scholarly journals Сharacteristics of nutrition and content of certain microelements in blood in adolescents with signs of metabolic syndrome

2021 ◽  
pp. 38-43
Author(s):  
O.V. Buznytska ◽  
◽  
L.A. Strashok ◽  
Keyword(s):  
Metabolic Syndrome ◽  
Eating Behavior ◽  
Magnesium Deficiency ◽  
International Diabetes Federation ◽  
Control Group ◽  
Healthy Children ◽  
Children And Adolescent ◽  
Key Words Adolescents ◽  
Unbalanced Diet ◽  
Restrictive Type

Purpose — to study the nature of nutrition and blood zinc and magnesium levels in adolescents with signs of metabolic syndrome (MS). Materials and methods. The 200 patients with obesity (aged 14–18: 100 boys and 100 girls) were examined at the clinic of the Institute of Children and Adolescent Health Care of the National Academy of Medical Sciences of Ukraine. All patients underwent a comprehensive clinical and laboratory examination. The study of eating behavior (EB) was conducted by questionnaire using the Dutch questionnaire (DEBQ, The Dutch Eating Behavior Questionnaire). The control group consisted of 30 healthy children of the same age category. The criteria for the diagnosis of MS in children, proposed by the International Diabetes Federation [IDF, 2007], were used, which allowed to divide patients into two groups: 1 — with signs of MS (50.0%) and 2 — without signs of MS (50.0%), each of which included 100 patients. Results and discussion. According to the anamnesis, adolescents had an unbalanced and irrational diet, as evidenced by complaints of pain and dyspepsia. Analysis of DEBQ data showed that in most adolescents there was a restrictive type of EB — (73.9±3.2%), also quite common variants were external (in 43.8±3.1%) and emotional type of EB (32.3±3.1%). The results showed significant zinc and magnesium deficiency in obese adolescents, in contrast to the surveyed control group (ϕ<0.05), in particular, the most pronounced (ϕ<0.05) deficiency of these trace elements was observed in the surveyed group with restrictive type of EB. Conclusions. Thus, an unbalanced diet naturally leads to disorders of both the digestive system and the formation of comorbid pathology, including obesity and MS. Analysis of the results of the DEBQ survey showed that patients with signs of MS were twice as likely to have EB disorders (71.8±3.7%) than patients without them (39.4±4.1%, ϕ<0.05). Among the violations of EB, the most common was the restrictive type (73.9%). Adolescents have a significant deficiency of zinc and magnesium in the blood (ϕ<0.05), in particular the most pronounced (ϕ<0.05) in the group of subjects with a restrictive type of EB. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local Ethics Committee of all participating institutions. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: adolescents, microelements, nutrition, insulin resistance, metabolic syndrome.

scholarly journals Anthropometric characteristics of adolescents with signs of metabolic syndrome

2021 ◽  
pp. 35-40
Author(s):  
L.A. Strashok ◽  
◽  
O.V. Buznytska ◽  
Keyword(s):  
Metabolic Syndrome ◽  
Waist Circumference ◽  
International Diabetes Federation ◽  
Resistance Index ◽  
Atherogenic Dyslipidemia ◽  
High Density Lipoproteins ◽  
Control Group ◽  
Healthy Children ◽  
Growth Ratio ◽  
Obese Adolescents

An analysis of recent global research on the prevalence of obesity and its consequences, including metabolic syndrome, among adolescents is a matter of considerable concern. The same unfavorable tendencies are observed in Ukraine among modern youth. Therefore, an effective strategy for the detection and follow-up of adolescents is urgently needed for the timely treatment of obesity and the prevention of threatening complications. Purpose — to analyze and generalize anthropometrical indicators in adolescents with signs of metabolic syndrome to improve the management of this category of patients. Materials and methods. 200 obese adolescents (aged 16 years: 100 boys and 100 girls) were examined in the clinic of the Institute of Children and Adolescents Health Care of the National Academy of Medical Sciences of Ukraine. The control group consisted of 30 healthy children of the same age category. The criteria for the diagnosis of metabolic syndrome (MS) in children, proposed by the International Diabetes Federation [IDF, 2007], were used, which allowed to divide patients into two groups: 1 — with signs of MS (50.0%) and 2 — without signs of MS (50.0%), each of which included 100 patients. Patients underwent an anthropometric examination with the calculation of the following indicators: body mass index (BMI), the waist;to;growth ratio (WC/height) and waist circumference to hip circumference ratio (WC/HC). Blood lipid profile as a marker of atherogenesis, carbohydrate metabolism (fasting serum glucose, the level of immunoreactive insulin with the calculation of insulin resistance index HOMA) were also studied in detail. Results. The anthropometric analysis showed that in adolescents with MS the main indicators (BMI, WC/height, WC/HC), the degree of abdominal obesity were statistically significantly higher (p<0.05). When comparing the results by gender, probable differences were found between boys and girls: indicators of body weight, waist circumference, WC/HC, which were statistically significantly higher in boys (p<0.05). Characterization of lipid metabolism in the patients showed signs of atherogenic dyslipidemia (increased cholesterol levels, low and very low density lipoproteins, atherogenic factor, triglycerides, β-lipoproteins levels and tendencies to lower the levels of high density lipoproteins) with a significant predominance among those surveyed with MS (p<0.05). Conclusions. Promising careful anthropometric monitoring of obese adolescents will identify and predict trends in the disease, the risk of complications, which will increase the effectiveness of preventive measures for metabolic syndrome. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of all participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: adolescents, metabolic syndrome, anthropometry, diagnostics, dyslipidemia.

Effect of leptin on the gallbladder in patients with metabolic syndrome

2016 ◽  
Vol 94 (4) ◽  
pp. 285-289 ◽  
Author(s):  
Natalia G. Virstyuk ◽  
N. R. Senyutovich
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
International Diabetes Federation ◽  
Resistance Index ◽  
High Density Lipoproteins ◽  
Control Group ◽  
Blood Levels ◽  
Model Assessment ◽  
Functional Changes ◽  
Group I

The study involved 58 patients with chronic noncalculous cholecystitis (CNC) divided into two groups. Group I included 30 CNC patients with metabolic syndrome (MS), group II 28 CNC patients without MS. The control group consisted of 20 healthy people. MS was diagnosed according to International Diabetes Federation guidelines (2005). The following anthropometric parameters were determined: body mass index (BMI), waist to hip ratio, blood lipid profile (total cholesterol, triglycerides, high density lipoproteins (HDL), and low density lipoproteins (LDL)). Leptin and insulin levels were measured using commercial ELISA kits «Leptin ELISA» and «Insulin ELISA» (DRG International, Inc., USA) respectively. Insulin resistance index HOMA-IR (Homeostasis Model Assessment of Insulin Resistance) was calculated. It was shown that leptin level in CNC patients with MS was 2.61 times that in healthy subjects (p <0.001) and 2.47 times higher than in CNC patients without MS (p <0.001). Significant direct correlations between leptin blood levels andBMI, HOMA-IR index, triglycerides, and cholesterol were documented. The relationships between blood levels of leptin and the thickness of the gallbladder (GB) wall, the amount of cholesterol crystals in bile, and decreased bile release rate from GB which suggests effect of leptin on the structural and functional changes in GB.

scholarly journals PREVALENCE OF NON-ALCOHOLIC FATTY LIVER DISEASE IN WOMEN WITH POLYCYSTIC OVARY SYNDROME AND ITS CORRELATION WITH METABOLIC SYNDROME

2015 ◽  
Vol 52 (2) ◽  
pp. 117-123 ◽  
Author(s):  
Mariana Drechmer ROMANOWSKI ◽  
Monica Beatriz PAROLIN ◽  
Alexandre C T FREITAS ◽  
Mauri J PIAZZA ◽  
Jorgete BASSO ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Liver Disease ◽  
Fatty Liver Disease ◽  
Polycystic Ovary ◽  
International Diabetes Federation ◽  
Control Group ◽  
Ovary Syndrome ◽  
Alcoholic Fatty Liver ◽  
Pcos Group ◽  
Alcoholic Fatty Liver Disease

Background The polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women at childbearing age. Metabolic syndrome is present from 28% to 46% of patients with PCOS. Non-alcoholic fatty liver disease (NAFLD) is considered the hepatic expression of metabolic syndrome. There are few published studies that correlate PCOS and NAFLD. Objective To determine the prevalence of NAFLD and metabolic syndrome in patients with PCOS, and to verify if there is a correlation between NAFLD and metabolic syndrome in this population. Methods Study developed at Gynecology Department of Clinical Hospital of Federal University of Parana (UFPR). The sessions were conducted from April 2008 to January 2009. One hundred and thirty-one patients joined the analysis; 101 were diagnosed with PCOS and 30 formed the control group. We subdivided the PCOS patients into two subgroups: PCOS+NAFLD and PCOS. All the patients were submitted to hepatic sonography. For hepatoestheatosis screening, hepatic ecotexture was compared do spleen’s. For diagnosis of metabolic syndrome, we adopted the National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATP III) criteria, as well as the criteria proposed by International Diabetes Federation. Statistical analysis were performed with t of student and U of Mann-Whitney test for means and chi square for proportions. Results At PCOS group, NAFLD was present in 23.8% of the population. At control group, it represented 3.3%, with statistical significance (P=0.01). Metabolic syndrome, by NCEP/ATP III criteria, was diagnosed in 32.7% of the women with PCOS and in 26.6% of the women at control group (no statistical difference, P=0.5). At PCOS+DHGNA subgroup, age, weight, BMI, abdominal circumference and glucose tolerance test results were higher when compared to PCOS group (P<0.01). Metabolic syndrome by NCEP/ATPIII criteria was present in 75% and by International Diabetes Federation criteria in 95.8% of women with PCOS+NAFLD with P<0.01. Insulin levels at SOP+DHGNA were higher than at PCOS group with P<0.01. Conclusion Almost 25% of the patients with PCOS were diagnosed for NAFLD. Metabolic syndrome was present between 32.7% and 44.6% of patients with PCOS. At subgroup PCOS+NAFLD, metabolic syndrome is highly prevalent. These patients are more obese, with higher BMI and higher glucose levels.

scholarly journals NUTRITION PECULIARITIES OF UKRAINIAN ADOLESCENTS WITH METABOLIC SYNDROME

2021 ◽  
Vol 74 (3) ◽  
pp. 492-497
Author(s):  
Larisa A. Strashok ◽  
Olena V. Buznytska ◽  
Olena M. Meshkova
Keyword(s):  
Metabolic Syndrome ◽  
Social Research ◽  
Magnesium Deficiency ◽  
Eating Behaviour ◽  
The Body ◽  
International Project ◽  
Medical Sciences ◽  
Survey Results ◽  
Digestive Disorders ◽  
Unbalanced Diet

The aim: To study the dietary peculiarities of Ukrainian adolescents with obesity and to identify the eating disorders on the background of metabolic syndrome. Materials and methods: A survey on the nutrition of Ukrainian adolescents was conducted at O. Yaremenko Ukrainian Institute for Social Research within the framework of the international project Health and Behavioral Orientations of Student Youth (HBSC), 2018. As a result, a sample of 200 adolescents with obesity (age 14-18 years: 100 boys and 100 girls) was formed, with the following examination by the Institute of Children and Adolescents Health Care of the National Academy of Medical Sciences of Ukraine. Results: A survey conducted revealed the problem of irrational and unbalanced diet in Ukrainian adolescents. Thus, irregular and unbalanced diet naturally causes digestive disorders and contributes to the formation of comorbid pathologies such as obesity and metabolic syndrome. The general analysis of the DEBQ survey results revealed that patients with metabolic syndrome were twice as likely to have abnormalities in eating behavior (71.8 ± 3.7)% than in patients without them (39.4 ± 4.1)%, (φ < 0.05). Adolescents with obesity experienced significant zinc and magnesium deficiency in the body (φ < 0.05). Conclusions: Modification of eating behaviour through healthy balanced nutrition and psychological support is one of the most important tasks in the treatment of patients with obesity and metabolic syndrome.

Urinary bisphenol A levels in prepubertal children with exogenous obesity according to presence of metabolic syndrome

2021 ◽  
Vol 34 (4) ◽  
pp. 495-502
Author(s):  
Esra Aktağ ◽  
Kadriye Yurdakök ◽  
Siddika Songül Yalçın ◽  
Nurgün Kandemir
Keyword(s):  
Metabolic Syndrome ◽  
Bisphenol A ◽  
High Performance ◽  
Linear Models ◽  
Age Groups ◽  
Control Group ◽  
Healthy Children ◽  
Obese Children ◽  
Potential Link ◽  
Drug Naïve

Abstract Objectives Recent studies have shown a potential link between chronic exposure to Bisphenol A (BPA) and exogenous obesity, the prevalence of which has been increasing dramatically in all age groups and particularly among children in the last decades. In this study, we aimed at comparing BPA exposure levels between controls and otherwise healthy, drug-naive, pre-pubertal children having exogenous obesity with/without metabolic syndrome. Methods A total of 63 pre-pubertal children with exogenous obesity whom 27 of them having metabolic syndrome attending Hacettepe University Ihsan Dogramaci Children’s Hospital were included in this study. The control group consisted of 34 age- and sex-matched healthy children with no significant underlying medical conditions. Urinary BPA levels were measured using LC-MS/MS (high-performance liquid chromatography coupled with tandem mass spectrometry) methodology. Results Urinary BPA levels among obese children were significantly higher than those of the control group (median: 22.9 μg/g-creatinine and 6.9 μg/g-creatinine, respectively; p=0.0001). When adjusted with generalized linear models for age, gender and z scores of body mass index, obese children having metabolic syndrome had significantly higher urinary BPA levels than obese children without metabolic syndrome and both obese groups had considerably elevated levels of urinary BPA than the controls (estimated marginal mean ± standard error: 42.3 ± 7.4 μg/g-creatinine, 22.6 ± 3.5 μg/g-creatinine and 12.1 ± 2.5 μg/g-creatinine, respectively, p=0.0001) Conclusions This study shows much higher BPA exposure among obese children with metabolic syndrome during the prepubertal period.

scholarly journals Peculiarities of cardiac remodeling and myocardial dysfunction in metabolic syndrome

2021 ◽  
Vol 11 (4) ◽  
pp. 52-59
Author(s):  
E. A. Bodrova ◽  
A. R. Babaeva ◽  
M. A. Osadchuk ◽  
K. S. Solodenkova
Keyword(s):  
Metabolic Syndrome ◽  
Diastolic Dysfunction ◽  
Blood Vessels ◽  
Myocardial Dysfunction ◽  
International Diabetes Federation ◽  
Control Group ◽  
Structural Abnormality ◽  
Lv Remodeling ◽  
Lv Diastolic Dysfunction ◽  
And Function

Introduction. In 2016, updated recommendations for echocardiographic diagnosis of diastolic dysfunction were developed. It requires a review of the degree of metabolic syndrome (MS) influence on the heart and blood vessels remodeling and the development of left ventricle (LV) diastolic dysfunction (DD).Purpose. Assessment of the MScontribution to the heart and blood vessels remodeling, as well as to the development of LVDD with an analysis of the LV remodeling types and the degree of LVDD.Materials and methods. The main group: 130 patients with MS (62 (47,7%) — men, 68 (52,3%) — women; average age — 59,8±9,5 years) who underwent in-patient examination and treatment in the cardiology department for arterial hypertension (AH) in 2015-2017. The control group included 36 patients with AH (18 (50%) — men, 18 (50%) — women; average age — 56,0±12,7 years) without abdominal obesity, not meeting the criteria of MS International Diabetes Federation.Results. MS is associated with increased prevalence of adverse LV remodeling and DD. In MS group concentric LV hypertrophy was detected significantly commoner than in group without MS, in which concentric remodeling was the most frequent structural abnormality. Eccentric LV hypertrophy was diagnosed only in pts with so-called complete MS. Moreover DD was detected in all pts with complete MS. Type 2 DD was present predominantly in subgroup with complete MS, reflecting relationship between the degree of LV DD and severity of MS in AH pts.Conclusions. Obtained results confirm adverse influence of central obesity and MS on LV myocardial structure and function.

scholarly journals Prevalence of Metabolic Syndrome in Patients with Psoriasis

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Ilkin Zindancı ◽  
Ozlem Albayrak ◽  
Mukaddes Kavala ◽  
Emek Kocaturk ◽  
Burce Can ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Proinflammatory Cytokines ◽  
Metabolic Diseases ◽  
Fasting Blood Glucose ◽  
International Diabetes Federation ◽  
Control Group ◽  
Peripheral Insulin Resistance ◽  
Arterial Blood

Background. Psoriasis is a chronic inflammatory skin disorder in which proinflammatory cytokines including IL-6 and TNF-αincrease both locally and systematically. It is thought that chronic inflammation results in metabolic diseases and proinflammatory cytokines give rise to the development of atherogenesis, peripheral insulin resistance, hypertension, and type 2 diabetes. Our aim was to investigate the prevalence of metabolic syndrome in patients with psoriasis vulgaris.Methods. Study consisted of 115 plaque-type psoriasis patients and 140 healthy individuals. Data including body weight, height, waist circumference, body-mass index, and arterial blood pressure were collected. Fasting blood glucose, triglyceride, and HDL levels were determined. International Diabetes Federation Criteria for Metabolic Syndrome and Insulin Resistance were used for evaluating patients with metabolic syndrome and diabetes.Results. Compared to the control group, metabolic syndrome, diabetes mellitus, and hypertension were found to be higher in psoriasis patients. Metabolic syndrome was increased by 3-folds in psoriasis patients and was more prevalent in women than in men. It was determined that the prevalence of metabolic syndrome was higher in psoriasis patients after the age of 40. Metabolic syndrome was not related to smoking, severity of psoriasis, and duration of disease.Conclusions. Our findings suggest that psoriasis preconditions occurrence of a group of diseases such as diabetes mellitus, hypertension, and metabolic syndrome. For this reason, patients with psoriasis should be treated early and they should be followed with respect to metabolic diseases.

scholarly journals Predictors of atherosclerosis development in children and adolescents with juvenile arthritis

2015 ◽  
Vol 96 (4) ◽  
pp. 602-609
Author(s):  
L A Balykova ◽  
E S Samoshkina ◽  
A V Krasnopol’skaya ◽  
N V Shchekina ◽  
P A Trupanova
Keyword(s):  
Metabolic Syndrome ◽  
Children And Adolescents ◽  
Metabolic Disorders ◽  
Pulse Therapy ◽  
Juvenile Arthritis ◽  
Control Group ◽  
Healthy Children ◽  
Laboratory Examination ◽  
Disease Modifying ◽  
Atherosclerosis Development

Aim. To study the prevalence of metabolic disorders in children with juvenile arthritis. Methods. A comprehensive clinical and laboratory examination of 82 children and adolescents aged 10-18 years with juvenile idiopathic arthritis and 50 healthy children of the control group was performed. All patients with juvenile arthritis received disease-modifying anti-rheumatic drugs and/or glucocorticoids (intraarticular injections or pulse therapy) and/or biologics. Results. Complete clinical picture of metabolic syndrome (a combination of the two mandatory criteria - hypertension, glucose intolerance or dyslipidemia with increasing waist circumference above the 90th percentile) was found in 30 (36.5%) of 82 patients and was not found in any child from the control group (p

scholarly journals Low Total Testosterone-Component of Metabolic Syndrome

2019 ◽  
Vol 26 (2) ◽  
pp. 145-148
Author(s):  
Prashant Goel ◽  
Amorin R. Popa
Keyword(s):  
Metabolic Syndrome ◽  
International Diabetes Federation ◽  
Mean Value ◽  
Control Group ◽  
Total Testosterone ◽  
Mean Values ◽  
The Metabolic Syndrome ◽  
Rising Incidence ◽  
The Mean ◽  
Definition Of

Abstract Background and aims: To assess the levels of total testosterone in the metabolic syndrome patients. Material and Methods: We included ninety-six patients in our study, forty-nine with metabolic syndrome according to the definition of International Diabetes Federation (IDF) and forty-seven as control. Anthropometric measurements were registered and blood samples were taken after an overnight fast. Results: The mean values of different parameters showed significant differences between both groups. The total testosterone mean value was (338,97±91,2 ng/ml) substantially lower as compared to patients with metabolic syndrome to control group. Conclusion: There is an inverse relationship between total testosterone and metabolic syndrome. Low total testosterone can be a predictor of rising incidence of metabolic syndrome.

scholarly journals Risk factors for the development of metabolic syndrome in obese children and adolescents

2015 ◽  
Vol 143 (3-4) ◽  
pp. 146-152 ◽  
Author(s):  
Nevena Folic ◽  
Marko Folic ◽  
Slavica Markovic ◽  
Marija Andjelkovic ◽  
Slobodan Jankovic
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Gestational Diabetes ◽  
Children And Adolescents ◽  
International Diabetes Federation ◽  
Modern Society ◽  
Control Group ◽  
Obese Children ◽  
Pediatric Clinic ◽  
Increased Risk

Introduction. High prevalence of metabolic syndrome (MetS) in children and adolescents is a great concern of the modern society. Objective. Our aim was to determine the influence of previously investigated, but also and potentially novel risk factors for the development of metabolic syndrome in children and adolescents. Methods. Observational case-control clinical study was conducted involving children and adolescents with obesity/metabolic syndrome, treated on inpatient basis from January 2008 to January 2012 at the Pediatric Clinic of the Clinical Centre Kragujevac, Kragujevac, Serbia. The group of ?cases? (n=28) included patients aged 10-16 years with the diagnosis of metabolic syndrome according to the International Diabetes Federation (IDF) criteria, while the control group included twice as many obese patients (n=56) matched to the compared group. Results. Presence of maternal gestational diabetes (ORadjusted: 39.426; 95% CI: 1.822-853.271; p=0.019), and/or lack of breastfeeding in the first six months of life (ORadjusted: 0.079; 95% CI: 0.009-0.716; p=0.024) were significant predictors for developing MetS. Also, microalbuminuria is associated with MetS in obese children and adolescents (ORadjusted: 1.686; 95% CI: 1.188-2.393; p=0.003). Conclusion. Presence of maternal gestational diabetes and/or lack of infant breastfeeding are considered as relevant factors that may contribute to the increased risk of developing MetS syndrome, while microalbuminuria is frequently associated with MetS in obese children and adolescents.

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