Genetic Determinants of Metabolism and Benign Prostate Enlargement: Associations with Prostate Volume

Background: To analyse causes of failure of medical management in benign prostate enlargement (BPE) in patients who undergo surgery following medical treatment and to elucidate parameters which warrant for early surgical treatment. Methods: Records of 747 patients who underwent surgery for BPE were reviewed for prostate volume, median lobe enlargement, post void residual urine, duration and type of medical treatment given for BPE. We used univariate and multivariate analysis to find out significant parameters for medical treatment failure. Results: A total of 601 patients (80.45%) received medical treatment for their lower urinary tract symptoms (LUTS), for a duration ranging between 3 months and 2 years. Statistically significant difference was found between age, prostate volume, intravesical projection, PSA and acute urinary retention with failure of medical treatment. Conclusions: BPE patients with failure to respond with medical management within 3–6 months and/or associated with large size prostate, intravesical projection and raised serum PSA should better be offered surgical treatment.

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Association between Hyperglycemia and Prostate Volume in Patients with Benign Prostate Enlargement : A Hospital Case-Control Study

Journal of Biomedicine and Translational Research ◽

10.14710/jbtr.v3i2.1971 ◽

2017 ◽

Vol 3 (2) ◽

pp. 46

Author(s):

Eriawan Agung Nugroho ◽

Rickky Kurniawan

Keyword(s):

Benign Prostate Hyperplasia ◽

Prostate Volume ◽

Significant Risk ◽

Significant Risk Factor ◽

Prostate Hyperplasia ◽

Increased Risk ◽

Prostate Enlargement ◽

Significant Difference ◽

Spearman Test ◽

Benign Prostate

Introduction: Prostate is a male organ which might enlarge mostly, either benign or malignant. Hyperglycemia is one of the factor that increase the risk of benign prostate hyperplasia. There is lack of studies which assessed the relationship between benign prostate hyperplasia and isolated hyperglycemia. The aim of this study was to evaluate the association between hyperglycemia and prostate volume in patients with benign prostate enlargement in dr. Kariadi Hospital Semarang. Method: We conducted a retrospective analysis of clinical data which obtained from 640 men between 2010 and 2012 who admitted to the hospital with diagnosis of benign prostate enlargement. By their medical records, these patients were evaluated of their plasma glucose level and prostate volume by trans rectal ultrasound. The presence of hyperglycemia was determined based on the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Patients have already been diagnosed with controlled diabetes mellitus by an internist. We allocated the subjects into two groups: patients with hyperglycemia and non-hyperglycemia. Logistic regression analysis was used to assess whether hyperglycemia was associated with the increased risk of benign prostate enlargement.Results: Significant difference of prostate volume found between groups. Prostate volume was significantly greater in hyperglycemia group compared with non-hyperglycemia ones in all sub-groups based on age (in decades). Odds Ratio (OR) in patients with hyperglycemia was 2.25 (95% CI: 1.23-4.11). By non-parametric Spearman test it obtained Group 1 (P1) p = 0.000 and r = 0.669, group 2 (P2) it obtained p = 0.000 and r = 0.672, group 3 (P3) it obtained p = 0.000 and r = 0.415 which implied strong positive associationConclusion: Hyperglycemia and prostate volume were significantly associated in patients with benign prostate enlargement. Hyperglycemia became a significant risk factor for prostate enlargement in patients with benign prostate enlargement in dr. Kariadi Hospital Semarang.

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Combination of solifenacin with tamsulosin reduces prostate volume and vascularity as opposed to tamsulosin monotherapy in patients with benign prostate enlargement and overactive bladder symptoms: Results from a randomized pilot study

International Journal of Urology ◽

10.1111/iju.13721 ◽

2018 ◽

Vol 25 (8) ◽

pp. 737-745 ◽

Cited By ~ 2

Author(s):

Vasileios Sakalis ◽

Vasileios Sfiggas ◽

Ioannis Vouros ◽

George Salpiggidis ◽

Athanasios Papathanasiou ◽

...

Keyword(s):

Pilot Study ◽

Overactive Bladder ◽

Prostate Volume ◽

Overactive Bladder Symptoms ◽

Prostate Enlargement ◽

Bladder Symptoms ◽

Benign Prostate

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Relationship between Serum Testosterone and Nocturia in Men without Benign Prostate Enlargement

Klinička psihologija ◽

10.21465/2016-kp-p-0032 ◽

2016 ◽

Vol 9 (1) ◽

pp. 167-167

Author(s):

S. Jeh ◽

◽

D. Seo ◽

S. Choi ◽

S. Kam ◽

...

Keyword(s):

Flow Rate ◽

Testosterone Level ◽

Prostate Volume ◽

Specific Antigen ◽

Multivariate Logistic Regression Analysis ◽

Serum Testosterone ◽

Total Testosterone ◽

Urinary Flow ◽

Prostate Enlargement ◽

Benign Prostate

Objective: To clarify the relationship between serum total testosterone and nocturia in males without an enlarged prostate. Design and Method: Among the 1029 male patients who visited our clinic for health screening from January 2010 to July 2014, 596 patients without benign prostate enlargement (BPE) were analyzed. To evaluate the effect of serum total testosterone on prevalence of nocturia and number of nocturia episodes, multivariate analyses were performed including the covariates of age, International Prostate Symptom Score (IPSS), International Index of Erectile Function (IIEF) score, body mass index, prostate specific antigen, prostate volume and maximal urinary flow rate. Results: Mean prostate volume was 21.70±4.34 ml and prevalence of nocturia (over 1 times/night) was 22.1%. Multivariate logistic regression analysis revealed positive associations of age (OR 1.048, P = 0.005), total IPSS (OR 1.217, P <0.001) and testosterone level (OR 1.115, P = 0.041) with the prevalence of nocturia. Although the mean testosterone level was progressively elevated as the number of nocturia episodes increased, no consistent association with the number of nocturia episodes was seen for testosterone after adjusting for age, IPSS, IIEF score and maximal urine flow rate. Conclusions: Serum total testosterone level is significantly positively associated with the prevalence of nocturia. Therefore, in men without enlarged prostate, testosterone seems to have an opposing role in the etiology of nocturia.

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Management of nocturia in patients with benign prostate enlargement and overactive bladder symptoms with Solifenacin and Tamsulosin combination treatment versus Tamsulosin monotherapy.

10.26226/morressier.59b63e41d462b8029238962d ◽

2017 ◽

Author(s):

Vasileios Sakalis

Keyword(s):

Overactive Bladder ◽

Combination Treatment ◽

Overactive Bladder Symptoms ◽

Prostate Enlargement ◽

Bladder Symptoms ◽

Benign Prostate

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Correlation of intravesical prostatic protrusion with severity of lower urinary symptoms among patients with benign prostatic hyperplasia

African Journal of Urology ◽

10.1186/s12301-020-00102-0 ◽

2021 ◽

Vol 27 (1) ◽

Author(s):

Babatunde K. Hamza ◽

Muhammed Ahmed ◽

Ahmad Bello ◽

Musliu Adetola Tolani ◽

Mudi Awaisu ◽

...

Keyword(s):

Flow Rate ◽

Bladder Outlet Obstruction ◽

Peak Flow ◽

Prostate Volume ◽

Outlet Obstruction ◽

Peak Flow Rate ◽

The Mean ◽

Benign Prostate ◽

Intravesical Prostatic Protrusion ◽

Lower Urinary

Abstract Background Benign prostate hyperplasia (BPH) is characterized by an increase in the number of epithelial and stromal cells in the periurethral area of the prostate. Lower urinary tract symptoms (LUTS) often develop as a manifestation of bladder outlet obstruction (BOO) due to benign prostate enlargement. When the prostate enlarges, protrusion into the bladder often occurs as a result of morphological changes of the gland. Prostatic protrusion into the bladder can be measured with ultrasound as intravesical prostatic protrusion (IPP). There are studies that have shown IPP as a reliable predictor of bladder obstruction index (BOOI) as measured by pressure flow studies. IPP is thereby reliable in assessing the severity of BOO in patients with BPH. The severity of symptoms in patients with BPH can be assessed through several scoring systems. The most widely used symptoms scoring system is the International Prostate Symptoms Score (IPSS). The aim of this study is to determine the correlation of IPP with IPSS in men with BPH at our facility. Methods The study was a cross-sectional observational study that was conducted at the Division of Urology, Department of Surgery, in our facility. The study was conducted on patients greater than 50 years LUTS and an enlarged prostate on digital rectal examination and/or ultrasound. All consenting patients were assessed with the International Prostate Symptoms Score (IPSS) questionnaire, following which an abdominal ultrasound was done to measure the intravesical prostatic protrusion (IPP), prostate volume (PV) and post-void residual (PVR) urine. All the patients had uroflowmetry, and the peak flow rate was determined. The data obtained were entered into a proforma. The results were analyzed using Statistical Package for Social Sciences (SPSS) software package version 20. Results A total of 167 patients were seen during the study period. The mean age was 63.7 ± 8.9 years, with a range of 45–90 years. The mean IPSS was 18.24 ± 6.93, with a range of 5–35. There were severe symptoms in 49.1%, while 43.1% had moderate symptoms and 7.8% had mild symptoms. The overall mean IPP was 10.3 ± 8 mm. Sixty-two patients (37.1%) had grade I IPP, 21 patients (12.6%) had grade II IPP and 84 patients (50.3%) had grade III IPP. The mean prostate volume and peak flow rate were 64 g ± 34.7 and 11.6 ml/s ± 5.4, respectively. The median PVR was 45 ml with a range of 0–400 ml. There was a significant positive correlation between the IPP and IPSS (P = 0.001). IPP also had a significant positive correlation with prostate volume and post-void residual and a significant negative correlation with the peak flow rate (P < 0.01). Conclusion Intravesical prostatic protrusion is a reliable predictor of severity of LUTS as measured by IPSS, and it also shows good correlation with other surrogates of bladder outlet obstruction.

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