ◽  
Bronchial Responsiveness

Bronchial hyper-responsiveness after human cardiopulmonary transplantation

1987 ◽  
Vol 73 (3) ◽  
pp. 299-303 ◽  
Author(s):  
Allan R. Glanville ◽  
Conor M. Burke ◽  
James Theodore ◽  
John C. Baldwin ◽  
James Harvey ◽  
...  
Keyword(s):  
Lung Transplant ◽  
Normal Subjects ◽  
Cholinergic Agonists ◽  
Bronchial Responsiveness ◽  
Heart Lung Transplant ◽  
The Mean ◽  
Bronchial Hyper Responsiveness ◽  
Airway Conductance

1. Bronchial responsiveness to inhaled methacholine was studied in ten heart-lung transplant (HLT) recipients a mean 10.6 months (range 1.5–28 months) post-HLT and in ten normal subjects. 2. The mean provocation dose of methacholine producing a 20% fall in FEV1 (PD20 FEV1) was significantly lower in the HLT recipients (1.70 ± 3.96 mg vs 11.55 ± 3.79 mg; P < 0.001), as was the mean provocation dose of methacholine producing a 50% fall in specific airway conductance (PD50 sGAW) (0.08 ± 0.08 mg vs 5.13 ± 5.47 mg; P < 0.005). 3. These results establish the presence of significant bronchial hyper-responsiveness to inhaled cholinergic agonists in the transplanted lung.

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