scholarly journals CONDITION OF THE MUSCULOSKELETAL SYSTEM IN PATIENTSWITH ACROMEGALY.

2010 ◽  
Vol 13 (1) ◽  
pp. 19-27
Author(s):  
A S Fedotova ◽  
N N Molitvoslovova ◽  
L I Alekseeva ◽  
L Ya Rozhinskaya ◽  
A. S. Fedotova ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Cochrane Collaboration ◽  
Premature Death ◽  
Social Adaptation ◽  
Mineral Density ◽  
Locomotor Apparatus ◽  
Low Incidence ◽  
Additional Therapy

Despite the relatively low incidence of acromegaly (60-70 cases per I million inhabitants), this disease has a special place among the heterogeneous group of diseases that lead to the defeat of the locomotor apparatus. The slow growth of the clinical manifestations of acromegaly and as a consequence, late diagnosis, the cause of early disability and premature death of patients. In order to improve the quality of life and social adaptation of patients to date is an obvious need to identify groups of patients with acromegaly, requiring additional therapy for osteoporosis and osteoarthritis. We performed the search in bibliographic bases MEDLINE and Cochrane Collaboration from 2000 on 2009. Key words were the following: acromegaly, acromegaly and arthropathy, osteoporosis and acromegaly, the bone mineral density and acromegaly, fractures and acromegaly. In this article the data about role of risk factors for the defeat ofosteoarticular apparatus, the dynamics of the articular syndrome and the state of bone tissue in acromegaly.

scholarly journals Fabry disease, a complex pathology not easy to diagnose

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Paolo Colomba ◽  
Simone Scalia ◽  
Giuseppe Cammarata ◽  
Carmela Zizzo ◽  
Daniele Francofonte ◽  
...  
Keyword(s):  
Fabry Disease ◽  
Vascular Endothelium ◽  
Clinical Manifestations ◽  
Premature Death ◽  
Lysosomal Storage ◽  
Familial Data ◽  
Enzyme Replacement ◽  
Cerebrovascular Complications ◽  
Cellular Events

Fabry disease is a multisystemic lysosomal storage disorder, inherited in an X-linked manner. It is a defect of metabolism of the glycosphingolipids, due to the reduction or absence of the activity of lysosomal enzyme α-galactosidase A. This reduction of activity causes the storage of globotriaosylceramide and derivatives in the lysosomes, triggering a cascade of cellular events, mainly in vascular endothelium. These events are the responsible for the systemic clinical manifestations and the renal, cardiac and cerebrovascular complications, or a combination of them. The symptomatology can lead to the premature death of patient between the fourth or fifth decade of life. The first symptoms can occur at different ages, generally in childhood, with different severity and course. Fabry disease is suspected on the basis of clinical and anamnestic-familial data, and it is confirmed by enzymatic and genetic assays. However, Fabry disease could be a pathology more complex than previously considered, and the diagnostic tests that are currently in use could be not always sufficient to confirm the clinical diagnosis. Probably, other factors could be also involved in the onset of symptomatology. In the last years, the knowledge of the disease is considerably increased but other studies are necessary to make a prompt and reliable diagnosis. An early diagnosis of Fabry disease is essential for the beginning of the enzyme replacement therapy, which can contribute to arrest its progression and improve the quality of life of patients.

scholarly journals ON THE ROLE OF HISTOMORPHOMETRIC (STEREOLOGICAL) MICROSTRUCTURE PARAMETERS IN THE PREDICTION OF VERTEBRAE COMPRESSION STRENGTH

2019 ◽  
Vol 38 (1) ◽  
pp. 63 ◽  
Author(s):  
Leszek Karol Wojnar ◽  
Aneta Gądek-Moszczak ◽  
Jacek Pietraszek
Keyword(s):  
Compression Strength ◽  
Correlation Coefficients ◽  
Diagnostic Techniques ◽  
Micro Ct ◽  
Compression Tests ◽  
Mineral Density ◽  
3D Images ◽  
Microstructure Parameters

The well-documented relation between bone mineral density (BMD) and bone compression strength constitutes the basis for osteoporosis diagnostics and the assessment of fracture risk. Simultaneously, this relation demonstrates a considerable scatter of results as bones of identical mineral density may have significantly different properties. The experimentally confirmed theorem that two materials or tissues of identical microstructure have identical properties leads to the evaluation of various quantitative stereological parameters (also referred to in biomedicine as histomorphology). These parameters, obtained from analysis of 2D or 3D images, have been used in numerous attempts to explain changes in bone strength. Although numerous correlation dependencies, often with high correlation coefficients, were evaluated, we do not know which parameters are worth evaluating, and there is no physical interpretation of these relations. An extended statistical analysis was accomplished on the basis of analysis of 3D images from 23 lumbar (L3) vertebrae scanned with micro-CT and the results of subsequent compression tests. A new parameter called SDF (structure destruction factor) was proposed in order to characterise the quality of 3D trabecular structures, and its significance was demonstrated. The final correlation function, which uses only three stereological parameters, made it possible to predict compression strength with considerable precision. The estimated values correlated very well with the apparent values (correlation coefficient r=0.96). Finally, the stereological parameters most suitable for characterisation of bone compression strength were chosen and a mechanism responsible for the changes in mechanical properties was proposed. The results obtained defined the necessary improvements in diagnostic techniques that would allow for more efficient quantitative microstructure evaluation and guidelines on how to improve treatment of patients with weakened bones.

scholarly journals Therapeutic effects of lignans in women in perimenopausal and postmenopausal periods (review of literature)

2021 ◽  
Vol 8 (1) ◽  
pp. 26-34
Author(s):  
Lyudmila A. Ozolinya ◽  
Valentina V. Litvinova
Keyword(s):  
Emotional Disorders ◽  
Alternative Methods ◽  
Therapeutic Effects ◽  
Female Population ◽  
Perimenopausal Women ◽  
Prevention And Treatment ◽  
Low Incidence ◽  
Positive Effect

Today, there is a tendency towards an increase of the number of the female population that has crossed the line of menopause, which makes it more urgent to improve the quality of life of women and to develop safe methods for the prevention and treatment of climacteric syndrome (CS), which is an integral medical, social and economic problems. In view of the presence of contraindications for use and defined risks of complications with the use of hormone menopausal therapy (HRT), it is necessary to develop alternative methods for the prevention and treatment of perimenopausal symptoms. This literary review of domestic and foreign sources demonstrates information about the role of the plant lignan 7-hydroxymatairezinol (7-HMR) in maintaining the physical and psychoemotional health of women in the period of peri- and postmenopause. As a result of the analysis of the therapeutic effects of the 7-HMR molecule, the ability to relieve the main symptoms of CS (neurovegetative presentations and emotional disorders), to improve the general state of health and metabolic profile of perimenopausal women was revealed. High safety and low incidence of side effects were noted, as well as a positive effect on the dynamics of body weight. The presence of a stable anti-inflammatory and antioxidant activity 7-HMR makes it possible to recommend this lignan to women in the climacteric period as an effective drug for the prevention of the formation of immune deficiency, which contributes to the development of oncological and autoimmune diseases. The proven antitumor activity confirms the promise of using the 7-HMR for the implementation of oncopreventive measures in women of peri- and postmenopausal age.

scholarly journals Changes in Plasma Phospholipid Metabolism Are Associated with Clinical Manifestations of Systemic Sclerosis

Diagnostics ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2116
Author(s):  
Marija Geroldinger-Simić ◽  
Thomas Bögl ◽  
Markus Himmelsbach ◽  
Norbert Sepp ◽  
Wolfgang Buchberger
Keyword(s):  
Systemic Sclerosis ◽  
High Performance ◽  
Clinical Manifestations ◽  
Plasma Phospholipid ◽  
Phospholipid Metabolism ◽  
Internal Organs ◽  
New Biomarkers ◽  
First Time

Systemic sclerosis (SSc) is an autoimmune disease with fibrosis of the skin and/or internal organs, causing a decrease in quality of life and survival. There is no causative therapy, and the pathophysiology of the SSc remains unclear. Studies showed that lipid metabolism was relevant for autoimmune diseases, but little is known about the role of lipids in SSc. In the present study, we sought to explore the phospholipid profile of SSc by using the lipidomics approach. We also aimed to analyze lipidomics results for different clinical manifestations of SSc. Experiments were performed using high-performance liquid chromatography coupled to mass spectrometry for the lipidomic profiling of plasma samples from patients with SSc. Our study showed, for the first time, significant changes in the level of phospholipids such as plasmalogens and sphingomyelins from the plasma of SSc patients as compared to controls. Phosphatidylcholine plasmalogens species and sphingomyelins were significantly increased in SSc patients as compared to controls. Our results also demonstrated a significant association of changes in the metabolism of phospholipids (phosphatidylcholine and phosphatidylethanolamine plasmalogens species and sphingomyelins) with different clinical manifestations of SSc. Further lipidomic studies might lead to the detection of lipids as new biomarkers or therapeutic targets of SSc.

scholarly journals Primary Hyperparathyroidism: Modern Conception and Clinical Observation

2020 ◽  
Vol 10 (2) ◽  
pp. 94-101
Author(s):  
L. M. Farkhutdinova
Keyword(s):  
Parathyroid Hormone ◽  
Primary Hyperparathyroidism ◽  
Parathyroid Adenoma ◽  
Clinical Manifestations ◽  
Premature Death ◽  
Developed Countries ◽  
Severe Form ◽  
Mineral Density ◽  
Target Organs ◽  
Increased Risk

The article is devoted to one of the actual medical and social problems — primary hyperparathyroidism, the late diagnosis of which leads to the development of severe complications and an increased risk of premature death. Unlike developed countries, where 80% of cases are represented by mild forms of the disease, in the Russian Federation this indicator does not exceed 30%, while 70% are manifest forms. Widespread awareness of doctors of various specialties in the diagnosis of parathyroid adenoma is necessary for the timely detection of the disease. The article reflects the main stages of the study of the disease, the pathogenesis of the clinical manifestations of primary hyperparathyroidism, the classic symptoms of which are changes in the target organs of the parathyroid hormone — bone tissue, urinary system and gastrointestinal tract, is considered. Bone disorders are the most common manifestation of hyperparathyroidism and are characterized by increased bone metabolism with a progressive decrease in bone mineral density. Typical changes in the kidneys include nephrolithiasis and nephrocalcinosis, causing the formation of renal failure. Gastrointestinal signs of hyperparathyroidism are erosion and ulcers of the stomach and duodenum, prone to bleeding, recurrent pancreatitis. Diagnosis of the disease is based on laboratory results, characterized by elevated levels of calcium and parathyroid hormone in the blood. Visualization of the paradenomas in most cases is provided by ultrasound and scintigraphy. Removal of parathyroid adenoma is the most effective treatment. A clinical case of a severe form of the disease is presented, indicating an urgent need to take measures to solve the problem of primary hyperparathyroidism.

scholarly journals Postmenopausal osteoporosis: a gynecologist’s view

2020 ◽  
Vol 4 (6) ◽  
pp. 358-363
Author(s):  
I.Yu. Il’ina ◽  
◽  
Yu.E. Dobrokhotova ◽  
Keyword(s):  
Postmenopausal Osteoporosis ◽  
Cardiovascular Events ◽  
Metabolic Disorders ◽  
Ovarian Function ◽  
Clinical Manifestations ◽  
Ovarian Activity ◽  
Hormonal Changes ◽  
Mineral Density ◽  
Russian Medical

Climacteric is a physiological period of woman’s life starting from the decline in ovarian activity until the end of ovarian function. The end of ovarian function associated with the significant reduction in estradiol progestin synthesis results in the hormonal changes that lead to the clinical manifestations of postmenopausal period. During this period, metabolic disorders and cardiovascular events are common. In addition, the risks of various cancers (i.e., breast, colorectal, pancreatic, bladder, and endometrial cancer) increase greatly. Moreover, the risk of osteoporosis, a condition that affects the quality of life, also increases. Considering this, menopausal hormone therapy and drugs promoting bone metabolism should be prescribed in addition to the changes in the lifestyle and encouraging physical activity.KEYWORDS: menopause, climax, bone mineral density, fractures, osteoporosis, ibandronic acid.FOR CITATION: Il’ina I.Yu., Dobrokhotova Yu.E. Postmenopausal osteoporosis: a gynecologist’s view. Russian Medical Inquiry. 2020;4(6):358–363. DOI: 10.32364/2587-6821-2020-4-6-358-363.

scholarly journals The Role of Physical Activity in the Quality of Life Frameworks, Social Adaptation and Physical Rehabilitation of Individuals With Disorders in the Energy Metabolism

2017 ◽  
pp. 188-194
Author(s):  
Iryna Zharova
Keyword(s):  
Quality Of Life ◽  
Fat Distribution ◽  
Rehabilitation Program ◽  
Physical Rehabilitation ◽  
Social Adaptation ◽  
Life Questionnaire ◽  
Distribution Features ◽  
Pedsql 4.0

There were described the role of motor activity in the quality of life frameworks, social adaptation and physical rehabilitation of the teens with obesity. In the paper were solved factor determining the foundation and direction of a physical rehabilitation program for the teens with primary obesity, it was a quality of life. During performed studies we’re using the common questionnaire PedsQL-4.0 (Pediatric Quality of Life Questionnaire) in the Ukrainian version of the two groups of the teens (group № 1, n = 72, teens with obesity, group № 2, n = 72, teens with normal body weight), it were rated basic components of the quality of life: as the physical functioning, emotional functioning, social functioning, school functioning and mental health. Through the data analyzation, the relationships scored indicators of quality of life parameters of physical condition that characterize the severity of obesity and fat distribution features.

scholarly journals Defective Lysosomal Lipolysis Causes Prenatal Lipid Accumulation and Exacerbates Immediately after Birth

2021 ◽  
Vol 22 (19) ◽  
pp. 10416
Author(s):  
Katharina B. Kuentzel ◽  
Ivan Bradić ◽  
Alena Akhmetshina ◽  
Melanie Korbelius ◽  
Silvia Rainer ◽  
...  
Keyword(s):  
Lipid Accumulation ◽  
Clinical Manifestations ◽  
Premature Death ◽  
Cholesterol Homeostasis ◽  
Hormone Sensitive Lipase ◽  
Infantile Form ◽  
Fetal Organ ◽  
Hormone Sensitive ◽  
Lipid Storage Disorder

Cholesterol and fatty acids are essential lipids that are critical for membrane biosynthesis and fetal organ development. Cholesteryl esters (CE) are degraded by hormone-sensitive lipase (HSL) in the cytosol and by lysosomal acid lipase (LAL) in the lysosome. Impaired LAL or HSL activity causes rare pathologies in humans, with HSL deficiency presenting less severe clinical manifestations. The infantile form of LAL deficiency, a lysosomal lipid storage disorder, leads to premature death. However, the importance of defective lysosomal CE degradation and its consequences during early life are incompletely understood. We therefore investigated how defective CE catabolism affects fetus and infant maturation using Lal and Hsl knockout (-/-) mouse models. This study demonstrates that defective lysosomal but not neutral lipolysis alters placental and fetal cholesterol homeostasis and exhibits an initial disease pathology already in utero as Lal-/- fetuses accumulate hepatic lysosomal lipids. Immediately after birth, LAL deficiency exacerbates with massive hepatic lysosomal lipid accumulation, which continues to worsen into young adulthood. Our data highlight the crucial role of LAL during early development, with the first weeks after birth being critical for aggravating LAL deficiency.

Empirically Validated Treatments: Health Psychology Interventions

1997 ◽  
Vol 14 (1) ◽  
pp. 6-8
Author(s):  
Jack E. James
Keyword(s):  
Population Level ◽  
Premature Death ◽  
Modern Medicine ◽  
Behaviour Pattern ◽  
Policy Makers ◽  
Psychological Practice ◽  
Health Practitioners ◽  
Public Health Practitioners

Whereas King's (1977) focus was clinical psychology, the present commentary considers empirical validation of psychological practice in health settings. Comparisons are made with the fact that most diagnostic and therapeutic medical practices in use have yet to be empirically validated. At the population level, modern medicine does not appear to have had a large impact on any of the major causes of premature death, past or present. Conversely, there is strong evidence that all current major causes of death are closely related to behaviour pattern. However, there are formidable obstacles to the uptake and future development of behavioural interventions in health settings. Issues subsumed under the rubric of quality of care are particularly important, including appropriateness (treatment should not be applied when it is not needed — avoidance of overservicing), and necessity (treatment should be available to persons in need — avoidance of underservicing). The general public, health practitioners, and health policy makers are relatively uninformed about relevant psychological practices and about the central role of psychological processes in all aspects of human health.

scholarly journals Increased frequency of Th17 cells and IL-17 levels are associated with low bone mineral density in postmenopausal women

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hetal Bhadricha ◽  
Vainav Patel ◽  
Amit Kumar Singh ◽  
Lalita Savardekar ◽  
Anushree Patil ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Th17 Cells ◽  
Premenopausal Women ◽  
Treg Cells ◽  
Bone Diseases ◽  
Mineral Density ◽  
Ovariectomized Mice ◽  
The Difference

AbstractOsteoporosis is one of the chronic and often neglected bone diseases in aging postmenopausal women that affect the quality of life. Studies on ovariectomized mice models indicated the reciprocal role of Th17 cells and Treg cells in the aetiology of osteoporosis. While Th17 cells promote osteoclastogenesis, Treg cells exhibit anti-osteoclastogenic activity. This exploratory study aimed to determine the difference in the frequency of these T-cell subtypes in pre-and postmenopausal women and to examine their association with BMD. In our study, the frequency of Treg cells, analyzed by flow cytometry, did not differ between pre-and postmenopausal women. However, plasma levels of IL-10 along with IL-10+CD4+T cells were higher in post- compared to premenopausal women. The frequency of Th17 cells was higher in postmenopausal women irrespective of their BMD, however, only postmenopausal women with low BMD had elevated IL-17 levels and their T-scores were associated with Th17 frequency. Collectively, the results suggest that estrogen insufficiency in postmenopausal women may lead to increased Th17 cell frequency and elevated IL-17 levels which are associated with low BMD. This study highlights, Th17 cells and IL-17 as key players in the pathogenesis of osteoporosis and they can be the potential targets for immunotherapy in the treatment of osteoporosis.

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