scholarly journals Investigation of Astaxanthin Effect on Cisplatin Ototoxicity in Rats by Using Otoacoustic Emission, Total Antioxidant Capacity, and Histopathological Methods

2019 ◽  
pp. 014556131986682 ◽  
Author(s):  
M. Emrah Kınal ◽  
Arzu Tatlıpınar ◽  
Selami Uzun ◽  
Serhan Keskin ◽  
Emrah Tekdemir ◽  
...  
Keyword(s):  
Protective Effect ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Otoacoustic Emission ◽  
The Other ◽  
Female Rats ◽  
Control Group ◽  
Hearing Level ◽  
Significant Difference ◽  
Total Antioxidant

Background: Cisplatin-induced ototoxicity is related to oxidative stress. Astaxanthin is one of the most powerful antioxidants in nature. Aims/objectives: To investigate the protective effect of astaxanthin on cisplatin-induced ototoxicity. Materials and Methods: Thirty-five Sprague Dawley female rats were divided into 5 groups: control, cisplatin, and cisplatin with 10, 20, and 40 mg/kg astaxanthin groups. Cisplatin group received a single intraperitoneal injection of 14 mg/kg cisplatin. While saline was administered in the control group, in the other 3 groups, 10, 20, and 40 mg/kg daily doses of astaxanthin were administered through orogastric cannula before administration of cisplatin. Baseline and 10th day otoacoustic emission tests were administered. An intracardiac blood sample was taken to measure total antioxidant capacity (TAC), and the cochleas of the animals were investigated histopathologically. Results: Hearing level of astaxanthin 40 mg/kg + cisplatin group was higher at 24 kHz and 32 kHz frequencies compared to the cisplatin group. The TAC value of the cisplatin group was lower than both the control and astaxanthin + cisplatin groups ( P < .05). On histopathological examination, the other groups were deformed compared to the control group, but no statistically significant difference was observed between the astaxanthin + cisplatin and cisplatin groups. Conclusions and significance: Astaxanthin showed protective effect at high frequencies when it was administered at high dose. Thus, astaxanthin may have protective effect against cisplatin-induced ototoxicity.

scholarly journals Blood Levels of Oxidant/Antioxidant Parameters in Rats Infected withToxoplasma gondii

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Somayeh Bahrami ◽  
Ali Shahriari ◽  
Mehdi Tavalla ◽  
Somayeh Azadmanesh ◽  
Hossein Hamidinejat
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Parasitic Infection ◽  
Chronic Phase ◽  
Antioxidant Defense System ◽  
Female Rats ◽  
Control Group ◽  
Blood Levels ◽  
Total Antioxidant

Toxoplasmosis is a common parasitic infection in the world. Since increased free radicals and oxidative stress are reported in many parasitic diseases the purpose of the present study was to evaluate the oxidative stress in acute and chronic toxoplasmosis. RH strains ofToxoplasmatachyzoites were used in the present study. Twenty-five female rats were infected with the parasite while 25 other rats were as the control group that received normal saline. Zero-, 5-, 7-, 10-, and 45-day postinfection (DPI) blood samples were taken. Some parameters related to oxidant and antioxidants such as antioxidant enzymes, malondialdehyde, and total antioxidant capacity were measured. On day 7 after infection, GPX activity and GSH level were significantly increased and in the mentioned day the amount of total antioxidant capacity was significantly reduced. In other cases, there were no significant differences between the groups in different days. Overall, based on the results it seems that, on day 7 after infection, in infected rats responses to oxidative stress were triggered and led to decrease of total antioxidant capacity. Furthermore, glutathione was increased to cope with stress. It seems that probably antioxidant defense system entered the infection to the chronic phase and changed the parasites stage.

scholarly journals Evaluation of Total Antioxidant Capacity of Saliva in High School Students

2015 ◽  
Vol 8 (4) ◽  
pp. 89 ◽  
Author(s):  
Mahmoud Rahmani ◽  
Vahideh Ghorchi ◽  
Fatemeh Rezaei ◽  
Asad Vaisi-Raygani
Keyword(s):  
High School ◽  
High School Students ◽  
Dental Caries ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Control Group ◽  
School Students ◽  
Significance Level ◽  
Significant Difference ◽  
Total Antioxidant

<p><strong>BACKGROUND &amp; OBJECTIVE: </strong>Imbalance between oxidative stress and saliva antioxidants plays a major role in initiation and spread of dental caries. The aim of this study was to evaluate the total antioxidant capacity (TAC) of saliva in dental caries.</p><p><strong>METHODS: </strong>In this case-control study which employed high school students (14-18 years), the un-stimulated saliva samples of 60 students without dental caries (control group) and 60 students with dental caries (with at least 5 teeth levels of dental caries) were gathered. Each group comprised of males (half of cases) and females (half of cases). TAC of saliva was measured by Zellbio® (Netherlands) in terms of micmol/L. The data were analyzed using the SPSS software (ver. 17.0) and t-test with considering significance level at 0.05.</p><p><strong>RESULTS</strong><strong>:</strong> TAC of saliva was significantly lower in cases with dental caries (0.256±0.106) compared to those without dental caries (0.396±0.077); P&lt; 0.001. There was no statistically significant difference of TAC of saliva between males (0.319±0.119) and females (0.333±0.113) irrespective of dental caries (P=0.507).</p><p><strong>CONCLUSION: </strong>The results of the study indicated that there was a reverse association between dental caries and TAC of saliva.</p>

scholarly journals Effects of Thymoquinone on Sperm Parameters, Apoptosis, Testosterone Level, and Oxidative Stress in a Mouse Model of D-Galactose-Induced Aging

2018 ◽  
Vol 24 (3) ◽  
pp. 180-186 ◽  
Author(s):  
Seyedeh Saleheh Attari ◽  
Shabnam Mohammadi ◽  
Alireza Ebrahimzadeh ◽  
Hossein Hosseinzadeh ◽  
Mohammad Soukhtanloo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mouse Model ◽  
Antioxidant Capacity ◽  
Testosterone Level ◽  
Total Antioxidant Capacity ◽  
Sperm Parameters ◽  
Control Group ◽  
Significant Difference ◽  
Total Antioxidant ◽  
And Oxidative Stress

Background: The aging process is accompanied by low secretion of sex hormones and testicular apoptosis. The antioxidant properties of thymoquinone (TQ) may prevent the effects of aging. Therefore, in the present study, the effects of different doses of TQ were investigated on sperm parameters, testosterone level, apoptosis, and oxidative stress in a mouse model of D-galactose-induced aging. Methods: In this experimental study, 30 adult male mice were randomly divided into 5 groups. The control group did not receive any injections, while the D-galactose group received an intraperitoneal injection of 300 mg/kg of D-galactose for 42 days. The TQ1-TQ3 groups received intraperitoneal injections of 5, 2.5, and 1.25 mg/kg of TQ plus D-galactose, respectively for 14 days (from the 1st to the 14th day of the experiment). The morphometric analysis, testicular apoptosis examination, and sperm analysis were performed, and testosterone level, total antioxidant capacity, and malondialdehyde level were evaluated on day 42 of the experiment. Data were analyzed using SPSS. Results: Administration of TQ in the TQ1 group caused a significant difference in sperm parameters, compared to the D-galactose group (P<0.05). The lowest amount of positive tunnel cells was related to 5 mg/kg of TQ and the highest to 2.5 mg/kg of TQ. There was no significant difference in the parameters of seminal vesicles, epididymis, prostate, and testis between the groups (P>0.05). The malondialdehyde level were decreased in the TQ1-TQ3 groups, compared to the D-galactose group (P<0.001). On the other hand, the total antioxidant capacity was increased significantly in the TQ1 group, compared to the D-galactose group (P<0.001). Conclusion: Administration of 5 mg of TQ for 14 days improved sperm quality and biochemical parameters, while reducing apoptotic cells of the testes in a mouse model of aging.

scholarly journals In Ovo Injection of GABA Can Help Body Weight Gain at Hatch, Increase Chick Weight to Egg Weight Ratio, and Improve Broiler Heat Resistance

Animals ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1364
Author(s):  
Chris Major Ncho ◽  
Akshat Goel ◽  
Chae-Mi Jeong ◽  
Mohamed Youssouf ◽  
Yang-Ho Choi
Keyword(s):  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Antioxidant Status ◽  
Body Weight Gain ◽  
Weight Ratio ◽  
The Other ◽  
Mrna Levels ◽  
In Ovo ◽  
Total Antioxidant ◽  
In Ovo Injection

The aim of this study was to explore the outcomes of an in ovo GABA injection in broilers challenged with HS. In Experiment 1, 210 Arbor Acres eggs were allocated to five treatments: no-injection, and in ovo injection of 0.6 mL of 0%, 5%, 10%, or 20% of GABA. Hatchling weight and CWEWR were significantly increased in the 5% GABA group. In ovo, injection of 10% GABA solution caused a significant decrease in plasma cholesterol and increased plasma total antioxidant capacity of hatchlings. Experiment 2 was conducted with 126 fertile Arbor Acres eggs distributed into one of two groups. At 17.5 days of incubation, one received no injection, and the other was fed 0.6 mL of 10% GABA. On day 10, one subgroup (4 replicates * 3 birds) from each treatment was submitted to HS (38 ± 1 °C for 3 h) while the other was kept at a thermoneutral temperature (29 ± 1 °C). An in ovo injection of GABA significantly increased total antioxidant capacity, but reduced malondialdehyde levels, hepatic mRNA levels of HSP70, FAS, and L-FABP with HS. In conclusion, an in ovo GABA injection improves CWEWR and antioxidant status at hatch, and enhances antioxidant status while downregulating the expression of HSP70 and fatty acid metabolism-related genes in young chicks under HS.

scholarly journals Radioprotective and anti-diabetic effects of Costus speciosus and carnosine

2020 ◽  
Vol 19 (1) ◽  
pp. 121-127
Author(s):  
Ebtisam A. Marzook ◽  
Fawzy A. Marzook ◽  
Ahmed E. Abd El Moneim
Keyword(s):  
Gamma Radiation ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Natural Antioxidants ◽  
Serum Levels ◽  
Serum Glucose ◽  
Control Group ◽  
Albino Rats ◽  
Costus Speciosus ◽  
Total Antioxidant

Purpose: To evaluate the possible radioprotective effect of Costus speciosus and carnosine as natural antioxidants in order to control the  hyperglycemia developed in male albino rats exposed to acute oxidative stress induced by gamma radiation. Methods: Twenty-eight adult male albino rats were divided into four groups. The first group was taken as a control group, while the three other groups were exposed to Ɣ irradiation at a single 7.5 Gy dose. Furthermore, the rats in the second and third groups were i.p. injected with Costus speciosus root powder and carnosine, respectively. On the 3rd day, after irradiation, the serum levels of glucose, insulin, C peptide, copper, iron, calcium, total antioxidant capacity (TAC) and malondialdehyde (MDA) were measureded. Results: The results revealed that exposure to Ɣ irradiation induced significant increases in serum glucose, iron, and malondialdehyde. However, the levels of serum calcium, copper, total antioxidant capacity and insulin significantly decreased (p < 0.05). A significant decrease was observed in Cpeptide in the exposed group, compared to control group. All the test parameters indicate improvement after treatment with Costus speciosus and carnosine (p < 0.05). Conclusion: Costus speciosus and carnosine ameliorate the effect of gamma radiation, indicating their role as antidiabetic agents and  radioprotectors; however, Costus speciosus was critically more efficient than carnosine. Keywords: Costus speciosus, Carnosine, Diabetes, Insulin, Gamma radiation protection

scholarly journals Evaluation of Salivary and Serum Total Antioxidant Capacity and Lipid Peroxidation in Postmenopausal Women

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Fatemeh Zovari ◽  
Hadi Parsian ◽  
Ali Bijani ◽  
Ameneh Moslemnezhad ◽  
Atena Shirzad
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Antioxidant Capacity ◽  
Postmenopausal Women ◽  
Total Antioxidant Capacity ◽  
Premenopausal Women ◽  
Control Group ◽  
Antioxidant Power ◽  
Whole Saliva ◽  
Total Antioxidant

Objective. In menopause, reduction of estrogen hormone affects oxidative stress process in serum. Oxidative stress in saliva plays a significant role in the pathogenesis of oral diseases. The aim of this study was to investigate the total antioxidant capacity and lipid peroxidation in the serum and saliva of premenopausal and postmenopausal women. Methods. In this case control study, 50 postmenopausal women (case group) and 48 premenopausal women (control group) were selected. The unstimulated whole saliva and serum of the postmenopausal and premenopausal women were collected. The total antioxidant capacity (TAC) of the saliva and serum was measured by ferric reducing antioxidant power (FRAP). Also, malondialdehyde (MDA) was measured by thiobarbituric acid reactive substance (TBARS) method for serum and saliva. Then, the obtained data were analyzed by SPSS 17, whereby Mann–Whitney test and Spearman’s correlation test were used. P < 0.05 was considered statistically significant. Results. The postmenopausal group had significantly lower mean serum TAC and higher mean serum MDA than the control group ( P < 0 < 001 and P < 0.01 , respectively). The mean salivary TAC and MDA, however, did not differ significantly between the case and control group ( P = 0.64 and P = 0.08 , respectively). Conclusion. In postmenopausal women, with elevation of serum MDA and reduction of serum TAC, the extent of serum oxidative stress grows, but MDA and TAC levels of saliva do not change.

Long-Term Protective Effect of N-Acetylcysteine against Amikacin-Induced Ototoxicity in End-Stage Renal Disease: A Randomized Trial

2018 ◽  
Vol 38 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Alperen Vural ◽  
İsmail Koçyiğit ◽  
Furkan Şan ◽  
Eray Eroğlu ◽  
İbrahim Ketenci ◽  
...  
Keyword(s):  
Protective Effect ◽  
Pure Tone Audiometry ◽  
The Other ◽  
Control Group ◽  
Tnf Α ◽  
Significant Difference ◽  
Hearing Test ◽  
Stage Renal Disease ◽  
End Stage

Background The aim of the study is to evaluate the long-term protective effect of N-acetylcysteine (NAC), an antioxidant agent, against aminoglycoside (AG)-induced ototoxicity. Methods A total of 40 patients receiving continuous ambulatory peritoneal dialysis (CAPD) and having their first peritonitis attacks and planned to be treated with AGs were enrolled in the study. They were randomized into 2 groups: 1 group received additional NAC and the other did not. All patients underwent hearing tests with pure tone audiometry (PTA) after the diagnosis, at 1 month and 12 months and at the same time the tumor necrosis factor (TNF)-α and interleukin (IL)-6 levels were measured. Results Patients taking NAC had better hearing test results in both ears at 1 month except 2,000 Hz for the left ear, which wasn't significantly different between the 2 groups. Although patients taking NAC had generally better PTA results at 12 months, differences between the 2 groups were not statistically significant. Baseline IL-6 level was significantly higher in the NAC group than the control group. Both TNF-α and IL-6 levels at 1 month were significantly lower in the NAC group than in the control group. On the other hand, there was no significant difference between the 2 groups in terms of TNF-α and IL-6 levels at 12 months. Conclusions The results of the current study showed that NAC, a potent anti-inflamatory drug, may be otoprotective, but that the effect is not long-lasting.

scholarly journals Pengaruh pemberian buah naga merah, jambu biji merah, dan kombinasinya terhadap kapasitas antioksidan total dan kadar malondealdehid pada remaja perokok

2020 ◽  
Vol 9 (1) ◽  
pp. 53-60
Author(s):  
Mohammad Zainul Ma'arif ◽  
Suradi Suradi ◽  
Sugiarto Sugiarto
Keyword(s):  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
The Body ◽  
Smoking Habits ◽  
Control Group ◽  
Male Adolescent ◽  
Dragon Fruit ◽  
Dpph Method ◽  
Total Antioxidant ◽  
The Mean

Background: Smoking habits enhance free radical in the body, which oxidize lipids to form malondialdehyde. One group that is vulnerable to smoking is adolescents. Red dragon fruit and red guava have the possibility as functional foods due to their vitamin and phytochemical content, which have antioxidant effects. This is an opportunity to prevent oxidative stress among adolescent smokers.Objectives: This study aimed to analyze the effect of red dragon fruit, red guava, and its combination to total antioxidant capacity (TAC) and malondialdehyde (MDA) levels among adolescent mild smokers.Methods: This research was an experimental study with a randomized pre-test and post-test control group design. Forty-eight subjects of male adolescent aged 16-17 years with mild smoking habits were divided into four groups: the control group (K), the intervention group with 200 grams of red dragon fruit (P1), 200 grams of red guava (P2), and the combination of both (100 grams red dragon fruit + 100 grams red guava) (P3), for 14 days. TAC examination used the DPPH method and MDA levels using the TBARS method were measured before and after the intervention.Results: After 14 days of intervention, the mean TAC was changed by -0,10±0,76 in the K group, 0,97±1,62 in the P1 group, 0,74±1,39 in the P2 group, and 0,74±1,29 in the P3 group. But the changes of TAC in all intervention groups were not significantly different from the control group (p>0,05). The mean MDA level changed by 0,229±0,371 in the K group, decreased by -0,654±0,922 in the P1 group, -0,592±0,818 in the P2 group, and -1,166±0,670 in the P3 group. The mean difference of the MDA level in all intervention groups was significantly different from the control group (p<0,05).Conclusion: Consumption of red dragon fruit, red guava, or a combination of red dragon fruit and red guava can reduce malondialdehyde levels significantly among male adolescent mild smokers. Whereas the total antioxidant capacity was changed but not significant.

scholarly journals PO-198 Effect of aerobic exercise on antioxidation ability of mice kidneys

2018 ◽  
Vol 1 (4) ◽  
Author(s):  
Sisi He ◽  
Haitao Wang
Keyword(s):  
Aerobic Exercise ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Kidney Tissue ◽  
Exercise Group ◽  
Control Group ◽  
Adult Group ◽  
Total Antioxidant ◽  
The Difference ◽  
Control Group Group

Objective To study the total antioxidant capacity of the kidney in the Aged mice Total Antioxidant Capacity(T-AOC), Malondialdehyde (MDA) and superoxide dismutase (SOD) expression level by aerobic exercise. Objective to explore the effect of aerobic exercise on antioxidation ability of mice. Methods 30 Male C57BL/6 strain mice were randomly divided into adult group ( group CC) in the 13 months old, in the control group (Group C), 5 months of quiet feeding, the aerobic exercise group (Group E) ran for 5 months, 10 per group, and the adult group (group CC) compared with the control group (Group C), The Analysis control Group (Group C) was compared with the aerobic exercise group (Group E). After 5 months of Treadmill running in Group E, Determination of antioxidant index of each group. The statistical method is processed by SPSS20.0 statistic software, the experimental data is expressed by the mean ± standard deviation, the two mean numbers are analyzed by independent sample t test, and the difference of (p<0.05) is statistically significant. Results T-AOC of adult Group was (0.99±0.13) U/mg Prot, control group was (0.27±0.07) u/mg prot, aerobic exercise group (0.39±0.10) U/mg prot, adult group SOD as (46.32± 1.84) U/mg, control Group (29.71±7.64) U/mg, aerobic exercise group (39.85±5.83) U/mg, adult group MDA (8.15±0.16) nmol/mg, control Group (8.83±0.26) nmol/mg, The aerobic exercise group was (6.31±1.23) nmol/mg, the adult group was SOD/MDA (5.69±0.32), the control group was (3.38±0.9) and the aerobic exercise group was (6.55±1.08). Compared with the adult group, the control group T-AOC and SOD decreased significantly, MDA significantly increased, the difference was very significant (p<0.01), sod/mda significantly decreased, SOD/MDA difference was significant (p<0.01). Compared with the control group, the aerobic exercise group T-AOC and SOD obviously increased, MDA significantly decreased, the difference was significant (p<0.01), SOD/MDA increased significantly, the difference was very significant (p<0.01). Conclusions To sum up, with the increase of the age of mice MDA expression is increased, the 18 months old SOD expression is lower than 13 months old, indicating that the antioxidant capacity with the increase in age,  The results of this study are consistent with the results of previous scholars. The results show that aerobic exercise has some antioxidant effect, and aerobic exercise can decrease expression of kidney tissue SOD, raise the expression of kidney tissue T-AOC, increase the expressionof kidney tissue, increase the expression  of SOD/MDA, and reduce the oxidative stress of kidney to some extent,  So as to protect the role of the kidney, aerobic exercise and kidney-related mechanisms also need our further study.

scholarly journals Pengaruh aplikasi gel teh hijau (Camellia sinensis) terhadap kadar total antioxidant capacity (TAOC) sebagai perawatan tambahan dari skeling dan root planing pada pasien dengan periodontitis kronisEffect of green tea (Camellia sinensis) gel application on the total antioxidant capacity (TAOC) levels as adjunct to scaling and root planing in patients with chronic periodontitis

2020 ◽  
Vol 32 (2) ◽  
pp. 156
Author(s):  
Nita Nurniza ◽  
Ina Hendiani ◽  
Ira Komara
Keyword(s):  
Antioxidant Capacity ◽  
Green Tea ◽  
Camellia Sinensis ◽  
Chronic Periodontitis ◽  
Total Antioxidant Capacity ◽  
Scaling And Root Planing ◽  
Root Planing ◽  
Significant Difference ◽  
Total Antioxidant ◽  
Test Side

Pendahuluan: Mekanisme peradangan periodontitis kronis menghasilkan reaksi oksidasi, diketahui melalui kadar total antioxidant capacity (TAOC) cairan sulkus gingiva. Teh hijau dapat menghambat bakteri patogen periodontal sehingga kerusakan jaringan periodontal tidak bertambah parah. Tujuan penelitian adalah menganalisis kadar TAOC sebelum dan sesudah skeling dan root planing disertai gel teh hijau sebagai antioksidan. Metode: Jenis penelitian eksperimen semu, rumus ukuran sampel untuk menguji perbedaan dua rata-rata data tidak berpasangan, setiap subyek memiliki poket ≥ 5 mm, dikelompokkan sisi uji (n=14) dan sisi kontrol (n=14) (split mouth). Pengambilan cairan sulkus gingiva dilakukan pada hari ke-0, 15, dan 30, menggunakan metode absorbing paper strip dengan cara intracrevicular. Kedua sisi dilakukan skeling dan root planing, sisi uji diberikan gel. Hasil: Perbandingan kadar TAOC antara sisi kontrol dan sisi uji pada hari ke-0 (p=0,986), hari ke-15 (p=0,836), dan hari ke-30 (p=0,371) menunjukkan tidak terdapat perbedaan bermakna (p-value>0,05). Perbandingan rerata selisih kadar TAOC dalam kedua kelompok antara hari ke-0 dengan ke-15 (p=0,946), hari ke-0 dengan hari ke-30 (p=0,504), serta hari ke-15 dengan hari ke-30 (p=0,811) jugwa menunjukkan tidak terdapat perbedaan bermakna. Simpulan: Tidak terdapat pengaruh aplikasi gel teh hijau (Camellia sinensis) terhadap kadar total antioxidant capacity (TAOC) pada perawatan periodontitis kronis berupa skeling dan root planing.Kata kunci: Gel teh hijau, periodontitis kronis, skeling dan root planing, total antioxidant capacity (TAOC). ABSTRACTIntroduction: The inflammatory mechanism of chronic periodontitis produces an oxidation reaction, measured through the level of total antioxidant capacity (TAOC) of the gingival crevicular fluid. Green tea can inhibit periodontal pathogenic bacteria so that periodontal tissue damage will not worsen. This study was aimed to analyse the levels of TAOC before and after scaling and root planing with green tea gel as an antioxidant. Methods: The research was quasi-experimental. The sample size formula was used to test the difference between two unpaired data means. Each subject has a pocket ≥ 5 mm, grouped by the test side (n = 14) and the control side (n = 14) (split-mouth). The gingival crevicular fluid was collected on days 0, 15, and 30, using the intracrevicular method with absorbing paper strips. Both sides were treated with scaling and root planing, and the test side was administered with the green tea gel. Results: Comparison of TAOC levels between the control side and the test side on day 0 (p = 0.986), day 15 (p = 0.836), and day 30 (p = 0.371) showed no significant difference (p-value > 0.05). Comparison of the mean difference of the TAOC levels in two groups between day 0 with day 15 was p = 0.946, day 0 with day 30 was p = 0.504, and day 15 with day 30 was p = 0.811; which also showed no significant difference. Conclusion: There is no effect of green tea gel (Camellia sinensis) application on the Total Antioxidant Capacity (TAOC) level in chronic periodontitis treatment in the form of scaling and root planing.Keywords: Green tea gel, chronic periodontitis, scaling and root planing, total antioxidant capacity (TAOC).

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