scholarly journals Correlation between plasma ZAG and adiponectin in older adults: gender modification and frailty specificity

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ya-Ping Lee ◽  
Chin-Hao Chang ◽  
Chin-Ying Chen ◽  
Chiung-Jung Wen ◽  
Hsien-Liang Huang ◽  
...  
Keyword(s):  
Older Adults ◽  
Linear Regression ◽  
Adiponectin Level ◽  
Linear Regression Analysis ◽  
Regression Analyses ◽  
Frailty Phenotype ◽  
Plasma Adiponectin ◽  
Plasma Adiponectin Level ◽  
Multivariable Linear Regression Analysis ◽  
Gender Specific

Abstract Background Adiponectin and zinc alpha2-glycoprotein (ZAG) are associated with frailty. This study aims to further examine the association of adiponectin with ZAG. Methods Outpatients aged 65 years or older with chronic disease followed up in a hospital-based program were recruited for a comprehensive geriatric assessment. We excluded outpatients who were bedridden, residing in a nursing home, with expected life expectancy less than 6 months, or with severe hearing or communication impairment. Plasma ZAG and adiponectin levels were measured. Association between plasma ZAG and adiponectin levels was analyzed by univariate and multivariable linear regression analyses. Results A total of 189 older adults were enrolled (91 men and 98 women, mean age: 77.2 ± 6.1 years). Log-transformed plasma ZAG level was 1.82 ± 0.11 μg/mL, and it was significantly higher in men than that in women (1.85 ± 0.12 vs 1.79 ± 0.10 μg/mL, P = .0006). Log-transformed plasma adiponectin level was 1.00 ± 0.26 μg/mL, and there was no significant gender difference (P = .195). Overall, plasma ZAG level positively correlated with plasma adiponectin level in the multivariable linear regression analysis (P = .0085). The gender-specific significance, however, was less clear: this relationship was significant in men (P = .0049) but not in women (P = .2072). To be more specific by frailty phenotype components, plasma adiponectin was positively correlated with weight loss (P = .0454) and weakness (P = .0451). Conclusions Both of ZAG and adiponectin may be potential frailty biomarkers. Plasma ZAG is an independent factor of plasma adiponectin, especially in older male adults.

scholarly journals Effect of Number of Clinics and Panel Size on Patient Continuity for Medical Residents

2009 ◽  
Vol 1 (2) ◽  
pp. 310-315 ◽  
Author(s):  
Maureen D. Francis ◽  
Whitney E. Zahnd ◽  
Andrew Varney ◽  
Steven L. Scaife ◽  
Mark L. Francis
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Medical Residents ◽  
Panel Size ◽  
Medical Education Program ◽  
Internal Medicine Residency Training ◽  
Multivariable Linear Regression Analysis ◽  
Linear Regression Modeling ◽  
Attending Physician

Abstract Background Accreditation Council for Graduate Medical Education program requirements for internal medicine residency training include a longitudinal, continuity experience with a panel of patients. Objective To determine whether the number of resident clinics, the resident panel size, and the supervising attending physician affect patient continuity. To determine the number of clinics and the panel size necessary to maximize patient continuity. Design We used linear regression modeling to assess the effect of number of attended clinics, the panel size, and the attending physician on patient continuity. Participants Forty medicine residents in an academic medicine clinic. Measurements Percent patient continuity by the usual provider of care method. Results Unadjusted linear regression analysis showed that patient continuity increased 2.3% ± 0.7% for each additional clinic per 9 weeks or 0.4% ± 0.1% for each additional clinic per year (P  =  .003). Conversely, patient continuity decreased 0.7% ± 0.4% for every additional 10 patients in the panel (P  =  .04). When simultaneously controlling for number of clinics, panel size, and attending physician, multivariable linear regression analysis showed that patient continuity increased 3.3% ± 0.5% for each additional clinic per 9 weeks or 0.6% ± 0.1% for each additional clinic per year (P < .001). Conversely, patient continuity decreased 2.2% ± 0.4% for every additional 10 patients in the panel (P < .001). Thus, residents who actually attend at least 1 clinic per week with a panel size less than 106 patients can achieve 50% patient continuity. Interestingly, the attending physician accounted for most of the variability in patient continuity (51%). Conclusions Patient continuity for residents significantly increased with increasing numbers of clinics and decreasing panel size and was significantly influenced by the attending physician.

BS3-5 Plasma adiponectin level is decreased in eNOS knockout mice

2008 ◽  
Vol 79 ◽  
pp. S16-S17
Author(s):  
Eun Hee Koh ◽  
Eun Hee Cho ◽  
Min-Seon Kim ◽  
Joong-Yeol Park ◽  
Kyung Soo Ko ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Adiponectin Level ◽  
Plasma Adiponectin ◽  
Plasma Adiponectin Level

scholarly journals Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese

2010 ◽  
Vol 163 (2) ◽  
pp. 251-257 ◽  
Author(s):  
Kwok Leung Ong ◽  
Mingfang Li ◽  
Annette W K Tso ◽  
Aimin Xu ◽  
Stacey S Cherny ◽  
...  
Keyword(s):  
Hong Kong ◽  
Genetic Variants ◽  
Adiponectin Level ◽  
Sandwich Elisa ◽  
Resistance Index ◽  
Nucleotide Polymorphisms ◽  
Adiponectin Gene ◽  
Plasma Adiponectin ◽  
Plasma Adiponectin Level ◽  
Significant Independent Factor

ObjectiveLow plasma adiponectin level can predict the development of hypertension after 5 years in our population. We therefore investigated whether single-nucleotide polymorphisms (SNPs) in the adiponectin gene influenced plasma adiponectin level and whether they were associated with hypertension.Design and methodsWe genotyped 14 tagging SNPs in 1616 subjects with persistent normotensive or hypertensive status during a 6.4-year follow-up period in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS-2). Plasma adiponectin level was measured in 1385 subjects using in-house sandwich ELISA.ResultsThe minor G allele of the SNP rs266729 was significantly associated with higher odds of hypertension (odds ratio (95% confidence interval)=1.49 (1.13–1.95), P=0.0044) after adjusting for covariates. In stepwise multiple logistic regression, this SNP (P=0.006) was a significant independent factor of hypertension, together with age (P<0.001), body mass index (P<0.001), triglycerides (P=0.021), and insulin resistance index (P<0.001). Among the 14 SNPs, rs266729 (β=−0.067, P=0.0037), −10677C>T (β=0.069, P=0.0027), rs182052 (β=−0.097, P<0.0001), and rs12495941 (β=0.103, P<0.0001) were significantly associated with adiponectin level after adjusting for covariates. No significant sex interaction was found for the associations of SNPs with hypertension and adiponectin level. Similar results were obtained in haplotype analysis.ConclusionIn our population, genetic variants in the adiponectin gene influenced plasma adiponectin levels, and one of them was associated with hypertension. This study has provided further evidence for a role of adiponectin in the development of hypertension.

The Relationship Between Plasma Adiponectin Level and Late Cardiac Remodeling Following Myocardial Infarction

2005 ◽  
Vol 11 (9) ◽  
pp. S280
Author(s):  
Toshihiro Mizuguchi ◽  
Hiroyasu Uzui ◽  
Akira Nakano ◽  
Naoki Amaya ◽  
Haruhisa Shirasaki ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiac Remodeling ◽  
Adiponectin Level ◽  
Plasma Adiponectin ◽  
Plasma Adiponectin Level ◽  
The Relationship

scholarly journals Neutrophil-Lymphocyte Ratio in Small Renal Masses

ISRN Urology ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Wassim M. Bazzi ◽  
Sheila Z. Dejbakhsh ◽  
Melanie Bernstein ◽  
Paul Russo
Keyword(s):  
Linear Regression ◽  
Linear Regression Analysis ◽  
Small Renal Masses ◽  
Clinicopathologic Characteristics ◽  
Renal Masses ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Tumor Pathology ◽  
Preoperative Serum ◽  
Multivariable Linear Regression Analysis

Introduction. To evaluate the association between preoperative neutrophil-lymphocyte ratio (NLR) and clinicopathologic characteristics in patients with small renal masses (SRM). Methods. Retrospective chart reviews of patients with renal masses ≤4 cm who underwent nephrectomy from January 2007 to July 2012 were conducted. Multivariable linear regression was used to examine the association between preoperative NLR and clinicopathologic variables. Results. In 1001 patients, we noted higher mean preoperative NLR in men (3.0±1.4 versus 2.6±1.3 in women, P<0.01) and Caucasians (2.9±1.4 versus 1.9±0.9 in African Americans, P<0.01) but no significant differences in patients with low (I-II) versus high (III-IV) American Society of Anesthesiologists (ASA) scores (2.8±1.4 versus 2.9±1.5, P=0.18) or benign versus malignant pathology (2.9±1.4 versus 2.8±1.3, P=0.75). Spearman correlation analysis (ρ) showed preoperative NLR significantly correlated with age (ρ=0.15, P<0.01) and preoperative serum creatinine (Crea) [ρ=0.13, P<0.01]. On multivariable linear regression analysis older age, male gender, Caucasian race, and preoperative Crea were predictive of higher preoperative NLR, but ASA score and tumor pathology were not. Conclusions. In patients with SRM, we found no association between preoperative NLR and tumor pathology.

scholarly journals Hypoadiponectinemia Is Associated with Impaired Endothelium-Dependent Vasodilation

2004 ◽  
Vol 89 (2) ◽  
pp. 765-769 ◽  
Author(s):  
K. C. B. Tan ◽  
A. Xu ◽  
W. S. Chow ◽  
M. C. W. Lam ◽  
V. H. G. Ai ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Brachial Artery ◽  
Adiponectin Level ◽  
Univariate Analysis ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Brachial Artery Diameter ◽  
Plasma Adiponectin ◽  
Plasma Adiponectin Level

Adiponectin may have an antiatherogenic effect by reducing endothelial activation. We hypothesized that plasma adiponectin levels were correlated with endothelial function. Plasma adiponectin level was determined by an in-house RIA assay using a rabbit polyclonal antibody in 73 type 2 diabetic patients and 73 controls. Endothelium-dependent and independent vasodilation of the brachial artery was measured by high-resolution vascular ultrasound. Plasma adiponectin level was lower in diabetic patients than in controls (4.73 ± 1.96 vs. 7.69 ± 2.80 μg/ml, respectively; P &lt; 0.001), and they also had impaired endothelium-dependent (5.6 ± 3.6 vs. 8.6 ± 4.5%, respectively; P &lt; 0.001) and -independent vasodilation (13.3 ± 4.9 vs. 16.5 ± 5.6%, respectively; P &lt; 0.001). Plasma adiponectin correlated with endothelium-dependent vasodilation in controls (P = 0.02) and diabetic patients (P = 0.04). On general linear-model univariate analysis, brachial artery diameter, the presence of diabetes, plasma adiponectin, and high-density lipoprotein were significant independent determinants of endothelium-dependent vasodilation. In vitro experiments showed that endothelial cells expressed adiponectin receptors, and adiponectin increased nitric oxide production in human aortic endothelial cells. In conclusion, low plasma adiponectin level is associated with impaired endothelium-dependent vasodilation, and the association is independent of diabetes mellitus. Adiponectin may act as a link between adipose tissue and the vasculature.

Sign in / Sign up

Export Citation Format

Share Document