scholarly journals Effects of 7-day supplementation with escalating doses of citrulline nitrate on resting and post-exercise blood pressure and safety biomarkers in healthy men: A randomized controlled trial

2021 ◽  
Vol 5 ◽  
pp. 239784732110386
Author(s):  
Nikola Todorovic ◽  
Valdemar Stajer ◽  
Laszlo Ratgeber ◽  
Jozsef Betlehem ◽  
Pongras Acs ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Controlled Trial ◽  
High Dose ◽  
Double Blind ◽  
Post Exercise ◽  
Hematological Indices ◽  
Healthy Men ◽  
Exercise Blood Pressure ◽  
Medium Dose ◽  
Apparently Healthy

We investigated the effects of 7-day supplementation with three different dosages of citrulline nitrate (CN) on blood pressure at rest and after exercise, biochemical safety markers, and self-reported outcome measures of adverse events in healthy men. 12 apparently healthy young men (age 25.9 ± 4.0 years; weight 78.6 ± 10.0 kg, height 181.0 ± 7.0 cm) volunteered to participate in this double-blind, randomized, placebo-controlled cross-over trial. The dosages of CN were 1.5 g per day (low dose), 3.0 g per day (medium dose), and 6.0 g per day (high dose). No significant differences were found for systolic and diastolic blood pressure and heart rate at rest and after exercise between varying doses of CN and placebo ( p > 0.05). In addition, hematological indices, biochemical variables, and clinical enzyme profiles were not affected by either intervention ( p > 0.05), and the type and frequency of side effects were comparable to the placebo group. Citrulline nitrate was safe and well tolerated when administered for 7 days in dosages up to 6 g per day.

scholarly journals Pterostilbene on Metabolic Parameters: A Randomized, Double-Blind, and Placebo-Controlled Trial

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Daniel M. Riche ◽  
Krista D. Riche ◽  
Chad T. Blackshear ◽  
Corey L. McEwen ◽  
Justin J. Sherman ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Weight Loss ◽  
Total Cholesterol ◽  
Mixed Models ◽  
Controlled Trial ◽  
Metabolic Parameters ◽  
Controlled Study ◽  
High Dose ◽  
Double Blind ◽  
Over Time

Introduction. The purpose of this trial was to evaluate the effect of pterostilbene on metabolic parameters.Methods. A prospective, randomized, double-blind, and placebo-controlled study that enrolled 80 patients with a total cholesterol ≥200 mg/dL and/orLDL≥100 mg/dL. Subjects were divided into four groups: (1) pterostilbene 125 mg twice daily; (2) pterostilbene 50 mg twice daily; (3) pterostilbene 50 mg + grape extract (GE) 100 mg twice daily; (4) matching placebo twice daily for 6–8 weeks. Endpoints included lipids, blood pressure, and weight. Linear mixed models were used to examine and compare changes in parameters over time. Models were adjusted for age, gender, and race.Results. LDL increased with pterostilbene monotherapy (17.1 mg/dL;P=0.001) which was not seen with GE combination (P=0.47). Presence of a baseline cholesterol medication appeared to attenuate LDL effects. Both systolic (−7.8 mmHg;P<0.01) and diastolic blood pressure (−7.3 mmHg;P<0.001) were reduced with high dose pterostilbene. Patients not on cholesterol medication (n=51) exhibited minor weight loss with pterostilbene (−0.62 kg/m2;P=0.012).Conclusion. Pterostilbene increases LDL and reduces blood pressure in adults. This trial is registered with Clinicaltrials.govNCT01267227.

scholarly journals Chronic resistance training does not affect post-exercise blood pressure in normotensive older women: a randomized controlled trial

AGE ◽  
2015 ◽  
Vol 37 (3) ◽  
Author(s):  
Aline Mendes Gerage ◽  
Raphael Mendes Ritti-Dias ◽  
Matheus Amarante do Nascimento ◽  
Fábio Luiz Cheche Pina ◽  
Cássio Gustavo Santana Gonçalves ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Randomized Controlled Trial ◽  
Resistance Training ◽  
Older Women ◽  
Controlled Trial ◽  
Post Exercise ◽  
Randomized Controlled ◽  
Exercise Blood Pressure

scholarly journals A pilot double‐blind safety and feasibility randomized controlled trial of high‐dose intravenous zinc in hospitalized COVID‐19 patients

2021 ◽  
Vol 93 (5) ◽  
pp. 3261-3267 ◽  
Author(s):  
Oneel Patel ◽  
Vidyasagar Chinni ◽  
John El‐Khoury ◽  
Marlon Perera ◽  
Ary S. Neto ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
High Dose ◽  
Double Blind ◽  
Randomized Controlled

scholarly journals Single High-Dose Vitamin D Supplementation as an Approach for Reducing Ultramarathon-Induced Inflammation: A Double-Blind Randomized Controlled Trial

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1280
Author(s):  
Jan Mieszkowski ◽  
Andżelika Borkowska ◽  
Błażej Stankiewicz ◽  
Andrzej Kochanowicz ◽  
Bartłomiej Niespodziński ◽  
...  
Keyword(s):  
Vitamin D ◽  
Inflammatory Marker ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
Oncostatin M ◽  
Control Group ◽  
High Dose ◽  
Double Blind ◽  
Single High Dose ◽  
High Dose Vitamin

Purpose: A growing number of studies indicate the importance of vitamin D supplementation for sports performance. However, the effects of a single high-dose vitamin D supplementation on ultramarathon-induced inflammation have not been investigated. We here analyzed the effect of a single high-dose vitamin D supplementation on the inflammatory marker levels in ultramarathon runners after an ultramarathon run (maximal run 240 km). Methods: In the study, 35 runners (amateurs) were assigned into two groups: single high-dose vitamin D supplementation group, administered vitamin D (150,000 IU) in vegetable oil 24 h before the start of the run (n = 16); and placebo group (n = 19). Blood was collected for analysis 24 h before, immediately after, and 24 h after the run. Results: Serum 25(OH)D levels were significantly increased after the ultramarathon in both groups. The increase was greater in the vitamin D group than in the control group. Based on post-hoc and other analyses, the increase in interleukin 6 and 10, and resistin levels immediately after the run was significantly higher in runners in the control group than that in those in the supplementation group. Leptin, oncostatin M, and metalloproteinase tissue inhibitor levels were significantly decreased in both groups after the run, regardless of the supplementation. Conclusions: Ultramarathon significantly increases the serum 25(OH)D levels. Attenuation of changes in interleukin levels upon vitamin D supplementation confirmed that vitamin D has anti-inflammatory effect on exercise-induced inflammation.

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