Alterations of serum levels of plasminogen, TNF-α, and IDO in granulomatosis with polyangiitis patients

Vascular ◽  
2021 ◽  
pp. 170853812098630
Author(s):  
Dobroslav Kyurkchiev ◽  
Tsvetelina Yoneva ◽  
Adelina Yordanova ◽  
Ekaterina Kurteva ◽  
Georgi Vasilev ◽  
...  
Keyword(s):  
Granulomatosis With Polyangiitis ◽  
Renal Involvement ◽  
Clinical Manifestations ◽  
Area Under The Curve ◽  
Serum Levels ◽  
Necrosis Factor Alpha ◽  
Cross Sectional ◽  
Spearman's Rho ◽  
Tnf Α ◽  
Spearman’S Rho

Background Granulomatosis with polyangiitis (GPA) is a representative of vasculitides associated with anti-neutrophil cytoplasmic autoantibodies. “Classical” antibodies directed against proteinase 3 are involved in the pathogenesis and are part of the GPA diagnosis at the same time. Along with them, however, antibodies against Lysosomal-Associated Membrane Protein-2 (LAMP-2) and antibodies directed against plasminogen have been described in GPA. Objectives and methodology: We performed a cross-sectional study enrolling 34 patients diagnosed with GPA. Our study was aimed at looking for correlations between serum levels of LAMP-2 and plasminogen and the clinical manifestations of the GPA. Furthermore, we examined serum levels of tumor necrosis factor-alpha (TNF-α) and its associated indoleamine-pyrrole 2,3-dioxygenase (IDO), as well as we looked for a correlation between these cytokines and the clinical manifestations of GPA. Results The results showed that in GPA, serum plasminogen levels were negatively associated with renal involvement (receiver operating characteristic (ROC) area under the curve (AUC) of 0.78) (95% CI 0.53–0.91), p = 0.035, and the extent of proteinuria, Spearman’s Rho = –0.4, p = 0.015. Increased levels of TNF-α and IDO correlated with disease activity, Spearman’s Rho =0.62, p = 0.001 and Spearman’s Rho = 0.4, p = 0.022, respectively, whereas only TNF-α was increased in severe forms of GPA with lung involvement (ROC AUC of 0.8) (95% CI 0.66–0.94), p = 0.005. Conclusions In this study, we demonstrate the alteration of soluble factors, which play an important role in the pathogenesis of GPA and their relationship with the clinical manifestations of the disease. Our main results confirm the associations of increased secretory TNF-α and some clinical manifestations, and we describe for the first time decreased serum plasminogen levels and their association with renal involvement.

Hubungan antara Tumor Necrosis Factor Alpha dengan Demam Berdarah Dengue

Sari Pediatri ◽  
2016 ◽  
Vol 15 (4) ◽  
pp. 244
Author(s):  
Felix Candra Sutanto ◽  
Max F.J. Mantik ◽  
Vivekenanda Pateda
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Spearman's Rho ◽  
Tnf Α ◽  
Spearman’S Rho ◽  
Factor Alpha ◽  
Necrosis Factor

Latar belakang. Sampai saat ini patogenesis demam berdarah dengue (DBD) belum dipahami secara sempurna. Pada kasus DBD didapatkan adanya peningkatan kadar TNF-α, sitokin yang poten dalam meningkatkan permeabilitas pembuluh darah. Penelitian sebelumnya mendapatkan adanya peningkatan kadar TNF-α yang bermakna pada DBD.Tujuan. Mengetahui hubungan antara kadar TNF-α dengan keparahan DBD.Metode. Penelitian analitik observasional dengan pendekatan potong lintang selama bulan Ju li hingga Desember 2011. Pasien didiagnosis DBD berdasarkan kriteria WHO. Data berupa hemoglobin, hematokrit, jumlah leukosit, jumlah trombosit, dan kadar TNF-α dikumpulkan selama penelitian. Analisis statistik menggunakan korelasi Spearman’s Rho dengan tingkat kemaknaan p<0,05.Hasil. Didapatkan tiga puluh delapan anak, 27 di antaranya didiagnosis DBD tanpa syok dan 11 DBD dengan syok. Rerata usia kelompok DBD tanpa syok adalah 7,56 (SB 3,06) tahun (95% IK 6,35-8,76 tahun) dan rerata usia kelompok DBD dengan syok adalah 6,82 (SB 3,25) tahun (95% IK 4,63-9,00 tahun). Rerata kadar TNF-α kelompok DBD tanpa syok adalah 13,13 (SB 7,57) pg/ml (95% IK 10,14-16,13 pg/ml) dan rerata kadar TNF-α kelompok DBD dengan syok adalah 260,52 (SB 239,08) pg/ml (95% IK 99,90-421,13 pg/ml). Didapatkan hubungan positif yang bermakna antara kadar TNFα plasma dengan tingkat keparahan/derajat DBD (rs 0,885; p<0,001).Kesimpulan. Semakin berat derajat DBD yang terjadi semakin tinggi kadar TNF-α

scholarly journals Hubungan antara Tumor Necrosis Factor Alpha dengan Demam Berdarah Dengue

Sari Pediatri ◽  
2016 ◽  
Vol 15 (4) ◽  
pp. 244
Author(s):  
Felix Candra Sutanto ◽  
Max F.J. Mantik ◽  
Vivekenanda Pateda
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Spearman's Rho ◽  
Tnf Α ◽  
Spearman’S Rho ◽  
Factor Alpha ◽  
Necrosis Factor

Latar belakang. Sampai saat ini patogenesis demam berdarah dengue (DBD) belum dipahami secara sempurna. Pada kasus DBD didapatkan adanya peningkatan kadar TNF-α, sitokin yang poten dalam meningkatkan permeabilitas pembuluh darah. Penelitian sebelumnya mendapatkan adanya peningkatan kadar TNF-α yang bermakna pada DBD.Tujuan. Mengetahui hubungan antara kadar TNF-α dengan keparahan DBD.Metode. Penelitian analitik observasional dengan pendekatan potong lintang selama bulan Ju li hingga Desember 2011. Pasien didiagnosis DBD berdasarkan kriteria WHO. Data berupa hemoglobin, hematokrit, jumlah leukosit, jumlah trombosit, dan kadar TNF-α dikumpulkan selama penelitian. Analisis statistik menggunakan korelasi Spearman’s Rho dengan tingkat kemaknaan p<0,05.Hasil. Didapatkan tiga puluh delapan anak, 27 di antaranya didiagnosis DBD tanpa syok dan 11 DBD dengan syok. Rerata usia kelompok DBD tanpa syok adalah 7,56 (SB 3,06) tahun (95% IK 6,35-8,76 tahun) dan rerata usia kelompok DBD dengan syok adalah 6,82 (SB 3,25) tahun (95% IK 4,63-9,00 tahun). Rerata kadar TNF-α kelompok DBD tanpa syok adalah 13,13 (SB 7,57) pg/ml (95% IK 10,14-16,13 pg/ml) dan rerata kadar TNF-α kelompok DBD dengan syok adalah 260,52 (SB 239,08) pg/ml (95% IK 99,90-421,13 pg/ml). Didapatkan hubungan positif yang bermakna antara kadar TNFα plasma dengan tingkat keparahan/derajat DBD (rs 0,885; p<0,001).Kesimpulan. Semakin berat derajat DBD yang terjadi semakin tinggi kadar TNF-α

scholarly journals High YKL-40 serum levels and its expression in the muscle tissues of patients with antisynthetase syndrome

2021 ◽  
Vol 61 (1) ◽  
Author(s):  
Renata Casseb de Souza Carboni ◽  
Gustavo Luiz Behrens Pinto ◽  
Samuel Katsuyuki Shinjo
Keyword(s):  
Clinical Laboratory ◽  
Disease Status ◽  
Inflammatory Cells ◽  
Serum Levels ◽  
Enzyme Linked Immunosorbent Assay ◽  
Antisynthetase Syndrome ◽  
Necrosis Factor Alpha ◽  
Cross Sectional ◽  
Muscle Tissues ◽  
Tnf Α

Abstract Background The protein chitinase-3-like-1 (YKL-40) is rarely analyzed in patients with myositis. Therefore, we aimed to evaluate YKL-40 serum levels; correlate them with laboratory and clinical parameters, disease status, and treatment schemes; and analyze the YKL-40 expression in the muscle tissues of patients with antisynthetase syndrome (ASSD). Methods This cross-sectional single-center study included 64 adult patients with ASSD who were age-, gender-, and ethnicity-matched to 64 healthy control individuals. Their YKL-40 serum levels were analyzed using the Enzyme-Linked Immunosorbent Assay (ELISA) kit method, while YKL-40 expression in muscle tissues was analyzed using an immunohistochemical technique. Disease status was assessed using the International Myositis Assessment and Clinical Studies Group (IMACS) set scores. Results The patients’ mean age was 44.8 ± 11.8 years, and median disease duration was 1.5 (0.0–4.0) years. These patients were predominantly female (82.8%) and Caucasian (73.4%). Most patients had stable disease. The median YKL-40 serum level was significantly higher in patients with ASSD when compared to the healthy individuals: 538.4 (363.4–853.1) pg/mL versus 270.0 (201.8–451.9) pg/mL, respectively; P < 0.001. However, YKL-40 serum levels did not correlate with any clinical, laboratory, disease status, or therapeutic parameters (P > 0.050), except tumor necrosis factor alpha (TNF-α) serum levels (Spearman’s correlation, rho = 0.382; P = 0.007). YKL-40 was highly expressed by inflammatory cells found in muscle biopsy specimens. Conclusions High YKL-40 serum levels were observed in patients with ASSD and correlated positively with TNF-α serum levels. Moreover, YKL-40 was expressed by the inflammatory cells of the muscle tissue.

scholarly journals Korelasi ekspresi Cyclooxygenase-2 (COX-2) dan TNF-α sebagai mediator cancer-related inflammation pada karsinoma nasofaring

2014 ◽  
Vol 43 (2) ◽  
pp. 91 ◽  
Author(s):  
Firman Nurdiansah ◽  
Sujahn Anto Pardede ◽  
Farhat Farhat ◽  
Delfitri Munir ◽  
Rizalina Arwinati Asnir ◽  
...  
Keyword(s):  
Nk Cells ◽  
Cyclooxygenase 2 ◽  
Cross Sectional ◽  
Exact Test ◽  
Spearman's Rho ◽  
Tnf Α ◽  
Spearman’S Rho ◽  
Fisher’S Exact Test ◽  
Cox 2 ◽  
Cross Sectional Design

Latar belakang: Karsinoma nasofaring (KNF) adalah suatu karsinoma sel skuamosa yang berasal dari sel epitel nasofaring. Cyclooxygenase (COX) merupakan enzim pada jalur biosintetik dari prostaglandin, tromboksan dan prostasiklin dari asam arakhidonat. Ekspresi seluler COX-2 meningkat di atas normal pada stadium awal karsinogenesis dan selama perkembangan serta pertumbuhan invasif tumor. TNF-α diperlukan untuk proliferasi dan fungsi yang normal dari NK cells, sel T, sel B, makrofag dan sel dendrit. Akan tetapi bukti yang terbarumenunjukkan bahwa TNF-α merupakan suatu mediator utama pada cancer-related inflammation dan juga berperan sebagai tumour-promoting factor.Tujuan: Untuk mengetahui ekspresi COX-2 dan TNF-α sebagai mediator cancer-related inflammation pada KNF. Metode: Penelitian ini bersifat deskriptif secara cross sectional design dengan 30 sampel dilakukan di RSUP. H. Adam Malik Medan. Ekspresi COX-2 dan TNF-α pada KNF diperiksa dengan immunohistokimia. Hasil: Dengan menggunakan Fisher’s exact test tidak ditemukan hubungan yang signifikan antara ukuran tumor primer, ukuran kelenjar getah bening serta stadium klinis dengan ekspresi COX-2 (p > 0,05). Ditemukan hubungan yang signifikan antara ukuran tumor primer dan ekspresi TNF-α (p < 0,05). Tidak ditemukan adanya hubungan antara ukuran kelenjar getah bening dan stadium klinis dengan ekspresi TNF-α (p >0,05). Dengan uji Spearman’s rho didapatkan bahwa COX-2 berkorelasi signifikan dengan TNF-α pada KNF (p <0,05). Kesimpulan: Terdapat korelasi signifikan ekspresi COX-2 dan TNF-α pada KNF.Kata kunci: Karsinoma nasofaring, cyclooxygenase-2, TNF-α.

scholarly journals POS0584 ULTRASONOGRAPHY OF THE MEDIAN NERVE IN PATIENTS WITH RHEUMATOID ARTHRITIS UNDER SUSPICION OF CARPAL TUNNEL SYNDROME

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 525.1-525
Author(s):  
S. Tsiami ◽  
E. Ntasiou ◽  
C. Krogias ◽  
R. Gold ◽  
J. Braun ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Carpal Tunnel Syndrome ◽  
Median Nerve ◽  
Carpal Tunnel ◽  
Nerve Conduction Velocity ◽  
Sectional Area ◽  
Cross Sectional ◽  
Spearman's Rho ◽  
Spearman’S Rho ◽  
Tunnel Syndrome

Background:Carpal tunnel syndrome (CTS) is the most common nerve compression syndrome and a common extra-articular manifestation of rheumatoid arthritis (RA). Different causes of CTS are known, among them inflammatory and non-inflammatory pathologies. Electroneurography (ENG) of the median nerve, the method of choice to diagnose CTS, measures impairment of nerve conduction velocity without explaining its underlying cause. However, because the electrical stimulation is often not well tolerated, ENG results may come out inconclusive. Using greyscale ultrasonography (GS-US) provides anatomic information including a structural representation of the carpal tunnel.Objectives:To investigate the performance of nerve GS-US in the diagnosis of CTS in patients with RA.Methods:Consecutive patients with active RA under suspicion of CTS presenting to a large rheumatologic center were included. Both hands were examined by an experienced neurologist including ENG and a GS-US (ML linear probe with 6-15 Hz) of the median nerve. An established grading system for ENG (1), and an established system for GS-US based on cut-offs for the nerve cross sectional area (CSA) [mild: 0,11-0,13cm2, moderate: 0,14-0,15 cm2, severe: > 0,15 cm2 CTS (2)] were used. In addition, the Boston Carpal Tunnel Syndrome Questionnaire (BCTSQ) was used to assess CTS symptoms (3).Results:Both hands of 58 patients with active RA (n=116) and clinical suspicion of CTS (in 38 cases bilaterally) were included. After clinical examination, CTS was suspicious in 96 hands (82.8%), and 59 of all hands had a final diagnosis of CTS (50.9%). Of the latter, 43 hands (72.9%) had a positive ENG and 16 (27.1%) a positive GS-US finding only, while 30 hands (50.8%) were positive in both examinations.There was a good correlation of the cross-sectional area (CSA) as well as the CSA-ratio to the ENG findings: the larger the CSA, the more severe was the CTS as assessed by ENG (Spearman’s rho=0.554; p<0.001). The more severe the GS-US findings of CTS were, the more definite were the distal motor latency (Spearman’s rho=0.554; p<0.001) and sensible nerve conduction velocity of the median nerve (Spearman’s rho=-0.5411; p<0.001).In the 46 hands positive in GS-US, tenosynovial hypertrophy of the flexor tendons was detected in 19 hands (41.3%), 7 of which (36.8%) also showed an additional cystic mass. In these 19 patients, clinical complains were more severely present than in patients with non-inflammatory CTS, as assessed by the BCTSQ with a total score of 68.8±13.4 vs. 59.3±13.7, respectively (p=0.007).Conclusion:In patients with active RA and clinical complains of CTS, ultrasound examinations provide additional information about inflammation which is helpful for a diagnosis of CTS. Thus, ENG and nerve GS-US should be used complementary for a diagnostic workup of CTS in RA patients with a suspicion of CTS. Power-Doppler may further improve the diagnostic performance of GS-US.References:[1]Padua L et al. Acta Neurol Scand 1997; 96:211–217[2]El Miedany et al., Rheumatology (Oxford). 2004 Jul; 43(7):887-895[3]Levine DW et al. J Bone Joint Surg Am 1993; 75: 1585-1592Figure 1.BCTSQ scores in patients with diagnosis of CTS and absence or presence of RA-related tenosynovial hypertrophyDisclosure of Interests:None declared

scholarly journals Serum immunoglobulin free light chains and their association with clinical phenotypes, serology and activity in patients with IgG4-related disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Eduardo Martín-Nares ◽  
Vanessa Saavedra-González ◽  
Reynerio Fagundo-Sierra ◽  
Blanca Estela Santinelli-Núñez ◽  
Teresa Romero-Maceda ◽  
...  
Keyword(s):  
Renal Involvement ◽  
Serum Levels ◽  
Serum Immunoglobulin ◽  
Light Chains ◽  
Free Light Chains ◽  
Cross Sectional ◽  
Clinical Phenotypes ◽  
Related Disease ◽  
Igg4 Related Disease ◽  
Head Neck

AbstractThe clinical utility of serum immunoglobulin free light chains (sFLC) in IgG4-related disease (IgG4-RD) is unknown. Herein we evaluated their association with clinical phenotypes, serology and activity in patients with IgG4-RD. Cross-sectional study that included 45 patients with IgG4-RD, and as controls 25 with Sjögren’s syndrome (SS) and 15 with sarcoidosis. IgG4-RD patients were classified in clinical phenotypes: pancreato-hepato-biliary, retroperitoneum/aorta, head/neck-limited and Mikulicz/systemic; as well as proliferative vs. fibrotic phenotypes. We assessed the IgG4-RD Responder Index (IgG4-RD RI) at recruitment and measured IgG1, IgG4, κ and λ sFLC serum levels by turbidometry. sFLC levels were similar among IgG4-RD, SS and sarcoidosis groups. Regarding the IgG4-RD patients, the mean age was 49 years, 24 (53.3%) were men and 55.5% had activity. Eight (17.7%) belonged to pancreato-hepato-biliary, 6 (13.3%) to retroperitoneum/aorta, 14 (31.1%) to head/neck-limited, 16 (35.5%) to Mikulicz/systemic phenotypes, whereas 36 (80%) to proliferative and 9 (20%) to fibrotic phenotypes. High κ sFLC, λ sFLC and κ/λ ratio were present in 29 (64.4%), 13 (28.9%) and 13 (28.9%) of IgG4-RD patients, respectively. There were no differences in sFLC among IgG4-RD phenotypes. κ sFLC and κ/λ ratio correlated positively with the number of involved organs and IgG4-RD RI. Patients with renal involvement had higher κ sFLC and λ sFLC. The AUC for κ sFLC and λ sFLC, for renal involvement was 0.78 and 0.72, respectively. Active IgG4-RD had higher levels of κ sFLC and more frequently a high κ/λ ratio. The AUC for κ sFLC and κ/λ ratio for predicting active IgG4-RD was 0.67 and 0.70, respectively. sFLC correlated positively with IgG1 and IgG4 levels. sFLC may be useful as a biomarker of disease activity as well as multiorgan and renal involvement. In particular, a high κ/λ ratio may identify patients with active disease.

HUBUNGAN PERILAKU MAHASISWA POLTEKKES YANG MENGGUNAKAN FIXED APLIANCE TENTANG MENYIKAT GIGI DENGAN NILAI OHI-S DI POLTEKKES KEMENKES MEDAN TAHUN 2013

2019 ◽  
Vol 8 (3) ◽  
pp. 211-217
Author(s):  
Herlinawati Herlinawati ◽  
Ngena Ria ◽  
Zuraidah Nasution
Keyword(s):  
Chi Square ◽  
Cross Sectional ◽  
Fixed Appliance ◽  
Spearman's Rho ◽  
Spearman’S Rho

Fixed appliance atau disebut juga pesawat orthodonti cekat merupakan alat orthodonti yang dilengketkanlangsung pada gigi. Dewasa ini pemakaian fixed appliance semakin banyak diminati kawula muda untukmemperbaiki dan mengoptimalkan fungsi gigi sebagai alat kunyah dan untuk mengoptimalkan fungsiestetika gigi. Piranti fixed appliance memiliki bentuk yang rumit sehingga mempermudah lengketnya plaklebih lama dan dapat meningkatkan resiko terjadinya karies, gingivitis dan penyakit periodontal. Adanyapiranti fixed appliance yang menempel pada gigi-gigi akan menyulitkan untuk membersihkan gigi sehinggacenderung terjadi penumpukan plak pada gigi disekitar bracket dan mahkota gigi pada tepi gingival.Penelitian ini bertujuan untuk mengetahui hubungan perilaku mahasiswa yang memakai fixed appliancetentang menyikat gigi dengan nilai OHI-S di Poltekkes Kemenkes Medan. Jenis penelitian yang digunakanadalah survei analitik dengan desain cross sectional . Populasi dalam penelitian ini berjumlah 122 orang dansampel adalah seluruh populasi yaitu 122 orang (total populasi). instrumen yang dipakai yaitu kaca mulut,pinset, sonde, nier bekken, handuk bersih kuesioner dan formulir pemeriksaan. Analisis data bivariatdengan menggunakan uji chi-square dan Spearman’s rho dengan derajat kepercayaan 95% (α = 0,05).Berdasarkan hasil penelitian, diperoleh kategori pengetahuan mahasiswa tidak berhubungan dengan kriteriaOHI-S (p > 0,05) sedangkan kategori sikap dan tindakan mempunyai hubungan dengan kriteria OHI-S (p <0,05). Nilai OHI-S rata-rata adalah 2,68. Dianjurkan kepada mahasiswa yang menggunakan fixed applianceagar lebih meningkatkan kebersihan gigi dan mulutnya, mengiku

scholarly journals Association of acylated ghrelin profiles with chronic inflammatory markers in overweight and obese postmenopausal women: a MONET study

2007 ◽  
Vol 157 (4) ◽  
pp. 419-426 ◽  
Author(s):  
David H St-Pierre ◽  
Jean-Philippe Bastard ◽  
Lise Coderre ◽  
Martin Brochu ◽  
Antony D Karelis ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Inflammatory Markers ◽  
Area Under The Curve ◽  
Blood Lipid ◽  
Cross Sectional Study ◽  
Acylated Ghrelin ◽  
Euglycemic Hyperinsulinemic Clamp ◽  
Cross Sectional ◽  
Tnf Α ◽  
Maximal Reduction

Objective: Recent reports have suggested that the existence of associations between hormonal dysregulation and chronic upregulation of inflammatory markers, which may cause obesity-related disturbances. Thus, we examined whether acylated ghrelin (AcylG) and total ghrelin (TotG) levels could be associated with the following inflammatory markers: C-reactive protein (CRP), tumor necrosis factor α (TNF-α), and soluble TNF receptor 1 (sTNF-R1). Design: Cross-sectional study consisting of 50 overweight and obese postmenopausal women. Methods: AcylG and TotG levels were assessed at 0, 60, 160, 170, and 180 min of the euglycemic/hyperinsulinemic clamp (EHC). We evaluated insulin sensitivity, body composition, and blood lipid profiles as well as fasting concentrations of CRP, TNF-α, and sTNF-R1. Results: In fasting conditions, sTNF-R1 was negatively correlated with AcylG (r = −0.48, P < 0.001) levels. In addition, AcylG/TotG was associated negatively with sTNF-R1 (r = −0.44, P = 0.002) and positively with TNF-α (r = 0.38, P = 0.009) values. During the EHC, TotG (at all time points) and AcylG (at 60 and 160 min) values were significantly decreased from fasting concentrations. AcylG maximal reduction and area under the curve (AUC) values were correlated to sTNF-R1 (r = −0.35, P = 0.02 and r = −0.34, P = 0.02, respectively). Meanwhile, the AcylG/TotG AUC ratio was associated negatively with sTNF-R1 (r = −0.29, P < 0.05) and positively with TNF-α (r = 0.36, P = 0.02). Following adjustments for total adiposity, sTNF-R1 remained correlated with fasting and maximal reduction AcylG values. Similarly, AcylG/TotG ratios remained significantly correlated with sTNF-R1 and TNF-α. Importantly, 23% of the variation in sTNF-R1 was independently predicted by fasting AcylG. Conclusion: These results are the first to suggest that both fasting and EHC-induced AcylG profiles are correlated with fasting values of sTNF-R1, a component of the TNF-α system. Thus, AcylG may act, at least in part, as one mediator of chronic inflammatory activity in human obesity.

scholarly journals Type 17 Immune Response Facilitates Progression of Inflammation and Correlates with Cognition in Stable Schizophrenia

Diagnostics ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 926
Author(s):  
Milica M. Borovcanin ◽  
Slavica Minic Janicijevic ◽  
Ivan P. Jovanovic ◽  
Nevena M. Gajovic ◽  
Milena M. Jurisevic ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Peripheral Blood ◽  
Cd4 T Cells ◽  
Serum Levels ◽  
Antipsychotic Therapy ◽  
Necrosis Factor Alpha ◽  
Positive Correlation ◽  
Tnf Α ◽  
Immune Pathway

Dysregulation of the type 17 immune pathway has already been considered in schizophrenia and we previously measured decreased sera values of interleukin (IL)-17 in early stages. We further explored the possible correlation of IL-17 systemic levels with proinflammatory cytokines and cognitive scores and additionally analyzed the percentage of IL-17 producing lymphocytes in peripheral blood of patients with stable schizophrenia. We included 27 patients diagnosed with schizophrenia (F20), after a three-month stable depot antipsychotic therapy (risperidone or paliperidone) and 18 healthy control subjects. Positive and Negative Syndrome Scale of Schizophrenia and the Montreal-Cognitive Assessment (MoCA) were conducted. Sera concentrations of IL-17, IL-6, tumor necrosis factor alpha (TNF-α) and soluble ST2 receptor (sST2) were measured. Flow cytometry and Natural Killer (NK) and T cell analyses were done in 10 patients and 10 healthy controls. Moderate positive correlation was established between IL-17 and TNF-α (r = 0.640; p = 0.001), IL-17 and IL-6 (r = 0.514; p = 0.006), IL-17 and sST2 (r = 0.394; p = 0.042). Furthermore, a positive correlation between the serum levels of IL-17 and MoCA scores was observed, especially with visuospatial and executive functioning, as well as language functioning and delayed recall (p < 0.05). Significantly higher percentage of IL-17 producing CD56+ NK cells was measured in peripheral blood of patients with schizophrenia in remission vs. healthy individuals (p = 0.001). The percentage of CD4+ T cells and CD4+ T cells that produce IL-17 was significantly increased in patients (p = 0.001). This study revealed the involvement of innate type 17 immune response in the progression of inflammation and this could be related to cognitive functioning in stable schizophrenia.

scholarly journals Pengaruh Dukungan Sosial Terhadap Kecemasan Pada Ibu Hamil di Puskesmas Jetis Kabupaten Ponorogo

2018 ◽  
Vol 5 (1) ◽  
pp. 55-66
Author(s):  
Ambika Kurnia Mustikawati
Keyword(s):  
Social Support ◽  
Pregnant Women ◽  
Correlation Coefficient ◽  
Sampling Technique ◽  
Cross Sectional ◽  
Spearman's Rho ◽  
Spearman’S Rho ◽  
The Social ◽  
The Face ◽  
Independent Variable

Background: Pregnancy is a valuable thing, but also one of the great stresses for awoman both physically and mentally. Pregnant women with high anxiety will increase therisk of hypertension, difficulty sleeping and stroke, seizures and even death in the motherand fetus. In Puskesmas Ponorogo district the number of pregnant women as much as5903 mothers, while in health centers Jetis the number of pregnant women as many as200 mothers. Interview results, 21 out of 27 mothers said were very anxious during herpregnancy. The purpose of this study was to analyze the factors of social support foranxiety in pregnant women.Subjects and Methods: The type of research is analytical with cross-sectional approach.The location of research at Jetis health center Ponorogo regency. Research conducted onSeptember 1 to October 15, 2016. Sample of 30 pregnant women using proportionalrandom sampling technique. Dependent variable is anxiety, while independent variable issocial support. Data collection techniques using questionnaires. Data analysis usingSpearman's Rho using SPSS 18.0 for windows computer program.Results: The results showed that from 40 respondents, almost half were 13 (32.5%)multiparous had mild anxiety and nearly half were 13 (32.5%) primipara experiencedmoderate anxiety. of the 40 respondents, nearly half (12%) of 3 trimester pregnantwomen had moderate anxiety and a small proportion of 9 (22.5%) of 2 trimester pregnantwomen had mild anxiety. The result of calculation using spearman's rho statistic testobtained p = 0,006 <α 0,05 mean there is influence between parity with anxiety inpregnant woman with correlation coefficient of -0,424 which show intensity of influenceof medium that is if the smaller parity hence more anxiety level. The calculation ofgestational age with spearman's rho p = 0,023 <α 0.05 means that there is an influencebetween parity with anxiety in pregnant women with a correlation coefficient of 0.359which shows the weakness of weak influence.Conclusion: The social support provided by husband and family will affect the level ofanxiety in each pregnant woman. It is hoped for a place of research to provide a solutionfor pregnant women who experience anxiety so that pregnancy can run smoothly andrespondents are expected to have a good coping mechanism in the face of anxiety forhealth and also the fetus.

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