scholarly journals Are Vitamin D Levels Associated With Risk of Deep Neck Infection?

2019 ◽  
pp. 014556131986549
Author(s):  
Mustafa Sıtkı Gozeler ◽  
Muhammed Sedat Sakat ◽  
Korhan Kilic ◽  
Abdulkadir Sahin ◽  
Arzu Tatar ◽  
...  
Keyword(s):  
Vitamin D ◽  
Immune System ◽  
Vitamin D Deficiency ◽  
Serum Levels ◽  
Control Group ◽  
Deep Neck Infection ◽  
Neck Infection ◽  
Vitamin D Receptors ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D

Deep neck infection (DNI) refers to infections in spaces created by superficial and deep cervical fascia around the muscles and organs in the neck. Vitamin D is highly important for an effective immune system. Vitamin D receptors (VDR) have been identified in immune system cells, and particularly in T and B lymphocytes, macrophages, and dendritic cells. Vitamin D deficiency is thought to result in impaired immune response, decreased leukocyte chemotaxis, and an increased disposition to infection. The purpose of this study was to investigate whether vitamin D deficiency is an underlying occult factor in the development of DNI. Sixty-five patients aged 6 to 90, diagnosed with DNI, and 70 healthy age- and sex-compatible cases were included in the study. Serum levels of calcium, phosphorus, parathyroid hormone, and 25-hydroxy vitamin D (25(OH)D) were determined in each case. 25-hydroxy vitamin D levels above 20 ng/mL were regarded as normal, 12 to 20 ng/mL as insufficient, 5 to 12 ng/mL as deficient, and less than 5 ng/mL as severely deficient. Mean serum 25(OH)D levels were 10.4 (6.2) ng/mL in the patient group and 15.5 (6.4) ng/mL in the control group ( P < .01). This difference was statistically significant ( P < .01). Vitamin D was within normal limits in 9.2% (n = 6) of cases in the study group, insufficient in 29.2% (n = 19), deficient in 35.3% (n = 23), and severely deficient in 26.2% (n = 17). The equivalent values in the control group were 21.4% (n = 15), 48.5% (n = 34), 30% (n = 21), and 0% (n = 0). Serum 25(OH)D levels were significantly lower in patients with DNI compared to the healthy cases; 25(OH)D levels may be a factor in the development of DNI.

scholarly journals Relationship between vitamin D deficiency and atopy in children

2018 ◽  
Vol 5 (5) ◽  
pp. 1705
Author(s):  
Kulthum Al Mahdi ◽  
Mariyah Albrahim ◽  
Fatimah Alkhars ◽  
Ola Alkhalifah ◽  
Rabab Alaithan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Immune System ◽  
Vitamin D Deficiency ◽  
Immunoglobulin E ◽  
Serum Levels ◽  
Inhibitory Effect ◽  
Vitamin D Receptors ◽  
System Integrity ◽  
Randomized Controlled Studies ◽  
Vitamin D Levels

Along with its role in regulation of calcium metabolism and bone health, vitamin D is essential for immune system integrity. Vitamin D is an essential immunomodulatory vitamin that interact with the immune system in response to foreign antigens. This interaction is mediated by the vitamin D receptors (VDR) expressed on the surface of various immune cells. Vitamin D has an inhibitory effect on synthesis and release of immunoglobulin E and thus is closely related to atopic disorders. Vitamin D deficiency is a risk factor for bronchial asthma, and it increased asthma-related exacerbation. Low vitamin D levels are encountered in patients with allergic rhinitis and increase the severity of the disease. Other allergic conditions such as atopic dermatitis, contact dermatitis, and food allergy were reported to be significantly correlated with vitamin D serum levels. Despite the established correlation between vitamin D and atopic disorders, double-blinded randomized controlled studies are still lacking to approve this relationship and to provide clear guidelines for the recommended supplementary doses of vitamin D to prevent or treat these conditions. This article aims to review the relationship between vitamin D deficiency and atopy in children.

Prevalence of Vitamin-D Deficiency in Patients with Acute Coronary Syndrome in Syria

2016 ◽  
Vol 9 (6) ◽  
pp. 3544-3548
Author(s):  
Aya Hallak ◽  
Malhis Mahmoud ◽  
Yaser Abajy Mohammad
Keyword(s):  
Vitamin D ◽  
Acute Coronary Syndrome ◽  
Vitamin D Deficiency ◽  
Hypovitaminosis D ◽  
Control Group ◽  
Coronary Syndrome ◽  
Normal Individuals ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
Coronary Syndromes

The objectives of this study were to estimate the prevalence of vitamin D deficiency in patients with acute coronary syndrome in comparison with normal individuals and study the correlation between these two conditions. We measured the plasma 25-hydroxy vitamin D (25-OH-D) levels in 60 patients with acute coronary syndromes (ACS) of both gender and in 30 age matched control individuals of both gender without any known cardiovascular or systemic diseases. The levels of 25-OH-D were measured by ELISA method and the results were statically analyzed to find out any possible correlation. We classified the cases according to their plasma 25(OH)D levels. 25(OH)D levels of ≥ 30 ng/ml were considered normal, levels < 30 and > 20 ng/ml were classified as insufficient, while levels of ≤ 20 ng/ml were classified as deficient. In the current study the prevalence of hypovitaminosis D in the patients group was much higher than it was in the control group. Vitamin D deficiency was observed in 80% and insufficiency in 13% of total patients of ACS, there by bringing the total count to 93%. Whereas only 7% of the patients had adequate vitamin D levels. Thus, these results indicate the existence of a significant correlation between the vitamin D deficiency and ACS in comparison to healthy controls

scholarly journals Serum levels of 25-hydroxy vitamin D correlate with idiopathic benign paroxysmal positional vertigo

2019 ◽  
Vol 39 (4) ◽  
Author(s):  
Jing Ding ◽  
Lei Liu ◽  
Wei-Kuan Kong ◽  
Xiao-Bing Chen ◽  
Xudong Liu
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Benign Paroxysmal Positional Vertigo ◽  
Serum Levels ◽  
Chinese Patients ◽  
Control Group ◽  
Binary Logistic Regression Analysis ◽  
Positional Vertigo ◽  
25 Hydroxy Vitamin D ◽  
Paroxysmal Positional Vertigo

Abstract Background: The present study aimed to evaluate serum 25-hydroxy vitamin D (25(OH) D) levels in Chinese patients with idiopathic benign paroxysmal positional vertigo (BPPV) and to investigate the possible relationship between the occurrence and recurrence of idiopathic BPPV and low 25(OH) D levels. Methods: Between 1 January 2017 and 31 May, 2018, consecutively older patients (age, older than 50 years) with idiopathic BPPV were recruited in the present study. For each patient, 2:1 sex and age matched healthy people were assigned as the control group. The influence of 25(OH) D levels on BPPV and recurrent BPPV were performed by binary logistic regression analysis. Results: In the present study, 174 patients with BPPV and 348 controls were included. The serum levels of 25(OH) D in those patients were lower than in those controls (P<0.001). One hundred eight patients were found to have vitamin D deficiency; thus, the prevalence was 62.1%, which was higher than that in the controls (42.8%). The data showed that patients with recurrent BPPV (N = 31) had lower serum levels of 25(OH) D compared with those who were not (11.2 ng/ml [interquartile range, 7.2–20.8 ng/ml] vs 18.7 ng/ml [14.2–24.8 ng/ml]). The regression analyses demonstrated that vitamin D deficiency was associated with BPPV and recurrent BPPV with an odds ratio of 2.15 (95% confidence interval [CI], 1.30–4.32; P=0.006) and 5.16 (95% CI, 1.00–34.12; P=0.05). Conclusion: Decreased serum levels of 25(OH)D were associated with the occurrence and recurrence of BPPV in a Chinese population, independent of other baseline markers.

scholarly journals Vitamin D and Immunological Patterns of Allergic Diseases in Children

Nutrients ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 177
Author(s):  
Agnieszka Lipińska-Opałka ◽  
Agata Tomaszewska ◽  
Jacek Z. Kubiak ◽  
Bolesław Kalicki
Keyword(s):  
Vitamin D ◽  
Immune System ◽  
Vitamin D Deficiency ◽  
Human Body ◽  
Clinical Course ◽  
Allergic Diseases ◽  
Control Group ◽  
Immunological Parameters ◽  
Vitamin D Receptors ◽  
Interleukin 22

Vitamin D, in addition to its superior role as a factor regulating calcium-phosphate metabolism, shows wide effects in other processes in the human body, including key functions of the immune system. This is due to the presence of vitamin D receptors in most cells of the human body. In our study, we aimed to assess whether there is a correlation between vitamin D content and the clinical course of allergic diseases as well as establish their immunological parameters in children. We found that vitamin D deficiency was significantly more frequent in the group of children with an allergic disease than in the control group (p = 0.007). Statistically significant higher vitamin D concentrations in blood were observed in the group of children with a mild course of the disease compared to children with a severe clinical course (p = 0.03). In the group of children with vitamin D deficiency, statistically significant lower percentages of NKT lymphocytes and T-regulatory lymphocytes were detected compared to the group of children without deficiency (respectively, p = 0.02 and p = 0.05), which highlights a potential weakness of the immune system in these patients. Furthermore, statistically higher levels of interleukin-22 were observed in the group of children with vitamin D deficiency (p = 0.01), suggesting a proinflammatory alert state. In conclusion, these results confirm the positive relationship between the optimal content of vitamin D and the lesser severity of allergic diseases in children, establishing weak points in the immune system caused by vitamin D deficiency in children.

scholarly journals Role of Vitamin D Receptor in Prediabetes

2020 ◽  
Vol 10 (1) ◽  
pp. 20-25
Author(s):  
Simmi Kharb ◽  
Kanika Goel ◽  
Rajesh Rajput
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Serum Vitamin ◽  
Receptor Protein ◽  
Control Group ◽  
Vitamin D Receptors ◽  
Serum Vitamin D ◽  
Protein Levels ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D

Background: Recent epidemiological evidence points towards the potential association of vitamin D insufficiency with adverse metabolic risk and in the pathogenesis of cancer, cardiovascular diseases, type 2 diabetes and other diseases. Vitamin D exerts its action in a variety of cell types through vitamin D receptors. No reports are available in the literature regarding vitamin D and vitamin D receptor status in prediabetics. The present study was planned to compare serum 25-hydroxy vitamin D [25(OH)D] and vitamin D receptor (VDR) protein levels in prediabetic cases and normoglycemic controls. Methods: The present study was conducted in 80 persons who were divided into two groups, Study group (n= 40) comprised of diagnosed cases of prediabetes and control group (n=40) comprised of healthy normoglycemic controls. Serum 25-hydroxy vitamin D [25(OH)D] was analyzed by radioimmunoassay (RIA). Serum vitamin D receptor (VDR) protein was analyzed by sandwich enzyme immunoassay (ELISA). Results: Serum 25(OH) vitamin D levels were significantly decreased in prediabetic cases as compared to normoglycemic controls [p<0.001]. Serum Vitamin D receptor protein levels were highly significantly decreased in prediabetic cases as compared to normoglycemic controls [p<0.00]. Serum 25(OH)D levels showed a highly significant positive correlation with serum VDR levels in both the groups [p<0.001 at both levels]. Conclusion: The findings of the present study indicate that vitamin D and VDR can serve as a possible screening marker and target for modulation of the management and alleviating the progress and complications of diabetes.

scholarly journals Association between Preeclampsia and vitamin D Deficiency

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A S Elhoussieny ◽  
M E Ibrahim ◽  
H F Gad ◽  
E H Mahdi
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Maternity Hospital ◽  
Control Group ◽  
Major Health Problem ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D

Abstract Background Preeclampsia is a pregnancy-specific disorder that affects 3–5% of pregnant women worldwide and is one of the most frequently encountered medical complications of pregnancy. Recent research has pointed towards some role of vitamin D deficiency in pathogenesis of preeclampsia. Vitamin D deficiency in pregnant women and their children is a major health problem, with potential adverse consequences for overall health. Aim of the Study The aim of this study is to investigate the serum vitamin D levels in preeclampsia and healthy normotensive pregnant women. Patients and Methods This case control study was conducted at Ain Shams University Maternity Hospital from November 2017. The study included pregnant women 20-35years this study will be carried out on pregnant women recruited at pre labour room (preeclamptic group) and (non preeclamptic group) at Ain Shams University Maternity Hospital, 50 women in each group. Results All samples were screened by DRG® 25-OH Vitamin D (total) ELISA (EIA-5396) and it was found that mean 25 hydroxy vitamin D levels were lower in preeclamptic group than normotensive control group. Mean level of 25 hydroxy vitamin D between preeclamptic cases was 13.98 ±4.98 ng/ml and between normotensive controls was15.62± 3.51 ng/ml. Conclusion This study has shown no association between vitamin D deficiency and pre-eclampsia, supporting no role for vitamin D as a preventative agent against preeclampsia.

scholarly journals Determining the Predictive Power of Vitamin D Levels in Iron Deficiency Anemia

2019 ◽  
Vol 1 (1) ◽  
pp. 29-35
Author(s):  
Sorush Niknamian
Keyword(s):  
Vitamin D ◽  
Iron Deficiency ◽  
Vitamin D Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Levels ◽  
Deficiency Anemia ◽  
Control Group ◽  
Case Group ◽  
Roc Curve Analysis ◽  
Vitamin D Levels

Background:Iron deficiency anemia is one of the most common hypochromic microcytic anemias and nutritional disorders in today’s world. Vitamin D is an important steroid hormone for the metabolism of serum calcium and phosphorus and plays a major role in the function of various body systems. Evidence suggests that vitamin D deficiency is associated with iron deficiency anemia. We aimed to compare the serum level of vitamin D between children with iron deficiency anemia and healthy ones. Methods: This case-control study was conducted on 60 patients with iron deficiency anemia and 60 healthy ones who did not suffer from iron deficiency anemia. Patients participated in the study voluntarily. Vitamin D levels were measured using HPLC and ferritin by RIA method. To estimate the predictive value of vitamin D levels in iron deficiency anemia, ROC curve analysis was used.  Results: In this study, 120 children aged 6-144 months with mean age of 30.2±31.4 months were analyzed; 49.2% of them were boys and 50.8% were girls. Vitamin D levels varied from 4.8 to 63.2 ng/ml with a mean of 23.87±12.57 ng/ml in all patients (19.25±9.15 ng/ml in the case group and 28.48±13.84 ng/ml in the control group (P<0.001). In other words, patients with a vitamin D level <23.6 ng/ml should be investigated for iron deficiency anemia, and sufficient vitamin D had a protective effect on iron deficiency anemia and each unit increase in vitamin D decreased the chance of iron deficiency anemia by 7.8%. Conclusion: The prevalence of simultaneous iron deficiency anemia and vitamin D deficiency is very high in children and there is a significant relationship between serum levels of 25(OH)D and hemoglobin.

scholarly journals Decreased Level of Vitamin D is Associated with Rheumatoid Arthritis Patients from Western Region of Nepal

2018 ◽  
Vol 11 (02) ◽  
pp. 46-50
Author(s):  
Basant Kumar Tamrakar ◽  
D Karki ◽  
A Nagila
Keyword(s):  
Rheumatoid Arthritis ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Research Centre ◽  
Control Group ◽  
Erythrocyte Sedimentation ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
Antibody Levels

Background: Rheumatoid Arthritis (RA) is a progressive, chronic type of autoimmune disease and the role of vitamin D in the pathogenesis of RA is under investigation. Objective: The objective of this study was to determine the vitamin D deficiency in patients with RA as compared to healthy controls and to assess the relationship between serum vitamin D and anti-cyclic citrullinated peptide (anti-CCP) antibody levels in patients with newly diagnosed rheumatoid arthritis. Methods: The study was conducted between January 2017 to February 2018 at Fishtail Hospital and Research centre. A total of 63 patients with early RA diagnosed and a control group of 56 healthy participants, not on vitamin D supplements were recruited from Department of Internal Medicine. Five ml of blood samples were drawn from cubital veins. Blood glucose, creatinine, uric acid, calcium, RA factor, 25-hydroxy vitamin D, anti-CCP antibody, and erythrocyte sedimentation rates were measured in a centralized laboratory of Fishtail Hospital and Research centre. Results: The level of serum 25-hydroxy vitamin D were significantly lower in RA group (20.03 ±9.97 ng/mL) in comparison to the control group (24.46 ±8.45 ng/mL) (p<0.003). Our result indicates the prevalence of vitamin D deficiency was more in RA group compared with control group (47.61% vs. 33.16%, p <0.002). The level of Anti-CCP is significantly high in RA group than control group. In RA patients serum 25-hydroxy vitamin D levels were negatively correlated to anti-CCP antibody levels (rs = 0.72, p <0.001), and erythrocyte sedimentation rate (rs = 3.95, p <0.005). Conclusion: In RA patient vitamin D deficiency is quite common and serum 25-hydroxy vitamin D level was negatively correlated to anti-CCP antibody level. Our results suggest that vitamin D level is a motivation factor rather than a consequence of RA activity.

Vitamin D among Patients of Pulmonary and Extrapulmonary Tuberculosis: A Prospective Case-control Study

2020 ◽  
Vol 16 (1) ◽  
pp. 59-65
Author(s):  
Doaa Gadallah ◽  
Ahmed Sedky ◽  
Hend Mohamed Esmaeel
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Extrapulmonary Tuberculosis ◽  
Serum Levels ◽  
Case Control ◽  
Normal Serum ◽  
Control Group ◽  
Tb Treatment ◽  
Vitamin D Levels ◽  
Control Study

Background: Vitamin D has an essential role in enhancing the immune system to fight and destroy bacteria. People with vitamin D deficiency are highly liable to develop active pulmonary and extrapulmonary tuberculosis. Objective: : To evaluate the serum level of vitamin D among patients with pulmonary and extrapulmonary tuberculosis. Patients and Methods: A case-control prospective study was conducted among patients with pulmonary and extrapulmonary tuberculosis and asymptomatic persons (controls). The study included 80 participants, 50 were TB patients, while 30 were controls. Vitamin D 1, 25(OH) assay was done for all. Results: Vitamin D assay of the included subjects revealed that 52 patients were vitamin D deficient, 7 patients had insufficient vitamin D and 21 had normal serum levels. Of the extrapulmonary TB patients, 35 (100%) had vitamin D deficiency, in pulmonary TB patients, 15 (100%) were vitamin D deficient. While 2 study subjects (6.7%) in the control group were deficient of vitamin D, 7 (23.3%) had insufficient vitamin D and 21cases had normal vitamin D levels. There was a statistically significant relationship between pulmonary and extrapulmonary TB cases and vitamin D deficiency (P< 0.001). Conclusion: Vitamin D deficiency was found among pulmonary and extrapulmonary tuberculosis patients especially among female patients and patients in rural residence. The current study needs additional work to evaluate the value of adding vitamin D to the TB treatment regimen.

scholarly journals To Supplement or not to Supplement? The Rationale of Vitamin D Supplementation in Systemic Lupus Erythematosus

2018 ◽  
Vol 12 (1) ◽  
pp. 226-247 ◽  
Author(s):  
Alessandra Nerviani ◽  
Daniele Mauro ◽  
Michele Gilio ◽  
Rosa Daniela Grembiale ◽  
Myles J. Lewis
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Lupus Erythematosus ◽  
Clinical Manifestations ◽  
Vitamin D Supplementation ◽  
Current Evidence ◽  
Systemic Lupus ◽  
Vitamin D Receptors ◽  
Vitamin D Levels

Background: Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease characterised by abnormal activation of the immune system, chronic inflammation and organ damage. Lupus patients are more prone to be vitamin D deficient. However, current evidence is not conclusive with regards to the role played by vitamin D in SLE development, progression, and clinical manifestations. Objective: Here, we will summarise the current knowledge about vitamin D deficiency prevalence, risk factors, molecular effects, and potential pathogenic role in SLE. We will focus on the link between vitamin D deficiency and lupus clinical manifestations, and on the clinical trials assessing the effects of vitamin D supplementation in SLE. Method: A detailed literature search was performed exploiting the available databases, using “vitamin D and lupus/SLE” as keywords. The relevant interventional trials published over the last decade have been considered and the results are reported here. Conclusion: Several immune cells express vitamin D receptors. Thus, an immunomodulatory role for vitamin D in lupus is plausible. Numerous observational studies have investigated the relationship between vitamin D levels and clinical/serological manifestations of SLE with contrasting results. Negative correlations between vitamin D levels and disease activity, fatigue, renal and cardiovascular disease, and anti-dsDNA titres have been described but not conclusively accepted. In experimental models of lupus, vitamin D supplementation can improve the disease. Interventional trials have assessed the potential therapeutic value of vitamin D in SLE, but further larger studies are needed.

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