scholarly journals Global differences in vitamin D status and dietary intake: a review of the data

2021 ◽  
Author(s):  
Kevin D. Cashman
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Published Data ◽  
World Region ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
Food And Agriculture ◽  
Micronutrient Status ◽  
Nationally Representative ◽  
Status Data

Background: Internationally, concern has been repeatedly raised about the little notable progress in the collection, analysis and use of population micronutrient status and deficiency data globally. The need for representative status and intake data for vitamin D has been highlighted as a research priority for well over a decade. Aim and methods: A narrative review which aims to provide a summary and assessment of vitamin D nutritional status data globally. It divides the World into the Food and Agriculture Organisation’s (FAO) major regions: the Americas, Europe, Oceania, Africa, and Asia. Emphasis was placed on published data on prevalence of serum 25-hydroxyvitamin D [25(OH)D] <25/30 and <50 nmol/L (reflecting vitamin D deficiency and inadequacy, respectively) as well as vitamin D intake, where possible from nationally representative surveys. Results: Collating data from the limited number of available representative surveys from individual countries might suggest a relatively low overall prevalence of vitamin D deficiency in South America, Oceania and North America, whereas there is more moderate prevalence in Europe and Asia, and possibly Africa. Overall, prevalence of serum 25(OH)D <25/30 and <50 nmol/L ranges from ~5% to 18% and 24% to 49%, respectively, depending on FAO World region. Usual intakes of vitamin D can also vary by FAO World region, but in general, with a few exceptions, there are very high levels of inadequacy of vitamin D intake. Conclusions: While the burden of vitamin D deficiency and inadequacy varies by World regions and not just by UVB availability, the global burden overall translates into enormous numbers of individuals at risk.

scholarly journals Vitamin D i pokazateli kal'tsiy-fosfornogo obmenau detey, prozhivayushchikh v sredney polose Rossii, v periodmaksimal'noy insolyatsii

2010 ◽  
Vol 13 (2) ◽  
pp. 2-6 ◽  
Author(s):  
A. V. Vitebskaya ◽  
G. E. Smirnova ◽  
A. V. Il'in
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Central Area ◽  
Hypovitaminosis D ◽  
Vitamin D Insufficiency ◽  
Winter Period ◽  
Published Data ◽  
Healthy Children ◽  
Hydroxyvitamin D ◽  
Oncological Diseases

Vitamin D deficiency is associated with rickets in children and osteomalation in adults. Published data support the role of vitamin D insufficiency in development of autoimmune, cardiovascular and oncological diseases. The most precise method to diagnose vitamin D insufficiency is measuring of 25-hydroxyvitamin D (25(OH)-D). We studded the levels of vitamin D and calcium-phosphate turnover parameters during the period of maximal insolation in 140 healthy children and adolescents permanently living in the central area of Russia. Vitamin D insufficiency (25(OH)-D < 20 ng/ml) was detected in 38,6%; in 2,9% of them severe vitamin D deficiency was diagnosed (25(OH)-D < 8 ng/ml). The results correlate with data on hypovitaminosis D prevalence in countries with the same geographical latitude. To clarify the real size of required prophylaxis we need investigation of the same parameters in winter period while minimal insolation.

scholarly journals Recommended intakes of vitamin D to optimise health, associated circulating 25-hydroxyvitamin D concentrations, and dosing regimens to treat deficiency: workshop report and overview of current literature

2015 ◽  
Vol 4 ◽  
Author(s):  
Michiel G. J. Balvers ◽  
Elske M. Brouwer-Brolsma ◽  
Silvia Endenburg ◽  
Lisette C. P. G. M. de Groot ◽  
Frans J. Kok ◽  
...  
Keyword(s):  
Vitamin D ◽  
The Netherlands ◽  
Vitamin D Deficiency ◽  
Vitamin D Status ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
Skeletal Disease ◽  
Health Council ◽  
Dosing Regimens ◽  
25 Hydroxyvitamin D

AbstractVitamin D is a fat-soluble hormone that traditionally has been linked to bone health. Recently, its involvement has been extended to other (extra-skeletal) disease areas, such as cancer, CVD, energy metabolism and autoimmune diseases. Vitamin D deficiency is a worldwide problem, and several recommendation-setting bodies have published guidelines for adequate vitamin D intake and status. However, recommendations from, for example, the Health Council of the Netherlands do not provide advice on how to treat vitamin D deficiency, a condition that is often encountered in the clinic. In addition, these recommendations provide guidelines for the maintenance of ‘minimum levels’, and do not advise on ‘optimum levels’ of vitamin D intake/status to further improve health. The NutriProfiel project, a collaboration between the Gelderse Vallei Hospital (Ede, the Netherlands) and the Division of Human Nutrition of Wageningen University (Wageningen, the Netherlands), was initiated to formulate a protocol for the treatment of vitamin deficiency and for the maintenance of optimal vitamin D status. To discuss the controversies around treatment of deficiency and optimal vitamin D status and intakes, a workshop meeting was organised with clinicians, scientists and dietitians. In addition, a literature review was conducted to collect recent information on optimal intake of vitamins, their optimal circulating concentrations, and effective dosing regimens to treat deficiency. This information has been translated into the NutriProfiel advice, which is outlined in this article.

scholarly journals Vitamin D deficiency is common and is associated with overweight in Mexican children aged 1–11 years

2017 ◽  
Vol 20 (10) ◽  
pp. 1807-1815 ◽  
Author(s):  
Amada Flores ◽  
Mario Flores ◽  
Nayeli Macias ◽  
Lucía Hernández-Barrera ◽  
Marta Rivera ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
School Children ◽  
School Age Children ◽  
School Age ◽  
Nutrition Survey ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
Mexican Children ◽  
25 Hydroxyvitamin D

AbstractObjectiveTo assess vitamin D dietary sources, intake and 25-hydroxyvitamin D status and their association with individual and sociodemographic characteristics in Mexican children.DesignData obtained from 2695 children aged 1–11 years from the Mexican National Health and Nutrition Survey (2012) were analysed. Diet was assessed by a 141-item FFQ. 25-Hydroxyvitamin D was measured by a chemiluminescent assay.ResultsMean vitamin D intake was 3·38 (se 0·09) µg/d (135·2 (se 3·6) IU/d) among pre-school children and 2·85 (se 0·06) µg/d (114·0 (se 2·4) IU/d) in school-age children. Milk accounted for 64·4 % of vitamin D intake in pre-school children and 54·7 % in school-age children. Vitamin D deficiency (serum 25-hydroxyvitamin D<50 nmol/l) was 25·9 % in pre-schoolers and 36·6 % in school-age children. Overweight/obese school-age children had a higher risk of vitamin D deficiency compared with normal-weight children (OR=2·23; 95 % CI 1·36, 3·66; P<0·05).ConclusionsVitamin D intakes are low in Mexican children, and milk is the main source of the vitamin. Vitamin D deficiency is common and associated with overweight in school-age children.

Vitamin D - From Essentiality to Functionality

2012 ◽  
Vol 82 (5) ◽  
pp. 321-326 ◽  
Author(s):  
Heike Bischoff-Ferrari
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Levels ◽  
Vitamin D Status ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
Severe Deficiency ◽  
Normal Vitamin ◽  
25 Hydroxyvitamin D ◽  
Muscle Health

Vitamin D is essential in bone and muscle health. Severe deficiency (25-hydroxyvitamin D serum levels < 25 nmol/l) can result in rickets and osteomalacia, fractures, myopathy and falls. All recent recommendations on vitamin D agree that children and adults should reach a target 25-hydroxyvitamin D range of at least 50 nmol/l (threshold for normal vitamin D status) and 50 % of the population may be below that threshold. A vitamin D intake of 600 to 800 IU per day as recommended today will prevent about 97 % of children and adults from vitamin D deficiency. Notably, a higher 25-hydroxyvitamin D threshold of more than 60 nmol/l is needed for optimal functionality, fall and fracture in adults age 65 and older.

scholarly journals Vitamin D Metabolism and Guidelines for Vitamin D Supplementation

2020 ◽  
Vol 41 (3) ◽  
pp. 103-126
Author(s):  
Indra Ramasamy
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D Supplementation ◽  
Vitamin D Status ◽  
Vitamin D Metabolism ◽  
Hydroxyvitamin D ◽  
Response Data ◽  
Vitamin D Intake ◽  
25 Hydroxyvitamin D ◽  
Significant Health

Vitamin D is essential for bone health and is known to be involved in immunomodulation and cell proliferation. Vitamin D status remains a significant health issue worldwide. However, there has been no clear consensus on vitamin D deficiency and its measurement in serum, and clinical practice of vitamin D deficiency treatment remains inconsistent. The major circulating metabolite of vitamin D, 25-hydroxyvitamin D (25(OH)D), is widely used as a biomarker of vitamin D status. Other metabolic pathways are recognised as important to vitamin D function and measurement of other metabolites may become important in the future. The utility of free 25(OH)D rather than total 25(OH)D needs further assessment. Data used to estimate the vitamin D intake required to achieve a serum 25(OH)D concentration were drawn from individual studies which reported dose-response data. The studies differ in their choice of subjects, dose of vitamin D, frequency of dosing regimen and methods used for the measurement of 25(OH)D concentration. Baseline 25(OH)D, body mass index, ethnicity, type of vitamin D (D2 or D3) and genetics affect the response of serum 25(OH)D to vitamin D supplementation. The diversity of opinions that exist on this topic are reflected in the guidelines. Government and scientific societies have published their recommendations for vitamin D intake which vary from 400–1000 IU/d (10–25 µg/d) for an average adult. It was not possible to establish a range of serum 25(OH)D concentrations associated with selected non-musculoskeletal health outcomes. To recommend treatment targets, future studies need to be on infants, children, pregnant and lactating women.

scholarly journals Dietary vitamin D2 – a potentially underestimated contributor to vitamin D nutritional status of adults?

2014 ◽  
Vol 112 (2) ◽  
pp. 193-202 ◽  
Author(s):  
Kevin D. Cashman ◽  
Michael Kinsella ◽  
Breige A. McNulty ◽  
Janette Walton ◽  
Michael J. Gibney ◽  
...  
Keyword(s):  
Vitamin D ◽  
Population Level ◽  
Food Composition ◽  
Dietary Vitamin ◽  
Published Data ◽  
Nutrition Survey ◽  
Limit Of Quantification ◽  
Hydroxyvitamin D ◽  
Measurable Serum ◽  
Nationally Representative

It has been suggested that vitamin D2 is not very prevalent in the human food chain. However, data from a number of recent intervention studies suggest that the majority of subjects had measurable serum 25-hydroxyvitamin D2 (25(OH)D2) concentrations. Serum 25(OH)D2, unlike 25(OH)D3, is not directly influenced by exposure of skin to sun and thus has dietary origins; however, quantifying dietary vitamin D2 is difficult due to the limitations of food composition data. Therefore, the present study aimed to characterise serum 25(OH)D2 concentrations in the participants of the National Adult Nutrition Survey (NANS) in Ireland, and to use these serum concentrations to estimate the intake of vitamin D2 using a mathematical modelling approach. Serum 25(OH)D2 concentration was measured by a liquid chromatography–tandem MS method, and information on diet as well as subject characteristics was obtained from the NANS. Of these participants, 78·7 % (n 884) had serum 25(OH)D2 concentrations above the limit of quantification, and the mean, maximum, 10th, 50th (median) and 90th percentile values of serum 25(OH)D2 concentrations were 3·69, 27·6, 1·71, 2·96 and 6·36 nmol/l, respectively. To approximate the intake of vitamin D2 from these serum 25(OH)D2 concentrations, we used recently published data on the relationship between vitamin D intake and the responses of serum 25(OH)D concentrations. The projected 5th to 95th percentile intakes of vitamin D2 for adults were in the range of 0·9–1·2 and 5–6 μg/d, respectively, and the median intake ranged from 1·7 to 2·3 μg/d. In conclusion, the present data demonstrate that 25(OH)D2 concentrations are present in the sera of adults from this nationally representative sample. Vitamin D2 may have an impact on nutritional adequacy at a population level and thus warrants further investigation.

Depressed Serum 25-Hydroxyvitamin D Levels Increase Hospital Stay and Alter Glucose Homeostasis in First-ever Ischemic Stroke

2019 ◽  
Vol 16 (4) ◽  
pp. 340-347
Author(s):  
Yuge Wang ◽  
Yanqiang Wang ◽  
Bingjun Zhang ◽  
Yinyao Lin ◽  
Sha Tan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Ischemic Stroke ◽  
Hospital Stay ◽  
Functional Outcome ◽  
Vitamin D Deficiency ◽  
Glucose Homeostasis ◽  
Clinical Severity ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Deficiency Group

Background and Objective: Vitamin D deficiency is internationally recognized among the potentially modifiable risk factors for ischemic cardio-cerebrovascular diseases. However, the association between vitamin D deficiency and stroke morbidity or mortality remains insufficiently known. Our aim is to investigate their relevance to 25-hydroxyvitamin D [25(OH) D] levels and clinical severity and outcome after 3 months in first-ever ischemic stroke. Methods: Retrospective analysis of 356 consecutive patients in first-ever ischemic stroke between 2013 and 2015. Serum 25(OH) D levels were measured at baseline. Stroke severity was assessed at admission using the National Institutes of Health Stroke Scale (NIHSS) score. Functional outcome after 3 months of onset was evaluated using the modified Rankin scale (mRS). Results: Among the 356 enrolled patients, HbA1c was higher in insufficiency/deficiency group than that in the sufficiency group (6.3 ± 1.7 vs. 5.9 ± 1.1, p =0.015). The hospital stay was longer in insufficiency/deficiency group than that in the sufficiency group (11 (8-17) vs. 9.5 (7-13), p = 0.035). There was a significant inversed trend between serum 25(OH) D levels and hospital stay (OR 0.960, P = 0.031), using logistic regression. Conclusions: 25(OH)D levels are associated with glucose homeostasis, 25(OH) D contributes to increase the length of hospital stay. Low serum 25-OHD level is an independent predictor for hospital stay in first-ever ischemic stroke. Vitamin D deficiency did not predict functional outcome in the span of 3 months.

scholarly journals Association of serum 25-hydroxyvitamin D with metabolic syndrome and type 2 diabetes: a one sample Mendelian randomization study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jing Xiao ◽  
Jingyi Lv ◽  
Shiyu Wang ◽  
Yang Zhou ◽  
Lunwen Chen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Mendelian Randomization ◽  
Middle Aged ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Randomization Analysis

Abstract Background Vitamin D deficiency has been associated with type 2 diabetes (T2D) and metabolic syndrome (MS) and its components. However, it is unclear whether a low concentration of vitamin D is the cause or consequence of these health conditions. Thus, this study aimed to evaluate the association of vitamin D concentrations and its genetic risk scores (GRSs) with MS and its component diseases, such as T2D, in middle-aged and elderly participants from rural eastern China. Methods A subset of 2393 middle-aged and elderly individuals were selected from 70,458 participants of the Nantong Chronic Diseases Study of 2017–2018 in China. We used two 25-hydroxyvitamin D (25[OH]D) synthesis single-nucleotide polymorphisms (SNPs) (DHCR7-rs12785878 and CYP2R1-rs10741657) and two 25(OH) D metabolism SNPs (GC-rs2282679 and CYP24A1-rs6013897) for creating GRSs, which were used as instrumental variables to assess the effect of genetically lowered 25(OH) D concentrations on MS and T2D based on the Wald ratio. F statistics were used to validate that the four SNPs genetically determined 25(OH) D concentrations. Results Compared to vitamin D sufficient individuals, individuals with vitamin D insufficiency had an odds ratio (OR [95% confidence interval {CI}]) of MS of 1.30 (1.06–1.61) and of T2D of 1.32 (1.08–1.64), individuals with vitamin D deficiency had an ORs (95% CI) of MS of 1.50 (1.24–1.79) and of T2D of 1.47 (1.12–1.80), and those with vitamin D severe deficiency had an ORs (95% CI) of MS of 1.52 (1.29–1.85) and of T2D of 1.54 (1.27–1.85). Mendelian randomization analysis showed a 25-nmol/L decrease in genetically instrumented serum 25(OH) D concentrations using the two synthesis SNPs (DHCR7 and CYP2R1 genes) associated with the risk of T2D and abnormal diastolic blood pressure (DBP) with ORs of 1.10 (95%CI: 1.02–1.45) for T2D and 1.14 (95%CI: 1.03–1.43) for DBP. Conclusions This one sample Mendelian randomization analysis shows genetic evidence for a causal role of lower 25(OH) D concentrations in promoting of T2D and abnormal DBP in middle-aged and elderly participants from rural China.

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