scholarly journals Combined antibiotic prophylaxis of infectious complications of prostate biopsy

2021 ◽  
Vol 22 (3) ◽  
pp. 49-55
Author(s):  
N. A. Grigoryev ◽  
I. I. Abdullin ◽  
B. R. Gvasalia ◽  
A. V. Loginov ◽  
E. V. Zhilyaev
Keyword(s):  
Antibiotic Prophylaxis ◽  
Prostate Biopsy ◽  
Antimicrobial Prophylaxis ◽  
Average Length ◽  
Infectious Complications ◽  
Fluoroquinolone Resistance ◽  
Single Shot ◽  
Average Length Of Stay ◽  
Transrectal Prostate Biopsy ◽  
Fosfomycin Trometamol

Introduction. Biopsy of prostate is a routine urologic procedure. Nevertheless the frequency of infectious-inflammatory complications remain high, despite the recommended antibiotic prophylaxis schemes.Purpose. The evaluation of effectiveness and safety of combined antimicrobial prophylaxis: fosfomycin trometamol and fluoroquinolones of 3rd generation.Materials and methods. Our clinical study included 80 patients who underwent prostate biopsy were divided into 2 groups. The first group of 40 patients received routine prophylaxis: levofloxacin 500 mg 6 h before the biopsy and 500 mg per day during 4 days after biopsy. The second group of 40 patients, along with standard prophylaxis as in the first group, additionally after biopsy received fosfomycin trometamol 3 gr single-shot.Results. In the first group, infectious and inflammatory complications occurred in 8 (20 %) patients, 12.5 % of patients from the first group were hospitalized for parenteral antibiotic therapy. The average length of stay in hospital was 3.4 ± 1.45 days. In all cases, in the first group of patients, Escherichia coli was detected, in 70 % of cases fluoroquinolone-resistant strain of the bacterium was received. In the second group of patients no hospitalization was required. One (2.5 %) patient out of forty from this group showed signs of urinary tract infection, which was not accompanied by an increase of body temperature, as well as changes in blood and urine tests.Conclusions. Our results show good effectiveness and safety of combined antibiotic prophylaxis for transrectal prostate biopsy. Since fluoroquinolone resistance grows, it is necessary to introduce alternative schemes, as well as monitoring of nosocomial infection and controlling of antimicrobial therapy.

scholarly journals Prevalence, Risk Factors, and Clinical Relevance of Fluoroquinolone-Resistant Organisms in Rectal Cultures: Should We Target Antibiotic Prophylaxis Prior to Prostate Biopsy?

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
J. Van Besien ◽  
P. Uvin ◽  
A. M. Van den Abeele ◽  
L. Merckx
Keyword(s):  
Antibiotic Prophylaxis ◽  
Prostate Biopsy ◽  
Infectious Complications ◽  
Fluoroquinolone Resistance ◽  
Resistant Bacteria ◽  
Confounding Variables ◽  
Transrectal Prostate Biopsy ◽  
Patients At Risk ◽  
Resistance Rates ◽  
Targeted Approach

The rise of infectious complications after prostate biopsy has been linked to the growing resistance of enterobacteria to fluoroquinolone (FQ) antibiotics. In this review, we investigated the potential benefit of targeted antibiotic prophylaxis based on rectal cultures prior to prostate biopsy. An electronic search for all related literature published in English was performed from April until June 2015 using the MEDLINE and EMBASE databases. Data were obtained regarding the true prevalence of FQ-resistant bacteria in the rectum of patients, the identification of those patients at risk of harbouring FQ-resistant bacteria, the risk of infectious complications after transrectal prostate biopsy in patients with FQ-resistant bacteria, and the effect of targeted prophylaxis. Although there is limited evidence that a targeted approach might be beneficial, we conclude that current studies on the use of rectal cultures in the prebiopsy setting have too many limitations and confounding variables to definitely accept this approach in clinical practice. Whether this methodology is useful in a certain region will greatly depend on local fluoroquinolone-resistance rates.

scholarly journals Options for antibacterial prophylaxis of infectious complications of prostate biopsy

2021 ◽  
Vol 14 (3) ◽  
pp. 150-155
Author(s):  
S.V. Popov ◽  
◽  
I.N. Orlov ◽  
D.Yu. Chernysheva ◽  
T.M. Topuzov ◽  
...  
Keyword(s):  
Antibiotic Prophylaxis ◽  
Prostate Biopsy ◽  
Clinical Guidelines ◽  
Urine Culture ◽  
Infectious Complications ◽  
Antibacterial Prophylaxis ◽  
Scientific Databases ◽  
Transrectal Prostate Biopsy ◽  
Long Time ◽  
Transperineal Biopsy

Introduction. Amount of prostate biopsy procedures rises every year and up to 95% of cases of prostate biopsy is performed via transrectal approach. The incidence of infectious complications of transrectal prostate biopsy reaches up to 17%, while incidence of such complications of transperineal biopsy is about 1%. The majority of international clinical guidelines recommends for obligatory antibiotic prophylaxis prior to prostate biopsy of any approach, but the choice of antibiotic is still debatable. The aim of this review is to sum up the approaches of international urological guidelines to the antibiotic prophylaxis prior to prostate biopsy. Materials and methods. We analyzed the search results in the scientific databases PubMed, Google Scolar, elibrary.ru for the queries «prostate biopsy», «antibacterial prophylaxis» and «guidelines». Results. According to the recommendations of most professional communities, antibacterial prophylaxis of infectious complications of prostate biopsy can be carried out in various ways - once or for a long time, one- or two-component, empirically or on the basis of urine culture on microflora. Conclusion. Despite the differences in the levels of sensitivity and resistance of coliform flora around the world, the clinical guidelines in most countries are uniform in terms of the choice of drugs to reduce the risk of developing infectious complications after prostate biopsy. Approaches to antibacterial prophylaxis after prostate biopsy differ only depending on the type of biopsy access.

scholarly journals The molecular mechanisms of fluoroquinolone resistance found in rectal swab isolates of Enterobacterales from men undergoing a transrectal prostate biopsy: the rationale for targeted prophylaxis

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Katarzyna Piekarska ◽  
Katarzyna Zacharczuk ◽  
Tomasz Wołkowicz ◽  
Mateusz Mokrzyś ◽  
Natalia Wolaniuk ◽  
...  
Keyword(s):  
Prostate Biopsy ◽  
Molecular Mechanisms ◽  
Transrectal Ultrasound ◽  
Infectious Complications ◽  
Quinolone Resistance ◽  
Fluoroquinolone Resistance ◽  
Oral Antibiotic ◽  
E Coli ◽  
Transrectal Prostate Biopsy ◽  
The Common

Abstract Background Transrectal ultrasound-guided prostate biopsy (TRUS-Bx) is considered an essential urological procedure for the histological diagnosis of prostate cancer. It is, however, considered a “contaminated” procedure which may lead to infectious complications. Recent studies suggest a significant share of fluoroquinolone-resistant rectal flora in post-biopsy infections. Methods The molecular mechanisms of fluoroquinolone resistance, including PMQR (plasmid-mediated quinolone resistance) as well as mutation in the QRDRs (quinolone-resistance determining regions) of gyrA, gyrB, parC and parE, among Enterobacterales isolated from 32 of 48 men undergoing a prostate biopsy between November 2015 and April 2016 were investigated. Before the TRUS-Bx procedure, all the patients received an oral antibiotic containing fluoroquinolones. Results In total, 41 Enterobacterales isolates were obtained from rectal swabs. The MIC of ciprofloxacin and the presence of common PMQR determinants were investigated in all the isolates. Nine (21.9%) isolates carried PMQR with qnrS as the only PMQR agent detected. DNA sequencing of the QRDRs in 18 Enterobacterales (E. coli n = 17 and E. cloacae n = 1) isolates with ciprofloxacin MIC ≥ 0.25 mg/l were performed. Substitutions in the following codons were found: GyrA—83 [Ser → Leu, Phe] and 87 [Asp → Asn]; GyrB codon—605 [Met → Leu], ParC codons—80 [Ser → Ile, Arg] and 84 [Glu → Gly, Met, Val, Lys], ParE codons—458 [Ser → Ala], 461 [Glu → Ala] and 512 [Ala → Thr]. Six isolates with ciprofloxacin MIC ≥ 2 mg/l had at least one mutation in GyrA together with qnrS. Conclusions This study provides information on the common presence of PMQRs among Enterobacterales isolates with ciprofloxacin MIC ≥ 0.25 mg/l, obtained from men undergoing TRUS-Bx. This fact may partially explain why some men develop post-TRUS-Bx infections despite ciprofloxacin prophylaxis.

Rectal culture-directed antibiotic prophylaxis before transrectal prostate biopsy: Reduced infectious complications and healthcare costs

2018 ◽  
Vol 42 (7) ◽  
pp. 465-472
Author(s):  
J.V. Baldissera-Aradas ◽  
L. Rodríguez-Villamil ◽  
R. Blanco-Fernández ◽  
C. Pérez-García ◽  
G. Viejo de la Guerra ◽  
...  
Keyword(s):  
Antibiotic Prophylaxis ◽  
Prostate Biopsy ◽  
Healthcare Costs ◽  
Infectious Complications ◽  
Transrectal Prostate Biopsy

scholarly journals Impact of Rectal Swabs on Infectious Complications after Transrectal Prostate Biopsy

2016 ◽  
Vol 97 (3) ◽  
pp. 340-346 ◽  
Author(s):  
Carlos Gustavo Trujillo ◽  
Mauricio Plata ◽  
Juan Ignacio Caicedo ◽  
Juan Guillermo Cataño Cataño ◽  
Angela Marcela Mariño Alvarez ◽  
...  
Keyword(s):  
Prostate Biopsy ◽  
Infectious Complications ◽  
Rectal Swabs ◽  
Transrectal Prostate Biopsy

scholarly journals Antimicrobial prophylaxis and febrile complication of transrectal prostate biopsy in Taipei TZU Chi Hospital

2016 ◽  
Vol 27 (2) ◽  
pp. S39
Author(s):  
Chun-Kai Hsu ◽  
Shang-Jen Chang ◽  
Chia-Da Lin ◽  
Stephen S. Yang
Keyword(s):  
Prostate Biopsy ◽  
Antimicrobial Prophylaxis ◽  
Transrectal Prostate Biopsy

scholarly journals Hepatitis C Transmission after Prostate Biopsy

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Karim Ferhi ◽  
Morgan Rouprêt ◽  
Pierre Mozer ◽  
Guillaume Ploussard ◽  
Alain Haertig ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antibiotic Prophylaxis ◽  
Prostate Biopsy ◽  
Viral Transmission ◽  
Risk Of Infection ◽  
Ultrasound Probe ◽  
Transrectal Prostate Biopsy ◽  
A Current

Prostate biopsy is a current and well-codified procedure; antibiotic prophylaxis and rectal enema limit the risk of infection. To date, there has been no reported viral transmission between patients due to a contaminated ultrasound probe. In this study, we report the case of a patient who contracted the hepatitis C virus after transrectal prostate biopsy as part of an individual screening for prostate cancer.

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