Neurovegetative status and 24 hours´ arterial pressure profile of hypertensive patients

10.12737/5483 ◽  
2014 ◽  
Vol 8 (1) ◽  
pp. 1-6
Author(s):  
Чеснокова ◽  
V. Chesnokova
Keyword(s):  
Arterial Pressure ◽  
Arterial Hypertension ◽  
Antihypertensive Therapy ◽  
Cardiac Rhythm ◽  
Pressure Profile ◽  
Control Group ◽  
Autonomic Balance ◽  
Efficient Treatment ◽  
National Joint Committee ◽  
Vegetative Status

The aim of research is study peculiar properties of vegetative status and 24 hours´ arterial pressure profile in inefficient antihypertensive therapy patients. It was examined 180 patients in age from 42 to 65 with diagnosis I-III degree of arterial hypertension on classification RSOC; volunteers without arterial hypertension and sporadic rise of pressure has been integrated into research (n=36). Clinical and biochemical monitoring realized to the whole of examines in accordance with standards on diagnostic of arterial hypertension. 24 hours´ profile arterial pressure will be done in conformity with guideline national joint committee on cure of arterial hypertension JNK VI, WHO/ISH. Determination predominant autonomic balance carried out from system for integrated vegetative status, by its results patients were divided into subgroups. Then the patients were separated into subgroups by predominant autonomic balance with a glance degree and phase of arterial hypertension; modification key indicator of 24 hours´ arterial pressure profile in subgroups was investigated. It has been found experimentally that type of predominant autonomic balance varies with the phase, by not with degree of arterial hypertension. Inefficient antihypertensive therapy patients have more high frequency and variability of cardiac rhythm, which combine with insufficient degree decrease of cardiac rhythm at night; more high value of systolic, diastolic, sphygmic and medium pressure comparison with control group. Complex hemodynamic rates (DP, maxIMP) and also bodymass index in inefficient antihypertensive therapy patients exceed the same in efficient treatment cluster.

Daily arterial pressure profile in young individuals with hereditary burden due to arterial hypertension

2019 ◽  
Vol 17 (2) ◽  
pp. 42-48
Author(s):  
I. A. Grebenkina ◽  
◽  
A. A. Popova ◽  
S. D. Mayanskaya ◽  
S. V. Tretyakov ◽  
...  
Keyword(s):  
Arterial Pressure ◽  
Arterial Hypertension ◽  
Pressure Profile

scholarly journals Prevalence of Arterial Hypertension and Characteristics of Nocturnal Blood Pressure Profile of Asthma Patients According to Therapy and Severity of the Disease: The BADA Study

2020 ◽  
Vol 17 (18) ◽  
pp. 6925
Author(s):  
Domenico Di Raimondo ◽  
Gaia Musiari ◽  
Alida Benfante ◽  
Salvatore Battaglia ◽  
Giuliana Rizzo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Blood Pressure Monitoring ◽  
Pressure Profile ◽  
Control Group ◽  
Cardiovascular Comorbidities ◽  
Cardiovascular Damage ◽  
Increased Risk ◽  
Asthma Patients ◽  
Severity Of The Disease

Background: several studies report an increased risk for asthmatic subjects to develop arterial hypertension and the relationship between these two diseases, frequently co-existing, still has some unclear aspects. Methods: The BADA (blood pressure levels, clinical features and markers of subclinical cardiovascular damage of asthma patients) study is aimed to evaluate the prevalence of the cardiovascular comorbidities of asthma and their impact on the clinical outcome. The main exclusion criteria were the presence of other respiratory diseases, current smoking, any contraindication to ambulatory blood pressure monitoring (ABPM). Results: The overall percentage of asthmatics having also hypertension was 75% (30 patients) vs. 45% (18 patients) of the control group (p: 0.012). Reduced level of FEV1 (but not inhaled steroid therapy) was associated to newly-diagnosed hypertension (p: 0.0002), higher day SBP levels (p: 0.003), higher day DBP levels (p: 0.03), higher 24 h-SBP levels (p: 0.005) and higher 24h-DBP levels (p: 0.03). The regression analysis performed taking into account sex, age, diabetes, fasting glucose, and body mass index confirms the independent role played by asthma: odds ratio (OR): 3.66 (CI: 1.29–11.1). Conclusions: hypertension is highly prevalent in asthma; the use of ABPM has allowed the detection of a considerable number of unrecognized hypertensives.

scholarly journals THE IMPACT OF FAMILY ENVIRONMENT ON PREVALENCE OF ARTERIAL HYPERTENSION AMONG SCHOOLCHILDREN

2017 ◽  
Vol 23 (2) ◽  
pp. 60-63
Author(s):  
Arzu F. Mekhtieva
Keyword(s):  
Risk Factors ◽  
Arterial Pressure ◽  
Arterial Hypertension ◽  
Family Environment ◽  
Tobacco Smoking ◽  
Well Being ◽  
Control Group ◽  
Weak Intensity ◽  
Material Conditions ◽  
The Impact

The purpose of study. To investigate characteristics of family environment as risk factors of development of arterial hypertension and high normal arterial pressure in school children.The methods. The thrice-repeated measurement of arterial pressure was implemented among 662 schoolchildren and questionnaire survey of their parents as well. The questionnaire included issues related to conditions of living, dimensions of housing area, material well-being and effect of passive tobacco smoking. The schoolchildren with arterial hypertension resided in 107 families, schoolchildren with high normal arterial pressure - in 78 families and other schoolchildren without arterial hypertension and high normal arterial pressure - in 477 families (control group).The results. The most exposure of arterial hypertension in schoolchildren was observed in families with unsatisfactory hygienic conditions of residence - 47.7±4.9% of cases; with housing, less than 4.0 m2 per one schoolchild - 27,1±4,3% of cases; and also in families with unfavorable material conditions - 62,6±4,7% of cases. The exposure of high normal arterial pressure is analogous. At strong intensity of tobacco smoking of parents’ exposure of arterial hypertension among schoolchildren made up to 45,8±4,8% of cases; at medium intensity - 33,6±4,6% of cases; at weak intensity - 12,1±3,2% of cases and in absence of passive tobacco smoking - 8,4±2,7% of cases. The similar picture is observed and at exposure of high normal arterial pressure.The conclusion. As far as positive social economic transformations are occurring and well-being of population is ameliorating, with time the impact of the first three noted risk factors of family environment of schoolchildren will become weaker. Yet, the impact of passive tobacco smoking on organisms of children can be minimized by force of available controlled explanatory work with parents.

scholarly journals Congenital immunity in patients with essential arterial hypertension and effectiveness of antihypertensive pharmacotherapy

2020 ◽  
pp. 27-33
Author(s):  
Vadim P. Mikhin ◽  
Evgenia V. Gavrilyuk ◽  
Irina V. Evsegneeva
Keyword(s):  
Blood Pressure ◽  
Innate Immunity ◽  
Arterial Hypertension ◽  
Antihypertensive Therapy ◽  
Complement System ◽  
Control Group ◽  
Target Values ◽  
Essential Arterial Hypertension ◽  
Group 2 ◽  
The Complement System

The purpose of the study was to assess the parameters of innate immunity in patients with essential arterial hypertension and to establish a relationship with the effectiveness of antihypertensive pharmacotherapy. Materials and methods. The study included 48 patients with essential arterial hypertension stage II, arterial hypertension 2 degree and hypertrophy of the left ventricular myocardium, which were divided into 2 groups: the first group (25 patients) - these are patients whose blood pressure reached the target values, and the second group (23 patients) are patients whose blood pressure did not reach the target values against the background of antihypertensive therapy (perindopril - 5 mg/day and amlodipine - 5 mg/day) (group 2). Indicators of 18 healthy donors were used as a comparison group (control group). Results. In patients with essential arterial hypertension of group 1, compared with the control group, the concentration of IL-1α, IL-6, IL-8, IL-10, IL-1 receptor antagonist, IL-2, C4- and C5a-components of the complement system and factor H is significantly higher and the level of C3 is lower-component of the complement system. In patients with essential arterial hypertension of group 2, more pronounced changes in the cytokine link of the immunity and the complement system were established before the start of antihypertensive therapy. After the antihypertensive therapy in patients with essential arterial hypertension of the 1st group in the blood plasma, the concentration of TNF, IL-1α, IL-8, IL-10, IL-1 receptor antagonist significantly decreased, but not to the values of the control group, and in patients of the 2nd group, the effectiveness of antihypertensive therapy in correcting parameters innate immunity was found to be less effective. Conclusion. Revealing the participation of innate immunity indicators in the formation of arterial hypertension opens up new possibilities for the pathogenetic therapy of this disease and developing measures to prevent or level the damage to target organs.

Blood pressure time load formation in patients with arterial hypertension without metabolic syndrome

2021 ◽  
Vol 25 (4) ◽  
pp. 282-289
Author(s):  
Tatjana Yu. Zotova ◽  
Anastasiya A. Lukanina ◽  
Mikhail L. Blagonravov
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Arterial Hypertension ◽  
Pressure Profile ◽  
Control Group ◽  
Double Product ◽  
Nocturnal Blood Pressure ◽  
Blood Pressure Profile ◽  
Pressure Time ◽  
Structural Point

Relevance . The study of the daily dynamics of blood pressure in arterial hypertension both on the basis of the daily index and on the basis of the time load is a relevant task, since, these indicators are associated in the literature with stable changes in the neurohumoral regulation of the cardiovascular system in arterial hypertension . The aim of the study was to compare data of the time load in patients with arterial hypertension , depending on the nocturnal blood pressure profile, with integrative indicators of the activity of the cardiovascular system in the form of a Circadian index, a structural point of blood pressure, double product. Materials and Methods. The study included 72 patients who were treated at the City Clinical Hospital No 13 in Moscow and signed a voluntary consent to participate in the research and the processing of personal data. Inclusion criteria: arterial hypertension. Exclusion criteria: metabolic syndrome, secondary forms of arterial hypertension and concomitant pathology. Depending on the daily index (DI10% and DI10%) patients were divided into 2 groups: 1 group (N= 32): patients with arterial hypertension without nocturnal decrease in blood pressure (non-dippers and night-pickers100%); Group 2 (N = 40): patients with arterial hypertension who had a nocturnal decrease in blood pressure (dippers and over dippers 100%). All patients and members of the control group (N=15) underwent daily monitoring of blood pressure (24-hour Arterial Blood Pressure Monitoring). The data were statistically processed to determine the 5% level of significance of differences (p0.05) (Students test). In the comparative analysis of integrative indicators at day and at night, a variance analysis was applied. Results and Discussion . As a result of the study, it was found that the values of Circadian Index for blood pressure vary depending on the type of night decrease in blood pressure and the blood pressure time load, while daily index and structural point of blood pressure remain on the same level as a reflection of the hemodynamic allostasis existing in both groups. Conclusion. Reflection of the allostatic load on hemodynamics is change of values of double product and of the structural point of blood pressure compared with the control group. These changes are not associated with the peculiarities of the nocturnal blood pressure profile in patients with hypertension without metabolic syndrome.

scholarly journals Endothelial damage and circadian blood pressure profile in rheumatoid arthritis

2019 ◽  
Vol 91 (5) ◽  
pp. 89-95 ◽  
Author(s):  
N P Shilkina ◽  
I E Yunonin ◽  
S V Butusova ◽  
E V Mikhailova ◽  
A A Vinogradov
Keyword(s):  
Rheumatoid Arthritis ◽  
Endothelial Dysfunction ◽  
Arterial Pressure ◽  
Pressure Profile ◽  
Endothelial Damage ◽  
Control Group ◽  
Endothelial Adhesion Molecule ◽  
Daily Monitoring ◽  
Immunoenzyme Analysis ◽  
Positive Correlations

Aim. To study the influence of the state of endothelium on the daily profile of arterial pressure (AP) in patients with rheumatoid arthritis (RA). Materials and methods. In 70 RA pts carried out C-reactive protein (CRP), vascular endothelial adhesion molecule type 1 (sVCAM-1), antigen von Willebrand Factor (AG WF), interleukin-8 (Il-8), rheumatoid factor (RF), IgG, endotheline-1 (ET-1), number of desquamated endotheliocytes cells (DE), VS, activity of renin by immunoenzyme analysis. The dysfunction of endothelium was evaluated by calculation of DE. The functional methods included the daily monitoring of arterial pressure (AP). Results. Arterial hypertension (AH) occurred in 40 (57.1%) pts. RA pts are revealed the signs of endothelial dysfunction, about which significant differences among the indices of activation of endothelium in comparison with control group testify. ET-1, sVCAM-1, vWF AG, Il-8, CRP content was higher in RA pts. Reliably above there was a number of DE. Reliable differences according to these indices depending of RA activity were discovered. With conducting of correlation analysis it is revealed, that markers of the activation of endothelium: sVCAM-1, vWF AG positively correlated with increasing RF IgG and indices of the immune inflammation: CRP, and DE number. In patients suffering from RA, showed signs of endothelial dysfunction. The positive correlation between endothelial damage and daily profile of AP show the relationship of these processes. Conclusion. Positive correlations between the damage of endothelium and disturbance of AP daily profile testify about the interrelation of these processes.

scholarly journals The use of telmisartan in patients with refractory arterial hypertension and obesity

2019 ◽  
Vol 18 (1) ◽  
pp. 73-81 ◽  
Author(s):  
I. Е. Deneka ◽  
A. V. Rodionov ◽  
V. V. Fomin
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Antihypertensive Therapy ◽  
Ace Inhibitor ◽  
Enzyme Inhibitor ◽  
Blood Pressure Monitoring ◽  
Main Group ◽  
Control Group ◽  
Angiotensin Ii Receptor Blocker ◽  
End Point

Aim.To evaluate the effectiveness of telmisartan as a component of triple antihypertensive therapy in patients with obesity and refractory arterial hypertension.Material and methods.The study included 30 patients with obesity and refractory arterial hypertension. All patients received an angiotensin II receptor blocker (ARB) or an angiotensin-converting enzyme inhibitor (ACE inhibitor) in an adequate dosage as part of a triple antihypertensive therapy that also includes a calcium antagonist and thiazide diuretic. Participants were randomly divided into two equal groups. In the main group, telmisartan (Dr. Reddy’s Laboratories) was prescribed at a dosage of 80 mg/day instead of the previously taken ARB or ACE inhibitor. In the control group, patients continued to receive a previously prescribed ARB or an ACE inhibitor. The primary end point was a decrease in mean daily systolic and/or diastolic blood pressure (SBP and DBP) according to 24-hour blood pressure monitoring at 10 mm Hg and more than 20 weeks after the start of the study. The secondary end point was a decrease in the concentration of inflammatory markers and an increase in the level of adiponectin by 15%.Results.After 20 weeks, in the telmisartan group, we noted a significant decrease in the average daily SBP and DBP: in the main group from 145,9±5,4/95,6±4,8 mm Hg to 134,8±3,0/84,9±4,2 mm Hg, in the control group with 147,2±4,9/96,4±5,6 mm Hg to 142,4±4,3/96,9±62 mm Hg. We also determined an increase in the serum adiponectin concentration from 9,3±5,6 μg/ml to 13,4±6,6 μg/ml in the main group and a decrease from 8,8±5,2 μg/ml to 8,6±5,6 μg/ml in the control group, as well as a decrease in the concentration of highly sensitive C-reactive protein (main group from 8,8±3,0 to 6,0±2,8 mg/l and the control group from 7,4±3,8 to 6,9±4,9 mg/l) and interleukin-6 (main group from 16,2±6,1 to 12,3±2,8 pg/ml, control group from 22,5±4,2 to 19,9±5,2 pg/ml).Conclusion.Telmisartan can be considered as a drug of choice as part of multi-component therapy in the treatment of patients with obesity and refractor arterial hypertension.

scholarly journals Cardiovascular and respiratory alterations in dogs during cervical myelography using ioversol

2013 ◽  
Vol 65 (4) ◽  
pp. 1024-1032
Author(s):  
S.R.A. Melo e Silva ◽  
E.A. Tudury ◽  
V.B. Albuquerque ◽  
F.P. Araújo ◽  
T.F.B. Souza ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Arterial Pressure ◽  
Cardiac Rhythm ◽  
Statistical Difference ◽  
Systolic Arterial Pressure ◽  
Control Group ◽  
Neck Flexion ◽  
Oxyhemoglobin Saturation ◽  
Cervical Myelography ◽  
Qt Intervals

Subarachnoid infusion of most contrast mediums and the steps involved in performing a cervical myelography have adverse affects that can discourage its use in the radiographic diagnosis of spinal cord diseases. Thus, the cardiovascular and respiratory alterations associated with neck flexion, subarachnoid puncture, and cerebrospinal fluid drainage during subarachnoid infusion of ioversol (320mgI/mL) in dogs under general anesthesia using isoflurane were evaluated. The dogs received subarachnoid infusion of autologous cerebrospinal fluid kept at 38°C - control group (GC); ioversol 0.3mL/kg at 25°C (GI25) and ioversol 0.3mL/kg heated to 38°C (GI38). Each dog had its heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), respiratory rate (RR), oxyhemoglobin saturation (SaO2) and electrocardiography readings (PR and QT intervals) recorded. Group comparisons showed no statistical difference regarding neck positioning, subarachnoid puncture, and subarachnoid infusion of contrast medium on HR, RR and SaO2, cardiac rhythm or conduction. However, isoflurane significantly increased PR and QT intervals. Based on these findings, it is concluded that the steps involved in cervical myelography and the use of ioversol 320mgI/mL at 0.3mL/kg (25ºC and 38ºC) during cervical myelography did not result in relevant cardiovascular and respiratory alterations, except for an elevation in arterial pressure after injection of ioversol.

scholarly journals Organoprotection with arterial hypertension 2-3 degrees

2018 ◽  
Vol 15 (4) ◽  
pp. 47-52
Author(s):  
I I Afonicheva ◽  
M V Melnik ◽  
S A Knyazeva ◽  
A A Kazyulin
Keyword(s):  
Endothelial Dysfunction ◽  
Arterial Hypertension ◽  
Antihypertensive Therapy ◽  
Ankle Brachial Index ◽  
Vascular Wall ◽  
Left Ventricular ◽  
Control Group ◽  
Renal Lesion ◽  
Study Group ◽  
Old Patients

Objective. Arterial hypertension (AH) is one of the most common and socially significant diseases worldwide. Despite years of experience gained in studying hypertension, the problems concerning selection of antihypertensive therapy with pleiotropic organ-protecting effects are still of current importance. Purpose - to assess therapeutic efficacy and pleiotropic organ-protective capability of third-generation calcium antagonist lercanidipine in patients with stage 2-3 hypertension. Materials and methods. Our study enrolled a total of ninety-two 31-to-84-year-old patients. Of these, 72 patients diagnosed as having stage 2 or 3 AH composed the Study Group and 20 apparently healthy subjects were included into the Control Group. At baseline and after 6 months, all patients of the Study Group underwent examinations consisting in measuring biochemical parameters [total cholesterol (TCH), triglycerides, low-density lipoprotein cholesterol (LDL CH), uric acid, urea, creatinine, glucose], 24-hour ambulatory BP monitoring, echocardiography in order to assess the dimensions and volume of the cardiac chambers, thickness of the left ventricular posterior wall (LVPW) and left-ventricular myocardium mass index (LVMMI), studying microalbuminuria (MAU), a known marker of endothelial dysfunction and early renal lesion; assessing the state of the vascular wall by the ankle-brachial index (ABI) and pulse pressure (PP). Antihypertensive therapy consisted in lercanidipine alone taken at a dose of 10-20 mg/day, failure to thereby achieve the target BP level was followed by additionally prescribing an angiotensin converting enzyme (ACE) inhibitor, enalapril, given at a dose of 5-20 mg twice daily. Results. All patients by the end of the study achieved the target level of AP (p≤0.05), also demonstrating significantly improved (p≤0.01) parameters of endothelial dysfunction and an early marker of renal damage (MAU), indices of elastic properties of the vascular wall ABI (p≤0.05) and PP (p=0.01). Significantly positive dynamics was observed for the following parameters: decreased creatinine concentration (p≤0.001), increased GFR (p≤0.001), decreased levels of TCH (p≤0.01) and LDL CH (p≤0.001). Conclusion. Lercanidipine therapy of patients with stage 2-3 AH proved highly efficient, well tolerated, metabolically neutral with pleiotropic organprotecting properties in the form of improved condition of the vascular wall, correction of endothelial dysfunction, nephroprotective action

scholarly journals Endothelial function in patients with asthma according to circadian blood pressure profile

2010 ◽  
Vol 16 (4) ◽  
pp. 390-394
Author(s):  
N. A. Karoli ◽  
A. A. Roschina ◽  
A. P. Rebrov
Keyword(s):  
Blood Pressure ◽  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Arterial Hypertension ◽  
Bronchial Asthma ◽  
Blood Pressure Monitoring ◽  
Pressure Profile ◽  
Control Group ◽  
Essential Arterial Hypertension ◽  
Functional Features

Objective. The aim of study is asses of the endothelial functional features in patient with bronchial asthma with different types of blood pressure (BP) circadial rhythm. Design and methods. 62 patients with bronchial asthma (from 25 to 60 years old) were included in our study. Control group was represented by 30 healthy people for examination of endothelial function and 77 patients with essential arterial hypertension for 24-h blood pressure rhythm analysis. We described 2 groups of patients («dippers» and «non-dippers») by ambulatory 24-h blood pressure monitoring. Results. «Non-dipper» type was significantly prevalent in patient with asthma in comparative with patients with essential arterial hypertension (51,6% opposite 33,7%). The flow-depended endothelial dysfunction is most common in patient with asthma (dippers and non-dippers) than in control group. Negative correlation between nitroglycerin-depended vasodilatation and night-depressing systolic and diastolic blood pressure degree was presented in the study. Conclusion. We founded associations between endothelial dysfunction and BP circadial rhythm in patients with bronchial asthma, especially in «non-dippers».

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