scholarly journals OR-005 Effects of HIITand MICT for 10 weeks on myocardial AMPK and PGC-1α in rats

2018 ◽  
Vol 1 (2) ◽  
Author(s):  
Hao Su ◽  
Zhongye Jiang ◽  
Guohuan Cao ◽  
Tianhao Wen ◽  
Jia Shao ◽  
...  
Keyword(s):  
Aerobic Oxidation ◽  
Interval Training ◽  
Adenosine Monophosphate ◽  
Male Rats ◽  
Moderate Intensity ◽  
Peroxisome Proliferators ◽  
Continuous Training ◽  
Training Groups ◽  
Maximal Speed ◽  
Wistar Male Rats

Objective: The improvement of cardiorespiratory fitness (CRF) is known as an effective strategy for prevention cardiovascular risk. Myocardial aerobic oxidation which control by the signal way of adenosine monophosphate -activated protein kinase (AMPK)- peroxisome proliferators γ activated receptor coativator-1-α (PGC-1α)  is the key for CRF. Previous studies only discuss the effect of the Moderate-Intensity Continuous Training (MICT) and High Intensive Interval Training (HIIT) on the signal way of AMPK- PGC-1α in skeletal muscle but not in the myocardium. The aim of this study was to compare the effects of 10 weeks HIIT and MICT on the expression of AMPK and PGC-1α in the myocardium of wistar male rats. Methods: Wistar male rats (n=30) aged 6 weeks were randomly divided into HIIT or MICT or control (CON) group. The training groups ran on a treadmill 5 days/week for 10 weeks. HIIT group ran six times 3 minutes (0° slope) 90% of Vmax separated by 3 minutes 50% of Vmax and MICT group ran for 50min (0° slope) at 60–70% of maximal speed (Vmax). The expression of AMPK and PGC-1α were assessed by Western Blotting. Results: After 10 weeks training, HIIT and MICT both increased the AMPK and PGC-1α expression compared with the CON group. Compared with the MICT group, the expression of AMPK and PGC-1α were significantly higher than the HIIT group (p<0.05). AMPK in MICT group were significant increased 1.16 times, and in HIIT group were significant increased 1.28 times to CON (P<0.05). PGC-1α level of HIIT was significant increased to 1.32 times to CON and also significant increased to 1.15 times to Group M (P<0.05); PGC-1α level of MICT was significant increased to 1.15 times to CON. Conclusion：HIIT seems to improve myocardial AMPK and PGC-1α more efficiently than MICT in rats after 10 weeks training. 

scholarly journals Changes in Mitochondrial Dynamic Factors (mfn2 and drp1) Following High Intensity Interval Training and Moderate Intensity Continuous Training in Obese Male Rats

2021 ◽  
Author(s):  
Maryamalsadat Hashemi Taklimi ◽  
Saeedeh Shadmehri
Keyword(s):  
Interval Training ◽  
Male Rats ◽  
Moderate Intensity ◽  
P Value ◽  
High Intensity Interval Training ◽  
Continuous Training ◽  
Mitochondrial Dynamic ◽  
Dynamic Factors ◽  
High Intensity Interval ◽  
Obese Male

Objective: Mitochondrial content and function are important determinants of oxidative capacity and metabolic efficiency of skeletal muscle tissue. The aim of this study was to investigate the changes in mitochondrial dynamic factors (mfn2 and drp1) following high intensity interval training (HIIT) and moderate intensity continuous training (MICT) in obese male rats. Materials and Methods: In this experimental study, 40 male wistar rats after inducing obesity with high fat diet (for 10 weeks), eight rats from the high-fat diet group (O) and eight rats of the standard dietary group (C) were sacrificed and other obese rats were randomly divided into three groups: obesity control (OC), MICT and HIIT groups. The HIIT protocol includes 10 bouts of 4-minute activity with intensity of 85-90% vo2max and 2-minute active rest periods and MICT protocol with intensity of 65-70% VO2max with covered distance was matched to that of HIT protocol for 12 weeks and 5 sessions per week. Protein levels of mfn2 and drp1 soleus muscle were measured by Western blot. For analyzing the data, One-way ANOVA and Tukey post hoc with SPSS–23 and the significance level was P-value≤ 0.05. Results: Induction of obesity was associated with a significant decrease in soleus muscle mfn2 and drp1 (P-value= 0.001). The intervention of HIIT and MICT significantly increased of mfn2 and drp1 compared to control group (P-value= 0.001). Also, mfn2 and drp1 were significantly higher in HIIT compared to MICT group (P-value= 0.001). Conclusion: It seems that HIIT and MICT increase the mitochondrial dynamic factors in skeletal muscle, and the effects of HIIT are significantly higher.

High-intensity interval training has a greater effect on reverse cholesterol transport elements compared with moderate-intensity continuous training in obese male rats

2019 ◽  
pp. 204748731988782 ◽  
Author(s):  
Saleh Rahmati-Ahmadabad ◽  
Mohammad-Ali Azarbayjani ◽  
Parvin Farzanegi ◽  
Lida Moradi
Keyword(s):  
High Intensity ◽  
Reverse Cholesterol Transport ◽  
Training Session ◽  
Interval Training ◽  
Male Rats ◽  
Moderate Intensity ◽  
Cholesterol Transport ◽  
High Intensity Interval Training ◽  
Continuous Training ◽  
High Intensity Interval

Objectives The present study compares the effect of high-intensity interval training (HIIT; 18 min) and moderate-intensity continuous training (MIT; 1 h) on reverse cholesterol transport (RCT) elements in obese subjects. Methods Thirty adult male rats were induced high-fat diet (HFD) for 12 weeks. After four weeks, the rats were randomly divided into three groups while simultaneously continuing the HFD for the remaining eight weeks. Group specificities were HFD–control, HFD–MIT and HFD–HIIT. The rats were sacrificed 48 h after the last training session and the samples were collected. Analysis of variance and Pearson’s correlation test were used for the statistical analyses (significance level: p ≤ 0.05). Results The results showed that both HIIT and MIT improved heart ABCA1, ABCG1, ABCG4, ABCG5, ABCG8, LXR-α and PPARγ gene expression as well as plasma Apo A1, LCAT, lipids and lipoproteins ( p ≤ 0.05). Moreover, higher cardiac ABCA1, ABCG1, ABCG4, ABCG5, ABCG8 and PPARγ expression and plasma high-density lipoprotein cholesterol ( p ≤ 0.05) concentrations were found in the HFD–HIIT group compared with the HFD–MIT group. Conclusion HIIT may have more cardioprotective effects than MIT against atherosclerosis, along with saving time, as supported by the changes observed in the main factors involved in the RCT process.

scholarly journals Bone Response to High-Intensity Interval Training versus Moderate-Intensity Continuous Training in Adolescents with Obesity

Obesity Facts ◽  
2021 ◽  
pp. 1-9
Author(s):  
Valérie Julian ◽  
Daniela Costa ◽  
Grace O’Malley ◽  
Lore Metz ◽  
Alicia Fillon ◽  
...  
Keyword(s):  
Weight Loss ◽  
Bone Density ◽  
Bone Mineral ◽  
High Intensity ◽  
Interval Training ◽  
Moderate Intensity ◽  
High Intensity Interval Training ◽  
Continuous Training ◽  
Training Groups ◽  
High Intensity Interval

<b><i>Introduction:</i></b> Since adolescents with obesity are prone to bone fragility during weight loss, the aim was to compare the impact of high-intensity interval training (HIIT) versus moderate-intensity continuous training (MICT) on bone density, geometry, and strength. <b><i>Methods:</i></b> Sixty-one adolescents were randomly assigned to 2 cycling trainings (HIIT and MICT) and a control (CTR, without training) group. Anthropometry, dual-energy X-ray absorptiometry with hip structural analysis and the trabecular bone score (TBS) were assessed before and after the 16-week intervention. <b><i>Results:</i></b> Body mass index (BMI) and fat mass (FM) percentage decreased at T1 versus T0 in both training groups (<i>p</i> &#x3c; 0.001 for HIIT, <i>p</i> = 0.01 for MICT), though to a larger extent in HIIT (<i>p</i> &#x3c; 0.05). Total body bone mineral density (BMD) and bone mineral content (BMC) increased in both training groups (<i>p</i> &#x3c; 0.001), but to a greater extent in HIIT for BMC (<i>p</i> &#x3c; 0.05). Lumbar spine BMD and BMC increased in both training groups (<i>p</i> &#x3c; 0.001 for HIIT, <i>p</i> &#x3c; 0.01 for MICT), with a time × group interaction between HIIT and CTR (<i>p</i> &#x3c; 0.05) only. TBS increased in both training groups (<i>p</i> &#x3c; 0.01 for HIIT, <i>p</i> &#x3c; 0.05 for MICT). Hip BMD and BMC increased in both HIIT (<i>p</i> &#x3c; 0.001 and <i>p</i> &#x3c; 0.01) and MICT (<i>p</i> &#x3c; 0.01 and <i>p</i> &#x3c; 0.05). At the narrow neck (NN), endocortical diameter, width (<i>p</i> &#x3c; 0.01), cross-sectional moment of inertia, and section modulus (Z) (<i>p</i> &#x3c; 0.05) increased only in the HIIT group, such as BMD and Z (<i>p</i> &#x3c; 0.05) at the intertrochanteric region (IT) and average cortical thickness (<i>p</i> &#x3c; 0.001) and width (<i>p</i> &#x3c; 0.05) at the femoral shaft. At the NN and IT, the buckling ratio decreased only in the HIIT group (<i>p</i> &#x3c; 0.05), predicting higher resistance to fracture. <b><i>Conclusions:</i></b> In addition to inducing greater BMI and FM percentage decreases in comparison to MICT, HIIT improves multisite bone density, geometry, and strength, which heighten the justification for HIIT as part of weight loss interventions in adolescents with obesity.

scholarly journals Acute and Chronic Effects of Low-Volume High-Intensity Interval Training Compared to Moderate-Intensity Continuous Training on Glycemic Control and Body Composition in Older Women with Type 2 Diabetes

Obesities ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 72-87
Author(s):  
Alexis Marcotte-Chénard ◽  
Dominic Tremblay ◽  
Marie-Michelle Mony ◽  
Pierre Boulay ◽  
Martin Brochu ◽  
...  
Keyword(s):  
Body Composition ◽  
Older Women ◽  
Interval Training ◽  
Moderate Intensity ◽  
Continuous Training ◽  
Glucose Levels ◽  
Mild Hyperglycemia ◽  
Low Volume ◽  
High Intensity Interval

Objective: To compare the acute and chronic effects of low-volume high-intensity interval training (HIIT) to moderate-intensity continuous training (MICT) on glycemic control, body composition and continuous glucose monitoring (CGM) in older women with type 2 diabetes (T2D). Methods: Thirty older women (68 ± 5 years) with T2D were randomized in two groups—HIIT (75 min/week) or MICT (150 min/week). Glucose homeostasis (A1c, glucose, insulin, HOMA-IR2) and body composition (iDXA) were measured before and after the 12-week exercise intervention. During the first and last week of training (24-h before and 48-h after exercise), the following CGM-derived data were measured: 24-h and peak glucose levels, glucose variability and time spent in hypoglycemia as well as severe and mild hyperglycemia. Results: While lean body mass increased (p = 0.035), total and trunk fat mass decreased (p ≤ 0.007), without any difference between groups (p ≥ 0.81). Fasting glucose levels (p = 0.001) and A1c (p = 0.014) significantly improved in MICT only, with a significant difference between groups for fasting glucose (p = 0.02). Neither HIIT nor MICT impacted CGM-derived data at week 1 (p ≥ 0.25). However, 24-h and peak glucose levels, as well as time spent in mild hyperglycemia, decreased in HIIT at week 12 (p ≤ 0.03). Conclusion: These results suggest that 12 weeks of low-volume HIIT is enough to provide similar benefit to MICT for body composition and improve the acute effect of exercise when measured with CGM.

Moderate-intensity continuous training and high-intensity interval training improve cognition, and BDNF levels of middle-aged overweight men

2021 ◽  
Author(s):  
Neumir Sales de Lima ◽  
Ricardo Augusto Leoni De Sousa ◽  
Fabiano Trigueiro Amorim ◽  
Fernando Gripp ◽  
Caíque Olegário Diniz e Magalhães ◽  
...  
Keyword(s):  
High Intensity ◽  
Interval Training ◽  
Moderate Intensity ◽  
High Intensity Interval Training ◽  
Middle Aged ◽  
Continuous Training ◽  
High Intensity Interval
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