Serum melatonin levels are associated with mortality in patients with malignant middle cerebral artery infarction

Objectives Lower serum melatonin levels are found in patients with ischaemic stroke compared with healthy controls. This study aimed to determine whether serum melatonin levels are associated with peroxidation status, antioxidant status, and mortality in patients with ischaemic stroke. Methods Patients with severe malignant middle cerebral artery infarction (MMCAI), defined as a Glasgow coma scale (GCS) score lower than 9, were included. Serum levels of melatonin, malondialdehyde (to assess lipid peroxidation), and total antioxidant capacity at the time of diagnosing MMCAI were determined. We chose 30-day mortality as the endpoint of the study. Results We found significantly higher serum levels of melatonin, total antioxidant capacity, and malondialdehyde in non-survivors (n = 32) than in survivors (n = 32) with MMCAI. Serum melatonin levels were associated with 30-day mortality (odds ratio = 2.205; 95% confidence interval = 1.294–3.759) after controlling for GCS score and age. We found a positive association between serum melatonin levels and total antioxidant capacity (rho = 0.36), and between serum melatonin and malondialdehyde levels (rho = 0.35). Conclusions Our study shows that serum melatonin levels are associated with peroxidation status, antioxidant status, and mortality in patients with MMCAI.

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In Ovo Injection of GABA Can Help Body Weight Gain at Hatch, Increase Chick Weight to Egg Weight Ratio, and Improve Broiler Heat Resistance

Animals ◽

10.3390/ani11051364 ◽

2021 ◽

Vol 11 (5) ◽

pp. 1364

Author(s):

Chris Major Ncho ◽

Akshat Goel ◽

Chae-Mi Jeong ◽

Mohamed Youssouf ◽

Yang-Ho Choi

Keyword(s):

Antioxidant Capacity ◽

Total Antioxidant Capacity ◽

Antioxidant Status ◽

Body Weight Gain ◽

Weight Ratio ◽

The Other ◽

Mrna Levels ◽

In Ovo ◽

Total Antioxidant ◽

In Ovo Injection

The aim of this study was to explore the outcomes of an in ovo GABA injection in broilers challenged with HS. In Experiment 1, 210 Arbor Acres eggs were allocated to five treatments: no-injection, and in ovo injection of 0.6 mL of 0%, 5%, 10%, or 20% of GABA. Hatchling weight and CWEWR were significantly increased in the 5% GABA group. In ovo, injection of 10% GABA solution caused a significant decrease in plasma cholesterol and increased plasma total antioxidant capacity of hatchlings. Experiment 2 was conducted with 126 fertile Arbor Acres eggs distributed into one of two groups. At 17.5 days of incubation, one received no injection, and the other was fed 0.6 mL of 10% GABA. On day 10, one subgroup (4 replicates * 3 birds) from each treatment was submitted to HS (38 ± 1 °C for 3 h) while the other was kept at a thermoneutral temperature (29 ± 1 °C). An in ovo injection of GABA significantly increased total antioxidant capacity, but reduced malondialdehyde levels, hepatic mRNA levels of HSP70, FAS, and L-FABP with HS. In conclusion, an in ovo GABA injection improves CWEWR and antioxidant status at hatch, and enhances antioxidant status while downregulating the expression of HSP70 and fatty acid metabolism-related genes in young chicks under HS.

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Serum Levels of B-cell Lymphoma-2 Anti-Apoptotic Protein and Malignant Middle Cerebral Artery Infarction Mortality

Journal of Stroke and Cerebrovascular Diseases ◽

10.1016/j.jstrokecerebrovasdis.2021.105717 ◽

2021 ◽

Vol 30 (5) ◽

pp. 105717

Author(s):

Leonardo Lorente ◽

María M. Martín ◽

Agustín F. González-Rivero ◽

Antonia Pérez-Cejas ◽

Luis Ramos-Gómez ◽

...

Keyword(s):

B Cell ◽

Middle Cerebral Artery ◽

Cerebral Artery ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Serum Levels ◽

Middle Cerebral Artery Infarction ◽

Apoptotic Protein

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Estimation of carotinoid, antioxidant, and oxidant statusby biophotonic scanning in healthy and sick persons with risk factorsof atherosclerosis

Bulletin of Siberian Medicine ◽

10.20538/1682-0363-2007-4-31-36 ◽

2007 ◽

Vol 6 (4) ◽

pp. 31-36

Author(s):

V. N. Kim ◽

G. V. Krivulina ◽

V. M. Shevelyev ◽

T. Ye. Suslova ◽

O. V. Gruzdeva ◽

...

Keyword(s):

Cardiovascular Diseases ◽

Antioxidant Capacity ◽

Dietary Supplements ◽

Total Antioxidant Capacity ◽

Antioxidant Status ◽

High Accuracy ◽

Cardiovascular Risks ◽

Total Antioxidant ◽

Healthy Persons

High accuracy of biophotonic scanning in estimation of skin carotinoid score (SCS) and antioxidant status after 8-week period of correction by LifePak, MarineOmega, and Tegreen97 active dietary supplements is proved in 45 healthy persons with cardiovascular risks and in patients with cardiovascular diseases. SCS increased by 42.8% (p = 0.005) and total antioxidant capacity of blood (TAC) increased by 36.4% (p = 0.005) in health people; while in patients SCS increased by 47.4% (p = 0.001) and TAC increased by 30.3% (p = 0.008). The SCS accuracy in estimation of antioxidant status was 87%.

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High serum levels of caspase-cleaved cytokeratin-18 are associated with malignant middle cerebral artery infarction patient mortality

BMC Neurology ◽

10.1186/s12883-018-1038-z ◽

2018 ◽

Vol 18 (1) ◽

Cited By ~ 7

Author(s):

Leonardo Lorente ◽

María M. Martín ◽

Antonia Pérez-Cejas ◽

Luis Ramos ◽

Mónica Argueso ◽

...

Keyword(s):

Middle Cerebral Artery ◽

Cerebral Artery ◽

Serum Levels ◽

High Serum ◽

Cytokeratin 18 ◽

Middle Cerebral Artery Infarction

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Low Serum Melatonin Levels Prior to Liver Transplantation in Patients with Hepatocellular Carcinoma are Associated with Lower Survival after Liver Transplantation

International Journal of Molecular Sciences ◽

10.3390/ijms20071696 ◽

2019 ◽

Vol 20 (7) ◽

pp. 1696

Author(s):

Leonardo Lorente ◽

Sergio Rodriguez ◽

Pablo Sanz ◽

Pedro Abreu-González ◽

Agustín González-Rivero ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Liver Transplantation ◽

Antioxidant Capacity ◽

Total Antioxidant Capacity ◽

Serum Levels ◽

High Serum ◽

Published Data ◽

Lower Serum ◽

Total Antioxidant ◽

One Year

Melatonin administration has been associated with different benefits in animals and patients suffering from liver diseases. However, there is no published data about circulating melatonin levels in patients with hepatocellular carcinoma (HCC) who underwent liver transplantation (LT). Thus, the objective of this observational and retrospective study was to determine whether patients with HCC with lower serum melatonin levels prior to LT have a higher risk of one-year mortality after LT. We measured serum levels of melatonin, malondialdehyde (to assess lipid peroxidation), and total antioxidant capacity (to assess antioxidant state) before LT. One-year surviving LT patients (n = 129) showed higher serum levels of melatonin (p = 0.001) and total antioxidant capacity (p = 0.001) and lower serum levels of malondialheyde (p = 0.01) than non-surviving LT patients (n = 16). Logistic regression analysis showed that high serum melatonin levels prior to LT were associated with lower one-year LT mortality (odds ratio = 0.525; 95% confidence interval (CI) = 0.331–0.834; p = 0.006). We found an association between serum levels of melatonin with serum levels of malondialheyde (rho = −0.22; p = 0.01) and total antioxidant capacity (rho = 0.21; p = 0.01). Thus, the novel findings of our study were the association between high serum melatonin levels prior to LT and survival at first year after LT and the association between serum levels of melatonin with malondialheyde and total antioxidant capacity.

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Radioprotective and anti-diabetic effects of Costus speciosus and carnosine

Tropical Journal of Pharmaceutical Research ◽

10.4314/tjpr.v19i1.19 ◽

2020 ◽

Vol 19 (1) ◽

pp. 121-127

Author(s):

Ebtisam A. Marzook ◽

Fawzy A. Marzook ◽

Ahmed E. Abd El Moneim

Keyword(s):

Gamma Radiation ◽

Antioxidant Capacity ◽

Total Antioxidant Capacity ◽

Natural Antioxidants ◽

Serum Levels ◽

Serum Glucose ◽

Control Group ◽

Albino Rats ◽

Costus Speciosus ◽

Total Antioxidant

Purpose: To evaluate the possible radioprotective effect of Costus speciosus and carnosine as natural antioxidants in order to control the hyperglycemia developed in male albino rats exposed to acute oxidative stress induced by gamma radiation. Methods: Twenty-eight adult male albino rats were divided into four groups. The first group was taken as a control group, while the three other groups were exposed to Ɣ irradiation at a single 7.5 Gy dose. Furthermore, the rats in the second and third groups were i.p. injected with Costus speciosus root powder and carnosine, respectively. On the 3rd day, after irradiation, the serum levels of glucose, insulin, C peptide, copper, iron, calcium, total antioxidant capacity (TAC) and malondialdehyde (MDA) were measureded. Results: The results revealed that exposure to Ɣ irradiation induced significant increases in serum glucose, iron, and malondialdehyde. However, the levels of serum calcium, copper, total antioxidant capacity and insulin significantly decreased (p < 0.05). A significant decrease was observed in Cpeptide in the exposed group, compared to control group. All the test parameters indicate improvement after treatment with Costus speciosus and carnosine (p < 0.05). Conclusion: Costus speciosus and carnosine ameliorate the effect of gamma radiation, indicating their role as antidiabetic agents and radioprotectors; however, Costus speciosus was critically more efficient than carnosine. Keywords: Costus speciosus, Carnosine, Diabetes, Insulin, Gamma radiation protection

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Serum total antioxidant capacity prior to liver transplantation for hepatocellular carcinoma is associated with 1-year liver transplantation survival

Journal of International Medical Research ◽

10.1177/0300060518768150 ◽

2018 ◽

Vol 46 (7) ◽

pp. 2641-2649 ◽

Cited By ~ 2

Author(s):

Leonardo Lorente ◽

Sergio T. Rodriguez ◽

Pablo Sanz ◽

Antonia Pérez-Cejas ◽

Pedro Abreu-González ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Lipid Peroxidation ◽

Liver Transplantation ◽

Antioxidant Capacity ◽

Total Antioxidant Capacity ◽

Serum Levels ◽

Study Endpoint ◽

First Year ◽

Inverse Association ◽

Total Antioxidant

Objective To determine whether there was an association between serum total antioxidant capacity (TAC) levels prior to in liver transplantation (LT) for hepatocellular carcinoma (HCC) and 1-year LT mortality. Methods This observational retrospective single-centre study of patients with LT for HCC measured serum levels of TAC and malondialdehyde (as a biomarker of lipid peroxidation) before LT. The study endpoint was 1-year LT mortality. Results This study included 142 patients who underwent LT for HCC. Patients who survived the first year ( n = 127) had significantly lower aged liver donors, significantly higher serum TAC levels, and significantly lower serum malondialdehyde levels compared with the non-survivors ( n = 15). Logistic regression analysis found that serum TAC levels (odds ratio [OR] 0.275; 95% confidence interval [CI] 0.135, 0.562) and the age of the LT donor (OR 1.050; 95% CI 1.009, 1.094) were associated with 1-year LT mortality. There was an inverse association between serum levels of TAC and malondialdehyde levels (rho = –0.22). Conclusions There was an association between low serum TAC levels prior to LT for HCC and mortality during the first year after LT. There was an inverse association between serum TAC levels and lipid peroxidation as measured by malondialdehyde levels.

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