scholarly journals A study on prevalence of various mood disorders in patients with multiple sclerosis in South Indian population Chennai, Tamil Nadu

2021 ◽  
Author(s):  
Sivaji Murugaiyan ◽  
Akshaya Rathin Sivaji ◽  
A. Marian Jude Vijay ◽  
Indumathi Sundaramurthi ◽  
Jawahar Marimuthu
Keyword(s):  
Multiple Sclerosis ◽  
Mood Disorders ◽  
Tamil Nadu ◽  
Pervasive Developmental Disorders ◽  
Developmental Disorders ◽  
Depressive Disorders ◽  
Rating Scale ◽  
South Indian Population ◽  
Multiple Sclerosis Patients ◽  
Depressive Episodes

Background: The prevalence of depressive disorders are more common in demyelination diseases like multiple sclerosis. Patients with multiple sclerosis have higher rates of depressive episodes than the general population. It is found that 40-50% incidence reported in many number of previous research studies .The aim is to study the prevalence of various depressive disorders in multiple sclerosis (MS) patient population.Methods: 176 MS patients were randomly selected from neurology outpatient department (OPD) of Tamil Nadu Government Multi Super Specialty Hospital and Rajiv Gandhi Government General Hospital, Chennai, Tamil Nadu, from September 2018 to December 2019. 128 patients were analyzed with the following methods of examinations such as the structured psychiatric clinical interview with diagnostic and statistical manual of mental disorders (DSM)-5 and international classification of diseases (ICD)-10 criteria, Hamilton depression rating scale (HAM-D) scale.Results: Various subtypes of mood disorders were found as follows major depressive disorder (MDD)-4%, MDD with anxiety-6%, pervasive developmental disorders (PDD) mixed-4%, premenstrual dysphoric disorder (PMDD)-8%, MIDD-2% and depressive disorders due to general medical conditions (secondary depression)-22%. In this present study 46% of the MS population were diagnosed with various depressive illness.Conclusions: Early identification and treatment of depressive disorders definitely favour the outcome of MS patients. The coping skills and good social support system play a vital role in the outcome of depressive disorders in MS population in addition to psychopharmacological management. 

Plasma redox and inflammatory patterns during major depressive episodes: a cross-sectional investigation in elderly patients with mood disorders

CNS Spectrums ◽  
2020 ◽  
pp. 1-11
Author(s):  
Barbara Carpita ◽  
Laura Betti ◽  
Lionella Palego ◽  
Natalia Bartolommei ◽  
Lucia Chico ◽  
...  
Keyword(s):  
Mood Disorders ◽  
Daily Living ◽  
Suicide Ideation ◽  
Rating Scale ◽  
Glutathione Transferase ◽  
Redox Systems ◽  
Cross Sectional ◽  
Antioxidant Power ◽  
Major Depressive Episodes ◽  
Depressive Episodes

Abstract Background. While both depression and aging have been associated with oxidative stress and impaired immune response, little is known about redox patterns in elderly depressed subjects. This study investigates the relationship between redox/inflammatory patterns and depression in a sample of elderly adults. Methods. The plasma levels of the advanced products of protein oxidation (AOPP), catalase (CAT), ferric reducing antioxidant power (FRAP), glutathione transferase (GST), interleukin 6 (IL-6), superoxide dismutase (SOD), total thiols (TT), and uric acid (UA) were evaluated in 30 patients with mood disorders with a current depressive episode (depressed patients, DP) as well as in 30 healthy controls (HC) aged 65 years and over. Subjects were assessed with the Hamilton Depression Rating Scale (HAM-D), the Hamilton Rating Scale for Anxiety (HAM-A), the Geriatric Depression Rating Scale (GDS), the Scale for Suicide Ideation (SSI), the Reason for Living Inventory (RFL), the Activities of Daily Living (ADL), and the Instrumental Activity of Daily Living (IADL). Results. DP showed higher levels than HC of AOPP and IL-6, while displaying lower levels of FRAP, TT, and CAT. In the DP group, specific correlations were found among biochemical parameters. SOD, FRAP, UA, and TT levels were also significantly related to psychometric scale scores. Conclusion. Specific alterations of redox systems are detectable among elderly DP.

Resilience and attempted suicide in depressed patients

2017 ◽  
Vol 41 (S1) ◽  
pp. s887-s887
Author(s):  
E. Gattoni ◽  
C. Gramaglia ◽  
D. Marangon ◽  
A. Feggi ◽  
C. Delicato ◽  
...  
Keyword(s):  
Coping Strategies ◽  
Clinical Characteristics ◽  
Depressive Disorders ◽  
Attempted Suicide ◽  
Suicide Ideation ◽  
Rating Scale ◽  
Suicide Attempts ◽  
Depressed Patients ◽  
Resilience Scale ◽  
Depressive Episodes

IntroductionAmong the patients, 6.6% with past-year major depressive disorders attempt suicide in their life. Resilience (the ability to respond positively to adversity) and coping strategies (the ability to manage living stresses) may be protective factors against suicide ideation and behavior. A study conducted on 100 abstinent substance dependent patients suggested that suicide attempters had significantly lower resilience scale scores. Other authors demonstrated that intrinsic religiosity, resilience, quality of life were associated with previous suicide attempts in depressed patients.AimTo examine the correlation among resilience, coping strategies and sociodemographic and clinical characteristics in depressed patients.MethodsFrom December 1st 2014 to December 31st 2015 we recruited inpatients and outpatients aged > 18 years with a diagnosis of depression (current or past). At baseline, patients were assessed with Montgomery Asberg Depression Rating Scale, Resilience Scale for Adult and Brief-COping with problems experienced; sociodemographic and clinical characteristics were gathered. Follow-up was conducted after 1 year in order to assess the possible presence of further depressive episodes and suicide attempts. Analysis was performed with SPSS.Results and discussionData collection are still ongoing; results and implications will be discussed. We expect to find higher attempted suicide rates in patients with lower resilience and less coping strategies.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Could Hypomanic Traits Explain Selective Migration? Verifying the Hypothesis by the Surveys on Sardinian Migrants

2012 ◽  
Vol 8 (1) ◽  
pp. 175-179 ◽  
Author(s):  
Carta MG ◽  
Moro MF ◽  
Kovess V ◽  
Brasesco MV ◽  
Bhat KM ◽  
...  
Keyword(s):  
Systematic Review ◽  
High Risk ◽  
Mood Disorders ◽  
Depressive Disorders ◽  
Self Esteem ◽  
Economic Conditions ◽  
Host Countries ◽  
Selective Migration ◽  
The People ◽  
Depressive Episodes

Introduction: A recent survey put forward the hypothesis that the emigration that occurred from Sardinia from the 1960’s to the 1980’s, selected people with a hypomanic temperament. The paper aims to verify if the people who migrated from Sardinia in that period have shown a high risk of mood disorders in the surveys carried out in their host countries, and if the results are consistent with this hypothesis. Methods: This is systematic review. Results: In the 1970’s when examining the attitudes towards migration in Sardinian couples waiting to emigrate, Rudas found that the decision to emigrate was principally taken by males. Female showed lower self-esteem than male emigrants. A study on Sardinian immigrants in Argentina carried out in 2001-02, at the peak of the economic crisis, found a high risk of depressive disorders in women only. These results were opposite to the findings recorded ten years earlier in a survey on Sardinian immigrants in Paris, where the risk of Depressive Episode was higher in young men only. Discussion: Data point to a bipolar disorder risk for young (probably hypomanic) male migrants in competitive, challenging conditions; and a different kind of depressive episodes for women in trying economic conditions. The results of the survey on Sardinian migrants are partially in agreement with the hypothesis of a selective migration of people with a hypomanic temperament. Early motivations and self-esteem seem related to the ways mood disorders are expressed, and to the vulnerability to specific triggering situations in the host country.

scholarly journals Network Analysis of the Symptoms of Depressive Disorders Over the Course of Therapy: Changes in Centrality Measures

2021 ◽  
Vol 18 (1) ◽  
pp. 48-58
Author(s):  
Seon-Cheol Park ◽  
Yaeseul Kim ◽  
Kiwon Kim ◽  
Young Sup Woo ◽  
Jung-Bum Kim ◽  
...  
Keyword(s):  
Network Analysis ◽  
Depressive Disorders ◽  
Rating Scale ◽  
Initial Period ◽  
Centrality Measures ◽  
Clinical Research Center ◽  
Hamd Score ◽  
First Onset ◽  
Using Data ◽  
Depressive Episodes

Objective Network analysis can be used in terms of a novel psychopathological approach for depressive syndrome. We aimed to estimate the successive network structures of depressive symptoms in patients with depressive disorder using data from the Clinical Research Center for Depression study.Methods We enrolled 1,152 South Korean adult patients with depressive disorders who were beginning treatment for first-onset or recurrent depressive episodes. We examined the network structure of the severities of the items on the Hamilton Depression Rating Scale (HAMD) at baseline and at weeks 2, 12, 25, and 52. The node strength centrality of all the HAMD items at baseline and at week 2, 12, 25, and 52 in terms of network analysis.Results In the severity networks, the anxiety (psychic) item was the most centrally situated in the initial period (baseline and week 2), while loss of weight was the most centrally situated item in the later period (weeks 25 and 52). In addition, the number of strong edges (i.e., edges representing strong correlations) increased in the late period compared to the initial period.Conclusion Our findings support a period-specific and symptom-focused therapeutic approach that can provide complementary information to the unidimensional total HAMD score.

scholarly journals Association of maternal developmental disorder traits with child maltreatment

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
T Fujiwara
Keyword(s):  
Child Maltreatment ◽  
Pervasive Developmental Disorders ◽  
Developmental Disorders ◽  
Adult Adhd ◽  
Developmental Disorder ◽  
Rating Scale ◽  
Self Report ◽  
Linear Regression Models ◽  
Maternal Characteristics ◽  
Child Mistreatment

Abstract Objective Maternal mental disorders are known risk factors for child mistreatment. However, little is known about the involvement of maternal developmental disorder traits. The aim of this study was to examine maternal traits related to Pervasive Developmental Disorder (PDD) and Attention Deficit Hyperactivity Disorder (ADHD), and their possible association with child maltreatment. Methods Maternal PDD and ADHD were assessed through a self-administered questionnaire (N = 846) during mid-pregnancy using the Pervasive Developmental Disorders Autism Society Japan Rating Scale (PARS) and Adult ADHD Self-Report Scale (ASRS). The mothers completed another questionnaire on child mistreatment when the offspring was approximately 18 months of age. The associations between maternal PDD and ADHD traits and child maltreatment score were analyzed using linear regression models adjusted for covariates. Results Mothers who exhibited stronger PDD traits showed significantly higher child maltreatment score, even after adjustment for maternal characteristics at baseline and ADHD traits. At the same time, ADHD traits were significantly associated with child maltreatment after adjustment of covariates, although the association became non-significant after adjustment of PDD traits. Conclusions Mothers who showed PDD and ADHD traits during pregnancy were more likely to maltreat their children. It is essential to educate mothers with such traits with appropriate, easy-to-follow childcare instructions, preferably in simple language combined with pictorial aids. Key messages Maternal developmental disorder traits are risk factor of child maltreatment. Specific parenting training intervention for mothers with developmental disorders are needed.

Long-term emotional state of multiple sclerosis patients treated with interferon beta

2006 ◽  
Vol 12 (6) ◽  
pp. 802-807 ◽  
Author(s):  
J Porcel ◽  
J Río ◽  
A Sánchez-Betancourt ◽  
M J Arévalo ◽  
M Tintoré ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Depressive Symptoms ◽  
Psychological Assessment ◽  
Interferon Beta ◽  
Rating Scale ◽  
Emotional State ◽  
Emotional Assessment ◽  
Multiple Sclerosis Patients

Objective: To assess the long-term emotional state of multiple sclerosis (MS) patients treated with interferon beta (IFNβ) for at least four years. Methods: Patients who had started IFNβ therapy prior to 2000 with a baseline psychological assessment were identified and scheduled for long-term emotional assessment with the following questionnaires-the Hamilton Depression Rating Scale, the Beck Depression Inventory and the State-Trait Anxiety Inventory. Results: A total of 262 patients started IFNβ therapy in our MS clinic within the period 1995-1999. Baseline emotional assessment was available from 246 MS patients. Long-term assessment was conducted on 234 patients. After a mean follow-up of 65 months (43-98), 52 patients (22.3%) had withdrawn from IFNβ therapy. The comparisons, obtained from baseline and follow-up scores, showed an improvement in the depressive and anxiety symptoms of patients who adhered to IFNβ treatment. Logistic regression analysis indicated that an increase in physical disability and the presence of depressive symptoms at baseline were best predictors for long-term depressive symptoms. Conclusions: The present results support the absence of emotional worsening in MS patients treated with IFNβ for a long period of time. Increased disability and the presence of baseline depressive symptoms predicted the presence of depressive symptoms at follow-up.

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