scholarly journals Esophageal leiomyoma and simultaneous overlying squamous cell carcinoma: a case report and review of the literature

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Saadat Mehrabi ◽  
Mohammad Javad Yavari Barhaghtalab ◽  
Safoora Hejazinia ◽  
Hossein Saedi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Esophageal Resection ◽  
Simultaneous Occurrence ◽  
Benign Tumors ◽  
Esophageal Leiomyoma ◽  
Epithelial Tumor ◽  
Pathological Evaluation ◽  
Esophageal Carcinomas

Abstract Background Squamous cell carcinoma is the most common epithelial tumor of the esophagus. Upper endoscopy with multiple minimally invasive biopsies should be performed to confirm the diagnosis. Leiomyoma of esophagus is rare, but it’s the most common benign submucosal mesenchymal tumor of the esophagus. The simultaneous occurrence of an overlying epithelial lesion and a mesenchymal lesion is very rare. This study aims to show a case operated due to squamous cell carcinoma of esophagus that was postoperatively diagnosed with coexistent esophageal leiomyoma and give a clear overview of the existing literature on it. Case presentation The patient was a 41-year-old woman who underwent three field esophagectomy (McKeown). Pathological evaluation was done, and the patient had poorly differentiated squamous cell carcinoma and multiple leiomyomas. A leiomyoma was found with an invading overlying squamous cell carcinoma. Conclusion It is concluded that esophageal carcinomas may coexist with leiomyomas; preexisting benign tumors may have played an important role in the development of the carcinoma by inducing constant stimulation of the overlying mucosa; endoscopic ultrasonography is recommended to avoid overestimating the extent of tumor invasion and the resultant aggressive radical surgery. As the developing countries had limited equipment, esophageal resection could be the modality of choice in the treatment.

scholarly journals Esophageal Leiomyoma and Simultaneous Overlying Squamous Cell Carcinoma: A Case Report and Review of the Literature

2020 ◽  
Author(s):  
Saadat Mehrabi ◽  
Mohammad Javad Yavari Barhaghtalab ◽  
Safoora Hejazinia ◽  
Hossein Saedi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Esophageal Resection ◽  
Simultaneous Occurrence ◽  
Benign Tumors ◽  
Esophageal Leiomyoma ◽  
Epithelial Tumor ◽  
Carcinoma Of Esophagus ◽  
Esophageal Carcinomas

Abstract Background: Squamous cell carcinoma is the most common epithelial tumor of the esophagus. Upper endoscopy with multiple minimally invasive biopsies should be performed to confirm the diagnosis. Leiomyoma of esophagus is rare, but it’s the most common benign submucosal mesenchymal tumor of the esophagus. The simultaneous occurrence of an overlying epithelial lesion and a mesenchymal lesion is very rare. This study aims to show a case operated due to squamous cell carcinoma of esophagus that was postoperatively diagnosed with coexistent esophageal leiomyoma and provide a clear overview of the existing literature on it. Case presentation: The patient was a 41-year-old lady who underwent three field esophagectomy (McKeown). In reviewing the pathology slides, the patient had poorly differentiated squamous cell carcinoma and also multiple leiomyomas. A leiomyoma was coexisted with an invading overlying squamous cell carcinoma. Conclusion: It is concluded that esophageal carcinomas may coexist with leiomyomas; preexisting benign tumors may have played an important role in the development of carcinoma by inducing constant stimulation of the overlying mucosa; endoscopic ultrasonography is recommended to avoid overestimating the extent of tumor invasion and the resultant aggressive radical surgery; and esophageal resection is still the modality of choice in treatment in developing countries and also countries with limited equipment.

Immunohistochemical Study of Esophageal Carcinomas Other Than Squamous Cell Carcinoma

1993 ◽  
pp. 502-506
Author(s):  
Yoshihisa Morisaki ◽  
Shingo Shima ◽  
Yutaka Yoshizumi ◽  
Yoshiaki Sugiura ◽  
Susumu Tanaka
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Immunohistochemical Study ◽  
Esophageal Carcinomas

scholarly journals Adenoid (Acantholytic) Squamous Cell Carcinoma of Mandibular Gingiva

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
T. Raut ◽  
S. Keshwar ◽  
M. R. Jaisani ◽  
A. Shrestha
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Neck Region ◽  
Epithelial Tumor ◽  
Histopathological Features ◽  
Histological Variant ◽  
Pearl Formation ◽  
The Right ◽  
Acantholytic Squamous Cell Carcinoma

Introduction. Adenoid (acantholytic) squamous cell carcinoma (ASCC) is a histological variant of squamous cell carcinoma which occurs mainly in the sun-exposed areas of the head and neck region. It is commonly seen among males which mainly occurs in the sixth and seventh decade of life with lip being predominately affected. Limited scientific literature is documenting the intraoral presentation of ASCC in contrast to its usual extraoral lesions associated with the skin. Characteristic pseudo glandular alveolar space formation seen in ASCC often mimics carcinoma of salivary gland origin. In-depth knowledge of histopathological features of ASCC is important to diagnose this uncommon variant. Case Description. An 80-year-old female presented with the chief complaint of the nonhealing lesion in the right lower back region of the jaw for 2 months, associated with pain. A provisional diagnosis of oral cancer was considered, and an incisional biopsy was done. Histopathological presentation of the epithelial tumor island, pseudo glandular duct-like structures, and neoplastic cells showing features of dysplasia and keratin pearl formation confirmed the diagnosis as adenoid (acantholytic) squamous cell carcinoma. Conclusion. The histopathological presentation of adenoid (acantholytic) squamous cell carcinoma reflects the prognosis and metastatic behavior of the diseases. The knowledge of histopathological features of ASCC would be a guide to the untrained eye for the diagnosis and management of this uncommon variant to minimize the rate of metastasis or reoccurrence.

Characterization of a Murine Monoclonal Antibody against Human Esophageal Squamous Cell Carcinoma-Associated Antigen

1998 ◽  
Vol 84 (5) ◽  
pp. 578-582 ◽  
Author(s):  
Jagdish S. Nadkarni ◽  
Pushpalaxmi R. Bhadsavle ◽  
Vivek S. Chitnis ◽  
Jayshree J. Nadkarni ◽  
Jitendra S. Vyas ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Line ◽  
Squamous Cell ◽  
Murine Monoclonal Antibody ◽  
Benign Tumors ◽  
Scatchard Analysis ◽  
Histopathological Diagnosis

A murine monoclonal antibody (MAb) 2G3 of the lgG1 type was raised using the human esophageal squamous cell carcinoma (SCC) cell line TE-2. Immunoblotting with 2G3 indicated that the antigen recognized by 2G3 has a molecular weight of 34 kD. Its activity was evaluated by immunoperoxidase and immunofluorescence on frozen and paraffin sections of various normal tissues, normal and benign tumors as well as various established cell lines. The pattern of reactivity revealed that the antigen recognized by 2G3 was expressed mainly by esophageal SCC. The only exception was represented by malignant breast tumors, where it reacted weakly. Scatchard analysis using 125I-labelled 2G3 showed that TE-2 has approximately 7.5 times more binding sites than the MCF-7 breast cancer cell line. The use of this new MAb is therefore proposed for the histopathological diagnosis of esophageal SCC.

Synchronous Triple Carcinoma of the Lung in One Patient

1987 ◽  
Vol 73 (5) ◽  
pp. 525-529 ◽  
Author(s):  
Paolo Badiali ◽  
Marco Alloisio ◽  
Luciano Lombardi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Squamous Cell ◽  
Lower Lobe ◽  
Small Cell ◽  
Simultaneous Occurrence ◽  
Lung Carcinomas ◽  
The Right ◽  
Common Cell

A case is reported of the simultaneous occurrence of a squamous cell carcinoma and a small cell carcinoma, both centrally located, in the right upper lobe and a peripheral adenocarcinoma in the right lower lobe. The simultaneous occurrence of three primary lung carcinomas is discussed in the light of a probable common cell origin.

PS01.161: THE VERRUCOUS CARCINOMA OF THE ESOPHAGUS: A RARE HIGHLY DIFFERENTIATED SQUAMOUS CELL CARCINOMA

2018 ◽  
Vol 31 (Supplement_1) ◽  
pp. 95-95
Author(s):  
Philipp Gehwolf ◽  
Georg Oberhuber ◽  
Thomas Schmid ◽  
Dietmar Öfner-Velano ◽  
Heinz Wykypiel
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Conflicts Of Interest ◽  
Verrucous Carcinoma ◽  
Case Series ◽  
Esophageal Resection ◽  
Toxic Exposure ◽  
Carcinoma Of The Esophagus ◽  
Mycotic Infections

Abstract Background The verrucous carcinoma of the esophagus is a rare, very slowly growing and uncommonly metastasizing locally progressive and highly differentiated squamous cell carcinoma. The genesis of the tumor is not completely clarified but often associated with human papilloma virus or chemical toxic exposure of the mucosa. On endoscopy it appears as an exophytic, villous, with whitish hyperkeratosis, endosonographically pretending a uT3N + situation. Patients often present with dysphagia and unspecific reflux symptoms. Often several biopsies of the tumor are needed to make the diagnosis, because few routinely taken standard biopsies often show unspecific inflammation or mycotic Infections. However, the carcinoma is subjacent. Diseases on rare occasions often need extensive diagnostics, therefore we want to cal in mind the verrucous carcinoma of the esophagus. Methods Small case series in a single center patient collective. Results From 2010 to 2017, 55 patients underwent an esophageal resection. In two patients (3,6%) a verrucous carcinoma was diagnosed. That is far more often than expected. Conclusion In patients with dysphagia and macroscopic villous structure on endoscopy, further samples should be taken despite benign primary histology and a reference pathologist should be involved. Disclosure All authors have declared no conflicts of interest.

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